Abstract: The disclosure discloses a channel combining and time-division processing circuit of a dual-plane pulse Doppler radar seeker. The circuit includes a time-division control circuit configured to receive a time-division control signal, control input of an elevation difference channel signal and an azimuth difference channel signal, combine the elevation difference channel signal and the azimuth difference channel signal and output a combined difference channel signal, and a hybrid bridge circuit configured to receive a sum channel signal, combine channels for the sum channel signal and the combined difference channel signal and output signals on a combined channel. With the circuit of the disclosure, signals received from a sum channel, an azimuth difference channel and an elevation difference channel can be combined into received signals from two channels for processing with one received signal processing channel hardware omitted.

Abstract: The invention provides sublingual epinephrine compositions including epinephrine fine particles formulated with pH-modifying excipients and penetration enhancers. The sublingual compositions are used to control absorption of epinephrine at the site of delivery in an oral cavity. The invention also provides methods for therapeutic use of the sublingual compositions for treatment of conditions responsive to epinephrine and/or for increasing sublingual bioavailability of epinephrine.

Abstract: A method for processing an artificial network by an electronic device includes obtaining, by using a first processor and a second processor, a neural network computation plan for performing computation of a first neural network layer of the artificial neural network, performing a first portion of a computation of the first neural network layer by using the first processor, and performing a second portion of the computation of the first neural network layer by using the second processor based on the obtained neural network computation plan, obtaining a first output value based on a performance result of the first processor and a second output value based on a performance result of the second processor, and using the obtained first output value and the second output value as an input value of a second neural network layer of the artificial neural network.

Abstract: The present disclosure provides compounds of the formula (I) wherein these compounds contain a ligand which binds to one or more target proteins such as CDK4 or CDK6 and a ligand which binds to the machinery associated with the ubiquitinating protein machinery. Also provided herein are methods of using these compounds in compositions or methods of treating patients with these compounds for the treatment of a disease or disorders such as cancer.

Abstract: Provided herein are systems and methods for the controlling the spatial positioning of a target polynucleotide in a compartment of a cell.

Abstract: Provided herein are non-naturally occurring, broadly reactive, pan-epitopic antigens derived from Dengue virus that are immunogenic and elicit a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against Dengue virus subtypes following introduction into a subject. Also provided are non-naturally, broadly reactive occurring immunogens, immunogenic compositions, vaccines, subviral particles (SVPs), and virus-like particles (VLPs) comprising Dengue virus proteins or encoding polynucleotides. Methods of generating an immune response in a subject by administering the immunogens, vaccines, SVPs, VLPs, or immunogenic compositions thereof are provided. In particular, the immunogens comprise a Dengue virus protein, or an antibody binding portion thereof.

Abstract: A nanostructured cross-wire memory architecture is provided that can interface with conventional semiconductor technologies and be electrically accessed and read. The architecture links lower and upper sets of generally parallel nanowires oriented crosswise, with a memory element that has a characteristic conductance. Each nanowire end is attached to an electrode. Conductance of the linkages in the gap between the wires encodes the information. The nanowires may be highly-conductive, self-assembled, nucleic acid-based nanowires enhanced with dopants including metal ions, carbon, metal nanoparticles and intercalators. Conductance of the memory elements can be controlled by sequence, length, conformation, doping, and number of pathways between nanowires. A diode can also be connected in series with each of the memory elements. Linkers may also be redox or electroactive switching molecules or nanoparticles where the charge state changes the resistance of the memory element.

Abstract: Ether-thioether functionalized porous aromatic framework (PAF) polymers provide high selectivity for iron(II) and iron(III) adsorption in aqueous samples.

Abstract: The present invention relates to a method and an apparatus for recovering copper, bronze and lead by allowing methane gas to flow into a reactor and heat-treating a mixture of copper oxide, tin oxide and lead oxide under a temperature condition of 700-900° C., and comprises the steps of: placing a mixture of copper oxide, tin oxide and lead oxide in a reactor; increasing the temperature inside the reactor; and allowing a reductive gas to flow into the reactor so as to heat-treat the mixture.

Abstract: A composite pin fin heat sink configured to dissipate heat generated by a heating element including a background region and a hot spot region having a higher temperature than the background region while the heating element is generating heat, the heat sink including a base plate having a first surface and a second surface, the first surface being configured to contact the heating element; and an array of pin fins protruding from the second surface and arranged at regular intervals. The base plate and the array of pin fins are divided into a first heat sink region corresponding to the hot spot region of the heating element, and a second heat sink region corresponding to the background region of the heating element. The first heat sink region is made of a material having a higher thermal conductivity than a material of which the second heat sink region is made.

