Patents Assigned to University
  • Radio frequency cavities
    Patent number: 10237963
    Abstract: A radio-frequency (RF) cavity apparatus for accelerating charged particles includes first and second cavity arms. The first and second cavity arms have respective first and second axes of rotational symmetry and each cavity arm includes at least one cell. The first and second cavity arms are connected by a resonance coupler. The cell(s) of the first cavity arm have an axial dimensional parameter that is equal to a corresponding axial dimensional parameter of the cell(s) of the second cavity arm, and the cell(s) of the first cavity arm have at least one non-axial dimensional parameter that differs from corresponding non-axial dimensional parameter(s) of the cell(s) of the second cavity arm.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: March 19, 2019
    Assignee: Oxford University Innovation Limited
    Inventors: Ivan Konoplev, Graeme Burt
  • Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury
    Patent number: 10233201
    Abstract: Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: March 19, 2019
    Assignee: University of Pittsburg—Of the Commonwealth System of Higher Education
    Inventors: Neil Hukriede, Billy W. Day, Lee A. McDermott
  • Magnetic resonance imaging contrast agent capable of detecting hydrogen peroxide and reducing reactive oxygen species
    Patent number: 10233205
    Abstract: The current invention provides metal ion complexes with an organic ligand, compositions comprising such complexes. In particular, these complexes are capable of reacting with a reactive oxygen species in a subject and increase their T1-weighted relaxivities so a clinical MRI scanner can detect an oxidative stress hotspot in the subject. The disclosed complexes also exhibit excellent anti-oxidant properties and low cell toxicity, therefore can be used as a therapeutic agent to relieve oxidative stress in the subject, or as both a MRI contrast agent and therapeutic agent in a composition.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: March 19, 2019
    Assignee: Auburn University
    Inventors: Dean D. Schwartz, Christian R. Goldsmith, Ronald J. Beyers, Meng Yu
  • Process for encapsulating soluble biologics, therapeutics, and imaging agents
    Patent number: 10231937
    Abstract: An “inverse” precipitation route to precipitate aqueous soluble species with copolymers as nanoparticles having a hydrophilic, polar core and a less polar shell is described.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: March 19, 2019
    Assignee: The Trustees of Princeton University
    Inventors: Robert F. Pagels, Robert K. Prud'homme
  • System and method for structured low-rank matrix factorization: optimality, algorithm, and applications to image processing
    Patent number: 10235600
    Abstract: The present invention provides a system and method for structured low-rank matrix factorization of data. The system and method involve solving an optimization problem that is not convex, but theoretical results should that a rank-deficient local minimum gives a global minimum. The system and method also involve an optimization strategy that is highly parallelizable and can be performed using a highly reduced set of variables. The present invention can be used for many large scale problems, with examples in biomedical video segmentation and hyperspectral compressed recovery.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: March 19, 2019
    Assignee: The Johns Hopkins University
    Inventors: Rene Vidal, Benjamin Haeffele, Eric D. Young
  • Three dimensional extrusion printed electrochemical devices
    Patent number: 10236528
    Abstract: Solid oxide electrochemical devices, methods for making the electrochemical devices, and methods of using the electrochemical devices are provided. The electrochemical devices comprise a plurality of stacked functional layers that are formed by a combination of three-dimensional (3D) extrusion printing and two-dimensional (2D) casting techniques.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: March 19, 2019
    Assignee: Northwestern University
    Inventors: Adam E. Jakus, Ramille N. Shah, Nicholas R. Geisendorfer, Scott A. Barnett, Zhan Gao
  • Method for highly sensitive detection of biomarkers for diagnostics
    Patent number: 10234394
    Abstract: This disclosure provides, among other things, a nanosensor comprising a substrate and one or a plurality of pillars extending from a surface of the substrate, where the pillars comprise a metallic dot structure, a metal disc, and a metallic back plane. The nanosensor comprises a molecular adhesion layer that covers at least a part of the metallic dot structure, the metal disc, and/or the metallic back plane and a capture agent bound to the molecular adhesion layer. The nanosensor amplifies a light signal from an analyte, when the analyte is specifically bound to the capture agent.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: March 19, 2019
    Assignee: The Trustees of Princeton University
    Inventors: Stephen Y. Chou, Liang-Cheng Zhou
  • Electromagnetic (EM) well logging tools and related methods
    Patent number: 10234592
    Abstract: An electromagnetic well logging tool for a wireline logging process, includes a shaft, a transmitter coil mounted on the shaft and configured to generate primary magnetic fields for propagation into a well formation, upon excitation by a first current, a receiver coil mounted on the shaft at a predefined distance from the transmitter coil and configured to receive secondary magnetic fields generated from the well formation, and a bucking coil mounted on the shaft in a concentric arrangement with the receiver coil, wherein the bucking coil is configured to generate magnetic fields at the receiver coil upon excitation by a second current, for cancelling the magnetic fields generated at the receiver coil due to direct coupling between the transmitter and receiver coils.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: March 19, 2019
