Patents Assigned to University
  • Oxytocin treatment to modify blood glucose and treat metabolic disease
    Patent number: 10314885
    Abstract: The disclosure provides a method for enhancing memory of a subject, lowering blood glucose levels in a subject, and treating schizophrenia, the methods comprise intranasally administering to the subject an amount of a oxytocin peptide or analog thereof having a beneficial effect.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: June 11, 2019
    Assignee: The Regents of the University of California
    Inventor: David Feifel
  • FCRN antagonists and methods of use
    Patent number: 10316073
    Abstract: Provided are novel FcRn antagonist compositions comprising a variant Fc region that binds specifically to FcRn with increased affinity and reduced pH dependence relative to the native Fc region. Also provided are FcRn antagonists with enhanced CD16 binding affinity. Also provided are methods of treating antibody-mediated disorders (e.g. autoimmune diseases) using the these FcRn antagonist compositions, nucleic acids encoding the FcRn antagonist compositions, recombinant expression vectors and host cells for making the FcRn antagonist compositions, and pharmaceutical compositions comprising the FcRn antagonist compositions.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: June 11, 2019
    Assignees: argenx BVBA, The Board of Regents of the University of Texas System
    Inventors: Peter Ulrichts, Christophe Blanchetot, Torsten Dreier, Johannes de Haard, E. Sally Ward Ober, Nicolas G. H. Ongenae
  • Game system, server, and donation control method
    Patent number: 10319190
    Abstract: Provided is a game system which performs control so as to allow a previously set donation amount to be donated when a user performs a cashing-out operation. A donation management server 40 stores settings related to donations made by a user in a donation setting information table 421 and when the user performs the cashing-out operation on a slot machine 1010, performs control so as to donate a donation amount selected by the user from among donation amount candidates set by the above-mentioned settings made by the user.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: June 11, 2019
    Assignee: Universal Entertainment Corporation
    Inventor: Kengo Takeda
  • Oral delivery of angiotensin converting enzyme 2 (ACE2) or angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension, cardiac dysfunction and development of autoimmune and experimental induced ocular disorders
    Patent number: 10314893
    Abstract: Emerging evidence indicates that diminished activity of the vasoprotective axis of the renin-angiotensin system, constituting angiotensin converting enzyme2 (ACE2) and its enzymatic product, angiotensin-(1-7) [Ang-(1-7)] contribute to pulmonary hypertension (PH). However, clinical success for long-term delivery of ACE2 or Ang-(1-7) would require stability and ease of administration to increase patient compliance. Chloroplast expression of therapeutic proteins enables their bioencapsulation within plant cells to protect from acids and gastric enzymes; fusion to a transmucosal carrier facilitates effective systemic absorption. Oral feeding of rats with bioencapsulated ACE2 or Ang-(1-7) attenuated monocrotaline (MCT)-induced increase in right ventricular systolic pressure, decreased pulmonary vessel wall thickness and improved right heart function in both prevention and reversal protocols.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: June 11, 2019
    Assignees: The Trustees of the University of Pennsylvania, University of Florida Research Foundation, Incorporated
    Inventors: Henry Daniell, Qiuhong Li, Mohan K. Raizada
  • Ex vivo engineered immune organoids for controlled germinal center reactions
    Patent number: 10317395
    Abstract: Provided are compositions and methods that relate ex vivo organoids that contain B cells and stromal cells in a three dimensional material includes a hydrogel. The hydrogel can be formed without exposure to ultraviolet light from an electronic ultraviolet light source. The hydrogel contains silicate nanoparticles (SiNPs) that are ionically bonded to a polyampholytic gelatin. The three dimensional material can be held at a temperature of at least 37 degrees Celsius and does not liquefy. The organoids exhibit mechanical properties that are similar to certain lymphoid tissues, and can include a germinal center. Methods of making the organoids are included, as are high throughput screening approaches that use the organoids for screening a variety of test agents. The organoids can synthesize a variety of compounds that can be recovered from the organoids or the organoid culture medium.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: June 11, 2019
