Patents Assigned to University
  • Patent number: 10251890
    Abstract: The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 me
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: April 9, 2019
    Assignee: University of Kentucky
    Inventors: Peter A. Crooks, Craig T. Jordan, Xiaochen Wei
  • Patent number: 10253071
    Abstract: This disclosure relates to selectin inhibitors, compositions, and methods related thereto. In certain embodiments, the disclosure relates to glycopeptides that contain one more modified amino acids conjugated to a saccharide or polysaccharide. In certain embodiments, the disclosure relates to uses of the glycopeptides as anti-inflammatory, anti-thrombotic, or anti-metastatic agents.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: April 9, 2019
    Assignees: Beth Israel Deaconess Medical Center, Inc., Emory University
    Inventors: Richard D. Cummings, Elliot L. Chaikof, Venkata R. Krishnamurthy, Mohammed Sardar
  • Patent number: 10253613
    Abstract: A drill guidance device, a method to control a trajectory of a drill, and a non-transitory computer readable medium that determine the corrected drill angle and send an output signal to a drill controller configured to control an angle of a drill. The corrected drill angle is determined by at least one of a slant angle data and a formation property data received from a sensor device. The drill guidance device, the method to control a trajectory of a drill, and the non-transitory computer readable medium can be implemented in a measuring while drilling model to provide live guidance during a drilling operation or a predictive model to plan prior to the start of a drilling operation. The corrected drill angle is acted upon by a drill controller to maximize the productivity of an oil reservoir.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: April 9, 2019
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Mohamed Hassan Awadh, Sami Abdulaziz Alnuaim
  • Patent number: 10257014
    Abstract: A method of amplifying a phase shift, comprises: receiving an input signal in response to an output signal; generating a reference signal; varying a modulation of at least one of the signals such that a ratio between modulation amplitudes of the input and reference signals is at least 0.9 and at most 1.1, and a phase difference between the reference and the input signals is from about 0.9 pi to about 1.1 pi; forming an output signal which comprises a sum of the reference and input signals, following the variation; and filtering the output signal by a bandpass filter to form a filtered output signal, wherein a bandwidth of the bandpass filter is selected such that XG<0.1, wherein X is a noise fluctuation average of the filtered output signal, and G is an expected amplification factor of a phase shift between the input and the reference signals.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: April 9, 2019
    Assignee: Ariel-University Research and Development Company Ltd.
    Inventors: Shmuel Sternklar, Moshe Ben-Ayun
  • Patent number: 10251938
    Abstract: The present invention provides methods for treating, preventing or reducing the severity of cerebral malaria. The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a modified angiopoietin molecule such as AngF1-Fc-F1.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: April 9, 2019
    Assignees: Regeneron Pharmaceuticals, Inc., University Health Network
    Inventors: Lisa Arleen Purcell Ngambo, Sarah J. Higgins, Kevin C. Kain
  • Patent number: 10252251
    Abstract: The present disclosure provides a method for producing organic compounds, such as esters, from an organic feedstock that includes at least one of a biopolymer or a lipid. The method includes heating the feedstock in the presence of a solid catalyst, such as a solid, inorganic Lewis acid catalyst, and reaction medium that includes an alcohol. At least certain ester products have an ester group corresponding to a substituent of the alcohol.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: April 9, 2019
    Assignee: Board of Regents of the Nevada System of Higher Education, on Behalf of the University of Nevada, Reno
    Inventors: Hongfei Lin, Lisha Yang
  • Patent number: 10257191
    Abstract: Methods and apparatuses for providing biometric authentication of a test user using a registration process where a reference data sample representative of one or more biometric attributes of a reference user is used to train a plurality of neural networks to achieve a target output. The weights that achieve this in the plurality of neural networks may be stored on a user device as a first data set. A second data set representative of one or more biometric attributes may be obtained from the test user using the authentication device or received from the user device. The first data set may be received by the authentication device and used as weights in an artificial neural network and the second data set may be used as inputs. The output of the neural network may determine a degree of correlation between the reference user and the test user to be authenticated.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: April 9, 2019
    Assignee: Nottingham Trent University
    Inventors: Tony John Allen, Sergio Grau Puerto
  • Patent number: 10251398
    Abstract: Methods of forming antimicrobial resin compositions comprising silver nanoparticles are disclosed, wherein the resin compositions that are generated exhibit lower initial color, reduced color shift upon storage and reduced levels of spontaneous polymerization. Such methods generally comprise: combining a silver-containing material with a self-cure and dual-cure base resin in situ wherein the base resin does not contain a catalytic amine; and adding a catalytic resin to the mixture of the resin and silver-containing material in order to form the final cured resin. Antimicrobial polymeric materials formed by said methods are also disclosed.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: April 9, 2019
    Assignee: The Board of Regents of the University of Texas System
    Inventor: Kyumin Whang
  • Patent number: 10251884
    Abstract: Disclosed herein are compositions comprising lopinavir alone or in combination with ritonavir for use as a medicament in the treatment of cancer or benign proliferative disorders (warts) or in the prevention of the development of cancer. Pharmaceutical compositions formulated for topical application comprising a therapeutically effective amount of lopinavir or a therapeutically effective amount lopinavir and ritonavir in a pharmaceutically acceptable vehicle are also provided. Also disclosed are methods of treating a patient having an HPV related dysplasia of the cervix comprising administering to said patient a therapeutically effective dose of the disclosed pharmaceutical compositions.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: April 9, 2019
    Assignee: The University of Manchester
    Inventors: Ian Hampson, Lynne Hampson