    Assignee: Duke University
    Inventors: Qing H. Liu, Zhiru Yu, Jianyang Zhou
  • Method of producing a fermented beverage
    Patent number: 10233414
    Abstract: A method for preparing a fermented beverage having a modulated aromatic profile is provided as well as a fermented beverage produced thereby. The method includes preparing a fermentable mixture, such as juice, must, or wort and introducing ammonium sulphide into the fermentable mixture at a predetermined concentration. The fermentable mixture is then subjected to fermentation. A C6 aldehyde, C6 alcohol or a combination thereof may be added to the fermentable mixture in combination with ammonium sulphide to enhance its effect on the aromatic profile of the fermented beverage.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: March 19, 2019
    Assignee: Stellenbosch University
    Inventors: Wessel Johannes Du Toit, Sebastian Vannevel
  • Device and method for measuring the depth of media
    Patent number: 10234320
    Abstract: This invention relates to a device and method for measuring the depth of water and sediment deposition in pipes, channels, overland flows and tidal beaches. Sediment deposition may be detrimental to flood control in sewer systems. The invention is specifically concerned with measuring an electrical property such as the conductivity or capacitance in different mediums and therefore quantifying the depths of the different mediums. The measurement of an electrical property such as conductance or capacitance of the medium may also indicate the nature of the medium such as sediment structure, water salinity, and the presence of pollutants. The device includes an array of elongate, substantially mutually parallel electrodes each having a predetermined length, the lengths being incremented stepwise from a shortest electrode to a longest electrode.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: March 19, 2019
    Assignee: The University of Bradford
    Inventor: Andrew Nichols
  • Systems and methods for administering spinal cord stimulation based on temporal patterns of electrical stimulation
    Patent number: 10232179
    Abstract: Systems and methods for administering spinal cord stimulation (SCS) based on temporal patterns of electrical stimulation are disclosed. According to an aspect, a method includes using a computational model of a wide-dynamic range (WDR) neuron to determine one or more non-regular temporal patterns that results in predetermined WDR neuronal output and stimulation activity for one of efficacy optimization and efficiency optimization. The method also includes administering to a subject spinal cord stimulation based on the determined one or more of the non-regular temporal patterns.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: March 19, 2019
    Assignee: Duke University
    Inventors: Warren M. Grill, Tianhe Zhang
  • Materials and methods for characterizing and using a 3-ketoacyl-acyl carrier protein (ACP) synthase III (KASIII) for production of bi-functional fatty acids
    Patent number: 10233432
    Abstract: A mutant Bacillus subtilis, which does not express a functional KASIIIA and/or KASIIIB, and method of making; a mutant Rhodospirillum rubrum, which does not express a functional PhaC1, PhaC2, and/or PhaC3, and method of making; method of characterizing substrate specificity of KASIII; method of making mutant KASIII with altered substrate specificity and/or altered level of activity and nucleic acid, vector, host cell/organism, and mutant KASIII; an in vitro, high-throughput spectrophotometric method of assaying KASIII activity; and materials and methods for using KASIII for production of bi-functional fatty acids and the materials so produced.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: March 19, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Shivani Garg, Huanan Jin, Marna Yandeau-Nelson, Basil J. Nikolau
  • Micro-fluidic mixer and method of determining pathogen inactivation via antimicrobial solutions
    Patent number: 10233482
    Abstract: A sample of produce wash water containing an antimicrobial sanitizer fluid, and a reference pathogen fluid are both injected into a pathogen inactivation region of a micro-fluidic mixer. The produce wash water (i.e. sanitizer fluid/pathogen fluid mix) is directed through mixer elements in the pathogen inactivation region of the micro-fluidic mixer. In the sanitizer deactivation region, a sanitizer deactivation solution is added to the sanitizer fluid/pathogen fluid mix to produce a deactivated solution. The deactivated solution is evaluated for the presence of the pathogen and the characteristics of the sanitizer. In the preferred embodiment, the sanitizer comprises chlorine and the pathogen comprises E. coli bacteria.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: March 19, 2019
    Assignees: The United States of America, as represented by The Secretary of Agriculture, University of Maryland
    Inventors: Yaguang Luo, Boce Zhang, Patricia D. Millner
  • Spectroscopic tissue analysis apparatus and methods
    Patent number: 10234443
    Abstract: An apparatus for spectroscopic tissue analysis is disclosed. The apparatus comprises: a light delivery system configured to direct an excitation signal on to a tissue sample; a light collection system configured to collect a backscattered signal comprising diffuse reflectance photons backscattered by the tissue sample; an imaging device; a spectrometer; an optical adaptor configured to direct a first portion of the backscattered signal to the imaging device and a second portion of the backscattered signal to the spectrometer; and an analysis system configured to apply polar decomposition to spectral image data of the tissue captured by the imaging device and the spectrometer and thereby derive polarization metrics for the tissue sample.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: March 19, 2019
