Abstract: In accordance with some embodiments, non-reciprocal circulators are provided, the circulators comprising: a 3?X/4-long ring section having a first end and a second end, wherein ? is an operating wavelength of the non-reciprocal circulator; and a N-path filter having a first port, a second port, and N-paths, each of the N-paths being connected to the first port and the second port. In some of these embodiments, the 3?/4-long ring section includes a transmit port, an antenna port, and a receive port. In some of these embodiments, the transmit port is ?/4 away from the antenna port. In some of these embodiments, the antenna port is ?/4 away from the receive port. In some of these embodiments, the receive port is at the first port of the N-path filter.

Abstract: The present invention is based, in part, on the identification of novel methods for defining predictive biomarkers of response to anti-cancer drugs.

Abstract: Provided is a gradient magnetic field generation module using multiple coils to generate a gradient magnetic field. Provided is a gradient magnetic field generation module including: a gradient coil formed inside a main magnet and generating a gradient magnetic field and including a plurality of coils; and a gradient amplifier controlling at least one of a shape of the gradient magnetic field, a strength of the gradient magnetic field, and slew rate of the gradient magnetic field generated by the gradient coil, in which the plurality of coils is grouped into a plurality of coil groups and current which flows in the plurality of coils is independently controlled by the unit of a group by the gradient amplifier.

Abstract: Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The disclosure further includes pharmaceutical compositions comprising the disclosed anti-factor XI monoclonal antibodies, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier.

Abstract: Ferrite films, antennas including ferrite films, and methods of making thereof are provided. The methods can include tape casting of a slurry to produce a green film, wherein the slurry includes a ferrite powder, a dispersant, and a binder in a suitable solvent; and densifying the green film to produce the ferrite film having a thickness of 50 ?m to 5 mm. The methods can be used to make large area films, for example the films can have a lateral area of about 1000 cm2 to 3000 cm2. VHF/UHF antennas are including the ferrite films are also provided.

Abstract: Compounds that disrupt the interaction between PCSK9 and LDLR, compositions that include the compounds, and methods for making and using the compounds and compositions.

Abstract: An object of the present invention is to conduct a search for a compound to be arranged at a terminal of a peptide nucleic acid effective in detecting a single nucleotide polymorphism. Provided is a tolan compound represented by the following formula (1): wherein R1 represents a phenyl group or a naphthyl group, the phenyl group may have 1 to 5 substituents that are identical to or different from each other, and the naphthyl group may have 1 to 7 substituents that are identical to or different from each other.

Abstract: The present invention provides compounds having a CB1 receptor-binding moiety and a directing moiety. In related aspects, the invention provides pharmaceutical compositions containing compounds of the invention, methods for inhibiting a pathway modulated in part by the CB1 receptor activity, and methods for treating a condition or disorder mediated in part by CB1 receptor activity. In certain embodiments, the compounds are compounds of Formula I. Methods of preparing compounds of Formula I are also described. In another aspect, the invention provides methods of identifying a selective agonist of the beta-arrestin pathway over the G-protein pathway.

Abstract: A system and method of treating hyperacusis is presented. The system uses a customizable, patient-specific, in-ear device combining sound attenuation with loudness suppression and a noise generator to expand the dynamic range of a patient. This device is used with novel software and counseling to provide a patient-specific treatment to hypersensitivity to sound.

Abstract: A haptic display system may comprise an array of vibratory elements, each vibratory element having a natural frequency different from the natural frequency of every other vibratory element in the array, a voice coil coupled to the array to impart vibrational energy to the array, and a microcontroller coupled to the voice coil to drive the array.

Abstract: Systems and methods for multi-mode radiation hardened multi-core microprocessors are disclosed. In some embodiments, a triplicated circuit includes a first core logic, a second core logic, a third core logic, and bus arbitration and control circuitry. The triplicated circuit is configurable to operate in both a Triple-Modular Redundant (TMR) mode of operation and a multi-threaded mode of operation. In some embodiments, there is essentially no overhead in soft mode and low overhead (power only) in hard mode. In most applications, it is expected that portions of missions require very hard systems (e.g., landing) where a failure is catastrophic. However, other portions require essentially no hardening (digital signal processor and signal processing activities) but much better throughput. Consequently, there is a huge opportunity to develop computer processors with low overhead in soft mode and unprecedented hardness in hard mode.

