Abstract: A kit for detection of an analyte of interest in a liquid sample, and methods of using, are provided. The kit may include a pipette and a disposable pipette tip configured to engage the pipette. The pipette tip may define an acoustic channel configured for allowing flow-through of a liquid. The kit may also include a vibratory device in communication with the acoustic channel and configured for imparting a vibratory force thereto. The impartation of the vibratory force may create standing acoustic waves, thereby separating any negative acoustic contrast particles (NACPs) from the remaining contents of the liquid sample. The NACPs may capable of biospecific recognition of the analyte of interest, thereby separating the analytes of interest, which can then be collected or analyzed accordingly.
Abstract: Described are a genetically modified microorganism and corresponding methods and products. The genetically modified microorganism may include a first gene that encodes an acyl transferase and a second gene that encodes a peptide or protein. One or both of the first and second gene may be heterologous. The genetically modified microorganism may include a modified acyl-CoA biosynthetic pathway configured for one or more of: inducible biosynthesis of an acyl-CoA and over-accumulation of the acyl-CoA. The genetically modified microorganism may be effective upon fermentation to cause acylation of the peptide or protein by the acyl transferase using the acyl-CoA to provide a N-acylated peptide or protein product.
Type:
Grant
Filed:
February 27, 2018
Date of Patent:
November 23, 2021
Assignee:
Duke University
Inventors:
Michael David Lynch, Romel Menacho Melgar
Abstract: According to one embodiment, a structure evaluation system according to an embodiment includes a plurality of sensors, a position locator, and an evaluator. The plurality of sensors detect elastic waves. The position locator locates positions of elastic wave sources by using the elastic waves among the plurality of elastic waves respectively detected by the plurality of sensors having an amplitude exceeding a threshold value determined according to positions of the sources of the plurality of elastic waves and the positions of the plurality of disposed sensors. The evaluator evaluates a deteriorated state of the structure on the basis of results of the position locating of the elastic wave sources which is performed by the position locator.
Type:
Grant
Filed:
August 27, 2019
Date of Patent:
November 23, 2021
Assignees:
Kabushiki Kaisha Toshiba, Kyoto University
Abstract: The present disclosure provides compounds of Formula (I?), Formula (II), and Formula (III). The compounds described herein may useful in treating and/or preventing protozoan infections in a subject in need thereof, treating and/or preventing trypanosomal infections (e.g., Trypanosoma cruzi (T. cruzi) or Trypanosoma brucei infections) and/or plasmodial infections in a subject in need thereof, treating and/or preventing diseases in a subject in need thereof (e.g., Chagas disease, malaria, and/or sleeping sickness), and may be useful in treating and/or preventing infectious diseases in a subject in need thereof. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein.
Type:
Grant
Filed:
January 17, 2017
Date of Patent:
November 23, 2021
Assignees:
University of Central Florida Research Foundation, Inc., The Regents of the University of California, Memorial Sloan-Kettering Cancer Center, The Broad Institute, Inc.
Inventors:
Derek Shieh Tan, Corinne N. Foley, Gustavo Moura-Letts, James McKerrow, Sivaraman Dandapani, Rahul Edwankar, Alyssa Verano, Debopam Chakrabarti, Bracken Roberts
Abstract: Provided are compositions and methods that include one or more of: (1) a “CasZ” protein (also referred to as a CasZ polypeptide), a nucleic acid encoding the CasZ protein, and/or a modified host cell comprising the CasZ protein (and/or a nucleic acid encoding the same); (2) a CasZ guide RNA that binds to and provides sequence specificity to the CasZ protein, a nucleic acid encoding the CasZ guide RNA, and/or a modified host cell comprising the CasZ guide RNA (and/or a nucleic acid encoding the same); and (3) a CasZ transactivating noncoding RNA (trancRNA) (referred to herein as a “CasZ trancRNA”), a nucleic acid encoding the CasZ trancRNA, and/or a modified host cell comprising the CasZ trancRNA (and/or a nucleic acid encoding the same).
