Abstract: Methods of inhibiting influenza A virus in a sample are provided. Aspects of the methods include contacting a sample comprising viral RNA (vRNA) having a PSL2 motif with an effective amount of an agent that specifically binds the PSL2 motif to inhibit the influenza A virus. Also provided are methods of treating or preventing influenza A virus infection in a subject. Also provided are methods for screening a candidate agent for the ability to inhibit influenza A virus in a cell, the method comprising: contacting a sample with a candidate agent; and determining whether the candidate agent specifically binds to the PSL2 motif of vRNA. Also provided are compounds and pharmaceutical compositions comprising an oligonucleotide sequence complementary to a PB2 vRNA region that find use in the subject methods.

Abstract: An object pose measurement system based on MEMS IMU includes: an accelerometer, a magnetometer, a gyroscope, an object vector information calculation unit, and a rotation compensation unit; wherein the object vector information calculation unit is connected respectively to the accelerometer, magnetometer, gyroscope to receive respective measurement data and calculate object vector information; the rotation compensation unit is connected to the object vector information calculation unit to receive the object vector information, compute and output rotation compensated object vector information; wherein the rotation compensation unit performs quaternion rotation compensation computation and outputs the rotation compensated quaternion as the rotation compensated object vector information.

Abstract: The disclosure provides for covalent organic frameworks (COFs) that constructed from weaving a plurality of long organic threads together. In particular, the disclosure provides for the construction of woven COFS, where long organic strands are connected together in a woven pattern using organic ligands/complexes that when orientated in certain geometries are capable of reversibly binding metal ions.

Abstract: Methods for distributing and providing access to stored content from remote storage comprising: receiving a first request to access a first portion of stored content from a requestor, wherein the first request is in a file system request format; creating a placeholder for the stored content so that the placeholder has at least one parameter identical to the stored content and the placeholder can hold the first portion of the stored content and at least a second portion of the stored content; requesting the first portion of the stored content from remote storage; receiving the first portion of the stored content from the remote storage; storing the first portion of the stored content in the placeholder; and before the second portion of the stored content has been stored in the placeholder, providing the first portion of the stored content to the requestor using a file system response format.

Abstract: A system includes a first energy storage device, a second energy storage device coupled to the first energy storage device and charged via a charging current from the first energy storage device, a power controller having a processor, a memory coupled to the processor and on which charging current instructions are stored, and a converter coupled to the processor and directed via switch control signals from the processor, and an output terminal via which power is provided to a load of the system. The converter is disposed between the first energy storage device and the output terminal. The converter is disposed between the first and second energy storage devices and configured to control a level of the charging current in accordance with the switch control signals. The charging current instructions are executed by the processor to cause the processor to generate the switch control signals such that the level of the charging current is regulated.

Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods for treating cancer using albumin-proaerolysin prodrugs. Accordingly, in one aspect, the present invention provides prodrug compositions. In certain embodiments, a prodrug composition comprises a prostate-specific antigen (PSA)-activated pro-aerolysin (PA), wherein a PSA cleavable linker replaces the native furin cleavage site within PA; and human serum albumin (HSA) or a fragment thereof fused to the N-terminus of the PSA-activated PA.

Abstract: The invention provides methods for engineering plants to have reduced levels of acetylation by decreasing expression of one or more Cas1L genes. Such plants can be used, e.g., to increase yield for biofuel production.

Abstract: An oblique submerged reverse deep rotary tilling device configured to be connected to a tractor. The tilling device includes a stander, a mounted frame, a gearbox and an oblique blade roller. The oblique blade roller has configured rotary blades whose tips bend to the same direction. The angle between the rotary tilling blade roller and an advancing direction of the tractor is 55˜70° while the rotary blade tips are all toward the right side of the advancing direction. Side force balance blades are installed to the left side of the oblique blade roller, rotate in a plane that is parallel to the advancing direction, and have a rotating center axis disposed at an angle to the oblique blade roller to balance the axial component force of the oblique blade roller.

Abstract: A flyback converter is provided, which includes a transformer comprising a primary winding and a secondary winding, the transformer for transforming a power inputted from an input power supply and outputting the transformed power, a switching part having one end connected to the primary winding and the other end connected to the input power supply, and an auxiliary circuit including an auxiliary capacitor, and an auxiliary winding coupled to the primary winding. In addition, a clamping diode and a two-series connected switch structure is utilized for the switch stage to relieve the voltage stress of the switch. Accordingly, it is possible to reduce the voltage stress of the switch and also reduce the ripple of the input current which are the causes of EMI.

