Abstract: The present invention relates to a memory device including a substrate and a lower electrode, buffer layer, seed layer, Magnetic Tunnel Junction (MTJ), capping layer, synthetic antiferromagnetic layer, and upper electrode formed on the substrate.

Abstract: Polyvinyl difluoride (PVDF) membranes prepared from casting solution including the biopolymer kappa-carrageenan (kCg) as an additive demonstrate improved structure and properties. The resulting asymmetrical structure has a thin layer on the upper surface, a porous sublayer with reduced volume of macro void space and increased porosity, and a spongy layer beneath the sublayer. This results in an increased hydrophilic nature, and provides enhanced wetting, membrane porosity, and water permeability—all important properties making these membranes suitable for a wide range of uses.

Abstract: Derivative polypeptide derived from a grass carp interferon and an application of the derivative polypeptide. An amino acid sequence of the derivative polypeptide is as shown in SEQ ID NO:1; the interferon-derived polypeptide has a high-efficiency antibacterial effect and can take effect against drug-resistant Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus agalactiae, Vibrio fluvialis or Aeromonas hydrophila. The interferon-derived polypeptide is less toxic to eukaryotes and can effectively reduce the mortality of mice in a mouse disease model caused by pathological bacteria. The interferon-derived polypeptide which is small in molecular weight is easily synthesized and has a good application value.

Abstract: Modulation of glucose homeostasis by administration of ciclopirox (6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one) is described. Methods can be utilized in treatment of conditions that involve loss of glucose homeostasis, such as diabetes, and in one particular embodiment type II diabetes. Ciclopirox is shown to stimulate p21 expression by mechanisms that are likely p53-independent.

Abstract: Systems, methods, and devices are disclosed for optimizing patient-specific stimulation parameters for spinal cord stimulation. A patient-specific anatomical model is developed based on a pre-operative image, and a patient-specific electrical model is developed based on the anatomical model. The inputs to the electric model are chosen, and the model is used to calculate a distribution of electrical potentials within the modeled domain. Models of neural elements are stimulated with the electric potentials and used to determine which elements are directly activated by the stimulus. Information about the models inputs and which neural elements are active is applied to a cost function. Based on the value of the cost function, the inputs to the optimization process may be adjusted. Inputs to the optimization process include lead/electrode array geometry, lead configuration, lead positions, and lead signal characteristics, such as pulse width, amplitude, frequency and polarity.

Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.

Abstract: Disclosed are methods for fabrication of flexible circuits and electronic devices in cost effective manner that can include integration of submicron structures directly onto target substrates compatible with industrial microfabrication techniques. In one aspect, a method to fabricate an electronic device, includes depositing an electrically conductive layer on a processing substrate including a weakly-adhesive interface layer on a support substrate; depositing an insulating layer on the conductive layer to attach to the conductive layer; forming a circuit on the processing substrate by etching selected portions of the conductive layer based on a circuit design; and producing a flexible electronic device by attaching a flexible substrate to the formed circuit on the processing substrate and detaching the circuit and the flexible substrate from the interface layer, in which the flexible electronic device includes the circuit attached to the flexible substrate.

Abstract: A power generation system comprising: a liquefied natural gas (LNG) regasification unit configured to perform a regasification process to regasify LNG supplied from an LNG source to produce natural gas, the regasification process producing cold energy; a gas turbine configured to combust the natural gas to output power, the combusting producing an exhaust gas; a thermal storage unit configured to store heat obtained from the exhaust gas; and a Stirling engine configured to output power, the Stirling engine having a hot end heated by the heat stored in the thermal storage unit and a cold end cooled by the cold energy from the regasification process.

Abstract: An optical demultiplexer/multiplexer, comprising: a multimode interference waveguide; at least one first coupling waveguide which meets the multimode interference waveguide at least one first location and a plurality of second coupling waveguides which meet the multimode interference waveguide at a plurality of second locations which are spaced in a direction of transmission in relation to the at least one first location, with the at least one first coupling waveguide and the second coupling waveguides together with the multimode interference waveguide providing a first angled multimode interferometer which operates to demultiplex a first optical signal having optical channels of a plurality of wavelengths or multiplex optical signals of a plurality of wavelengths into a first optical signal having optical channels of the plurality of wavelengths; at least one third coupling waveguide which meets the multimode interference waveguide at least one third location and a plurality of fourth coupling waveguides whi

Abstract: A microelectromechanical device is disclosed and described. The microelectromechanical device can include a base having a raised support structure. The microelectromechanical device can also include a biasing electrode supported by the base. The microelectromechanical device can further include a displacement member supported by the raised support structure. The displacement member can have a movable portion extending from the raised support structure and spaced from the biasing electrode by a gap. The movable portion can be movable relative to the base by deflection of the displacement member. The displacement member can also have a piezoelectric material associated with the movable portion. In addition, the microelectromechanical device can include a voltage source electrically coupled to the piezoelectric material and the biasing electrode.

