Abstract: The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.
Type:
Grant
Filed:
September 25, 2015
Date of Patent:
June 25, 2019
Assignee:
The Regents of the University of California
Inventors:
Christopher J. Chang, Carolyn R. Bertozzi, Genevieve C. van de Bittner, Elena A. Dubikovskaya
Abstract: The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.
Type:
Grant
Filed:
August 23, 2018
Date of Patent:
June 25, 2019
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Stephen R. Quake, Thomas M. Snyder, Hannah Valantine
Abstract: Provided are a lateral light emitting diode device and a method for fabricating the same. The lateral light emitting diode device includes a substrate; an n-type GaN layer disposed on the substrate; an activation layer disposed on the n-type GaN layer; a p-type GaN layer disposed on the activation layer, a plurality of holes being formed in the p-type GaN layer; a current spreading layer disposed on the p-type GaN layer; a p-electrode disposed on the current spreading layer; a seed layer disposed on bottom surfaces of the plurality of holes; metal oxide structures grown on the seed layer in a crystalline state to fill the plurality of holes; and an n-electrode disposed on the n-type GaN layer exposed by removing portions of the current spreading layer, the p-type GaN layer, the activation layer, and the n-type GaN layer.
Type:
Grant
Filed:
June 21, 2017
Date of Patent:
June 25, 2019
Assignee:
Korea University Research and Business Foundation
Inventors:
Tae Yeon Seong, Ki Seok Kim, Sung-joo Song
Abstract: A method of electrochemically reducing CO2 to form at least one alcohol, preferably ethanol. The method includes (a) contacting an electrode system with an aqueous solution comprising at least one electrolyte and CO2, wherein the electrode system comprises a working electrode, a counter electrode, and a reference electrode, wherein the working electrode comprises a base electrode and a coating of a composite comprising graphene nanosheets and Cu2O nanoparticles disposed on a surface of the base electrode, and (b) applying a negative potential to the working electrode to reduce the CO2 and form the at least one alcohol.
Type:
Grant
Filed:
November 1, 2016
Date of Patent:
June 25, 2019
Assignee:
King Fahd University of Petroleum and Minerals
Abstract: The present invention provides methods for identifying metastases by detecting nucleic acid hypermethylation of one or more genes in one or more samples, and in particular in the lymph nodes. The invention further relates to DNA methylation as a predictor of disease recurrence and patient prognosis, specifically in the field of cancer biology.
Type:
Grant
Filed:
February 14, 2014
Date of Patent:
June 25, 2019
Assignee:
The Johns Hopkins University
Inventors:
Malcolm V. Brock, Stephen B. Baylin, James G. Herman
Abstract: A molecular sensor that utilizes dichroism can be used to identify the presence of a target nucleic acid molecule in a sample, for example during or after amplification reactions such as PCR/thermocyling reactions and isothermal reactions. A sensor element for use in the molecular sensor may comprise an alignable scaffold/receptor complex, the receptor of said complex comprising a nucleic acid sequence which is complementary to at least a portion of a target nucleic acid molecule.
Abstract: A magnet assembly for use in high power pulsed magnetron sputtering comprises a configuration of magnets having a magnetic field topology comprising magnetic field components Bx, By and Bz. A tangential magnetic field B// distribution on an x-y plane above the configuration of magnets comprising an outer continuous ring and one or more inner continuous rings contained in the outer continuous ring. A total magnetic field Btot distribution on an x-z plane intersecting the configuration of magnets comprises an outer closed loop and one or more inner closed loops contained in the outer closed loop, where, as a function of x, a tangential magnetic field B// alternates between (a) high field values greater than 200 G and high gradients in the z-direction of at least 1000 G/in, and (b) low field values of less than 50 G and low gradients in the z-direction of at most 250 G/in.
