Abstract: Aspects of the subject disclosure may include, for example, a process that determines a field-of-view of an immersive video viewer, determines present orientation of the immersive video viewer at a first time, and predicts a future orientation of the immersive video viewer occurring at a second time based on the present orientation of the immersive video viewer. A subsegment of an entire immersive video frame corresponding to the second time is identified based on the predicted orientation of the immersive video viewer and the field-of-view. Wireless transmission of the subsegment of the entire immersive video frame to the immersive video viewer is facilitated for presentation at the immersive video viewer at the second time, without requiring transmission of the entire immersive video frame. Other embodiments are disclosed.

Abstract: The invention relates, in part, to compounds, compositions, and methods to assess characteristics of mitochondrial antiviral-signaling (MAVS) polypeptides and also to methods of modulating MAVS polypeptide characteristics. In addition, the invention relates, in part, to assays to assess characteristics of polypeptides.

Abstract: Chemically inert, mechanically tough, cationic metallo-polyelectrolytes designed as durable anion-exchange membranes (AEMs) via ring-opening metathesis polymerization (ROMP) of cobaltocenium-containing cyclooctene with triazole as the only linker group, followed by backbone hydrogenation to provide a new class of AEMs with a polyethylene-like framework and alkaline-stable cobaltocenium cation for ion transport, which exhibit excellent thermal, chemical and mechanical stability, as well as high ion conductivity.

Abstract: The technology relates to a prophylactic bandage contact lens that prevents microbial infections in an eye as well as treats infection by dispensing antimicrobial medication at controlled rates. In one embodiment, the invention provides a bandage with nanostructures, and provides a continuous treatment over 10 days and shields the eye from the environment, significantly diminishing the risk of infection while allowing damaged tissues to heal.

Abstract: The present invention is a method, comprising: obtaining a sample of an esophageal tissue from a subject, wherein the sample of the esophageal tissue comprises or is suspected of comprising a break of chromosome 2 (chr2), a break of chromosome 10 (chr10), a break of chromosome 16 (chr16), or any combination thereof, and detecting in the sample of esophageal tissue whether the break of chr2 is present, whether the break of chr10 is present, whether the break of chr16 is present, or any combination thereof, by contacting the sample of esophageal tissue with a first detectably labeled probe, a second detectably labeled probe, a third detectably labeled probe, or any combination thereof, and detecting binding between: the first detectably labeled probe and the break of chr2, the second detectably labeled probe and the break of chr10, the third detectably labeled probe and the break of chr16, or any combination thereof.

Abstract: A method includes receiving a processor design of a processor, receiving an application to be executed by the processor, and receiving a security policy. The method includes simulating the execution of the application on the processor to identify information flow violations generated by the application based on the security policy.

Abstract: A new variety of Citrus ichangensis x C. maxima plant named ‘Tift2-16’ produces fruit with a reduced number of seeds, making it valuable as a backyard fruit tree. Also, it is a desirable tree for landscaping.

Abstract: The invention encompasses novel sensor designs that can operate in complex samples like whole blood. The use of protective filtering membranes prevents fouling and erroneous signal drift in sensors such as aptamer based electrochemical sensors. In one aspect, the invention encompasses implantable sensors that can be deployed to the circulatory system of an animal where they can accurately and continuously measure the concentration of a target species, such as a drug, with very short resolution times, for extended periods without signal drift. These sensor designs and associated methods provide a means of accurately dosing animals based on real-time monitoring of drugs and other chemical markers and biomarkers.

Abstract: Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively binds to and stabilizes G-quadruplex DNA in the promoter of the c-MYC gene to the subject. The methods are also of use to decrease the size and/or number of metastases. Compounds for use in the disclosed methods are also provided.

Abstract: Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.

Abstract: The invention generally relates to compositions (including polynucleotides, constructs, fusion proteins, vectors, and cells) and methods of using such compositions for enhancing gene expression, protein production and viral replication. More specifically, the invention relates to use of m6A sequences and/or YTHDF polypeptides to enhance gene expression or viral replication.

