Abstract: The disclosure relates to the identification of salivary biomarkers for diagnosis and monitoring of type 2 diabetes in a subject. Also provided are methods for noninvasively diagnosing and monitoring type 2 diabetes in a subject. More particularly, the expression of salivary biomarkers, including MUC-1, MUC-2, MUC-4, and MUC-5B, are highly associated with A1C level in African American patients with type 2 diabetes.

Abstract: The present invention relates, in general, to gene expression profiles, and in particular, to a peripheral blood gene expression profile of an environmental exposure, ionizing radiation. The invention further relates to methods of screening patients for radiation exposure based on gene expression profiling and to kits suitable for use in such methods.

Abstract: An optical-electronic device can be controlled by a bias voltage to simulate an electronic component such as a resistor, capacitor, inductor with resistor, or capacitor with resistor. The optical-electronic device can be connected in a network to perform computations, model problems, simulate properties such as physical properties (for instance heat transfer), and achieve circuit performances to carry out computations in the analog domain, all at faster speed with smaller size and at less energy.

Abstract: A surge protection device for an LED lighting system provides a failure detection circuit which shuts off an indicator lamp when upon failure of surge protection components. Surge suppression circuits are coupled between respective first and second, and second and third lines for receiving an AC mains input. The surge suppression circuits include a thermal cutoff device and a clamping device, with a fault detection circuit coupled between each respective series circuit. The fault detection circuit activates an indicator lamp when the surge protection device is in a normal operation mode. The fault detection circuit shuts off the indicator lamp when the surge protection device is in a short circuit fault mode, corresponding to failure of at least one component from a surge suppression circuit. Detection of an unlit indicator lamp may serve as a warning to an operator that the associated surge protection device should be replaced.

Abstract: A system and method for improving intelligibility of speech is provided. The system and method may include obtaining an input audio signal frame, classifying the input audio signal frame into a first category or a second category, wherein the first category corresponds to the noise being stronger than the speech signal, and the second category corresponds to the speech signal being stronger than the noise, decomposing the input audio signal frame into a plurality of sub-band components; de-noising each sub-band component of the input audio signal frame in parallel by applying a first wavelet de-noising method including a first wavelet transform and a predetermined threshold for the sub-band component, and a second wavelet de-noising method including a second wavelet transform and the predetermined threshold for the sub-band component, wherein the predetermined threshold for each sub-band component is based on at least one previous noise-dominant signal frame received by the receiving arrangement.

Abstract: A method of determining matching between at least a first sample comprising a sequence of tokens A and a second sample comprising a sequence of tokens B may include, for monotonically decreasing values of n, performing operations including recording a subset SA of n-grams of A in a hash table LA, such that a value of each n-gram determines an index in LA and a location of each respective n-gram in A is recorded as the value in LA, recording a subset SB of n-grams of B in a hash table LB, such that a value of each n-gram determines an index in LB and a location of each respective n-gram in B is recorded as the value in LB, for each location L that is occupied in both LA and LB, examining a region in A centered on LA(L) and a region in B centered on LB(L), and reporting a largest matching region aligning LA(L) with LB(L) that does not include already-matched tokens in A or B and marking the largest matching region as matched.

Abstract: Recombinant polypeptides comprising a DR?1 domain, an antigenic peptide, and a linker sequence are disclosed. The linker sequence comprises a first glycine-serine spacer, a thrombin cleavage site and a second glycine-serine spacer. Further disclosed are pharmaceutical compositions comprising the recombinant polypeptides, methods of treating inflammatory disease using said pharmaceutical compositions, and expression constructs comprising nucleic acids that encode the recombinant polypeptides.

Abstract: The present invention relates to novel fluorophores and their use in combination with novel nucleic acid molecules, called aptamers, that bind specifically to the fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.

Abstract: A composition comprising mesoporous aggregates of magnetic nanoparticles and free-radical producing enzyme (i.e., enzyme-bound mesoporous aggregates), wherein the mesoporous aggregates of magnetic nanoparticles have mesopores in which the free-radical-producing enzyme is embedded. Methods for synthesizing the enzyme-bound mesoporous aggregates are also described. Processes that use said enzyme-bound mesoporous aggregates for depolymerizing lignin, removing aromatic contaminants from water, and polymerizing monomers polymerizable by a free-radical reaction are also described.

