Abstract: An ultra-high temperature fracturing fluid, including the following components in mass percentages: 0.4 wt %-0.8 wt % of a polymer thickener, 0.015 wt %-0.02 wt % of a non-metallic crosslinking agent, 0.04 wt %-0.06 wt % of a gel breaker and the rest is water. The polymer thickener is obtained by a polymerization of acrylamide, acrylic acid, 2-acrylamido-2-methylpropanesulfonic acid, rigid monomer and cationic hydrophobic monomer in a weight ratio of 55-70:15-20:15-20:0.5-3:0.1-1.0, the polymerization temperature is 30-40° C. and the polymerization time is 8-10 hours. The fracturing fluid of the present invention can effectively solve the technical problems that traditional fracturing fluids are easily decomposed at high temperatures and affect performance.

Abstract: The titanium plating solution production method including measuring a titanium plating solution containing fluorine and titanium by cyclic voltammetry under the following conditions, and adding titanium to the titanium plating solution so that the potential difference between the spontaneous potential and the Ti3+/Ti4+ redox potential is 0.75 V or more. Conditions: when the temperature of the titanium plating solution is 650° C. to 850° C. and when glassy carbon is used as a working electrode, platinum is used as a pseudo-reference electrode and titanium is used as a counter electrode, the potential scanning is repeatedly performed on the working electrode for at least five times at a scanning speed of 1 mV/sec to 500 mV/sec between a lower potential limit which is the immersion potential of the working electrode and an upper potential limit which is a potential that is 2 V to 4 V higher than the lower potential limit.

Abstract: The present disclosure provides a method of solid-phase peptide synthesis from the N terminus to C terminus without detectable epimerization of the C-terminal amino acid.

Abstract: The transmembrane metalloproteinase-disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors, and extracellular matrix components. ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple-negative breast cancers (TNBCs). High ADAM8 levels predicted poor patient outcome, and ADAM8 promoted an aggressive phenotype of TNBC cells in culture. Tumors derived from TNBC cells with ADAM8 knockdown failed to grow beyond a palpable size and displayed poor vascularization. Circulating tumor cells and brain metastases were also significantly reduced. ADAM8 stimulated angiogenesis through release of VEGF-A and cell migration through ?1-integrin activation. Treatment with anti-ADAM8 antibody in vivo resulted in reduced primary tumor burden and reduced metastases. Furthermore, antibody treatment of established tumors profoundly decreased metastases in a resection model.

Abstract: Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce fluid pressure as a fluid passes through the constriction portion from the channel portion, whereby the tip assemblies form pores in the membranes of cells and introduce material into the cells. The material includes for example one selected from the group of: an inorganic compound, a drug, a genetic material, a protein, a carbohydrate, a synthetic polymer, and a pharmaceutical composition.

Abstract: Many embodiments provide a high frequency near-field probe based on a tapered waveguide combined with at least one optically-pumped high frequency radiation source and at least one optically-probed high frequency radiation detector.

Abstract: Embodiments of the present invention relate to a novel approach to automatically detect the occurrence of evoked potentials, quantify the attributes of the signal and visualize the effect across a high number of spinal cord epidural stimulation parameters. This new method is designed to automate the current process for performing this task that has been accomplished manually by data analysts through observation of the raw EMG signals, which is laborious and time-consuming as well as being prone to human errors. The proposed method provides fast and accurate framework for activation detection and visualization of the results within five main algorithms.

Abstract: A processor is configured with a learning framework to characterize the residuals of attribute information and its coherence with network information for improved anomaly detection.

Abstract: The present invention provides a method of placing a plate fixation device in a foot comprising the steps of: plantarly placing a reverse locking plate on the foot; and utilizing a locking guide to dorsally place reverse locking screws into the foot to mate with the reverse locking plate.

Abstract: A cell for a optically pumped magnetic sensor measures magnetic field by setting alkali metal atoms to a predetermined excitation state by a pump beam and detecting the excitation state by a probe beam. The cell is provided with a glass substrate which seals the alkali metal atoms and an enclosing gas and transmits the pump beam and the probe beam and a coating layer provided on an inner surface of the glass substrate. The coating layer is made of an inorganic material.

Abstract: A method for influencing cerebral perfusion in a patient by modifying a volume of a volume adaptor introduced into a cerebral ventricle of the patient, the method comprising identifying a timing of a cerebral blood inflow and/or outflow in a cardiac activity of the patient, modifying a volume of the volume adaptor in synchronization to the identified timing of the cerebral blood flow, to an amount sufficient to modify an intracranial pressure in the cerebral ventricle, such that a flow of the cerebral blood flow is enhanced. In some exemplary embodiments of the invention, the inflation duration of the volume adapter is short relative to the cardiac cycle.