  • Patent number: 10253028
    Abstract: The compound 3,3,3-trifluoro-N-((1,4-trans)-4-((3-((S)-2-methylmorpholino)-IH-pyrazolo[3,4-d]pyrimidin-6-yl)amino)cyclohexyl)propane-1-sulfonamide having the Formula (I) or a salt thereof, its opposite enantiomer, compositions comprising the compound and its use in the treatment or prevention of leishmaniasis, particularly visceral leishmaniasis.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: April 9, 2019
    Assignees: GlaxoSmithKline Intellectual Property Development Limited, University of Dundee
    Inventors: Timothy James Miles, Michael George Thomas
  • Patent number: 10251977
    Abstract: Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damage, ischemic, ulcer cells, tissues or organs in a subject preferably a human, with diseases, such as PAD and CLI, using a decellularized extracellular matrix of the invention are provided. Methods of preparing culture surfaces and culturing cells with absorbed decellularized extracellular matrix are provided.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: April 9, 2019
    Assignee: The Regents of the University of California
    Inventors: Karen Christman, Jessica DeQuach
  • Patent number: 10253297
    Abstract: The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, undo dermal, and mesodermal embryonic germ layers, e.g., stem cells.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: April 9, 2019
    Assignees: Regents of the University of Minnesota, Katholieke Universiteit Leuven
    Inventors: Wei-Shou Hu, Kartik Subramanian, Catherine M. Verfaillie
  • Patent number: 10254262
    Abstract: A hydrogen sulfide (H2S) detecting apparatus for measuring the concentrations of hydrogen sulfide species in a given sample is disclosed. The hydrogen sulfide detecting apparatus can comprise a plurality of reaction chambers separated from a plurality of trapping chambers by a (H2S) permeable membrane, with the reaction chambers and trapping chambers each having buffer component(s) and/or reactive agents that expose the incoming sample to a particular pH and chemical environment in order to allow for the selective liberation and trapping of hydrogen sulfide from the sample.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: April 9, 2019
    Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Louisiana Tech University
    Inventors: Christopher G. Kevil, John D. Glawe, Clifton F. Frilot, Leland Weiss
  • Patent number: 10253203
    Abstract: Articles are provided comprising a substrate and a coating. The coating comprises a polyelectrolyte complex having surface roughness. The polyelectrolyte complex has a thickness of at least 10 micrometers and a roughness of at least 1 micrometer.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: April 9, 2019
    Assignee: The Florida State University Research Foundation, Inc.
    Inventor: Joseph B. Schlenoff
  • Patent number: 10251842
    Abstract: Nanocapsules of bioactive compounds derived from natural products as an adjunct treatment for cancer. Nanocapsules of bioactive compounds showed synergy in the treatment of cancer therapy-induced toxicity.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: April 9, 2019
    Assignee: King Abdulaziz University
    Inventors: Amna Ali Nasser Saddiq, Shaker Ahmad Mousa, Deena Shaker Mousa
  • Patent number: 10256439
    Abstract: The present invention relates to a tandem organic light-emitting element, more particularly to a tandem organic light-emitting element which may decrease a driving voltage in a driving region of a charge generation layer by sequentially laminating an electronics layer, which is doped with a metal dopant, and an electronics layer, which is doped with an organic dopant, on one side of the charge generation layer, thereby having increased power efficiency and life span.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: April 9, 2019
    Assignees: Corning Precision Materials Co., Ltd., University-Industry Cooperation Group of Kyung Hee University
    Inventors: Hyung Seok Lee, Kwang Je Woo, Jang Dae Youn, Jang Hyuk Kwon, Young Hoon Son
  • Patent number: 10253256
    Abstract: The presently disclosed subject matter provides processes for preparing nanocrystals, including processes for preparing core-shell nanocrystals. The presently disclosed subject matter also provides sulfur and selenium compounds as precursors to nanostructured materials. The presently disclosed subject matter also provides nanocrystals having a particular particle size distribution.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: April 9, 2019
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jonathan S. Owen, Mark P. Hendricks, Michael P. Campos
  • Patent number: 10253371
    Abstract: A method of treating leukemia in a patient, the method including obtaining a plasma sample from a patient at a first time point and at a second time point, measuring a gene expression level of a set of core clock genes, and at least one of a first set of peripheral clock genes and a second set of peripheral clock genes, each in the plasma sample at the first time point and in the plasma sample at the second time point. Then determining that a first treatment is effective or ineffective for the patient when a correlation of the gene expression level of the set of core clock genes, the first set of peripheral clock genes, and the second set of peripheral clock genes, and treating the patient accordingly.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: April 9, 2019
    Assignees: National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center
    Inventors: Mohamed Boudjelal, Ahmed Al Askar, Alshaimaa Alhallaj, Atef Nehdi, Hina Rehan, Sabhi Rahman, Gamal Edin Gmati, Khadega A. Abuelgasim
  • Patent number: 10252525
    Abstract: An apparatus for a lead-free piezoelectric ink-jet printhead is disclosed. Piezoelectric printheads, while more expensive are favored because they use a wider variety of inks. The piezoelectric printhead includes a diaphragm, a plurality of piezoelectric actuators comprising a lead-free piezoelectric material, at least one nozzle, at least one ink chamber, a top electrode, and a drive circuit. The deflection of the diaphragm on the body chamber contributes to a pressure pulse that is used to eject a drop of liquid from the nozzle. According to an exemplary embodiment, a lead-free piezoelectric printhead operated at smaller thicknesses and significantly higher electric fields is disclosed, along with methods of making such printheads.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: April 9, 2019
    Assignees: Xerox Corporation, Brown University
    Inventors: Peter J. Nystrom, Gary D. Redding, Angus Ian Kingon, Seunghyun Kim, Nicholas Mostovych
  • Patent number: 10251914
    Abstract: The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: April 9, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Michael J. Sadowsky, Alexander Khoruts, Alexa R. Weingarden, Matthew J. Hamilton