Abstract: A method of screening, isolating and purifying rare cells includes obtaining cell groups with rare cells from a sample, removing cells not to be screened from the cell groups, and drawing the remaining cells as a cell suspension sample. An introduction device is activated to load the cell suspension sample onto an optically-induced dielectrophoresis chip including a cell isolation zone having a division arrangement wherein at least one optical pattern is configured on the cell isolation zone for screening, isolating and purifying the rare cells. The at least one optical pattern is configured to migrate, rotate or both. The at least one optical pattern is activated to attract the rare cells into a collection tank on the chip, and a liquid drawing device is activated to draw the rare cells out of the collection tank, thereby obtaining purified rare cells from the sample.

Abstract: Systems, devices, and methods of the present application can accelerate and reduce medical complications associated with healing of amputation wounds. The devices and methods utilize a compression structure and negative pressure to cause the amputation wound to preferentially close from the deepest portion of the wound to the shallowest portion.

Abstract: Detecting the presence of target vehicles in front of a host vehicle by obtaining, using one or more visual sensors, an image of a field of view in front of a host vehicle and detecting, individually, a plurality of parts of one or more target vehicles in the obtained image. The detected plurality of parts, of the one or more target vehicles, are extracted from the obtained image and paired to form a complete target vehicle from the plurality of parts. The pairing is only performed on selective individual parts that overlap and have similar sizes indicating that they belong to the same target vehicle. A complete target vehicle is detected in response to forming a substantially complete target vehicle.

Abstract: Lignin is electro-oxidized to commercially useful products using a binary transition metal catalyst. In particular, the transition metal catalyst includes nickel or cobalt as a first metal and any other transition metal as a second metal. The binary catalyst system prevents poisoning of the catalyst, extending the useful life of the catalyst.

Abstract: The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present invention provides a method of generating an immune response in a mammal, that includes administering to the mammal, a composition having a chimeric protein having at least one of: a portion of a cholera toxin, a portion of a heat-labile toxin, and a portion of a shiga toxin; and an antigen having at least one of: an antigenic material from S. aureus and an antigenic material from a S. aureus-specific polypeptide.

Abstract: Aspects of the subject disclosure may include, for example, upon receiving a request for media content, a first signal quality may be determined, a first quality level may be selected based on the first signal quality, and segments of the first quality level may be retrieved, stored in a buffer, and played from the buffer. When the buffer is sufficiently occupied first inferior segments stored in the buffer may be replaced by determining a second signal quality selecting a second quality level based on the second signal quality, identifying the first inferior segment based on the second quality level, and replacing the first inferior segment with a first replacement segment, the first replacement segment corresponding to the first inferior segment. These processes may be performed iteratively. Other embodiments are disclosed.

Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective legality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.

Abstract: The invention relates to a compound of formula (I) with low cytotoxicity for blocking the ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of disorders including, but not limited to, multiple myeloma, cancers, neurodegenerative diseases, inflammatory disorders, autoimmune disorders and metabolic disorders.

Abstract: The disclosure relates to power electronics technology and aims to provide a control method of constant-voltage-gain isolation type bidirectional full-bridge DC/DC converter, which is based on a single-phase-shifting modulation method. By enabling the difference between the M times of the input voltage and primary-referred value of the output voltage to be constantly zero, to realize the control goal that the ratio value between the primary-referred value of the output voltage and the input voltage is constantly M; the ratio value between the primary-referred value of the output voltage and the input voltage is defined as the voltage gain M, wherein an adjusting range is 0.5˜2; through introducing a feedforward compensator involving the input and output voltages and the input and output currents, a linear controller of the system is implemented.

Abstract: The present invention provides a recombinant herpes simplex virus (HSV), comprising (a) a mutation of the glycoprotein B (gB) at position 285 or 549, (b) a plurality of copies of one or more microRNA target sequences inserted into a locus of an HSV gene required for HSV replication, wherein said target sequence is the reverse complement of microRNA miR-124 and wherein said target sequence is present in the ICP4 gene, and (c) a transgene encoding a matrix metalloproteinase. The present invention also provides a method of killing a cancerous cell using a recombinant HSV according to the invention and a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a recombinant HSV according to the invention.

