Abstract: A method for magnetic resonance imaging (MRI) includes steps of acquiring by an MRI scanner undersampled magnetic-field-gradient-encoded k-space data; performing a self-calibration of a magnetic-field-gradient-encoding point-spread function using a first neural network to estimate systematic waveform errors from the k-space data, and computing the magnetic-field-gradient-encoding point-spread function from the systematic waveform errors; reconstructing an image using a second neural network from the magnetic-field-gradient-encoding point-spread function and the k-space data.

Abstract: The present invention discloses a natural gas hydrate-bearing sediment intergranular micro-force testing device and a testing method thereof. The testing device comprises: a high pressure reactor, a natural gas cylinder, a natural gas buffer tank, a condensate circulation device, a water source and a gas-liquid saturated tank, wherein a gas inlet of the natural gas buffer tank communicates with the natural gas cylinder through a first pipeline, a gas outlet of the natural gas buffer tank communicates with a gas inlet of the high pressure reactor through a second pipeline, a water inlet of the high pressure reactor communicates with a water outlet of the gas-liquid saturated tank through a third pipeline, a water inlet of the gas-liquid saturated tank communicates with the water source through a fourth pipeline, the gas outlet of the natural gas buffer tank communicates with the fourth pipeline through a fifth pipeline.

Abstract: Disclosed is an energy-saving bidirectional ship lift by gravity balancing, including: a ship lift body. A first support is provided in a middle of the ship lift body. A second support is provided at a side of the first support. A third support is provided at the other side of the first support. A space between the second support and the first support forms a first shaft. A space between the first support and the third support forms a second shaft. A first ship-carrying chamber and a second ship-carrying chamber are respectively provided in the first shaft and the second shaft to allow two ships to be transported at the same time. An entry water tank and an exit water tank are provided at two sides of each ship-carrying chamber to adjust the weight of the two ship-carrying chambers.

Abstract: Methods are described for identifying CDI patients as well as CDI patients at risk for recurrence. Embodiments include: (1) flow cytometry of circulating peripheral blood mononuclear cells (PBMC) to phenotype for the less efficient immunoglobulin response to bacterial toxins and surface antigens that characterizes patients who will become recurrent; (2) stratification by means of complete blood count (CBC) using a Coulter counter to detect the differences in lower angle light scatter (LAL), which has a larger range in the recurrent population; and (3) stratification by means of complete blood count (CBC) using a Coulter counter to detect the lower axial light loss (AL2) exhibited in recurrent patients.

Abstract: The invention concerns a cartridge for an inhalation device for delivering anaesthetic to a human or animal wherein anaesthetic in said cartridge is dispersed in an anaesthetic control release medium; an inhalation device for use with said cartridge and a formulation comprising at least one selected anaesthetic and anaesthetic control release medium.

Abstract: A semiconductor memory device includes a bitline driver configured to drive a global bitline; a memory cell array including a first memory cell that is coupled between a cell wordline and a cell bitline; a bitline decoder including a bitline switch that couples the global bitline and the cell bitline; a wordline decoder including a wordline switch that couples a global wordline and the cell wordline; a sense amplifier configured to output a sensing signal corresponding to a state of the first memory cell based on a voltage of the global bitline; and a control circuit configured to control the bitline driver, the bitline decoder, the wordline decoder and the sense amplifier during a first read operation for the first memory cell.

Abstract: Methods of treating hemophilia A in a subject with an F8 gene mutation, wherein the F8 gene is repaired and the resultant repaired gene, upon expression, confers improved coagulation functionality to the encoded FVIII protein of the subject compared to the non-repaired F8 gene. The invention also includes methods of inducing immune tolerance to a FVIII replacement product ((r)FVIII) in a subject having a FVIII deficiency, wherein the F8 gene mutation is repaired and the repaired gene, upon expression, provides for the induction of immune tolerance to an administered replacement FVIII protein product. The invention also includes isolated nucleic acids, vectors, recombinant viruses, cells, and pharmaceutical compositions to repair the F8 gene.

Abstract: An end-user system in accordance with the present disclosure includes a communication device configured to communicate with a server, a display screen, one or more processors, and at least one memory storing instructions which, when executed by the processor(s), cause the end-user system to access a physical world geographical location from a user, access two-dimensional physical world map data for a region surrounding the physical world geographical location, render for display on the display screen a three-dimensional mirrored world portion based on the two-dimensional physical world map data and render an avatar at a mirrored world location corresponding to the physical world geographical location, access geotagged social media posts which have geotags in the region and which the user is permitted to view, and render the geotagged social media posts as three-dimensional objects in the mirrored world portion.

