Abstract: A pre-prodrug, comprising a drug, e.g., doxorubicin, which has off-target toxicity (e.g., cardiotoxicity) with respect to its antineoplastic activity, and an amine functionality of the drug incorporated into a disubstituted maleimide (DMI). The pre-prodrug may be linked to a targeting or de-targeting agent or a polar modulator, e.g., charged ligand, amino acid, peptide, etc., to increase therapeutic index. The pre-prodrug is hydrolyzed to the prodrug, having a disubstituted maleamic acid (DMA). A polar modulator such as glutamic acid prevents cellular uptake of the prodrug, but not the doxorubicin drug released from the prodrug after dissociation. The prodrug is pH sensitive, and below pH 7.0, tends to cleave to form free drug and cyclized maleic anhydride. Tumor environments tend to be more acidic, e.g., pH 6.8, than cardiac tissue, e.g., pH 7.4, and therefore the heart is spared while the drug is selectively released within a tumor.

Abstract: Systems and methods for assessing glaucoma loss using optical coherence topography. One method according to an aspect comprises receiving optical coherence image data and assessing functional glaucoma damage from retinal optical coherence image data. In an aspect, the systems and methods can map regions and layers of the eye to determine structural characteristics to compare to functional characteristics.

Abstract: A framework for joint computation, caching, and request forwarding in data-centric computing-based networks comprises a virtual control plane, which operates on request counters for computations and data, and an actual plane, which handles computation requests, data requests, data objects and computation results in the physical network. A throughput optimal policy, implemented in the virtual plane, provides a basis for adaptive and distributed computation, caching, and request forwarding in the actual plane. The framework provides superior performance in terms of request satisfaction delay as compared with several baseline policies over multiple network topologies.

Abstract: The present invention relates to a method for treating cancer. This method involves providing a first agent comprising a first targeting component coupled to a first cancer therapeutic component and providing a second agent comprising a second targeting component coupled to a second cancer therapeutic component. The first and second targeting components have different biodistributions and/or pharmacokinetics. The first and second agents are administered to a subject having cancer to treat the cancer. Also disclosed is a combination therapeutic comprising the first and second agents.

Abstract: This disclosure relates to compounds according to Formula (I), salts, prodrugs and pharmaceutical formulation comprising the compound are provided herein for the treatment of CXCR4 and CCR5 related conditions. The conditions may include viral infections, abnormal cellular proliferation, retinal degeneration and inflammatory diseases, or the compounds may be used as immunostimulants or immunosuppressants. Furthermore, the compounds may be used in combination with another active ingredient selected from an antiviral agent or chemotherapeutic agent.

Abstract: In one embodiment, a sensor unit includes an outer housing including a top plate and a base member that together define an interior space, the top plate being configured to directly receive and support the leg of the piece of furniture, a load cell provided within the interior space configured to measure forces imposed by the leg on the top plate, the load cell including a planar metal plate having a deformable element to which the top plate is mounted and a sensor element mounted to the planar metal plate at a location at which the deformable element extends from the remainder of the planar metal plate, and an internal platform provided within the interior space and associated with the base member that supports the planar metal plate of the load cell in a manner in which the deformable element of the planar metal plate is free to deform when a force is imposed by the leg on the top plate.

Abstract: This disclosure enables the generation and patterning of color centers with nanometer-scale spatial control in a variety of materials in repeatable fashion and without the use of radiation. Embodiments in accordance with the present disclosure employ a layer of vacancy-injection material disposed on a host-material, where the vacancy-injection material forms a compound with host-material atoms at elevated temperatures. During compound formation, lattice vacancies are generated in the host material and diffuse within the substrate lattice to bond with impurity atoms, thereby forming color centers. High-resolution lithographic patterning of the vacancy-injection film and the short diffusion lengths of the lattice vacancies enables nanometer-level spatial control over the lateral positions of the color centers. Furthermore, the depth of the color centers in the substrate can be controlled by controlling the coating material, thickness, anneal time, and anneal temperature.

Abstract: An induction machine with localized voltage unbalance compensation is disclosed. The use of an induction machine with a voltage unbalance correction compensator (VUC) may be used to maintain proper working conditions of the machine during intervals of voltage unbalance.

Abstract: Methods and systems for sensing a physiological characteristic of a subject. At least one receiver antenna can be provided in proximity to a portion of the subject's body to obtain at least one receiver signal resulting from at least one transmitter signal that has propagated to the receiver antenna and has been reflected, diffracted, scattered, or transmitted by or through the portion of the subject's body. One or more coherent signal pairs can be formed. Then, amplitude and phase information of a plurality of frequency components for each signal pair can be determined. A set of comparison values can be determined for each signal pair by comparing respective frequency component phases and respective frequency component amplitudes of the signals. Physiological characteristics of the subject can then be determined from these comparison values.