Abstract: A pyridine based ionic liquid with a fluoride counter anion which catalyzes Fischer indole reaction and click chemistry. Methods of preparing the ionic liquid, and methods of utilizing the ionic liquid as a catalyst to synthesize indoles/indolenines and tetrazoles are also provided.

Abstract: Disclosed herein are methods for monitoring expression of C9ORF72 mRNA and protein in an animal with C9ORF72 specific inhibitors. Such C9ORF72 specific inhibitors include antisense compounds.

Abstract: A homologous series of cyclic carbonate or propylene carbonate (PC) analog solvents with increasing length of linear alkyl substitutes were synthesized and used as co-solvents with PC for graphite based lithium ion half cells. A graphite anode reaches a capacity around 310 mAh/g in PC and its analog co-solvents with 99.95% Coulombic efficiency. Cyclic carbonate co-solvents with longer alkyl chains are able to prevent exfoliation of graphite when used as co-solvents with PC. The cyclic carbonate co-solvents of PC compete for solvation of Li ion with PC solvent, delaying PC co-intercalation. Reduction products of PC on graphite surfaces via single-electron path form a stable Solid Electrolyte Interphase (SEI), which allows the reversible cycling of graphite.

Abstract: An integrated circuit includes one or more portions having error detection and error correction circuits and which is operated with operating parameters giving finite non-zero error rate as well as one or more portions formed and operated to provide a zero error rate.

Abstract: A plasma separator includes a vertical chamber with a membrane or membranes partially or fully covering the internal chamber walls and forming an inner cavity to accommodate whole blood. The plasma separator further includes a plasma collection space separated from the inner cavity with one or more membranes and a plasma removal port.

Abstract: One embodiment include an image acquisition circuit that accesses a pre-treatment and a post-treatment image of a region of tissue demonstrating non-small cell lung cancer (NSCLC), a segmentation and registration circuit that annotates the tumor represented in the images, and that registers the pre-treatment image with the post-treatment image; a feature extraction circuit that selects a set of pre-treatment and a set of post-treatment radiomic features from the registered image; a delta radiomics circuit that generates a set of delta radiomic features by computing a difference between the set of post-treatment radiomic features and the set of pre-treatment radiomic features; and a classification circuit that generates a probability that the region of tissue will respond to immunotherapy based on the difference, and that classifies the region of tissue as a responder or non-responder. Embodiments may generate an immunotherapy treatment plan based, at least in part, on the classification.

Abstract: A broad-based remediation mechanism against MRFs and alternative fecal indicators such as multidrug resistant Pseudomonas aeruginosa, including nanotechnology formulations and methodologies that may be used to develop novel treatment strategies against certain drug resistant bacterial strains. The current invention relates to the treatment of drug resistant bacteria from nosocomial infections, for example in hospitals and in food animals. The invention uses hybrid nanomaterials comprising oligo-chitosan and zinc oxide formulated as nanoparticles and micelles. The inventors unexpectedly found unique properties of very small oligomers of chitosan that effectively treat multi-drug resistant bacteria without compromising the balance of the beneficial flora in the physiological and ecological microenvironments in a host. Also, the combination of chitosan with zinc oxide demonstrated synergistic and unexpected effects in remediation of important food-borne bacteria including the resistant types.

Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

Abstract: Full-cycle rapid scan (RS) electron paramagnetic resonance (EPR) can be performed without the instability of prior art methods and with a higher scan rate than traditional half-scan methods. In particular, a full scan is performed, but the constant RF driving B-field can be mathematically represented as two step functions, each corresponding to one half of a full scan cycle. This mathematical representation can be carried through the deconvolution such that two deconvolutions, one for the up cycle and one for the down cycle, can be performed. The solutions to these two deconvolutions can then be summed to give a single spectrum having a higher signal-to-noise ratio than half-cycle RS scans.

Abstract: In some embodiments, an antenna includes a dielectric substrate having a first surface and a second surface opposite to the first surface, a planar central antenna element provided on the first surface, and a planar electromagnetic bandgap structure provided on the first surface and surrounding the central antenna element.