Abstract: Electrowetting-actuated optical shutters based on total internal reflection or beam steering. An electrowetting cell contains a conducting liquid and a non-conducting liquid configured to form a liquid-liquid interface extending to the inner walls of the cell. A beam of light is directed to the liquid-liquid interface at an angle near the total internal reflection angle of the interface. Voltage changes the shape of the liquid-liquid interface, without separating it from the inner walls of the cell. Thus, when depending on the voltage applied, the beam is either transmitted in part or substantially totally internal reflected.

Abstract: Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate nanoparticles and materials comprising the nanoparticles, and methods of using the compositions to treat cancer or bone-related disorders (e.g., bone-resorption-related diseases, osteoporosis, Paget's disease, and bone metastases) and as imaging agents.

Abstract: Described herein is a method for eliminating or reducing ototoxicity in patients receiving a platinum based chemotherapeutic. In particular, are methods of reducing ototoxicity in a pediatric patient. The methods described herein include administering an effective amount of sodium thiosulfate to a patient in need thereof to reduce ototoxicity.

Abstract: Disclosed herein, the invention pertains to methods and compositions that find use in radiosensitization of tumors and tumor samples based on the ability of a tumor sample to cleave a MTS molecule of the present invention. The MTS molecules of the present invention have a formula as disclosed herein and wherein A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X and Y are linkers; P is an optional pre-targeting moiety; M is an optional macromolecular carrier; and T is a radiosensitization agent for delivery to a target, including for example a therapeutic compound.

Abstract: A pluggable trust architecture addresses the problem of establishing trust in hardware. The architecture has low impact on system performance and comprises a simple, user-supplied, and pluggable hardware element. The hardware element physically separates the untrusted components of a system from peripheral components that communicate with the external world. The invention only allows results of correct execution of software to be communicated externally.

Abstract: A method and systems of reconstructing a complex-valued X-ray refractive index distribution of an object having undergone X-ray phase-contrast tomography. The method includes acquiring at least one X-ray image of an object using an edge illumination X-ray phase-contrast tomography (EIXPCT) model, discretizing the model, jointly reconstructing the complex-valued refractive index distribution of the object using penalized least squares estimation of real and imaginary parts of the distribution, and solving the penalized least squares estimation using a batch gradient algorithm.

Abstract: Co-clustering based on generalized conceptual relationships can automatically detect story forms incorporating archetypes/targets and actions. Co-clustering can help in identifying similarities that exist in low-dimensional sub-spaces of sparse data such as textual paragraphs. Through co-clustering, the clusters themselves and their characteristic features are identifiable which can be useful in describing and summarizing their contents. The residual error of factorization with concept-based features is significantly lower than the error with prior keyword-based features. Qualitative evaluations also suggest that concept-based features yield more coherent, distinctive and interesting story forms compared to those produced by using prior keyword-based features.

Abstract: The present application is directed to electric double layer capacitance (EDLC) devices. In one aspect, the present application is directed to an electrode comprising an activated carbon cryogel having a tunable pore structure wherein: the surface area is at least 1500 m2/g as determined by nitrogen sorption at 77K and BET analysis; and the pore structure comprises a pore volume ranging from about 0.01 cc/g to about 0.25 cc/g for pores having a pore diameter of 0.6 to 1.0 nm. In another aspect, the present application is directed to an Electric Double Layer Capacitor (EDLC) device comprising an activated cryogel.

Abstract: A cochlear implant device comprises a receiver, a processing device, a first electrode and a second electrode. The receiver is configured to receive outside voice signal. The processing device is coupled to the receiver, configured to receive and transfer the voice signal to an electrical stimulation signal. The first electrode connects to the processing device, disposed on stapes footplate ligament or oval window. The second electrode connects to the processing device, disposed on round window. Wherein the electrical stimulation signal is applied to stapes footplate ligament, oval window or round window to stimulate acoustic nerve through the first electrode or the second electrode.

Abstract: An object has a durable superhydrophic, self-cleaning, and icephobic coating includes a substrate and a layer disposed on the substrate, the layer resulting from coating with a formulation having an effective amount of hierarchical structuring micro/nanoparticles, liquid silane having one or more groups configured to graft to a hierarchical structuring micro/nanoparticle and at least another group that results in hydrophobicity. The hierarchical structuring micro/nanoparticles are dispersed in the liquid silane. Another effective amount of synthetic adhesive, selected from thermosetting binders, moisture curing adhesives or polymers that form a strong interaction with a surface, is in solution with a solvent. Upon curing, the layer has a contact angle greater than 90° and a sliding angle of less than 10° and, less than 5% of an area of the layer is removed in a Tape test.

Abstract: Aspects of the disclosure relate to compositions and methods useful for treating Huntington's disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (HTT) and methods of treating Huntington's disease using the same.