Type:
Grant
Filed:
October 8, 2015
Date of Patent:
June 25, 2019
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
David N. Ruzic, Ivan A. Shchelkanov, Priya Raman
Abstract: In one aspect, a method includes conducting a plurality of tests on process variables of a thermal process, with a test of the plurality of tests being conducted on two or more process variables, the test comprising: locally heating a region of a structure, wherein the local heating results in formation of a thermal field in the structure; assessing one or more temperature integrals of the thermal field; and based on results of the plurality of tests, generating a process map of the one or more temperature integrals of the thermal field, with the one or more temperature integrals based on a function of the two or more process variables.
Abstract: Compounds and compositions, and methods of use thereof, are provided and have utility in inhibiting hedgehog signaling and/or phosphodiesterase-4 activity.
Type:
Grant
Filed:
March 7, 2017
Date of Patent:
June 25, 2019
Assignee:
Vanderbilt University
Inventors:
Charles C. Hong, Charles H. Williams, Jonathan Hempel, T K Feaster, Don H. Rubin, Gary Sulikowski, Jijun Hao, Audrey Frist
Abstract: Provided is an electromechanical-linkage hydraulic control gate valve actuator. The actuator includes a hand-operated speed-increasing gearbox assembly and a bidirectional throttle valve. In the present invention, a motor is driven to rotate through the hand-operated speed-increasing gearbox and thus a hydraulic system is driven to finally open and close a gate valve. An opening and closing speeds of the gate valve can be regulated and controlled through the bidirectional throttle valve. The present invention drives the motor through the hand-operated speed-increasing gearbox under emergency conditions such as repair and power failure, thereby controlling to open and close the gate valve. Meanwhile, a hydraulic system respectively regulates the speeds of two states of opening and closing through a bidirectional throttling technique, so as to effectively eliminate a water hammer phenomenon. The present invention has simple structure, light weight and modular installation, and enhances safety and reliability.
Abstract: The invention provides rare earth-free permanent magnetic materials and methods of making them. The materials can be used to produce magnetic structures for use in a wide variety of commercial applications, such as motors, generators, and other electromechanical and electronic devices. Magnets fabricated using the materials can be substituted for magnets requiring rare earth elements that are costly and in limited supply. The invention provides two different types of magnetic materials. The first type is based on an iron-nickel alloy that is doped with one or more doping elements to promote the formation of L10 crystal structure. The second type is a nanocomposite particle containing magnetically hard and soft phases that interact to form an exchange spring magnetic material. The hard phase contains Fe or FeCo, and the soft phase contains AlMnC.
Type:
Grant
Filed:
July 16, 2012
Date of Patent:
June 25, 2019
Assignees:
Northeastern University, Carnegie Mellon University
Abstract: The present invention provides methods for purifying a layer of carbon nanotubes comprising providing a precursor layer of substantially aligned carbon nanotubes supported by a substrate, wherein the precursor layer comprises a mixture of first carbon nanotubes and second carbon nanotubes; selectively heating the first carbon nanotubes; and separating the first carbon nanotubes from the second carbon nanotubes, thereby generating a purified layer of carbon nanotubes. Devices benefiting from enhanced electrical properties enabled by the purified layer of carbon nanotubes are also described.
Type:
Grant
Filed:
November 17, 2016
Date of Patent:
June 25, 2019
Assignees:
The Board of Trustees of The University of Illinois, Northwestern University, University of Miami
Inventors:
John A. Rogers, William L. Wilson, Sung Hun Jin, Simon N. Dunham, Xu Xie, Ahmad Islam, Frank Du, Yonggang Huang, Jizhou Song
Abstract: The presently disclosed and/or claimed inventive concept(s) relates generally to the reduction of carbon dioxide by heterogeneous catalysis. More particularly, but not by way of limitation, the presently disclosed and/or claimed inventive concept(s) relates to the reduction of carbon dioxide by heterogeneous catalysis with a heterogeneous hydrogenation catalyst comprising structurally frustrated Lewis pairs, wherein, for example but not by way of limitation, formic acid is produced and hydrocarbons are indirectly produced. In one non-limiting embodiment, the heterogeneous catalyst comprises hexagonal boron nitride (h-BN) having structurally frustrated Lewis pairs therein.
Type:
Grant
Filed:
March 28, 2017
Date of Patent:
June 25, 2019
Assignee:
University of Central Florida Research Foundation, Inc.