Type:
Grant
Filed:
February 12, 2020
Date of Patent:
November 23, 2021
Assignee:
The Regents of the University of California
Inventors:
Jennifer A. Doudna, David Burstein, Janice S. Chen, Lucas B. Harrington, David Paez-Espino, Jillian F. Banfield
Abstract: Provided herein is a vaccine comprising a Porcine Epidemic Diarrhea Virus (PEDV) antigen. The antigen can be a consensus antigen. Also disclosed herein is a method of treating a porcine in need thereof, by administering the vaccine to the porcine.
Type:
Grant
Filed:
January 22, 2016
Date of Patent:
November 23, 2021
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
David Weiner, Emma L. Reuschel, Karuppiah Muthumani
Abstract: A weather forecasting system may receive satellite image samples and identify an updraft and components of the updraft within a cloud. These satellite image samples are collected over time (e.g., at 30 second to 1 minute time intervals). The system may identify an area of rotation and/or divergence at cloud top in a cumulus cloud or mature convective storm over time by comparing the samples and determine a parameter indicative of the updraft based on the area of rotation and divergence. The system may estimate aspects of the environment related to storm development and predict the occurrence of a weather event in the future based on the parameter and generate an output indicative of the occurrence.
Type:
Grant
Filed:
March 20, 2020
Date of Patent:
November 23, 2021
Assignee:
Board of Trustees of the University of Alabama
Abstract: A phase imaging method and apparatus are provided, the phase imaging method including causing a quantum beam from a radiation source to be incident on a detector through a test object and at least one phase grating and obtaining a phase image of the test object, based on intensity distribution of a beam in a pixel constituting the detector. The intensity distribution of the beam at least includes information of absorption (a0), visibility (V), and phase (?). At least three adjacent pixels are assumed to have a substantially identical value for each of the absorption (a0), the visibility (V), and the phase (?) through variable approximation of an image. The absorption, the visibility, and the phase are obtained, based on at least one measurement image.
Abstract: The invention provides, inter alia, a nucleic acid (e.g. expression vector) that comprises at least a first coding sequence and a second coding sequence. Each conding sequence is under the control of an inducible promoter of defined strength. Different promoters can have different strengths. Each promoter is responsive to the same inducer. The invention also provides: methods of expressing coding regions, methods of making a product of a multi-enzyme pathway, and methods of optimizing the yield of a product of a multi-enzyme metabolic pathway using the nucleic acids provided by the invention. Also disclosed is a method of non-enzymatic gene cloning useful for practicing the invention.
Type:
Grant
Filed:
June 20, 2019
Date of Patent:
November 23, 2021
Assignees:
National University of Singapore, Massachusetts Institute of Technology
Inventors:
Heng Phon Too, Ruiyang Zou, Gregory N. Stephanopoulos
Abstract: A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors.
Type:
Grant
Filed:
July 2, 2019
Date of Patent:
November 23, 2021
Assignee:
The Regents of the University of Colorado, a Body Corporate
Inventors:
Gregory Thomas Everson, Steve Mark Helmke
Abstract: A method and system that includes a wearable device having a plurality of EEG sensors to detect an EEG signal in a window of a predetermined length, a bandpass filter to remove frequency bands of the EEG signal to obtain a combined signal of remaining frequency bands, and a wireless device connection for wireless transmission of information from the wearable device. The information including the EEG signal and the combined signal. A mobile device includes a communication device for receiving the transmitted information, at least one processor for processing a machine learning model. The machine learning model classifies the combined signal to obtain a classification result of mental stress or not mental stress, and a display device displays a mental stress assessment based on the EEG signal and the classification result.
Type:
Grant
Filed:
May 19, 2021
Date of Patent:
November 23, 2021
Assignee:
King Abdulaziz University
Inventors:
Ubaid M. Al-Saggaf, Mohammed U. Alsaggaf, Muhammad Moinuddin, Syed Saad Azhar Ali, Syed Faraz Naqvi
Abstract: A device for cleansing the teeth is provided. The device that improves the ability of the user to quickly, efficiently and thoroughly floss all interproximal spaces at once.
Type:
Grant
Filed:
October 5, 2020
Date of Patent:
November 23, 2021
Assignee:
King Abdulaziz University
Inventors:
Maha Ahmed Salim Bahammam, Seba Abdulqader Salem Alhebshi
Abstract: A method and an apparatus for determining a presence or an amount of a polyamine or its derivative in a sample, the method including: applying the sample on an electrochemical detector having a substance selection structure, wherein the substance selection structure is sensitive to the polyamine or its derivative; applying at least one voltage bias to the electrochemical detector; and detecting a change of electrical characteristics of the electrochemical detector so as to determine the presence or the amount of the polyamine or its derivative in the sample.
