Abstract: Examples of systems and methods described herein may be used to track a tagged object through a scene. Techniques are described herein to calculate a position of the tag using wireless communication with multiple anchor devices. In some examples, the anchor devices may be self-localizing, e.g., they may dynamically determine their position and relationship to one another. In some examples, position of a tag may be calculated by calculating multiple candidate positions using different localization techniques—such as geometric localization techniques and/or optimization-based techniques. An error may also be identified associated with each candidate position. A final position may be determined for the tag based on the errors associated with the candidate positions (e.g., the candidate position with the smallest error may be utilized as the position, e.g., the determined position, of the tag).
Abstract: A phantom for fibrous tissue, the phantom formed from a precursor solution including about 30-90 wt % of water, acrylamide, and alginate, where the acrylamide and alginate, in combination, are about 10 to 70 wt % of the precursor solution, and where a ratio of acrylamide to alginate is in the range of about 60:40 to about 99:1 w/w.
Abstract: The present disclosure features a protein-polymer conjugate, including a multivalent polymer building block, a stimuli-responsive protein covalently conjugated to the multivalent polymer building block to provide a protein-polymer conjugate, wherein the protein undergoes a modification upon exposure to a predetermined stimulus, and the protein modification triggers a physical and/or chemical response in the protein-polymer conjugate.
Type:
Grant
Filed:
April 30, 2019
Date of Patent:
October 10, 2023
Assignee:
University of Washington
Inventors:
Cole Alexander DeForest, Jared Shadish, Luman Liu
Abstract: Described herein is (4R,7,S)-2-(3-(4-chlorophenyl)ureido)-9-methyl-5,6,7,8-tetrahydro-4H-4,7-epiminocyclohepta[b]thiophene-3-carboxamide mesylate, including crystalline forms and solvates thereof.
Type:
Grant
Filed:
August 31, 2018
Date of Patent:
October 10, 2023
Assignee:
University of Washington
Inventors:
Graham Johnson, Edwin Aret, Alexei Tchesnokov
Abstract: The current disclosure provides recombinant adenoviral vectors and adenoviral genomes that can accommodate or that contain a large transposon payload, for instance a transposon payload of up to 40 kb. The adenoviral vectors and genomes can deliver the large transposon payload into a target genome, for instance for gene therapy.
Type:
Application
Filed:
April 12, 2021
Publication date:
October 5, 2023
Applicants:
Fred Hutchinson Cancer Center, University of Washington
Inventors:
Andre Lieber, Hans-Peter Kiem, Hongjie Wang
Abstract: The present disclosure provides the use of prelithiated hard carbon in the preparation of lean lithium metal anode electrode, the incorporation of the lean lithium metal anode electrode into full cells, and the evaluation of the electrochemical performances in the full cell under practical conditions. A full cell using the prelithiated hard carbon with lean lithium metal anode electrode and a high-capacity cathode can exhibit high energy density, high Coulombic efficiency, and long cycling life.
Type:
Application
Filed:
June 29, 2021
Publication date:
October 5, 2023
Applicant:
UNIVERSITY OF WASHINGTON
Inventors:
Jihui Yang, Yao Liu, Xianyong Wu, Xiaoyu Jiang, Jun Liu
Abstract: Described herein are methods and compositions related to treatments for cancer. Various embodiments relate to the determination of microsatellite instability as a marker for the likelihood of whether a given cancer will respond to certain therapies, including checkpoint inhibitor immunotherapies, and methods of treatment based upon those determinations.
Type:
Application
Filed:
June 23, 2021
Publication date:
October 5, 2023
Applicant:
UNIVERSITY OF WASHINGTON
Inventors:
Stephen J. SALIPANTE, Adam S. WAALKES, Dustin LONG, Ronald HAUSE
Abstract: Nanostructures and nanostructure-based vaccines that display antigens capable of eliciting immune responses to infectious agents such as bacteria, viruses, and pathogens are provided. Some vaccines are useful for preventing or decreasing the severity of infection with an infectious agent, including, for example and without limitation, lyme disease, pertussis, herpes virus, orthomyxovirus, paramyxovirus, pneumovirus, filovirus, flavivirus, reovirus, retrovirus, meningococcus, or malaria. The antigens may be attached to the core of the nanostructure either non-covalently or covalently, including as a fusion protein or by other means. Multimeric antigens may optionally be displayed along a symmetry axis of the nanostructure. Also provided are proteins and nucleic acid molecules encoding such proteins, vaccine compositions, and methods of administration.
Type:
Grant
Filed:
February 28, 2019
Date of Patent:
October 3, 2023
Assignee:
University of Washington
Inventors:
Neil King, David Baker, Lance Stewart, Brooke Fiala, Daniel Ellis, Lauren Carter, Rashmi Ravichandran, George Ueda, Jorge Fallas, Una Nattermann
Abstract: Methods of uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a nucleus, a plurality of nuclei, a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs and/or cDNAs.
Type:
Application
Filed:
April 21, 2023
Publication date:
September 28, 2023
Applicant:
UNIVERSITY OF WASHINGTON
Inventors:
Georg SEELIG, Alexander B. ROSENBERG, Charles ROCO
Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
Type:
Application
Filed:
January 17, 2023
Publication date:
September 21, 2023
Applicant:
University of Washington
Inventors:
Georg Seelig, Richard Muscat, Alexander B. Rosenberg
Abstract: Systems, materials, and methods for making and using in vivo screening and highly parallel tissue grafting assay arrays are described. An implantable assay array may include a biocompatible substrate. The biocompatible substrate may define a number of mutually isolated microcompartments. The number of mutually isolated microcompartments may be determined based at least in part on a size of the implantable assay array. The size of the implantable assay array may be determined based at least in part on a size of an implantation subject.
