Abstract: The invention provides a method of promoting reprogramming of a cardiac fibroblast into a cardiomyocyte by contacting the cardiac fibroblast with an isolated polynucleotide molecule comprising at least two functional miRNA sequences using a multicistronic expression system for reprogramming of fibroblasts into functional mature cardiomyocytes.

Abstract: A distributed optimization control method for an aircraft energy system considering loss includes the following steps: S1, based on characteristics of the actual near-space aircraft energy system and the near-space environment, the multi-bus DC microgrid system model is established for the near-space aircraft energy system according to Kirchhoff's law; S2, according to the energy scheduling requirement of the near-space aircraft energy system, the system control target is established; S3, according to the system control target, the optimal scheduling problem of the aircraft energy system considering operating loss is established; and S4, based on projection and penalty, the distributed optimization control algorithm is designed. The distributed optimization control method realizes bus voltage regulation and current distribution.

Abstract: In certain embodiments methods of identifying T cell receptors that respond to specific target cell antigens are provided, where the methods comprise providing a substrate bearing a plurality of target cells (e.g., mammalian cells); contacting the target cells on the substrate with CD8+ T cells; and using label-free optical imaging to identify an increase in mass of a T-cell and/or a decrease in mass of a target cell, where an increase in mass of a T cell and/or a decrease in mass of a target cell is an indicator that said T cell bears a T cell receptor activated by antigens presented on said target cell.

Abstract: A method for detecting an analyte comprises the following steps: providing a SERS-active substrate and a Raman spectra database; applying a sample onto the SERS-active substrate; applying an incident light by a Raman spectrometer onto the SERS-active substrate to generate a Raman spectrum of the sample; and comparing the Raman spectrum of the sample with a Raman spectra database to identify an analyte in the sample. The SERS-active substrate comprises: a support; a first dielectric layer disposed on the support, wherein the first dielectric layer is formed by a plurality of first nanofibers; and a plurality of noble metal particles formed on the plurality of first nanofibers.

Abstract: The present invention belongs to the technical field of stress detection and provides a method and device for testing stress of a high-temperature component of a power plant boiler. The adjusting assembly includes a plurality of bearing blocks, each bearing block is provided with an accommodating groove vertically, limiting blocks are disposed at two ends of the accommodating groove symmetrically, an elastic member, a first connecting rod, and a second connecting rod are disposed in the accommodating groove, and a limiting plate is fixedly connected to one end of each of the first connecting rod and the second connecting rod. According to the present invention, lengths of the first connecting rod and the second connecting rod extending out of the accommodating groove are adjusted, so that the device can be adjusted according to a caliber of a pipeline of the power plant boiler.

Abstract: Approaches, techniques, and mechanisms are disclosed for packaging electric power components. A power module comprises: a three-dimensional (3D) cooling structure that has a plurality of planar sides; a first set of mountable power components that are mounted on a first planar side in the plurality of planar sides of the 3D cooling structure; a second set of mountable power components that are mounted on a second planar side in the plurality of planar sides of the 3D cooling structure. The second planar side represents an opposing side, of the 3D cooling structure, to the first planar side. The 3D cooling structure includes an interior space containing one or more cooling channels in which cooling fluid is to flow. The interior space of the 3D cooling structure is spatially surrounded by other planar sides in the plurality of planar sides in combination with the first and second planar sides.

Abstract: Radial-armed thin-film bilayers are designed and fabricated from a metal and an oxide to produce grippers that interact with the yarns or fibers of the fabric and form a mechanical tangle attachment to the fabric. MEMs devices attached to the grippers enable the MEMs devices to be adhered to a flexible and/or extensible fabric. Fabrics comprise conventional textile, smart textiles, functional fibers or other smart materials. The fabrics thus incorporate wearable sensors, medical devices, and other functional MEMs for commercial, biomedical, industrial and scientific applications.

Abstract: A system and method for wirelessly and passively powering and/or interrogating an implanted stent using a touch probe assembly through a near-field electrical connection not over an air interface. The stent apparatus includes at least one stent member functioning as an antenna and an electronics module coupled to the at least one stent member. Also, a wirelessly and passively powered power meter for use with implanted stents. The power meter includes an electronics module coupled to a stent member, wherein the electronics module includes a programmable oscillator structured to generate an oscillating signal that is proportional to an amount of AC power received by the implantable stent apparatus power meter through the stent member.

Abstract: Microfluidic sensing devices utilizing microfluidic sensing electrodes are provided. In one embodiment, a method for fabrication of a microfluidic sensing electrode device for detection of analyte(s) in a fluid is provided, the method comprising: generating a chamber comprising: a tube hole configured to receive a tube, wherein the tube hole extends from a first end of the chamber to a second end of the chamber; and a plurality of electrode holes configured to receive a plurality of electrodes, wherein each of the plurality of electrode holes is in contact with the tube hole; inserting the tube into the tube hole; inserting the plurality of electrodes into the plurality of electrode holes; applying a resin to the chamber; removing the tube from the tube hole, wherein removing the tube from the tube hole exposes a sensing zone that allows the plurality of electrodes to be in contact with the fluid.

Abstract: Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpreS1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.

Abstract: A machine-readable medium and methods of reading and writing same are disclosed. The machine-readable medium comprises a substrate having an array of addressable locations thereon, each addressable location adapted to be physically associated with a collection of non-polymeric molecules. The molecules in each collection are selected from a set of unambiguously identifiable molecules, each molecule uniquely associated with a predetermined position in a numerical value, wherein the presence of the molecule in the collection indicates a predetermined digit at the associated position and the absence of said molecule in the collection indicates a zero at said associated position.