Abstract: Disclosed herein are solutions for use with machine perfusion of one or more organs. In some embodiments, the solutions comprise acellular cross-linked hemoglobin in a physiologically acceptable medium. Also disclosed herein are methods for machine perfusion of one or more organs, for example utilizing the disclosed perfusion solutions. In some embodiments, the methods include perfusing an organ with an oxygenated solution (such as the disclosed solutions) which is at a temperature between about 12-37° C., for example at a temperature of about 21° C.

Abstract: Bifunctional fusion proteins having Tumstatin active fragments and CD137L extracellular regions are provided. The proteins exhibit activities to inhibit the proliferation of human umbilical vein endothelial cells and to costimulate the proliferation of T cells. They can be used for the treatment of various tumor-related diseases and the regulation of angiogenesis and immunological effects in humans.

Abstract: The present disclosure relates to methods and compositions suitable for changing metabolite levels in a subject in need thereof. In particular, this application provides methods and compositions for changing metabolite levels in a subject diagnosed with Autism Spectrum Disorder (ASD). Methods of preventing or treating an ASD in a subject thereof, as well as methods of selecting a treatment plan for treating an ASD in a subject are also provided.

Abstract: Nano-sized delivery vehicles utilize carbon nanotubes (CNTs) for the generic, targeted and passive transport of biomolecules into plant cells.

Abstract: Methods for diagnosing a cancer in a subject are provided in which a biological sample is provided from a subject including one or more exosomes. The exosomes are isolated from the biological sample and are used to identify a type and/or amount of one or more tumor suppressor miRNAs encapsulated by the exosomes. A measurable difference in the type and/or amount of the tumor suppressor miRNAs as compared to control levels allows for a diagnosis of cancer in the subject. Methods of selecting or modifying a treatment and methods for determining whether to initiate or continue prophylaxis or treatment for a cancer based on the exosomal miRNAs is further provided.

Abstract: Aspects of the subject disclosure may include, for example, receiving a request for media content, the media content being divided into a plurality of chunks, obtaining information about the chunks and constraints, determining whether there is a remaining layer to be downloaded, in response to determining that there is a remaining layer to be downloaded, determining a list of chunks that can be downloaded at a current layer and a downloading schedule according to the list of chunks that can be downloaded at the current layer, in response to determining that there is no remaining layer to be downloaded, producing a composite schedule for downloading the media content, and downloading the media content according to the composite schedule. Other embodiments are disclosed.

Abstract: A processor-implemented method implementing a convolution neural network includes: determining a plurality of differential groups by grouping a plurality of raw windows of an input feature map into the plurality of differential groups; determining differential windows by performing, for each respective differential group of the differential groups, a differential operation between the raw windows of the respective differential group; determining a reference element of an output feature map corresponding to a reference raw window among the raw windows by performing a convolution operation between a kernel and the reference raw window; and determining remaining elements of the output feature map by performing a reference element summation operation based on the reference element and each of a plurality of convolution operation results determined by performing respective convolution operations between the kernel and each of the differential windows.

Abstract: A system-on-a-chip (SoC) comprises a power supply circuit coupled to an energy harvesting transducer and configured to operate using energy from the energy harvesting transducer; a microcontroller coupled to a system bus of the SoC; an interface configured to communicate with the microcontroller via the system bus of the SoC, the interface configured to generate data upon occurrence of an event; and a computation accelerator configured to establish, based on an energy consumption level of the SoC, a data path between the interface and the computation accelerator that at least partially bypasses the system bus such that the data is transmitted to the computation accelerator via the data path.

Abstract: A NOD.Cg-PrkdcscidH2rgtm1 Wjl/SzJ.(NOD-scid-IL2r?null, NSG) mouse which is genetically modified such that the en NSG mouse lacks functional major histocompatibility complex I (MHC I) and lacks functional major histocompatibility complex II (MHC II) is provided according to aspects of the present, invention. According to specific aspects the genetically modified NSG mouse, is a NOD.Cg-PrkdcscidH2-K1tml Bpe H2-Ab1eml Mvw H2-D1tml Bpe H2rgtm Wjl/SzJ (NSG-Kb Db)null(IAnull)) mouse, NSG-RIP-DTR (Kb Db)null(IAnull) mouse, or a NOD.Cg-B2mtmlUnePrKdcscidH2dlAb1-E?H2rgtm1 Wjl/SzJ (NSG-B2Mnull(IA IEnull)) mouse. Human, immune cells and/or human: tumor cells are administered to a genetically modified immunodeficient mouse according to aspects described herein and assays of one or more test substances can be performed using the provided mice.