Patents Assigned to University of Washington
  • Speech detection using image classification
    Patent number: 12073837
    Abstract: Speech detection can be achieved by identifying a speech segment within an audio segment using image classification. An audio segment of radio communications is obtained. An audio sub-segment within the audio segment is extracted. A sampled histogram is generated of a plurality of sampled values across a sampled time window of the audio sub-segment. A two-dimensional image is generated that represents a two-dimensional mapping of the sampled histogram along a first dimension and a predefined histogram along a second dimension that is orthogonal to the first dimension. The two-dimensional image is provided to an image classifier previously trained using the predefined histogram. An output is received from the image classifier based on the two-dimensional image. The output indicates whether the audio sub-segment contains speech.
    Type: Grant
    Filed: June 7, 2022
    Date of Patent: August 27, 2024
    Assignees: The Boeing Company, University of Washington
    Inventors: Stephen Gregory Dame, Les Eugene Atlas
  • COMPOSITIONS AND METHODS FOR FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY BIOMARKER DETECTION
    Publication number: 20240280590
    Abstract: Methods and compositions for diagnosing or detecting Facioscapulohumeral Dystrophy (FSHD) are provided. One aspect provides a method for the evaluation of risk, progression, and therapeutic response of FSHD in human subjects. The method includes measuring/detecting an overall expression pattern or expression level of neutrophil extracellular traps (NETs) in one or more biological samples obtained from the subject and comparing the measured levels of these NETs to overall expression pattern or level of the neutrophil extracellular traps (NETs) from a biological sample of a normal subject. The method further comprises detecting the expression level of a mitochondrial protein in the one or more biological samples of the subject.
    Type: Application
    Filed: February 20, 2024
    Publication date: August 22, 2024
    Applicant: University of Washington
    Inventors: Joel R. Chamberlain, Jan Christian Lood
  • ZWITTERIONIC COPOLYMER COATINGS AND RELATED METHODS
    Publication number: 20240279504
    Abstract: Zwitterionic carboxybetaine copolymers and their use in coatings to impart non-fouling and functionality to surfaces, particularly surfaces of blood-contacting medical devices.
    Type: Application
    Filed: September 12, 2023
    Publication date: August 22, 2024
    Applicant: University of Washington
    Inventors: Shaoyi Jiang, Xiaojie Lin, Jonathan Himmelfarb, Buddy D. Ratner
  • COMPLEX CLIPPING FOR IMPROVED GENERALIZATION IN MACHINE LEARNING
    Publication number: 20240281639
    Abstract: Provided is a method including obtaining time-series data; computing a transform of the time-series data; performing, with a complex clipping algorithm, a complex clipping operation of the transform of the time-series data to obtain a clipped data representation of the transform; classifying, using a classifier, the time-series data based on the clipped data representation; and storing a result of the classifying in memory.
    Type: Application
    Filed: February 22, 2024
    Publication date: August 22, 2024
    Applicants: The Covid Detection Foundation d/b/a Virufy, University of Washington, Stanford University
    Inventors: Les Atlas, Ankit Virmani, Nicholas R. Rasmussen, Mert Pilanci, Felix Schwock
  • Ultrasound system for shearing cellular material
    Patent number: 12066362
    Abstract: A system for processing biological or other samples includes an array of transducer elements that are positioned to align with sample wells in a microplate. Each transducer element produces ultrasound energy that is focused towards a well of the microplate with sufficient acoustic pressure to cause inertial cavitation. In one embodiment, the transducers are configured to direct ultrasound energy into cylindrical wells. In other embodiments, the transducer elements are configured to direct ultrasound energy into non-cylindrical wells of a microplate.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: August 20, 2024
    Assignee: University of Washington
    Inventors: Thomas J. Matula, Karol Bomsztyk, Brian MacConaghy, Justin Reed, Adam D. Maxwell
  • Metasurfaces for full-color imaging
    Patent number: 12061347
    Abstract: Metasurfaces and systems including metasurfaces for imaging and methods of imaging are described. Such metasurfaces may be formed on a substrate from a plurality of posts. The metasurfaces are configured to be optically active over a wavelength range and in certain embodiments are configured to form lenses. In particular, the metasurfaces described herein may be configured to focus light passed through the metasurface in an extended depth of focus. Accordingly, the disclosed metasurfaces are generally suitable for generating color without or with minimal chromatic aberrations, for example, in conjunction with computational reconstruction.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: August 13, 2024
    Assignee: University of Washington
    Inventors: Shane Colburn, Alan Zhan, Arka Majumdar
  • THAWING OF CRYOPRESERVED MATERIALS USING AUTOMATIC SINGLE-MODE ELECTROMAGNETIC RESONANCE
    Publication number: 20240260568
    Abstract: An example method for rewarming a cryopreserved material includes identifying a parameter indicating a state of a container enclosing a single-mode electromagnetic field. The method further includes maintaining the single-mode electromagnetic field by adjusting, based on the parameter, a frequency and/or a power of the electromagnetic waves.