Abstract: Embodiments relate to a sensor system configured to detect physical rotation, entire or relative, of one or more objects and/or their environment and/or proximity of a magnetic field, by measuring the degree of localization of a medium trapped in a ring-shaped artificial lattice. The lattice structure can be configured to comprise of lattice sites distributed with a lattice period around an azimuth of a closed ring. The site depths of the plurality of lattice sites can be configured to be modulated with a modulation period different from the lattice period to affect the onsite energies of each lattice site and the eigenstates of the system. Physical rotation of the sensor and/or the proximity of magnetic field will alter the localization properties so as to cause the degree of localization of the medium to change (e.g., the medium becomes more confined in space or more spread out in space).

Abstract: The invention provides a diagnostic kit for metastasis and invasion of breast cancer and a use of an shRNA molecule for silencing expression of human LINC01614. The shRNAs obtained by the invention can interfere with the expression of LINC01614, thereby reducing the migration and invasion ability of tumor cells, inhibiting the expression of EMT proteins, and inhibiting tumor formation and lung metastasis in an animal model in vivo. The invention provides a new solution for targeted therapy of breast cancer. Therefore, the kit for diagnosing metastasis and invasion of breast cancer and the medication for treating metastasis and invasion of breast cancer are developed. The invention provides a new way and strategy for diagnosing and treating metastasis and invasion of breast cancer.

Abstract: A method of cutting (e.g. micro-milling) brittle materials where a protective ductile layer is present on the brittle material during the cutting step. The method offers an improved edge quality of the machined profile relative to previous cutting (e.g. micro-milling) techniques. A machined product obtained by or obtainable by this method is disclosed.

Abstract: A double-inverse opal photonic crystal resin film is formed by embedding nanospheres in pores of polyacrylate inverse opal framework material and then filling the pores of the double-inverse opal photonic crystal resin film with an ethanol solution with hydrophilic acrylamide dissolved therein followed by photopolymerization to form a polyacrylamide network, so as to obtain the double-inverse opal photonic crystal resin film using water as ink. A mass fraction of hydrophilic acrylamide in the ethanol solution is 2 to 8 wt. %. The resin film can induce water to penetrate into the pores of the double-inverse opal photonic crystal resin film, making the nanospheres in the pores of the inverse opal framework distribute from random to order under the action of buoyancy force, thereby eliminating scattering interference and producing brilliant structural colors by regulating refractive index contrast.

Abstract: A fault-tolerant computer system includes a plurality of redundant processor cores configured to simultaneously execute identical sets of processor-executable instructions, and a coprocessor component including a data storage component and a configurable logic region, where the plurality of processor cores are configured with processor-executable instructions to perform operations including configuring the configurable logic region of the coprocessor component with a first coprocessing module, and controlling the first coprocessing module to perform first processing operations on data located in the data storage component. In various embodiments, the redundant processor cores and the coprocessor component may be implemented on an FPGA, and the redundant processor cores may be configured to swap out different coprocessing modules using Partial Reconfiguration (PR) to perform data processing algorithms using hardware acceleration.

Abstract: The invention relates to a microfluidic poration device having narrow channels slightly smaller than the width of a target cell, wherein the channels are lined with a plurality of nanospikes in a row extending down the middle of the channel, i.e. in a row parallel to the sides of the channel. In one embodiment, one channel may have 2 nanospikes (or 2 nanolancets). Thus, in particular embodiments, the invention provides microfluidic poration devices capable of simultaneously squeezing cells while piercing holes in their membranes for allowing foreign molecules into cells. The holes in porated cells spontaneously close after exiting the channels, thus entrapping the foreign molecules inside of the target cells. This porated cell population has approximately a 95% viability with greater than 50% containing at least one foreign molecule.

Abstract: Numerical weather prediction data during a time period of interest for a multi-airport system is used to generate a three-dimensional (3-D) tensor data for the time period of interest. The 3-D tensor data is then used to predict hourly runway configurations for each of a plurality of airports of the multi-airport system during the time period of interest using the 3-D tensor data as input to a plurality of runway configuration convolutional neural networks (CNN) branches and to predict an AAR for each of the plurality of airports of the multi-airport system during the time period of interest using the 3-D tensor data as input to an airport acceptance rate (AAR) CNN branch. The predicted hourly runway configuration for each of the plurality of airports and the predicted AAR for each of the plurality of airports are then used to manage flights within the multi-airport system.

Abstract: A data processing system and method for accessing a heterogeneous memory system including a processing unit are provided. The heterogeneous memory system includes a memory module and high bandwidth memory (HBM) including a processing-in-memory (PIM) circuit combined with a memory controller. The memory controller is configured to detect a data array required for an arithmetic operation from a memory module or the HBM by using a border index value when the arithmetic operation is performed by the PIM circuit of the HBM and generate a memory module command set and an HBM command set using physical address spaces respectively designated in the memory module and the HBM.

Abstract: In an aspect, a method for additive manufacture of a three-dimensional object based on a computational model comprises steps of: grayscale photohardening a precursor material to form a portion of the object; and applying a hardened meniscus coating at a feature of the object; wherein the three-dimensional object is formed via at least the combination of the steps of gray scale photohardening and applying the meniscus coating. In some embodiments, the grayscale photohardening step is a grayscale photopolymerization step. In some embodiments, the applying a hardened meniscus coating step is a meniscus equilibrium post-curing step.