Abstract: Microfluidic devices, systems and techniques in connection with particle sorting in liquid, including cytometry devices and techniques and applications in chemical or biological testing and diagnostic measurements.

Abstract: The present invention provides a compound having the structure:

Abstract: A double swirl burner including an annular air nozzle, an annular fuel nozzle coaxially disposed within the annular air nozzle, and a central air nozzle coaxially disposed within the annular fuel nozzle. An annular air nozzle may include at least one first inlet port on a peripheral wall of the annular air nozzle, where the first inlet port may be configured to allow for tangentially injecting a first air stream into the annular air nozzle. A first air stream may be tangent to a circular cross-section of the exemplary annular air nozzle, and a first axial inlet that may be configured to allow for axially injecting a second air stream into the annular air nozzle along a centerline of the annular air nozzle.

Abstract: A multifunctional dendrimer nanoparticle and method of treating diseases of the posterior segment of the eye is presented. The functionalized polyamidoamine (PAMAM) dendrimer effectively delivers drugs and/or genes to the posterior eye, thereby providing for the effective, non-invasive, and topical treatment of diseased in the posterior eye. The multifunctional dendrimer nanoparticle has shRNA-encoding DNA and small molecule drug encapsulated cyclodextrin complexed to the outer surface of the dendrimer for delivery to the posterior segment of the eye.

Abstract: A Lactobacillus species strain isolated from kimchi or human feces is described. The particular bacillus species strain described is highly safe by being isolated from kimchi or human feces and has various functionalities, such as excellent blood sugar control activity, anti-obesity activity, blood cholesterol-lowering activity, blood neutral lipid-lowering activity, arteriosclerosis-inhibiting activity or inflammation-inhibiting activity. Accordingly, the particular bacillus species strain described can be used as a useful food and drug material for preventing, alleviating or treating a metabolic syndrome including diabetes, obesity, fatty liver, glycosuria, hyperlipidemia, cardiovascular disease, hypertension, arteriosclerosis and/or diabetes, an inflammatory disease, and the like.

Abstract: Disclosed is a marker for observing an effect of a compound or a drug on cells in real time. The marker is: 1) an amino acid sequence shown in SEQ No. 1 and/or SEQ No. 2; or 2) an amino acid sequence having a function for observing an effect of a compound or a drug on cells in real time and having at least more than 80%, preferably more than 85%, more preferably 90%, further preferably 95%, and most preferably 99% homology with the amino acid sequence shown in SEQ No. 1 and/or SEQ No. 2.

Abstract: A system and method for depositing a coating may comprise a coating chemical reactor, surface activation component, and a deposition component. A target surface may be prepared for deposition with the surface activation component. The coating chemical reactor may comprise a coating chemical dispenser and a coating chemical verifier that prepares the coating chemical for deposition. The coating chemical verifier may utilize an optical excitation source and at least one optical detector, wherein chemical substances are identified by unique signatures composed of binary code. The coating chemical may be received by the deposition component to depositing the coating chemical on the target surface.

Abstract: Skeletonized blood vessels for use as vascular grafts are protected from biomechanical injury and/or certain cellular and extracellular changes by application of a biocompatible hydrogel to the vessel exterior. The hydrogel may be applied to the vessel graft before or after harvesting from a donor patient.

Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function.

Abstract: Systems and methods for providing reinforcement learning for a deep learning network are disclosed. A reinforcement learning process that provides deep exploration is provided by a bootstrap that applied to a sample of observed and artificial data to facilitate deep exploration via a Thompson sampling approach.

Abstract: A method of manufacturing a microneedle includes: an emulsion producing operation of dissolving a soft material as a raw material of the coating layer in a solvent and mixing porogen with the dissolved soft material to produce emulsion; an emulsion coating operation of coating the emulsion on a surface of the needle body; an emulsion drying operation of drying the emulsion in the needle body after the emulsion coating operation; and a porogen removing operation of removing the porogen from the emulsion dried in the needle body, and the method further comprising a body manufacturing operation of using metal to manufacture the needle body, wherein the porogen comprises at least one of phosphate buffer saline (PBS), water-soluble hydrogel, and salt.