    Assignee: Cornell University
    Inventors: Ankur Singh, Alberto Purwada
  • Non-invasive method to treat urological and gastrointestinal disorders
    Patent number: 10315029
    Abstract: Provided herein are methods and devices useful for inhibiting or treating urological conditions, such as overactive bladder (OAB) symptoms including bladder overactivity, urinary frequency, urinary urgency, urinary incontinence, interstitial cystitis (IC), urinary retention, and pelvic pain; gastrointestinal conditions, such as fecal incontinence, irritable bowel syndrome (IBS), and constipation; and sexual conditions, such as premature ejaculation, erectile disorder, and female sexual arousal disorder by non-invasive transcutaneous electrical stimulation of the foot.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 11, 2019
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventor: Changfeng Tai
  • Packet encoding and decoding method and apparatus
    Patent number: 10320522
    Abstract: A method for encoding and decoding information data using a polar code is provided. The method for encoding includes segmenting information data into a plurality of first packets, generating a plurality of second packets corresponding to the plurality of first packets by adding a corresponding packet Cyclic Redundancy Check (CRC) code to each of the plurality of first packets, fragmenting each of the plurality of second packets into a plurality of data blocks, polar code encoding each of the plurality of data blocks included in a corresponding second packet of the plurality of second packets, and generating a plurality of third packets corresponding to the plurality of second packets by concatenating each polar code encoded data block included in the corresponding second packet. The method for decoding includes decoding the third packet to obtain the information data based on the method for encoding.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: June 11, 2019
    Assignees: Samsung Electronics Co., Ltd., Sungkyunkwan University Research & Business Foundation
    Inventors: Hongsil Jeong, Sang-Hyo Kim, Jong-Hwan Kim, Daehyeon Ryu, Seho Myung
  • Continuous electrokinetic dewatering of phosphatic clay suspensions
    Patent number: 10315165
    Abstract: Various methods and systems are provided for electrokinetic dewatering of suspensions such as, e.g., phosphatic clay. In one example, among others, a system for continuous dewatering includes a cake formation zone including a first anode and a first cathode each extending across a first portion of a separation chamber; a cake dewatering zone including a second anode and a second cathode; an inlet configured to supply a dilute feed suspension comprising solids suspended in water to the cake formation zone; and a conveying belt extending between the first anode and the first cathode and between the second anode and the second cathode. A first electric field between the first anode and the first cathode forms a cake on the conveying belt by consolidating the solids, and a second electric field between the second anode and the second cathode dewaters the cake on the conveying belt.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: June 11, 2019
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Mark E. Orazem, Rui Kong, Saeed Moghaddam, Yuelong Huang, Dazhi Yu, Han Lai, David A. Horner, David Bloomquist
  • Methods and compositions for preventing and treating tooth erosion
    Patent number: 10314771
    Abstract: An oral composition is provided comprising crosslinked polyvinylpyrrolidone (PVP) and xylitol. The xylitol and the crosslinked PVP are in a ratio of about 5:1, and the oral composition is in the form of a lozenge or lollipop. Methods are also provided.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: June 11, 2019
    Assignee: University of Tennessee Research Foundation
    Inventors: Mojdeh Dehghan, Daranee Versluis, Hassan Almoazen
  • Method of inspecting quality of organic light-emitting diode and inspecting system for performing the method
    Patent number: 10317457
    Abstract: A method of inspecting the quality of an organic light-emitting diode (OLED) and an inspecting system for performing the method are disclosed. In one aspect, the method includes applying an input voltage to the OLED, measuring an OLED voltage across the OLED and an OLED current flowing through the OLED, estimating a parameter of the OLED based at least in part on the OLED voltage and the OLED current, and extracting a physical characteristic of the OLED based at least in part on the parameter.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: June 11, 2019
    Assignees: Samsung Display Co., Ltd., Korea University Research and Business Foundation
