Abstract: The present invention provides a pharmaceutical composition and a treatment method to be combined with radiotherapy, for treatment of triple negative breast cancer. More specifically, the pharmaceutical composition comprises a PD-1 blockade and a PI3K? ? inhibitor, and it has excellent effects of inhibiting tumor and enhancing immunity by combining the PD-1 blockade and PI3K? ? inhibitor with radiotherapy, compared to single therapy of each therapeutic agent.

Abstract: A gallium oxide crystal manufacturing device includes a crucible to hold a gallium oxide source material therein, a crucible support that supports the crucible from below, a crucible support shaft that is connected to the crucible support from below and vertically movably supports the crucible and the crucible support, a tubular furnace core tube that surrounds the crucible, the crucible support and the crucible support shaft, a tubular furnace inner tube that surrounds the furnace core tube, and a resistive heating element including a heat-generating portion placed in a space between the furnace core tube and the furnace inner tube. Melting points of the furnace core tube and the furnace inner tube are not less than 1900° C. A thermal conductivity of a portion of the furnace core tube located directly next to the crucible in a radial direction thereof is higher than a thermal conductivity of the furnace inner tube.

Abstract: Methods of vulcanization using a high content sulfur polymer, instead of elemental sulfur, have been developed. These high sulfur content polymers are referred to as Chalcogenide Hybrid Inorganic/Organic Polymers (CHIP) materials and have good polymer compatibility in that they are soluble in a number of polymers. Furthermore, CHIP materials may have weaker bonds than the S—S bonds of elemental sulfur and thus provide for a higher crosslinking efficiency vulcanization.

Abstract: A system for computational localization of fibrillation sources is provided. In some implementations, the system performs operations comprising generating a representation of electrical activation of a patient's heart and comparing, based on correlation, the generated representation against one or more stored representations of hearts to identify at least one matched representation of a heart. The operations can further comprise generating, based on the at least one matched representation, a computational model for the patient's heart, wherein the computational model includes an illustration of one or more fibrillation sources in the patient's heart. Additionally, the operations can comprise displaying, via a user interface, at least a portion of the computational model. Related systems, methods, and articles of manufacture are also described.

Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.

Abstract: Provided herein are oxazolidinone derivatives that can exhibit anti-microbial activity and/or activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity anti-microbial activity (e.g., potent activity against Gram-positive positive bacteria including methicillin-resistant Staphylococcus aureus). The compounds can exhibit potent activity against biofilms. In some cases, the compounds can exhibit both anti-microbial activity and biofilm modulation properties.

Abstract: An automated segmentation system for medical imaging data segments data into muscle and fat volumes, and separates muscle volumes into discrete muscle group volumes using a plurality of models of the medical imaging data, and wherein the medical imaging data includes data from a plurality of imaging modalities.

Abstract: A method for PET image reconstruction acquires PET data by a PET scanner; reconstructs from the acquired PET data a seed PET image; builds a feature space from the seed PET image and anatomical images co-registered with the seed PET image; performs a penalized maximum-likelihood reconstruction of a PET image from the seed PET image and the feature space using a penalty function that is calculated based on the differences between each voxel and its neighbors both on the PET image and in the feature space regardless of their location in the image.

Abstract: Tetrameric N-terminally acetylated ?-synuclein is prepared by transforming an expression system with an expression vector encoding ?-synuclein, wherein the expression system expresses a native NatB acetylase complex or ortholog thereof and/or wherein an exogenous NatB acetylase complex or ortholog thereof is co-expressed in the expression system, inducing protein expression in the transformed expression system, lysing cells in the transformed expression system to produce a cell lysate, performing salt precipitation of the cell lysate, recovering tetrameric N-terminally acetylated ?-synuclein by centrifugation, and purifying the tetrameric N-terminally acetylated ?-synuclein. Compositions comprising the same and methods for identifying compounds that stabilize natively folded tetrameric ?-synuclein are also provided.

Abstract: The invention discloses a strontium ferrite-based sacrificial mortar and its preparation method, the strontium ferrite-based sacrificial mortar mainly comprises 720-1000 parts of sulphoaluminate cement, 100-300 parts of strontium ferrite, 600-650 parts of quartz sand, 400-450 parts of water and 0.01-35 parts of superplasticizer. The preparation process is simple, and the strontium ferrite-based sacrificial mortar can be prepared by using a conventional forced single horizontal shaft concrete mixer. The obtained mortar has excellent working performance, compressive strength and corrosion resistance. It can be used in the current third and future fourth generation nuclear power plant core catchers, and has obvious engineering application value.