Abstract: A synergistic adjuvant is provided comprising synergistically effective amounts of at least one type 1 interferon and at least one CD40 agonist, wherein these moieties may be in the same or separate compositions. In addition, fusion proteins and DNA conjugates which contain a type 1 interferon/CD40 agonist/antigen combination are provided. The use of these compositions, protein and DNA conjugates as immune adjuvants for treatment of various chronic diseases such as HIV infection and for enhancing the efficacy of vaccines (prophylactic and therapeutic) is also provided.
Type:
Grant
Filed:
July 1, 2015
Date of Patent:
June 25, 2019
Assignee:
The Regents of the University of Colorado
Inventors:
Ross Kedl, Phillip J. Sanchez, Catherine Haluszczak
Abstract: The apparatus and method for testing the ability of materials to protect photolabile materials provides an accurate measurement by directly observing the degradation level in a photolabile material. The apparatus is an assembly having primary and secondary cells and a light source. The primary and secondary cells are arranged in different configurations with respect to one another such that any light that reaches the photolabile materials must first go through the protective material under test. The method includes placing a protective material under test in the primary cell; placing a photolabile material in the secondary cell; subjecting the assembly to a light source for a predetermined amount of time; and removing and testing the photolabile material for degradation.
Type:
Grant
Filed:
March 27, 2018
Date of Patent:
June 25, 2019
Assignee:
King Saud University
Inventors:
Mohd Aftab Alam, Fahad Ibrahim Al-Jenoobi
Abstract: Provided herein is a method of treating a subject believed to have suffered a stroke. This method comprises administering to the subject a therapeutically effective amount of a composition comprising conivaptan or an active derivative, stereoisomer, pro-drug, or pharmaceutically acceptable salt thereof.
Abstract: The sulindac derivatives are compounds of the formula: wherein R is one of twenty-five substituted or unsubstituted phenyl substituents; and pharmaceutically acceptable salts thereof. The sulindac derivatives are synthesized by refluxing sulindac hydrazide with appropriately substituted benzaldehydes in the presence of ethanol and catalytic amounts of glacial acetic acid. The sulindac derivatives may be used as active ingredients in pharmaceutical compositions for the treatment of inflammation or inflammatory diseases. The sulindac derivatives may also be used as analgesic and/or gastric sparing agents.
Type:
Grant
Filed:
October 3, 2018
Date of Patent:
June 25, 2019
Assignee:
King Saud University
Inventors:
Mashooq Ahmad Bhat, Mohamed A. Al-Omar, Nawaf Abdulaziz Alsaif, Syed Hidayathulla
Abstract: A linear element with two stable points, it can be used as trust element allows for change in length. It can transform structure from one shape to another thus allowing for morphable configuration. A new model is presented herein for a linear bi-stable compliant mechanism and design guidelines for its use. The mechanism is based on the crank-slider mechanism. This model takes into account the first mode of buckling and post-buckling behavior of a compliant segment to describe the mechanism's bi-stable behavior. The kinetic and kinematic equations, derived from the Pseudo-Rigid-Body Model, were solved numerically and are represented in plots. This representation allows the generation of step-by-step design guidelines. Because different applications may have different input requirements, two different design approaches are described herein with different parameters subsets as inputs.
Abstract: A smart window controller includes circuitry configured to establish a representative model of one or more building zones based on occupancy, construction, lighting, or cooling properties of a building. A lighting control strategy is implemented for the one or more building zones based on the representative model or one or more user preferences input at a first user interface screen of an external device. Automatic operations of one or more smart windows, cooling systems, or artifcial lighting systems are controlled based on trigger points associated with the lighting control strategy, and a performance level of the lighting control strategy for the one or more building zones is determined based on one or more predetermined financial metrics.
Type:
Grant
Filed:
July 12, 2018
Date of Patent:
June 25, 2019
Assignee:
King Fahd University of Petroleum and Minerals
Inventors:
Mohammed Abdul Fasi, Ismail Mohammad Budaiwi