    Inventors: Jung-Jin Yang, Won-Jun Song, Mun-Chae Yoon, Gyu-Tae Kim, Tae-Woong Yoon
  • Photoluminescent semiconductor nanocrystal-based luminescent solar concentrators
    Patent number: 10317602
    Abstract: The present disclosure describes luminescent solar concentrators that include photoluminescent nanoparticles. The photoluminescent nanoparticles include a semiconductor nanocrystal that sensitizes the luminescence of a defect. The defect can include, for example, an atom, a cluster of atoms, or a lattice vacancy. The defect can be incorporated into the semiconductor nanocrystal, adsorbed onto, or otherwise associated with the surface of the semiconductor nanocrystal.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: June 11, 2019
    Assignees: Western Washington University, University of Washington Through Its Center For Commercialization
    Inventors: David Patrick, John Gilbertson, Stephen McDowall, Christian Erickson, Daniel R. Gamelin, Liam Bradshaw, Emily Jane McLaurin, Kathryn E. Knowles
  • Electronic beam machining system
    Patent number: 10319563
    Abstract: The disclosure relates to an electronic beam machining system. The system includes a vacuum chamber; an electron gun located in the vacuum chamber and used to emit electron beam; a holder located in the vacuum chamber and used to fix an object; a control computer; and a diffraction unit located in the vacuum chamber; the diffraction unit includes a two-dimensional nanomaterial; the electron beam transmits the two-dimensional nanomaterial to form a transmission electron beam and a plurality of diffraction electron beams; the transmission electron beam and the plurality of diffraction electron beams radiate the object to form a transmission spot and a plurality of diffraction spots.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: June 11, 2019
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Peng Liu, Wei Zhao, Xiao-Yang Lin, Duan-Liang Zhou, Chun-Hai Zhang, Kai-Li Jiang, Shou-Shan Fan
  • Collective memory transfer devices and methods for multiple-core processors
    Patent number: 10318444
    Abstract: This disclosure provides systems, methods, and apparatus for collective memory transfers. A control unit may be configured to coordinate a transfer of data between a memory and processor cores. For a read data transfer operation, the control unit may receive a trigger packet identifying a read data transfer operation and identifying a first plurality of data lines based on data values included in the trigger packet. The control unit may read the first plurality of data lines from the memory sequentially and send a second plurality of data lines to the processor cores. For a write data transfer operation, the control unit may send a request for at least one data line to a plurality of processor cores, may receive and reorder the requested data lines, and may write the data lines to a memory. The control unit may determine a mapping between processor cores and the memory.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: June 11, 2019
    Assignee: The Regents of the University of California
    Inventors: Georgios Michelogiannakis, John Shalf
  • Compositions and methods for treating and preventing venom related poisoning
    Patent number: 10314860
    Abstract: This invention relates to compositions and methods for treating, ameliorating and preventing the toxic effects of venom poisoning. In particular, the invention provides compositions comprising carbon monoxide releasing molecules (CORM) or compositions comprising CORM and iron releasing molecules (IRM) for one or more of enhancing coagulation, reducing fibrinolysis, and/or inactivating venom related metalloproteinase activity in a subject suffering from or at risk of suffering from venom poisoning.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: June 11, 2019
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Vance G. Nielsen, Leslie V. Boyer
  • IVF egg collection chamber
    Patent number: 10314616
    Abstract: The present invention relates to egg chambers for use in collection, inspection and selection of eggs for in vitro fertilization (IVF) procedures. The egg chamber, in use, provides an effectively closed and fluid filled system which minimizes the environmental changes that a harvested egg is exposed to, thus maximizing viability. The egg chamber comprises a vessel which can be made airtight, comprising at least one side wall, an upper wall and a lower wall, at least a portion of the upper wall being transparent and at least a portion of the lower wall being light permeable; a first inlet with a sealable port; a first outlet with a sealable port; a filter with a pore size appropriate for egg collection disposed within the vessel between the first inlet and the first outlet and configured to separate the vessel into a first internal chamber and a second internal chamber.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: June 11, 2019