Abstract: Provided herein are compositions and methods for treating pulmonary vascular disease in a subject comprising administering to the subject a therapeutically effective amount of a YAP/TAZ inhibiting composition and/or a GLS1 inhibiting composition.

Abstract: The present disclosure provides a circadian rhythm correcting apparatus including a bio-illuminance measuring part configured to measure bio-illuminance of external light, a light source configured to irradiate light of a circadian wavelength band toward a retinal ganglion cell, a light source driver configured to drive the light source by supplying power to the light source, and a controller configured to control the light source driver on the basis of the bio-illuminance measured by the bio-illuminance measuring part, to correct the circadian rhythm.

Abstract: The present invention aims to provide a novel low-molecular-weight compound showing an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.

Abstract: Implementations of the present disclosure relate to apparatuses, systems, and methods for anastomosing vascular systems in medical procedures. A pair of similar or identical coupling devices may be disposed at the ends of two vessels, either natural or synthetic. The coupling devices may be capable of hermaphroditically connecting to one another to provide a simple and secure connection which promotes growth of the vessels between the bio-absorbable coupling devices.

Abstract: Provided is a nanogel exhibiting anticoagulation and antioxidation activities, including a graphene-like nanosheet and a polysaccharide, which are complexed to form a cross-linked supramolecular structure. Also provided is a method of preparing the nanogel, including carbonizing the polysaccharide by dry heating. By the heating process, at least a portion of the polysaccharide is conversed into the graphene-like nanosheet, thereby forming a graphene-like nanosheet-embedded phenolic-polysaccharide nanogel that has exceptional polyphenolic structure and high binding affinity toward thrombin. Further provided is a method of preventing or treating a disease or a condition susceptible to amelioration by anticoagulants or antioxidants by using the nanogel.

Abstract: The present invention includes compositions and methods for treating T cell lymphomas and leukemias. In certain aspects, the compositions and methods include CAR T cells targeting CD2, CD5, or CD7 and modified cells wherein CD2, CD5, or CD7 has been knocked-out.

Abstract: Disclosed is a comprehensive inspection vehicle for a subway tunnel, including a positioning system, an acquisition system and a flatcar. The flatcar runs on a railway of the subway tunnel. The positioning system and the acquisition system are arranged on the flatcar. The positioning system includes a laser ranging module and an inertial navigation module. The comprehensive inspection vehicle further includes an independent power supply system and a central control system arranged on the flatcar. The independent power supply system supplies power for the acquisition system, the positioning system and the central control system. The central control system includes an acquisition industrial computer and a positioning industrial computer which are respectively connected to the acquisition system and the positioning system.

Abstract: Systems, methods, and computer program products for determining an application status of an applicant for an educational program may include receiving cohort performance data comprising first data entries for participants that have respectively achieved outcomes for the educational program and applicant performance data comprising second data entries for the applicant, calculating adjusted cohort performance data based on the cohort performance data and first data characteristics, providing a predictor model based on the adjusted cohort performance data and the outcomes, sequentially changing predictive parameters of the first data characteristics to create second data characteristics and creating an adjusted predictor model based on the second data characteristics and the outcomes, calculating adjusted applicant performance data based on the applicant performance data and the second data characteristics, and calculating a probability of success for the applicant in the educational program based on the adjust

Abstract: The disclosed subject matter provides systems and methods for spatial and spectral modulation of light. An example system for modulating light can include a substrate and a plurality of meta units, coupled to the substrate and configured to spatially and spectrally modulate the light, wherein the plurality of meta units includes a perturbation and forms a perturbed lattice supporting a quasi-bound state in the continuum.

Abstract: A method for constructing a dam inside a dump of an inner-dump strip mine includes: taking an upper surface connection line of a primary water-resisting layer as upper filling reference datum boundary of an artificial water-resisting layer; arranging a dam foundation pit and a trapezoidal abutment on a midline of the dam foundation pit; building and reinforcing a step-shaped retaining dam core wall on the artificial water-resisting layer; laying a foundation impervious layer, waterproof geotextile, and an earth blanket on one side, close to the primary aquifer, of the retaining dam core wall; strengthening advance of a dumping working face on one side, away from the primary aquifer, of the retaining dam core wall, and dumping overburden of a strip mine to form a support; filling a space between the earth blanket and the primary aquifer to form a blocker; and proceeding with construction and forming a continuous retaining dam.