Abstract: A method may include receiving, from a client, a query dictated by a user. The query may request to retrieve, from a database, data stored in the database. A structure determination may be performed by identifying one of a plurality of ground truth query strings having a minimum edit distance relative to a transcription of the dictated query. Each the plurality of ground truth query strings may be consistent with at least a syntax of a query language associated with the dictated query. A rendered query string is generated by performing a literal determination that includes by comparing a literal token in the identified ground truth query string to one or more literal tokens present in the database. The rendered query string may be executed to retrieve, from the database, data requested by the dictated query string. Related methods and computer program products are also provided.

Abstract: A system for determining a colonoscopy image is disclosed. The system includes a bowel preparation evaluation unit, an image processing unit electrically or communicatively connected to the bowel evaluation unit, and a convolutional neural network unit electrically or communicatively connected to the image processing unit. The bowel preparation evaluation unit determines whether a bowel in the colonoscopy image is clean. The image processing unit receives the colonoscopy image determined to have a clean bowel and outputted by the bowel preparation evaluation unit, and performs an image process on the colonoscopy image with clean bowel to adjust a contrast thereof. The convolutional neural network unit comprises a convolutional neural network and in a working mode, receives and determines whether the processed colonoscopy image is a cecal image, a non-cecal image, or an indeterminable colonoscopy image.

Abstract: The present invention provides an expression cassette containing a polynucleotide coding sequence for a hydroxycinnamoyl-CoA hydratase-lyase (HCHL), which is operably linked to a heterologous promoter. Also provided are methods of engineering plants that have reduced lignification, as well as cells, plant parts, and plant tissues from such engineered plants.

Abstract: Provided are antigen-binding molecules capable of binding to IL-11R?, and methods of medical treatment and prophylaxis using the same.

Abstract: Waveguides and electromagnetic cavities fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. Devices comprising electromagnetic cavities fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. Devices comprising waveguides fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. The devices include electromagnetic splitters, filters, and sensors.

Abstract: The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations.

Abstract: In one aspect, in accordance with one embodiment, a method includes acquiring magnetic resonance (MR) data corresponding to bone tissue in an area of interest of a subject that is heated from the application of localized energy. The acquiring includes applying a three-dimensional (3D) ultra-short echo time (UTE) spiral acquisition sequence. The method also includes detecting, from the acquired magnetic resonance data, a change in MR response signal due to a change in at least one of relaxation rate and magnetization density caused by heating of the bone tissue; and determining, based at least in part on the change in the MR response signal, that the temperature of the bone tissue has changed.

Abstract: The invention discloses a data storage access method, device and apparatus for persistent memory. The method includes: enabling a file system in device to receive, in a kernel space, an access request of a user library, where the user library operates in user mode, and the access request is initiated by third-party application through user library and carries operation type; if the operation type is read operation, enabling the file system to allow third-party application to directly access persistent memory space of device through user library; and if the operation type is not read operation, enabling the file system to allow third-party application to access persistent memory space of device through user library and kernel thread, where kernel thread operates in kernel mode. In this way, the present invention can achieve both high performance and data security of persistent memory, and provide technical support for scalability in multi-core scenario.

Abstract: This invention relates to polypeptides, including variants of interleukin-37 (IL-37), and related therapeutics and compositions. The invention also relates to the use of the polypeptides and compositions in methods of treating inflammatory diseases or conditions. The present invention provides a monomeric anti-inflammatory polypeptide comprising an amino acid sequence of an IL-37 monomer, the amino acid sequence having a mutation or modification for preventing the anti-inflammatory peptide from forming a homodimer.

Abstract: Systems and methods are described herein for determining that a patient has indications mild cognitive impairment (MCI) or early stage Alzheimer's disease (AD). Microperimetry is used to assess the functional integrity of the patient's retina. Optical Coherence Tomography is used to assess the structural integrity of the patient's retina. Reductions in the size and function of the patient's retina indicate that the patient may have MCI or early stage AD.

Abstract: An analog neuromorphic circuit is disclosed having resistive memories that provide a resistance to each corresponding input voltage signal. Input voltages are applied to the analog neuromorphic circuit. Each input voltage represents a vector value that is a non-binary value included in a vector that is incorporated into a dot-product operation with weighted matrix values included in a weighted matrix. A controller pairs each resistive memory with another resistive memory. The controller converts each pair of resistance values to a single non-binary value. Each single non-binary value is mapped to a weighted matrix value included in the weighted matrix that is incorporated into the dot-product operation with the vector values included in the vector. The controller generates dot-product operation values from the dot-product operation with the vector and the weighted matrix where each dot-product operation is a non-binary value.

Abstract: Provided herein are plants that reduce growth of a fungal pathogen, increase resistance of the plant to a fungal pathogen, or a combination thereof. The plant includes a polynucleotide that reduces expression of a coding region present in a fungal pathogen, such as Sclerotinia sclerotiorum or Botrytis cinerea. The polynucleotide can be present on the surface of the plant, expressed by a plant, or a combination thereof. Also provided are methods of making and methods of using the plants.