    Type: Application
    Filed: May 26, 2022
    Publication date: August 8, 2024
    Applicant: University of Washington
    Inventors: Dayong Gao, Shaohang Hao, Ye Jin, Ruidong Ma, Shen Zen, Zhiquan Shu, Ziyuan Wang, Ming Chen
  • CHROMOPHORIC POLYMER DOTS WITH NARROW-BAND EMISSION
    Publication number: 20240254288
    Abstract: Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.
    Type: Application
    Filed: May 15, 2023
    Publication date: August 1, 2024
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Daniel T. Chiu, Changfeng Wu, Yu Rong, Yong Zhang, Yi-Che Wu, Yang-Hsiang Chan, Xuanjun Zhang, Jiangbo Yu, Wei Sun
  • Methods and kits for labeling cellular molecules
    Patent number: 12043864
    Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
    Type: Grant
    Filed: January 24, 2023
    Date of Patent: July 23, 2024
    Assignee: University of Washington
    Inventors: Georg Seelig, Richard Muscat, Alexander B. Rosenberg
  • DIALYSIS SYSTEM INCORPORATING A TOXIN-REMOVAL LOOP
    Publication number: 20240238493
    Abstract: A protected fluid circuit can utilize osmotic membranes or other membrane types that are highly selective to urea transport. The membranes can achieve sufficient diffusional flux of urea in a forward osmosis geometry. When combined with a oxidation unit, this protected geometry can have a high selective flux of urea from the spent dialysate side to the urea removal side; balance of fluid (water) levels in patients by forward osmotic flow by controlling water evaporation rate through an vapor permeable membrane; protection of patient dialysate/blood loop from oxidation by-products; and an ability to optimize oxidation system performance (pH, ionic strength, other electrolytes, etc.) that would be otherwise incompatible with blood contact.
    Type: Application
    Filed: April 4, 2022
    Publication date: July 18, 2024
    Applicant: University of Washington
    Inventors: Guozheng SHAO, Bruce J. Hinds
  • Ultrasensitive capacitive sensor composed of nanostructured electrodes
    Patent number: 12038309
    Abstract: A capacitive sensor including an electrically conductive material, and a single electrode applied with positive potential, wherein the distance between the single electrode and the electrically conductive material determines the spherical radius for a proximity sensing range.
    Type: Grant
    Filed: December 29, 2022
    Date of Patent: July 16, 2024
    Assignee: University of Washington
    Inventors: Jae-Hyun Chung, Sang-Gyeun Ahn, Tianyi Li, Zhongjie Qian, Vigneshwar Sakthivelpathi
  • SPENT COFFEE GROUND BIOCHAR, RELATED METHODS OF MAKING, ENVIRONMENTAL REMEDIATION SYSTEMS, AND METHODS OF REMOVING CONTAMINANTS FROM SOLUTION
    Publication number: 20240228327
    Abstract: A method of producing biochar from spent coffee grounds, biochar, such as biochar produced according to the methods of the present disclosure, an environmental remediation system including biochar according to embodiments of the present disclosure, and methods of removing contaminants from an aqueous solution using biochar according to embodiments of the present disclosure are described. In an embodiment, the method of producing biochar from spent coffee grounds comprises heating dried spent coffee grounds in an oven in a first pyrolysis temperature range to provide an intermediate biochar; and heating the intermediate biochar and a caustic in the oven in a second pyrolysis temperature range to provide the biochar.
    Type: Application
    Filed: October 27, 2021
    Publication date: July 11, 2024
    Applicant: University of Washington
    Inventors: Jessica Ray, Jessica Steigerwald
  • ANTIBODIES THAT BIND THE TUMOR (T) ANTIGEN OF MERKEL CELL POLYOMAVIRUS AND RELATED DIAGNOSTICS
    Publication number: 20240226257
    Abstract: Antibodies that bind the tumor (T) antigen of the Merkel cell polyomavirus are disclosed. The antibodies can be use used in cell-based immunotherapies, antibody-based therapies, diagnostics, and detection assays, among other uses.
    Type: Application
    Filed: October 23, 2023
    Publication date: July 11, 2024
    Applicants: Fred Hutchinson Cancer Center, University of Washington
    Inventors: Justin J. Taylor, Denise Galloway, Paul Nghiem, David Koelle, Haroldo Rodriguez, Joseph Carter
  • OXIDIZED NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD+) PRECURSOR TREATMENT FOR HEART FAILURE ALLEVIATION INDEPENDENT OF MITOCHONDRIAL PROTEIN DEACETYLATION
    Publication number: 20240216412
    Abstract: The current disclosure provides provides boosting intracellular NAD+ with nicotinamide riboside chloride (NR) to protect from cardiac dysfunction, NR being a natural NAD+ precursor that bypasses nicotinamide phosphoribosyltransferase (NAMPT) to stimulate intracellular NAD+ synthesis.