Abstract: An adjustable wheelchair headrest system to provide wheelchair users with the ability to control their headrest without assistance form another individual. Some wheelchair users are unable to adjust their headrests without assistance, and as a result, have no control over their head and neck positioning throughout the day. The system provides wheelchair users with a multi-directional adjustable headrest that may be controlled through a mobile device. The system includes a universal mounting system and manually adjustable starting positions for each linear translation and rotational assembly, which allows the system to easily mount to any existing wheelchair. The system enables users to adjust their headrest to suit any situation (driving, watching a movie, eating, etc.). Wheelchair reliant individuals can now enjoy day-to-day comfort, control their own upper body posture, and perform additional tasks without assistance.

Abstract: A system and method for removing residual glutaraldehyde from a natural polymer scaffold crosslinked with glutaraldehyde is provided. The system includes a cleaning solution comprising carbon dioxide and one or more polar solvents and an environmental chamber that can include and a treatment chamber. The environmental chamber is maintained at a temperature greater than 31.1° C. and the carbon dioxide is maintained at a pressure greater than 7.38 megapascals to form supercritical carbon dioxide. A crosslinked natural polymer scaffold treated via the glutaraldehyde removal system and method can have a glutaraldehyde content of less than about 3 parts per million. A crosslinked natural polymer scaffold cleaning solution comprising supercritical carbon dioxide and one or more polar solvents is also provided.

Abstract: Nitro oleic acid and related metabolites are agonists of PPAR-?. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-?, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-?.

Abstract: A radiation therapy treatment method includes providing a patient model, dosimetric constraints, delivery motion constraints, and delivery coordinate space of a radiation delivery device, where the delivery coordinate space is represented as a mesh with vertices connected by edges, where the vertices correspond to directions of a beam eye view (BEV) of the radiation delivery device. BEV region connectivity manifolds are constructed from the patient model, the dosimetric constraints, the delivery coordinate space, and existing beam trajectories, wherein each of the BEV region connectivity manifolds represents connections between contiguous 2D target regions. Beam trajectories are selected based on region connectedness information in the BEV region connectivity manifolds, the dosimetric constraints, the delivery motion constraints, and the existing beam trajectories. Radiation is delivered using the radiation delivery device in accordance with the selected beam trajectories.

Abstract: Described herein are systems and methods for performing multi-parametric diagnosis for liver disease. Systems and methods as described herein can include positioning a subject-in association with a medical imaging device and using the medical imaging device to measure the subject's liver for extracellular fluid and iron content. Systems and methods as described herein can further include determining whether iron overload may be indicated or present from the measurement for iron content, and if indicated, correcting the measurement for extra cellular fluid. Systems and methods as described herein can further include measuring the liver for hepatic lipid content (HLC). Systems and methods as described herein can determine the presence or absence of liver disease from measurements obtained from a subject. In certain embodiments, the medical imaging device is a magnetic resonance (MR) scanner. In certain embodiments, the liver is measured for iron overload.

Abstract: Disclosed are cell-free systems for metabolic engineering, methods for cell-free metabolic engineering, kits for preparing the disclosed systems, and kits for performing the disclosed methods. The disclosed systems, methods, and kits may be utilized to prepare a chemical product and to optimize conditions for preparing a chemical product. The disclosed systems, methods, and kits also may be utilized for combinatorial cell-free metabolism engineering.

Abstract: Embodiments of the invention provide a method of forming a metal matrix composite including introducing a plurality of nanoparticles into a flow of metal material, and mixing of at least a partial portion of the flow of metal material with at least some of the plurality of nanoparticles to form a mixture of the metal material and at least some of the nanoparticles. The method further includes forming a metal matrix composite from the mixture, where the metal matrix composite includes a bulk region and an outer surface including a plurality of hydrophobic regions dispersed within a hydrophilic surface region. Further, the plurality of hydrophobic regions is formed or derived from the plurality of nanoparticles, and the hydrophobic regions have a first diameter, and an average spacing between the hydrophobic regions is a second diameter, where the first and second diameters are about 100 nm to 400 nm.

Abstract: The present invention relates in general to the field of parallel data processing, and more particularly to machine learning and classification of extremely large volumes of unstructured gene sequence data using Collaborative Analytics Gene Sequence Classification Learning Systems and Methods.

Abstract: Method, system and non-transitory computer-accessible medium can be provided for performing magnetic resonance spectroscopy for at least one structure. For example, with such method and/or computer-accessible medium, it is possible to receive information related to a substantially simultaneous acquisition of a stimulated echo pathway and a double spin echo associated with at least one portion of the at least one structure.

Abstract: Full-color pixel arrangements for use in devices such as OLED displays are provided, in which multiple sub-pixels are configured to emit different colors of light, with each sub-pixel having a different optical path length than some or all of the other sub-pixels within the pixel.