Abstract: According to some embodiments of the invention, a tensegrity robot includes a plurality of compressive members, and a plurality of tensile members connected to the compressive members to form a spatially defined structure without the compressive members forming direct load-transmitting connections with each other. Each compressive member has an axial extension with a first axial end and a second axial end and a central axial region. The tensegrity robot also includes a plurality of actuators, each attached to one of the compressive members within a corresponding central axial region thereof. The tensegrity robot also includes a plurality of controllers, each attached to one of the compressive members. Each actuator is operatively connected to a corresponding tensile member so as to selectively change a tension on the tensile member in response to commands from a controllers to thereby change a center of mass of the tensegrity robot to effect movement thereof.

Abstract: The present disclosure provides monoclonal antibodies that bind ?-Synuclein. In certain aspects, the antibodies preferentially bind to ?-Synuclein fibrils over ?-Synuclein monomer. In other aspects, the invention comprises a method of treating ?-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting ?-Synuclein fibrils using any of the antibodies of the invention.

Abstract: A method of producing a pluripotent stem cell is provided. The method is comprising contacting a non-pluripotent donor cell obtained from a mammalian donor with a compound characterized by general formulas (1) and (3). Furthermore, methods for inducing OCT4 and NANOG, increasing histone 3 lysine methylation and the maintenance of pluripotency are provided.

Abstract: Disclosed herein are quinoline-based compounds and method for inhibiting CDK8 or CDK19 for the intervention in diseases, disorders, and conditions. The quinoline-based composition comprise substituents at quinoline ring positions 4 and 6, wherein the substituent at position 4 is selected from a substituted or unsubstituted arylalkylamine or a substituted or unsubstituted arylhetrocyclylamine. Pharmaceutical compositions comprising the substituted qunioline compositions, methods of inhibiting CDK8 or CDK19, and methods of treating CDK8/19-associated diseases, disorders, or conditions are also disclosed.

Abstract: The present invention provides a method for extracting heat-sensitive Antarctic krill oil comprising the following steps. Firstly, frozen Antarctic krill is thawed and minced; a surfactant is added to the minced Antarctic krill to form a supercritical micelle system; extract the Antarctic krill multiple times after pressurizing and liquefying mixed gases; at the same time, a low-carbon alcohol solvent is added to strip the material in the critical micelle; after the extraction is completed, the extractant is removed; the extraction product and the residue after the extraction are subsequently collected; the heat-sensitive Antarctic krill oil can be obtained by high-speed centrifugal separation of the oil-water mixed extraction product. The present method has the advantages of simple operation, low extraction pressure and high safety. The extraction method of gas pressure liquefaction is completed under low temperature sealing conditions.

Abstract: A method of accelerating a training process of a neural network includes acquiring activations used in the training process and a bit-vector corresponding to the activations, selecting activations requiring an operation from among the acquired activations by using the bit-vector, and performing backward propagation using the selected activations and filters corresponding to the selected activations.

Abstract: The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for ASD treatment in a subject in need thereof comprising or consisting essentially of administering a therapeutic composition comprising a fecal microbe or a fecal microbiota preparation to the subject. Also provided here is a method comprises administering an antibiotic to a human subject; subjecting the human subject to a bowel cleanse; and administering purified fecal microbiota to the human subject. Further provided are evaluation and quantitative characterization of patient symptom improvements upon treatment described here.

Abstract: Some embodiments include a dipolar antenna system to electrically power an implantable miniature device and/or to stimulate bioelectrically excitable tissue. Other related systems and methods are also disclosed.

Abstract: A gas sensor includes a substrate, a pair of spaced-apart electrodes, and a detecting layer. The electrodes are disposed on the substrate with a region of the substrate exposed therefrom. Each of the electrodes is made of a graphene-based material. The detecting layer is disposed on the exposed region of the substrate and the electrodes. A method of making the gas sensor is also disclosed.