Abstract: The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide comprising a G-protein coupled receptor (GPCR) or a fragment thereof, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.

Abstract: A ring composite spinning method based on film filamentization is provided, which belongs to a textile technical field. According to the method, a film cutting drafting device is arranged above each drafting system on a ring spinning machine for cutting film material into ribbon-shaped multi-filaments to achieve the film filamentization, which changes a conventional formation of filament through linear spraying by spinneret orifices; then the multi-filaments formed pass through first and second filament drafting zones in sequence for drawing, so as to enhance and attenuate the multi-filaments.

Abstract: An autostereoscopic display system includes a display including a plurality of addressable pixels. Each of the plurality of pixels includes two or more sub-pixels. The display is adapted to have n views in the horizontal direction wherein n is an integer greater than or equal to 2. A native pixel density of the display in the horizontal direction divided by n is greater than 75% of a native pixel density in the vertical direction. The system further includes a view selector that, for each of two or more viewing perspectives, makes one of the views visible and a multiplexer system in operative connection with the display. The multiplexer system is adapted to controllably shift light horizontally from at least one of the plurality of pixels.

Abstract: The present invention identifies ? decay and other events included in the emission of an LaBr3 scintillator and only collects ? ray events. An LaBr3 scintillation detector is provided with an LaBr3 scintillator 10, a photomultiplier tube 12, an oscilloscope 14, and a computer 18. The computer 18 detects a peak value Vp and a total charge amount Qtotal of a voltage waveform signal and calculates an error propagation expression function for a ratio of the peak value Vp to the total charge amount Qtotal. This error propagation expression function is used as a threshold function for identifying and removing ? decay events. The ? decay events are identified from the peak value Vp and total charge amount Qtotal, which are measurement values that can be measured in real time.

Abstract: A multiplier signal, and multiplier circuits and methods are provided to improve the total harmonic distortion (THD) and power factor (PF) for a flyback type power factor correction (PFC) circuit. The multiplier signal has a “pulled-up” waveshape that is configured to compensate for the “push-down” effect of varying off times of an electronic switch of the PFC on a line current of the PFC. The multiplier circuit is configured to reduce the multiplier signal during a first operational mode of the multiplier circuit and is further configured to maintain a typical multiplier signal during a second operational mode. The first operational mode occurs before a first phase angle and after a second phase angle during each half-cycle of a power source coupled to the PFC circuit. The second operational mode occurs between the first and second phase angles during each half-cycle.

Abstract: Provided herein are aptamers, aptamer probes and biosensor systems that detect C. difficile glutamate dehydrogenase (GDH). Also provided are methods of detecting C. difficile GDH using the aptamers, probes and biosensors and methods of determining whether a subject has a C. difficile infection.

Abstract: Systems, methods, and media for providing interactive refocusing are provided, the systems comprising: a lens; an image sensor; and a processor that: causes the image sensor to capture a plurality of images over a predetermined period of time, wherein each of the plurality of images represents a scene at a different point in time; changes a depth of field between at least a pair of the plurality of images; concatenates the plurality of images to create a duration focal volume in the order in which the images were captured; computes a space-time in-focus image that represents in-focus portions from each of the plurality of images based on the duration focal volume; and computes a space-time index map that identifies an in-focus image for each location of the scene from among the plurality of images based on the duration focal volume and the space-time in-focus image.

Abstract: [Problem] To provide a highly safe and efficacious antitumor agent that is derived from probiotics. [Solution] The present invention relates to an antitumor agent comprising a compound represented by formula (1) or a complex thereof as an active ingredient. In formula (1): R1 represents a hydrogen atom or a hydroxymethyl group; R2 represents a hydrogen atom, a methyl group or a hydroxymethyl group; and R3, R4 and R5 each independently represent a methyl group, an N5-(trans-5-hydroxy-3-methylpent-2-enoyl) group, an N5-(cis-5-hydroxy-3-methylpent-2-enoyl) group or an N5-(trans-4-carboxy-3-methylpent-2-enoyl) group. According to the present invention, a highly safe and efficacious antitumor agent can be provided.

Abstract: Methods and devices for controlling pressures in microenvironments between a deposition apparatus and a substrate are provided. Each microenvironment is associated with an aperture of the deposition apparatus which can allow for control of the microenvironment.