Abstract: The present invention provides a multi-load wireless power transfer system based on high-order Anti-PT symmetry. By introducing a “W-shaped” anti-resonance mode into a basic WPT platform, an effective Anti-PT non-Hermitian system is conveniently constructed. The “level attraction” of the anti-resonance mode is combined with the “level splitting” of the anti-resonance mode and the resonance mode, to study the “level pinning” effect of high-order Anti-PT symmetry. Compared with the traditional resonant WPT, the anti-resonant WPT has higher security, stability, transfer efficiency, and flexibility. Considering the miniaturization and integration of devices, a “meta coil” is designed by using a “synthetic dimension”, and used to construct a high-order Anti-PT symmetric system, thereby achieving multi-load efficient WPT. The new WPT technology based on the “level pinning” effect of high-order Anti-PT symmetry provides a good application research platform for enriching non-Hermitian physics.

Abstract: Embodiments described herein provide systems and methods to prevent, or provide a countermeasure, to a co-existence attack, for example, that may occur in a Security Credential Management System (SCMS) where both regular butterfly key (RBK) protocol and unified butterfly key (UBK) protocol are supported. Embodiments described herein provide, support, employ, or implement hardware acceleration for a Hardware Security Module (HSM), for example, for cryptographic operations (e.g., block ciphers, digital signature schemes, and key exchange protocols).

Abstract: A pharmaceutical composition is described herein, including an antimicrobial agent and a compound having Formula A, or Formula B. Methods of using the pharmaceutical compositions to treat microbial infection are also described.

Abstract: Methods for light-induced electroplating of aluminum are disclosed herein. Exemplary methods may comprise preparing an ionic liquid comprising aluminum chloride (AlCl3) and an organic halide, placing the silicon substrate into the ionic liquid, illuminating the silicon substrate, the illumination passing through the ionic liquid, and depositing aluminum onto the silicon substrate via a light-induced electroplating process, wherein the light-induced electroplating process utilizes an applied current that does not exceed a photo-generated current generated by the illumination.

Abstract: A metamaterial electromagnetic absorber includes a substrate having a first surface on which electromagnetic waves are incident and a second surface opposite the first surface. The substrate is made of a metamaterial. The metamaterial electromagnetic absorber also includes a first inductive conduction pattern and a second inductive conduction pattern formed on the first surface and the second surface, respectively.

Abstract: The present invention concerns a material, based on fibrillar, elongated, or disk-like colloidal particles, that has a high scattering efficiency, a method that is suitable for preparing such a material, and the use of such a material. The material can be used as, or as a part of, a pigment, paint or protective coating in various industries, but due to its high scattering, and due to the fact that the material appears white even as a thin membrane, it is an interesting option also in the paper and pulp, cosmetic and medical industries.

Abstract: The filter for carbon dioxide adsorption according to the present invention is composed of multiple unit filters that are mutually connected and stacked, and the unit filters include a repeating three-dimensional patterned part formed using one selected from vat photopolymerization, powder bed fusion, or additive manufacturing processes; flow paths formed in the three-dimensional patterned part; a three-dimensional exposed surface that is exposed to the mixed gas flowing through the flow paths; and a carbon dioxide adsorption layer coated on the exposed surface.

Abstract: The present application provides a hydrophilic and hydrophobic composite packing-based rotating packed bed and a system. A hydrophobic packing and a hydrophilic packing are formed into a composite packing. When said packing cuts liquid, the hydrophobic packing can sufficiently disperse the liquid so as to make the dispersion of the liquid in the packing zone more uniform, and the wettability of the hydrophilic packing allows the liquid to spread sufficiently so as to increase the wetting efficiency of said packing. The phenomenon of droplet aggregation caused to liquid in a single hydrophobic packing zone and the phenomenon of reduction of liquid turbulence caused to liquid in a single hydrophilic packing zone can be avoided. Therefore, applying a hydrophilic and hydrophobic composite packing to a rotating packed bed can further improve the mass transfer and mixing performance thereof.

Abstract: A biokinetic energy collection apparatus and a fabrication method thereof are provided. The apparatus includes: a counter weight, configured to oscillate with a movement of a wearer, to convert a mechanical energy generated by the movement into kinetic energy of the counter weight; a rotating frame, mechanically coupled to the counter weight, and configured to receive the kinetic energy from the counter weight; a planetary gear train, mechanically coupled to the rotating frame, to rotate as the rotating frame moves; and a stator assembly and a rotor assembly, coupled to each other, where the stator assembly includes a coil, the rotor assembly includes a rotor and a third permanent magnet located on the rotor, and the rotor is mechanically coupled to the planetary gear train and receives the kinetic energy from the planetary gear train, to cause the third permanent magnet to rotate with the rotor.

Abstract: A heterostructured catalyst includes a 2-dimensional (2D) array of titanium including nanocavities that are all directly attached to a substrate. Each of the titanium including nanocavities have a pore with a nanopore size and a wall with a nanowall thickness. The titanium including nanocavities can be titania nanocavities with a metal layer or a metal compound layer on the titania nanocavities including inside the pores, or the titanium including nanocavities can include SrTiO3 or consist of SrTiO3, each with a surface layer of reduced SrTiO3.

Abstract: The present disclosure relates to a composition for preventing, alleviating, or treating allodynia caused by anticancer agents, containing cinnamic acid or a pharmaceutically acceptable salt thereof as an active ingredient. The composition of the present disclosure can prevent, alleviate, or treat allodynia by being administered to a subject scheduled to receive anticancer agents or having received anticancer agents.