Abstract: Methods of treating leukodystrophy are provided. Accordingly there is provided a method of treating leukodystrophy in a subject, the method comprising administering to the subject a therapeutically effective amount of an agent capable of up-regulating activity and/or expression of a component participating in a Sigma-1 Receptor (Sig-1R) signaling pathway. Also provided are agents and methods of up-regulating activity of Sig-1R in a cell and treating a disease that can benefit from up-regulating activity of Sig-1R. Also provided are agents and methods of modulating activity of sonic hedgehog (SHH) in a cell and treating a disease that can benefit from modulating activity of SHH.

Abstract: A compound for inhibiting BMI-1/MCL-1 having a structure of Formula (I), wherein the various groups are as described. A pharmaceutical composition for treating cancer includes an effective amount of a compound of Formula (I).

Abstract: A method of training an N-bit neural network (N?2), is proposed to include: providing the N-bit neural network that includes a plurality of weights to be trained, each of the weights being composed of N bits that respectively correspond to N bit orders which are divided into multiple bit order groups, wherein the bits of the weights are divided, based on the bit orders to which the bits of the weights correspond, into multiple bit groups that respectively correspond to the bit order groups; and determining the weights for the N-bit neural network by training the bit groups one by one.

Abstract: A BIPOLAR-CMOS-DMOS (BCD) semiconductor device and manufacturing method, which can integrate a Junction Field-Effect Transistor (JFET), two classes of Vertical Double-diffusion Metal Oxide Semiconductor (VDMOS), a Lateral Insulated-Gate Bipolar Transistor (LIGBT) and seven kinds of Laterally Diffused Metal Oxide Semiconductor (LDMOS), a low-voltage Negative channel Metal Oxide Semiconductor (NMOS), a low-voltage Positive channel Metal Oxide Semiconductor (PMOS), a low-voltage Negative-Positive-Negative (NPN) transistor and a low-voltage Positive-Negative-Positive (PNP) transistor, and a diode in the same chip. Bipolar devices in the analog circuit, power components in the switch circuit, Complementary Metal Oxide Semiconductor (CMOS) devices in the logic circuit and other kinds of lateral and vertical components are integrated. This present invention saves costs at the same time greatly improve chip integration.

Abstract: A method of education is to be implemented by a processing unit of an electronic device which includes an input unit and an output unit, and the processing unit is capable of accessing a lexical database that includes a plurality of terms. The method includes: controlling the output unit to output a question; determining whether a user answer matches a correct answer to the question; when the user answer does not match the correct answer, determining whether the user answer corresponds to one of the terms in the lexical database; and when the user answer corresponds to one of the terms, controlling the output unit to output a definition of said one of the terms.

Abstract: Aspects of the subject disclosure may include, for example, communicating with a source of streaming media, wherein the streaming media is variable bitrate encoded, wherein the streaming media comprises a first plurality of chunks, wherein each of the first plurality of chunks corresponds to a first portion of the streaming media, wherein the streaming media comprises a second plurality of chunks, wherein each of the second plurality of chunks corresponds to a second portion of the streaming media, wherein the streaming media comprises a third plurality of chunks, and wherein each of the third plurality of chunks corresponds to a third portion of the streaming media; obtaining, from the source, a first one of the first plurality of chunks; and determining which of the second plurality of chunks and third plurality of chunks to obtain. Other embodiments are disclosed.

Abstract: Atomically thin layers including pores, their method of manufacture, and their use are disclosed. In some embodiments, pores may be formed in an atomically thin layer by growing the atomically thin layer on exposed portions of a substrate that includes islands comprising a material that is different than the material of the substrate. In some embodiments, pores and/or defects may be formed in an atomically thin layer by employing growth conditions that promote the formation of defects and/or pores. In certain embodiments, pores and/or defects may be etched to enlarge their size.

Abstract: Provided herein are methods of treating a patient having a cancer that exhibits (i) a hemizygous loss of the TP53 gene; (ii) a hemizygous loss of the POLR2A gene; and/or (iii) a decreased level of expression of a POLR2A gene product relative to a reference (i.e., control) expression level. The methods comprise administering a therapeutically effective amount of a POLR2A inhibitor (e.g., a nucleic acid that inhibits the expression of a POLR2A protein, an amatoxin, alpha-amanitin, or alpha-amanitin conjugated to a cell targeting moiety, such as an EpCAM antibody) to a patient having or determined to have (i) a hemizygous loss of the TP53 gene; (ii) a hemizygous loss of the POLR2A gene; and/or (iii) a decreased level of expression of a POLR2A gene product relative to a reference (i.e., control) level.

Abstract: Disclosed herein are compositions and methods for treating obesity involving satiation gut peptide administration to the mouth of a subject for a predetermined dose and frequency. In other embodiments, materials and methods of treating certain psychological disorders are disclosed involving satiation gut peptides. In exemplary embodiments, the satiation gut peptide pertains to PYY.