Abstract: A finite state machine circuit can include a plurality of rows of gain cell embedded Dynamic Random Access Memory (GC-eDRAM) cells that can be configured to store state information representing all N states expressed by a finite state machine circuit. A number of eDRAM switch cells can be electrically coupled to the plurality of rows of the GC-eDRAM cells, where the number of eDRAM switch cells can be arranged in an M×M cross-bar array where M is less than N, and the number of eDRAM switch cells can be configured to provide interconnect for all transitions between the all N states expressed by the finite state machine circuit.

Abstract: A device and a method for reducing an influence of interference between signals using an aperture array in chip-to-chip wireless communication are provided. The device includes a transmitter including at least one transmission antenna for transmitting a signal, a receiver including at least one reception antenna for receiving the signal, a guide structure including at least one opening for guiding a path of the signal, and the at least one transmission antenna, the at least one reception antenna, and the at least one opening are arranged to correspond to one another.

Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.

Abstract: A greenhouse framework (22) is assembled out of a framework material (24) such as typical pipes and the like, and the outer periphery of the greenhouse framework (22) is covered by a sheet outer surface member (30) formed from a plastic sheet; a sheet inner surface member (32) is formed on the inner side of the greenhouse framework (22) in a manner of being spaced by intervals to a certain extent from the sheet outer surface member (30) by using a heat shield sheet such that all of a floor surface (32a), a wall surface (32b), and a ceiling surface (32c) are substantially in a sealed state; and an air conditioning device (40) is installed. Thus, a desirable thermal insulation property is achieved between the inside of the greenhouse and the outside of the greenhouse, and air conditioning can be implemented with high energy efficiency. In other words, a greenhouse for plant cultivation that has a simple configuration and can be air conditioned with high energy efficiency can be provided.

Abstract: A method for determining a threshold voltage for a batch of sensing chips includes steps of: a) selecting at least three of micro-machined transceivers; b) conducting for each of the at least three of the micro-machined transceivers the following sub-steps of: b1) introducing a blank liquid into a micro-channel via an inlet port, b2) applying an alternate voltage to a micro-machined transmitter for a period of time, and b3) measuring an amplitude of an electric signal from a micro-machined receiver to obtain a maximum value and a minimum value; c) measuring a mid-value; and d) determining the threshold voltage. Also disclosed is a method for increasing sensitivity of the batch of sensing chips based on the threshold voltage.

Abstract: A carbon nanotube composite material (1) includes a metal base material (10) and carbon nanotube electrically-conductive path portions (20). The metal base material (10) is made from a polycrystalline substance in which a plurality of rod-shaped metal crystal grains (11) are oriented in a direction. The carbon nanotube electrically-conductive path portions (20) are made from doped carbon nanotubes having a dopant, existing in parts of grain boundaries (15) between the rod-shaped metal crystal grains (11) in a cross section of the metal base material (10), and forming an electrically-conductive path which is electrically conductive in a longitudinal direction of the metal base material (10), by existing along the longitudinal direction (L).

Abstract: The present disclosure provides pharmaceutical agents of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents for the treatment of a variety of diseases and disorders are also provided.

Abstract: The present disclosure relates to devices and methods for delivery of a ferrofluid to a targeted treatment site, such as delivery of a ferroadhesive to a pathological fistula to occlude the fistula. A device includes a catheter having a lumen and a distal opening. A hollow solenoid is coupled to a distal section of the catheter, and a hollow core of the solenoid allows passage of a ferrofluid through the catheter and through the hollow core so that it may exit past the distal end of the hollow solenoid. The solenoid may be selectively actuated to maintain or control the position of the delivered ferrofluid.

Abstract: The present invention is directed to an automatable method for directing electrophysiology catheter movement toward the site of arrhythmia origin using the cardiac activation sequence measured during arrhythmia and during pacing. The purpose of this method is to improve the speed and accuracy of localizing the site of arrhythmia origin for the purpose of targeting therapeutic ablation of the arrhythmia.

Abstract: Example devices and methods of tongue stimulation for communication of information to a user are disclosed herein. In an example, a tongue stimulation device may include a body configured to be placed entirely within a mouth of the user and atop the tongue of the user. An array of electro-tactile elements may be distributed on the body, wherein each of the electro-tactile elements is configured to stimulate an area of the tongue adjacent the electro-tactile element. A wireless receiver coupled to the body may be configured to receive stimulation information wirelessly from outside the mouth of the user. At least one processing unit coupled to the body may be configured to transform the received stimulation information into a stimulation signal for each of the electro-tactile elements, and to provide the stimulation signals to the electro-tactile elements.