Abstract: This disclosure provides methods and compositions related to microbial gene expression. In one aspect, a synthetic polypeptide having a xylose import activity.

Abstract: The present invention discloses scalarane sesterterpenoids represented by formula (I) and meroditerpenoid represented by formula (II), which are extracted from Carteriospongia sp. sponge: where R1 is —CH3 or —C2H5. The compounds of formula (I) can be used to be an anticancer, act as an inhibitor targeting to topoisomerase II and hsp90 and a pharmaceutical composition for anticancer.

Abstract: A photocatalyst includes a composite fiber having at least two crystalline semi-conductors that provide a heterojunction structure in the composite fiber.

Abstract: Offset-cancellation sensing circuit (OCSC)-based Non-volatile (NV) memory circuits are disclosed. An OCSC-based NV memory circuit includes a latch circuit configured to latch a memory state from an input signal. The OCSC-based NV memory circuit also includes a sensing circuit that includes NV memory devices configured to store the latched memory state in the latch circuit for restoring the memory state in the latch circuit when recovering from a reduced power level in an idle mode. To avoid the need to increase transistor size in the sensing circuit to mitigate restoration degradation, the sensing circuit is also configured to cancel an offset voltage of a differential amplifier in the sensing circuit. In other exemplary aspects, the NV memory devices are included in the sensing circuit and coupled to the differential transistors as NMOS transistors in the differential amplifier, eliminating contribution of offset voltage from other differential PMOS transistors not included.

Abstract: Disclosed are compositions, kits, and methods for treating cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat a tumor in a subject in situ. The compositions, kits, and methods comprise or utilize cytotoxic particles, immune checkpoint inhibitors, and/or T-cell stimulatory agents.

Abstract: The retractor is a generally U-shaped device for protecting the cheek and tongue from instruments used during dental and prosthodontic procedures. The retractor has a planar base defined by two spaced arms, a pair of upright shields extending from the arms, and a posterior connector connecting the shields. The base is contoured to grip the tooth adjacent to the tooth to be treated, and thereby, secure the retractor within the patient's mouth.

Abstract: This disclosure relates to compositions of isolated polypeptides and methods of their use for the treatment and prevention of disease or disease symptoms associated with MARCKS phosphorylation and/or dissociation from the cell membrane, including but not limited to allergic inflammation, asthma, chronic bronchitis, COPD, infection, hyper-reactivity, cystic fibrosis, ulcerative colitis, Crohn's disease, irritable bowel syndrome, rosacea, eczema, psoriasis, acne, arthritis, rheumatoid arthritis, psoriatic arthritis, and systemic lupus erythematosus.

Abstract: A sensor of a brightness limiting system of a vehicle may sense light from light sources around the vehicle and provide a light measurement signal. The light measurement signal may include information about brightness levels and positions of light sources relative to a window of the vehicle. A brightness controller may monitor the light source measurement signal and perform comparisons of brightness levels from the light measurement signal with brightness thresholds. The brightness controller may determine that a brightness level of a light source exceeds a brightness threshold and may provide a brightness control signal to a brightness control layer positioned adjacent to the window of the vehicle. The brightness control layer may receive the brightness control signal and limit the brightness level of light based on the brightness threshold at a brightness control area of the brightness control layer.

Abstract: A system and method for in vivo detection and quantification of drusen present in the retina via administering an excitation signal to the retina of the eye and detecting an electromagnetic emissions spectrum from the retina in response to the excitation signal. The electromagnetic emissions spectrum may be used to identify a plurality of component emissions spectra, each component emissions spectrum corresponding to fluorescence from a component of the retina, one of the component emissions spectra corresponding to a target emissions spectrum.

Abstract: A method for automatically mapping a store layout includes identifying a path for traversing a retail area and capturing images of the retail area at various points along the path. The images may be analyzed to identify visual characteristics which may be compared to a template of retail products in a template library. When an object depicted in the image matches with a retail product in the template library, the object may correspond to the retail product. Additionally, a retail department for the object may also be identified. The retail department may be compared to the retail product corresponding to the object, and when the retail product is not associated with the retail department, another retail product which is associated with the retail department may be identified as corresponding to the object. A map of the store layout may be generated based on the identified retail products.

Abstract: A wafer-level manufacturing method for embedding a passive element in a glass substrate is disclosed.