Abstract: An isolated polynucleotide encoding a fusion protein which comprises a catalytically inactive CRISPR associated 9 (dCas9) protein linked to a TET protein is disclosed. Use thereof and of the fusion protein itself is also disclosed.

Abstract: The invention includes methods, kits, and pharmaceutical compositions for enhancing liver regeneration in a mammal in need thereof, comprising administering a therapeutically effective amount of an agent that increases nicotinamide adenine dinucleotide (NAD) activity. The methods may include administering a therapeutically effective amount of an agent that increases nicotinamide adenine dinucleotide (NAD) activity and a sirtuin 1 (Sirt1) agonist. The agent that increases NAD activity may be a NAD precursor. The NAD precursor may include one or more of tryptophan, nicotinic acid, nicotinic acid riboside, nicotinamide riboside (NR), nicotinamide, NADP, and NAD itself and a pharmaceutically acceptable salt thereof.

Abstract: The subject invention provides a selectively cleavable probe comprising an F(ab) fragment linked to one or more labels by a chemically cleavable disulfide bond. The subject invention also provides a process of immunostaining a sample comprising staining the sample with a selectively cleavable probe. The subject invention further provides a process of immunostaining a sample comprising (a) obtaining a probe comprising a primary antibody against a preselected target linked to biotin, (b) staining the sample with the probe of step (a), and (c) staining the sample with a selectively cleavable probe, wherein the F(ab) fragment is an anti-biotin F(ab) fragment.

Abstract: The present disclosure enhances the capabilities of educational institutions to refine educational offerings to evolving labor markets and employment opportunities in a dynamic way. Educational institutions are enabled to adjust the offered curriculum to maximize the effectuality of each course taken, and to enable learners to choose the most effective path towards a given educational goal. The present disclosure further enables employers to meaningfully participate in the educational process by providing feedback that can be incorporated to further improve educational outcomes.

Abstract: A power supply and distribution device for solar-powered aircraft includes at least two power supply and distribution sub-systems having same configurations. A disconnection of an electrical connection between a plurality of components of each power supply and distribution sub-system can be controlled through a first switch. An electrical connection between the same components of the power supply and distribution sub-systems can be established by controlling a second switch. The power supply and distribution device for solar-powered aircraft has a centralized-distribution design. Specifically, each power supply and distribution sub-system is designed in a centralized mounting manner and has separated power supply and power distribution functions that can work separately.

Abstract: A wearable device includes: at least one compliant region adapted and configured to be placed over a joint of a subject and at least two flexible but less compliant regions coupled to opposite ends of the compliant region. The device provides a wearable robotic device including a wearable and at least one actuator adapted and configured to move the flexible but less compliant regions relative to each other.

Abstract: The invention provides novel formulations comprising a stable inclusion complex of tributyrin and a cyclodextrin. In one particular embodiment, the formulation comprises an oven dried inclusion complex of tributyrin and ?-cyclodextrin that is effective in minimizing or preventing the unpleasant taste and odor of tributyrin, thus making it suitable for oral administration and delivery to the digestive tract and intestines. The invention provides compositions of these inclusion complexes and methods of using them that are advantageous as food, medicinal and other products, where the negative sensory properties of tributyrin can be a liability.

Abstract: Compositions and methods are provided for detecting activity of nucleotide pool repair enzymes. In the methods of the invention, a sample suspected of having nucleotide pool repair enzyme activity is combined with a detection compound provided herein, which detection compound comprises (i) a substrate for the enzyme of interest, (ii) a polyphosphate linker; and (iii) a detection moiety that is active when released by the enzyme of interest cleaving the linker.

Abstract: Methods and kits are provided for determining lung cancer disease progression or for pathological stratification of solitary indeterminate nodules detected during lung cancer screening or for determining the likelihood of disease progression in a subject. The method includes obtaining a biological sample from the subject and assaying a level in the biological sample of a biomarker in a panel of biomarkers where the panel includes at least one biomarker. The method further includes comparing the biomarker level in the subject's sample to a cutoff value for each biomarker measured for the panel of biomarkers and determining whether the biomarker level is above or below the cutoff value.