    Assignee: National University of Singapore
    Inventor: Zhiwei Huang
  • BCL6 expression in eutopic endometrium as a marker for endometriosis and subfertility
    Patent number: 10234465
    Abstract: Methods for identifying subjects as candidates for embryo implantation are provided. In some embodiments, the methods include providing a sample of endometrium isolated from a subject during the second half of the subject's menstrual cycle and determining whether the subject is a candidate based on the expression of BCL6 in the sample. Also provided are methods for identifying an increased risk for implantation failure subsequent to in vitro fertilization (IVF) and/or frozen embryo transfer (FET), methods for detecting endometrial receptivity, methods for facilitating diagnoses of infertility, methods for increasing the likelihood of embryo implantation, methods for detecting the presence of endometriosis, and methods for managing treatment of subjects with potential endometriosis, subfertility, or both.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: March 19, 2019
    Assignees: The University of North Carolina at Chapel Hill, Greenville Health Systems
    Inventors: Steven Young, Bruce Lessey
  • Restrictive inverted terminal repeats for viral vectors
    Patent number: 10233428
    Abstract: This invention relates to modified parvovirus inverted terminal repeats (ITRs) that do not functionally interact with wild-type large Rep proteins, synthetic Rep proteins that functionally interact with the modified ITRs, and methods of using the same for delivery of nucleic acids to a cell or a subject. The modifications provide a novel Rep-ITR interaction that limits vector mobilization, increasing the safety of viral vectors.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: March 19, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Curtis Hewitt, Richard Jude Samulski
  • Method of treating hyperglycemic disorders using apolipoprotein AIV
    Patent number: 10232019
    Abstract: Methods for treating hyperglycemia disorders in a subject in need thereof and pharmaceutical compositions for the treatment of hyperglycemia disorders are disclosed. The methods include administering an effective amount of apolipoprotein A-IV to the subject. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject having hyperglycemic disorders, including insulin resistant disorders, such as prediabetes, metabolic syndrome, polycystic ovary disease, type A syndrome, gestational diabetes, and endocrine conditions associated with hyperglycemia, including Cushing's Disease, glucagon excess (glucagon secreting tumors) and acromegaly.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: March 19, 2019
    Assignee: University of Cincinnati
    Inventors: Patrick Tso, Fei Wang, Sean Davidson, Stephen Woods
  • MIMO systems with independent oscillators and phase noise mitigation method thereof
    Patent number: 10236948
    Abstract: Disclosed is a phase noise mitigation method using a MIMO system in which each antenna has an independent oscillator. The phase noise mitigation method includes: receiving a transmission signal transmitted from a transmitting antenna, through a receiving antenna and an oscillator; estimating multiple parameters for a phase noise of a transmission terminal and a phase noise of a receiving terminal on the basis of a result of mathematical modeling of signals transmitted and received through the MIMO system in which each antenna has an independent oscillator; and mitigating phase noises of the transmission terminal and the receiving terminal which are estimated from the received signal.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: March 19, 2019
    Assignee: Korea University Research and Business Foundation
    Inventors: Young Chai Ko, Tae Jun Lee, Byung Ju Lim
  • Polarized light source device
    Patent number: 10234726
    Abstract: A polarized light source configured for use in display device and backlight unit is described. The polarized light source comprising: at least one optically active structure comprising a plurality of nanorods configured to emit light of one or more wavelengths in response to exciting pumping field, said plurality of nanorods comprising nanorods aligned with a predetermined alignment axis so as to produce a desired polarization direction of the emitted light; and a light directing assembly comprising one or more optical elements in optical path of light emitted from the light emitting structure, said light directing assembly being configured to enhance output of the emitted light from the emitting structure while substantially maintaining the polarization of the emitted light passing therethrough. Preferably, layers associated with the polarized light source are aligned with parallel principal axes.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: March 19, 2019
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Qlight Nanotech Ltd.
    Inventors: Uri Banin, Ehud Shaviv, Hagai Arbell
  • Photovoltaic cell enhancement through UVO treatment
    Patent number: 10236460
    Abstract: Photovoltaic cells, methods of fabricating photovoltaic cells, and methods of using photovoltaic cells to capture light energy are provided. A photovoltaic cell can include an electron transporting layer, a photoactive layer, and a hole transporting layer. The electron transporting layer can be ultraviolet ozone treated. The photovoltaic cell can have an inverted configuration.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: March 19, 2019
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Franky So, John R. Reynolds, Song Chen, Cephas Small