Type:
Application
Filed:
August 12, 2021
Publication date:
September 21, 2023
Applicant:
UNIVERSITY OF WASHINGTON
Inventors:
Kelly Rose Stevens, Chelsea Fortin, Colleen O'Connor
Abstract: The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.
Type:
Application
Filed:
December 12, 2022
Publication date:
September 14, 2023
Applicants:
Cornell University, University of Washington
Inventors:
Hazel H. Szeto, Peter S. Rabinovitch, Dao-Fu Dai
Abstract: N-oxide and monomers, N-oxide polymers and copolymers, methods for making the N-oxide monomers, polymers, and copolymers, compositions and materials that include N-oxide polymers and copolymers, and methods for using the N-oxide monomers, N-oxide polymers, and N-oxide copolymers.
Type:
Grant
Filed:
June 29, 2018
Date of Patent:
September 12, 2023
Assignee:
UNIVERSITY OF WASHINGTON
Inventors:
Shaoyi Jiang, Priyesh Jain, Jinrong Ma, Bowen Li
Abstract: Methods, devices, and systems for performing digital assays are provided. In certain aspects, the methods, devices, and systems can be used for the detection of nucleic acids and proteins. Also provided are methods, devices, systems, and compositions for improved detection and quantification of target molecules using encoded probes. In certain aspects, the methods, devices, and systems provided herein are useful in multiplexed digital assays. In certain aspects, the methods, devices, and systems can be used for the recognition, detection, and sizing of compartmentalized volumes in a volume. Also provided are compositions and kits suitable for use with the methods and devices of the present disclosure.
Type:
Grant
Filed:
November 1, 2018
Date of Patent:
September 12, 2023
Assignee:
UNIVERSITY OF WASHINGTON
Inventors:
Daniel T. Chiu, Jiangbo Yu, Jason E. Kreutz, Jiasi Wang
Abstract: An apparatus and method for cooling an optical fiber, comprising impinging electromagnetic radiation from a laser on an optical fiber comprising a core, in which the electromagnetic radiation is substantially confined, and a cladding, in thermal communication with the core, configured to provide optically activated cooling of the core via the electromagnetic radiation from the laser.
Type:
Grant
Filed:
January 27, 2021
Date of Patent:
September 12, 2023
Assignee:
University of Washington
Inventors:
Peter J. Pauzauskie, Anupum Pant, Xiaojing Xia, Elena Dobretsova, E. James Davis, Alexander B. Bard, Robert G. Felsted
Abstract: Kits, methods, polypeptides, systems, and non-transitory, machine-readable storage media for detecting a nucleic acid in a sample are described. In an embodiment, the kit comprises a loop primer nucleic acid molecule configured for loop-mediated isothermal amplification (LAMP), the loop primer nucleic acid molecule comprising: a targeting sequence complementary to a target portion of a target nucleic acid sequence; and an adapter sequence; a displacement nucleic acid probe comprising: a fluorophore adapter sequence; and the adapter sequence; and a fluorophore adapter complement nucleic acid molecule complementary to the fluorophore adapter sequence, wherein the fluorophore adapter sequence or the fluorophore adapter complement nucleic acid molecule is coupled to a fluorophore. In an embodiment, the system comprises a thermal subsystem for heating a sample disposed therein, and an optical subsystem for optically excited the sample and detecting light emitted from the sample.
Type:
Application
Filed:
July 9, 2021
Publication date:
August 31, 2023
Applicant:
UNIVERSITY OF WASHINGTON
Inventors:
Enos Kline, Michael Roller, Robert G. Atkinson, Nuttada Panpradist, Daniel Leon, Ian Hull, Qin Wang, Barry R. Lutz
Abstract: Systems and methods for high frequency epidural stimulation to control sensation are disclosed herein. In one embodiment, a method for restoring physiological function in a subject having a neurological impairment includes generating a stimulation pattern. The stimulation pattern includes pulses at a first frequency, where the pulses of the stimulation pattern are modulated by a modulation pattern at a second frequency. The second frequency is higher than the first frequency. The method also includes stimulating a region of the spinal cord with the stimulation pattern via one or more electrodes.
Type:
Application
Filed:
June 2, 2021
Publication date:
August 31, 2023
Applicants:
UNIVERSITY OF WASHINGTON
Inventors:
Chet T. MORTIZ, Abed KHORASANI, Soshi SAMEJIMA, Nicholas TOLLEY
Abstract: The present disclosure describes simple, stable, and scalable antiviral therapeutic agent compositions that transform short-acting antiviral (e.g., anti-HIV) therapeutic agents that would otherwise require daily short-acting oral administration into long-acting injectable forms that lasts for many weeks per administration. A mixture of water-soluble and water-insoluble antiviral therapeutic agents can be present in the long-acting and drug-combination composition.
Abstract: This document provides methods and materials for expanding antigen-specific T cells (e.g., antigen-specific CD4+ T cells and/or antigen-specific CD8+ T cells) in culture. For example, methods and materials for performing a polyclonal stimulation step for a particular duration (e.g., from about 1 hour to about 48 hours) to increase the expansion of T cells having a desired antigen specificity are provided.
Type:
Grant
Filed:
April 14, 2020
Date of Patent:
August 29, 2023
Assignees:
Mayo Foundation for Medical Education and Research, University of Washington
Inventors:
Peter A. Cohen, Sandra J. Gendler, Latha B. Pathangey, Dustin B. McCurry, Jessica E. Gorman, Mary L. Disis