Abstract: Provided is a biomarker capable of specifically diagnosing acute kidney injury. An acute kidney injury-specific biomarker is a miRNA that is primarily present in the blood. The miRNA is miRNA-5100. Furthermore, miRNA-5100 can be used as a method for diagnosing acute kidney injury. In this diagnosis, when the expression of miRNA-5100 is decreased in the blood, it is diagnosed as acute kidney injury. As an acute kidney injury test kit, it is also possible to include a reagent for measuring miRNA-5100.

Abstract: The invention provides a compound of formula I and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the formula I compounds, as well as methods of using such as therapeutic agents for the treatment of pain-related disorders and diseases and in combination with other therapeutic agents.

Abstract: Compositions and method for reducing the concentration of uremic toxins in the body of a patient suffering from some degree of kidney failure are disclosed. The methods can be used to delay the need for conventional dialysis treatment or as an adjunct therapy to reduce the frequency of dialysis sessions, and in some instances, as an alternative to such dialysis sessions.

Abstract: Provided herein are methods for treating small round cell tumor(s) by administering anti-androgen receptor therapy to a subject. The anti-androgen receptor therapy may comprise an AR antisense oligonucleotide and may be administered in combination with an additional anti-cancer agent.

Abstract: A highly permeable sorbent platform based on polysulfone and polystyrene-b-poly(acrylic acid) composite membranes. The membranes possess a fully interconnected network of poly(acrylic acid)-lined pores, which enables the surface chemistry to be tailored through sequential attachment of polyethyleneimine moieties and metal-binding terpyridine ligands. The polyethyleneimine moieties increase the saturation capacity, while the addition of terpyridine enables high-affinity binding to a diversity of transition metal ions. This membrane platform removes such metal contaminants from solution. The metal capture performance of the functionalized membranes persists even in high concentrations of competitive ions. Also, fluorescence quenching of the terpyridine moiety upon metal ion complexation offers an in-situ probe to monitor the extent of sorbent saturation.

Abstract: The present invention discloses a method for selectively detecting dopamine based on magnetic resonance nuclear spin singlet state. The method uses the nuclear spin singlet of three hydrogen atoms on the dopamine benzene ring to achieve selective detection of dopamine signals in a complicated system. The present invention is based on magnetic resonance technology to detect dopamine, has good accuracy, sensitivity and selectivity, can accurately detect the signal of dopamine from the complicated system, and the interference of signals of other substances are well eliminated. Meanwhile, the present invention further has the advantages of simple operation and non-intervention, can be used for monitoring the content and distribution of the dopamine in a living body, and has important application value in the fields of biology and medicine.

Abstract: Provided are a composition for diagnosing Alzheimer's dementia, the composition including an agent for measuring levels of mRNAs of one or more genes selected from the group consisting of neurotrimin (NTM), peptidylglycine-?-amidating monooxygenase (PAM), receptor-type tyrosine-protein phosphatase N2 (PTPRN2), opioid-binding protein/cell adhesion molecule (OPCML), 14-3-3 protein ?/? (YWHAZ), chromogranin-A (CHGA), and secretogranin-1 (CHGB), or levels of proteins expressed therefrom; a kit for diagnosing Alzheimer's dementia, the kit including the composition; and a method of providing information for the diagnosis of Alzheimer's dementia, the method including the steps of measuring the levels of mRNAs of the genes or the levels of proteins expressed therefrom, and comparing the measured levels with those measured in a sample isolated from a normal individual.

Abstract: Treatment delivery apparatuses include a treatment administration device, a multi-lumen catheter reversibly couplable with the treatment administration device, and a controller. The treatment administration device has a housing cartridge-pump interfaces disposed within the housing, each cartridge-pump interface being reversibly couplable with a medication cartridge type. The treatment administration device further includes pumps disposed within the housing, each pump being in fluidic connection with at least one cartridge-pump interface. The controller enables the treatment administration device to: receive a treatment selection, determine available medications based upon medication cartridges coupled with the cartridge-pump interfaces, and administer a treatment to the multi-lumen catheter, based at least upon the treatment selection.

Abstract: A monooxygenase having an amino acid sequence obtained by mutation of the amino acid sequence shown in SEQ ID NO:2 is disclosed. The use of the monooxygenase of the present invention in production of chiral sulfoxide-based drugs has advantages including mild reaction conditions, environmental friendliness, high yield, high optical purity of products, less peroxide products, and the like, and therefore the monooxygenase in the present invention has a good industrial application prospect in the production of proton pump inhibitors for the treatment of gastric ulcers.

Abstract: Provided is use of Penicillium sclerotiorum SCAUMCX01, under accession number GDMCC No. 60249, in the preparation of plant growth regulators or inducers. The plant growth regulators or inducers containing Penicillium sclerotiorum, Penicillium sclerotiorum spores, a culture solution thereof and an extract of the culture solution have the effects of promoting the early germination of seeds, promoting the growth of the underground roots of crops and the branching of above-ground parts of crops, improving the bioavailability of crops, delaying the aging progress of crops, and enhancing the growth of crops.