Type:
Grant
Filed:
September 11, 2018
Date of Patent:
November 23, 2021
Assignee:
City University of Hong Kong
Inventors:
A. L. Roy Vellaisamy, Chi-Chung Yeung, Shishir Venkatesh, Hon-Wah Lam
Abstract: A system and method is presented for cuff-less blood pressure measurement in a mobile device. A key aspect of this disclosure is the discovery of a new location for blood pressure measurement at the fingertip of a subject and that reflectance-mode photoplethysmography can be used to help make this measurement. Through experiments in human subjects, it was discovered that it is indeed possible to measure systemic blood pressure by having a subject press the fingertip against a reflectance-mode photo-plethysmography-force sensor unit under visual guidance and then compute blood pressure from the resulting variable-amplitude blood volume oscillations and applied pressure via an oscillometric algorithm.
Type:
Grant
Filed:
July 18, 2019
Date of Patent:
November 23, 2021
Assignee:
Board of Trustees of Michigan State University
Abstract: Evaluating the engagement and attentiveness of persons in a group by preparing a streaming video of the group, extracting faces of the persons in the group, aligning the extracted faces, assigning an identity to each of the faces, recognizing the emotional state of each face by a temporal emotion recognition module, and estimating the attentiveness of each person based on the recognized emotional state of each face of each person. The estimated attentiveness may also include recognizing the gaze of each person.
Type:
Grant
Filed:
January 18, 2019
Date of Patent:
November 23, 2021
Assignee:
Board of Regents, The University of Texas Systems
Abstract: The present invention includes compositions and methods for treating or preventing certain dermal disorders including dermal atrophy, pseudoscars, actinic keratosis, seborrheic or actinic keratoses, lentigines, focal areas of dermal thickening, and coarse wrinkles. In certain embodiments, the compositions useful within the invention comprise a therapeutically effective amount of a mTORC1 inhibitor and a dermatologically acceptable carrier.
Type:
Grant
Filed:
May 21, 2020
Date of Patent:
November 23, 2021
Assignee:
Drexel University
Inventors:
Christian Sell, Timothy Nacarelli, Ashley Azar
Abstract: Disclosed are cellulose-based flexible gels containing cellulose nanorods, ribbons, fibers, and the like, and cellulose-enabled inorganic or polymeric composites, wherein the gels have tunable optical, heat transfer, and stiffness properties. The disclosed gels are in the form of hydrogels, organogels, liquid-crystal (LC) gels, and aerogels, depending on the solvents in the gels.
Type:
Grant
Filed:
January 11, 2018
Date of Patent:
November 23, 2021
Assignee:
The Regents of the University of Colorado, a body corporate
Inventors:
Andrew J. Hess, Qingkun Liu, Ivan I. Smalyukh
Abstract: Peptides are described herein, in particular peptides having antimicrobial properties, as are compositions, articles, and kits comprising such peptides, and methods for using the peptides.
Type:
Grant
Filed:
November 26, 2019
Date of Patent:
November 23, 2021
Assignee:
George Mason University
Inventors:
Barney Bishop, Monique Van Hoek, Stephanie Barksdale
Abstract: Provided are a method and a system for controlling the overlapping in the single-layer laser cladding of a shaft-like workpiece, and a method, a device and a system for dynamically adjusting a height of the laser head of a laser cladding machine. In the method for controlling the overlapping in the laser cladding of the shaft-like workpiece, the motions of the spindle and the feed shaft are planned based on an S-curve acceleration and deceleration method. The motion planning is dynamically adjusted by comprehensively considering the overlapping rate and the clamping allowance of the workpiece in a feed direction.
Type:
Grant
Filed:
March 11, 2021
Date of Patent:
November 23, 2021
Assignee:
Shandong University
Inventors:
Chengrui Zhang, Yisheng Yin, Wei Ma, Jie Wu, Tieshuang Zhu, Tianliang Hu