    Type: Application
    Filed: November 22, 2023
    Publication date: July 4, 2024
    Applicant: University of Washington
    Inventors: RONG TIAN, MATTHEW WALKER
  • POROUS CUBIC SODIUM YTTRIUM FLUORIDE GELS, SYSTEMS, METHODS, AND MATERIALS THEREOF
    Publication number: 20240217835
    Abstract: Systems, devices, materials, and methods including nanostructured gels are provided. A nanostructured gel includes a primary crystalline phase including cubic sodium yttrium fluoride, a secondary crystalline phase including cubic yttrium fluoride, and an amorphous phase including sodium ions and yttrium fluoride.
    Type: Application
    Filed: April 29, 2022
    Publication date: July 4, 2024
    Applicant: University of Washington
    Inventors: Alexander Bard, Kevin Guesang Lee, Greg Felsted, Vincent Holmberg, Peter Pauzauskie
  • PORTABLE HEMOFILTRATION COMPONENTS, SYSTEMS, AND METHODS
    Publication number: 20240216595
    Abstract: A portable hemopurification system can remove one or more uremic toxins from blood of a patient. The hemopurification system includes a dialyzer with a dialyzing membrane. Blood from a patient is provided to the dialyzer on one side of the dialyzing membrane, and a negative-pressure pump applies negative pressure on the opposite side of the dialyzing membrane to provide ultrafiltration of uremic toxins from the blood. The system includes a replacement fluid line to deliver replacement fluid to the blood. The system includes load cells to measure the replacement fluid flow, effluent flow, and returned blood flow. The systems uses the fluid weights for the control of pumps to provide stable flow through the system.
    Type: Application
    Filed: May 3, 2022
    Publication date: July 4, 2024
    Applicant: University of Washington
    Inventors: Shen Ren, Dayong Gao, Ye Jin
  • Methods and compositions for activation of innate immune responses through RIG-I like receptor signaling
    Patent number: 12023375
    Abstract: Compositions and methods are provided that enable activation of innate immune responses through RIG-I like receptor signaling. The compositions and methods incorporate synthetic nucleic acid pathogen associated molecular patterns (PAMPs) that comprise elements initially characterized in, and derived from, the hepatitis C virus genome.
    Type: Grant
    Filed: April 4, 2022
    Date of Patent: July 2, 2024
    Assignee: University of Washington
    Inventors: Michael J. Gale, Jr., Gretja Schnell, Yueh-Ming Loo
  • TECHNIQUES FOR AUTOMATICALLY SEGMENTING OCULAR IMAGERY AND PREDICTING PROGRESSION OF AGE-RELATED MACULAR DEGENERATION
    Publication number: 20240206727
    Abstract: In some embodiments, a computer-implemented method of automatically predicting progression of age-related macular degeneration is provided. An image analysis computing system receives optical coherence tomography data (OCT data). The image analysis computing system determines an optical attenuation coefficient for each pixel of the OCT data to create optical attenuation coefficient data (OAC data) corresponding to the OCT data. The image analysis computing system determines an area exhibiting geographic atrophy based on at least one of the OCT data and the OAC data. The image analysis computing system measures one or more attributes within an adjacent area that is adjacent to the area exhibiting geographic atrophy, and the image analysis computing system determines a predicted enlargement rate based on the one or more attributes within the adjacent area.
    Type: Application
    Filed: April 29, 2022
    Publication date: June 27, 2024
    Applicant: University of Washington
    Inventors: Ruikang K. Wang, Zhongdi Chu
  • ARTIFICIAL REGULATORY CASSETTES FOR MUSCLE-SPECIFIC GENE EXPRESSION
    Publication number: 20240200093
    Abstract: A library of artificial muscle-specific expression cassettes (MSECs) for muscle-specific gene expression is described. Different members of the library can be selected for varied transcription levels in different muscle cell types, for different research or therapeutic purposes. MSECs within the library can be used to develop treatments for muscle-related disorders.
    Type: Application
    Filed: April 7, 2022
    Publication date: June 20, 2024
    Applicant: University of Washington
    Inventors: Jeffrey S. Chamberlain, Stephen D. Hauschka
  • ANALYTE SEQUENCING WITH NANOPORES
    Publication number: 20240201134
    Abstract: Provided herein are methods and systems pertaining to sequencing units of analytes using nanopores. In general, arresting constructs are used to modify an analyte such that the modified analyte pauses in the opening of a nanopore. During such a pause, an ion current level is obtained that corresponds to a unit of the analyte. After altering the modified analyte such that the modified analyte advances through the opening, another arresting construct again pauses the analyte, allowing for a second ion current level to be obtained that represents a second unit of the analyte. This process may be repeated until each unit of the analyte is sequenced. Systems for performing such methods are also disclosed.
    Type: Application
    Filed: January 18, 2024
    Publication date: June 20, 2024
    Applicant: University of Washington
    Inventors: Jens H. Gundlach, Ian M. Derrington, Marcus D. Collins