    Assignees: Labman Automation Ltd., University of Newcastle Upon Tyne, Newcastle Upon Tyne Hospitals NHS Foundation Trust
    Inventors: Robert Hodgson, Alison Murdoch
  • Selective androgen receptor degrader (SARD) ligands and methods of use thereof
    Patent number: 10314797
    Abstract: This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including heterocyclic anilide rings and their synthetic precursors, R-isomers, and non-hydroxylated and/or non-chiral propanamides, and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: June 11, 2019
    Assignee: University of Tennessee Research Foundation
    Inventors: Ramesh Narayanan, Duane D. Miller, Thamarai Ponnusamy, Dong-Jin Hwang, Yali He
  • Method for optimizing plastic compositions used in packaging to increase shelf-life of perishable products and a system thereof
    Patent number: 10316183
    Abstract: The present invention relates to relates to a method of optimizing a plastic composition formed from a plurality of resin feedstocks. A plurality of resin feedstocks are provided. The plurality of resin feedstocks are blended to form the plastic composition. One or more properties of the plastic composition, including radiation absorption, radiation transmission, gas evolution, radiation fluorescence, or melting properties, are measured. The ratio of the plurality of resin feedstocks being blended into the plastic composition is adjusted, based on said measuring, to form an optimized plastic composition. A system for performing the method is also disclosed.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: June 11, 2019
    Assignees: Iowa State University Research Foundation, Inc., Cal Poly Corporation
    Inventors: Keith Vorst, John Wyatt Brown, Jeffrey E. Danes, Greg Curtzwiler
  • Method for making organic light emitting diode
    Patent number: 10319932
    Abstract: A method for making an organic light emitting diode includes providing a preform structure including an anode electrode, a hole transport layer, and an organic light emitting layer stacked on each other in that order. A carbon nanotube composite structure including a polymer and a plurality of first carbon nanotubes dispersed in the polymer is also provided. The plurality of first carbon nanotubes is substantially parallel to each other, and a part of surface of the plurality of first carbon nanotubes is exposed from the polymer. The preform structure, the carbon nanotube composite structure and a cathode electrode are stacked on each other in that order.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 11, 2019
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Wen Ning, Peng Liu, Kai-Li Jiang, Shou-Shan Fan
  • Eye alignment monitor and method
    Patent number: 10314482
    Abstract: An eye alignment monitor and method are described for the detection of variability of the relative alignment of the two eyes with each other, thereby detecting deficits of binocular function, for use as a screening device for these abnormalities especially in infants and young children. Each embodiment includes means for tracking of the positions of a subject's two eyes simultaneously, and furthermore includes repetitive calculation of the relative positions of the two eyes with respect to each other. The embodiments do not require fixation by either eye on a specific point. Typically, a movie on a video display is used for viewing by the subject. Variability of relative alignment of the two eyes with each other is typically determined by variability of the relative positions of images of the pupils of the eyes with respect to each other over time.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: June 11, 2019
    Assignee: The Johns Hopkins University
    Inventors: David L. Guyton, Kristina Irsch, Howard S. Ying, Boris I. Gramatikov, Robert Geary, Jing Tian, Kurt Simons
  • Polyfunctional sorbent materials
    Patent number: 10315185
    Abstract: Disclosed herein is a material comprising a functionalized solid support surface, wherein the functionalization comprises a thioalkylene linker bound to the support surface and the thioalkylene linker is coupled to a moiety derived from a ligand, wherein the ligand includes a terminal alkenyl and at least one first functional group configured to bind to at least one predetermined target species.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: June 11, 2019
    Assignees: University of Oregon, Battelle Memorial Institute
    Inventors: Kara Nell, Darren W. Johnson, Jonathan Pittman, Wilaiwan Chouyyok, Raymond Shane Addleman, Marvin G. Warner