Abstract: An information management system includes: a mobile communication terminal capable of obtaining location information; and a medical institution provided with a regional medical data bank system and a transmitter. The mobile communication terminal transmits a space-time tag and a terminal ID to the system. The space-time tag is constituted of time information and location information. A space-time ID information processing unit of the system generates a space-time ID in a folder for each user based on a plurality of space-time tags and stores it in space-time ID information DB. A terminal device of the medical institution transmits the location information of the mobile communication terminal and the time information to the system. A verification processing unit verifies information from the mobile communication terminal against information from a utilization terminal and transmits the information to the utilization terminal when a request for transmission of the information is valid.

Abstract: Disclosed herein is a functionalized eyewear device that is adapted for collecting and analyzing disease biomarkers. Specifically, exemplified is a contact lens that has aptamer molecules associated therewith for binding to a specific biomarker (or biomarkers). The eyewear device is useful for detecting and diagnosing medical conditions.

Abstract: Described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a targeting agent. The composition can include a therapeutic agent. The therapeutic agent can be an antisense oligonucleotide (ASO). Exemplary ASOs are targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1; or targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Also described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a therapeutic agent that is an ASO such as an ASO targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1 or an ASO targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Pharmaceutical formulations, methods of making the lipid nanoparticles, and methods of using the lipid nanoparticles, for example for treating cancers, are also disclosed.

Abstract: A vertical-mode tunnel field-effect transistor (TFET) is provided with an oxide region that may be laterally positioned relative to a source region. The oxide region operates to reduce a tunneling effect in a tunnel region underlying a drain region, during an OFF-state of the TFET. The reduction in tunneling effect results in a reduction or elimination of a flow of OFF-state leakage current between the source region and the drain region. The TFET may have components made from group III-V compound materials.

Abstract: The present invention relates to systems and methods for measuring chromosome structure and gene expression. In one embodiment, the present invention includes an assay for determining the spatial organization of gene expression in the nucleus. The present invention also includes a method based on fluorescence in situ hybridization (FISH) that simultaneously yields information on the physical position and expression of individual genes. By lighting up a large number of targets on a particular chromosome using a bar-coding scheme, the large scale structure of an entire chromosome can be determined.

Abstract: This invention is about the compositions and methods for assessing and treating vascular endothelial dysfunction. Various aspects provide a method for treatment of vascular endothelial dysfunction, comprising administering a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient to a subject. In one embodiment the dose is administered to subjects in response to the indicator. In another embodiment the dose is administered chronically to subjects.

Abstract: Disclosed are compositions, articles, and method for enhancing exercise performance in a subject. The method involves contacting the oral cavity of the subject with a composition comprising a sweet and caloric food product for a period sufficient to cause a cephalic phase response in the subject.

Abstract: The present invention relates to robotic surgical devices. More specifically, the present invention relates to robotic surgical devices that can be inserted into a patient's body and can be positioned within the patient's body.

Abstract: In various embodiments, a device for inserting an implant on a human or animal body may be provided. The device may include an operable portion configured to make an incision on the human or animal body and configured to hold the implant for insertion on the human or animal body. The device may further include an actuator mechanism coupled to the operable portion, the actuator mechanism configured to move the operable portion along a first axis and configured to vibrate the operable portion along a second axis substantially perpendicular to the first axis.

Abstract: The present invention includes compositions and methods of inhibiting or activating TLR7 signaling. In one aspect, a composition includes an inhibitor of TLR7 signaling is described, where the inhibitor of TLR7 signaling is a TLR7 inhibitory oligonucleotide, a TLR7 antibody, or a TLR7 antagonist. In another aspect, a composition and method are described for preventing and treating viral infection of a T cell in a subject. Methods for decreasing T cell proliferation by administering a composition with a TLR7 ligand or agonist or inducing T cell anergy in a subject by stimulating T cells with a TLR7 ligand or agonist are also described.

Abstract: Example apparatuses and methods relating to antennas are provided. An example apparatus in the form of an antenna assembly includes a first conductor formed into a first helical structure wound around a central axis and a second conductor formed into a second helical structure wound around the central axis. The first helical structure may have a first coil sense and the second helical structure may have second coil sense that is opposite the first coil sense. The first conductor may have a first conductor proximal end and a first conductor distal end and the second conductor may have a second conductor proximal end and a second conductor distal end. The first conductor distal end may be adjacent the second conductor proximal end. The antenna assembly may further include first, second, and third ground planes with one disposed at each end of the conductors and one disposed between the conductors.

Abstract: A hover controlling device includes a sensing unit and a hover control unit. The sensing unit includes a plurality of first electrostatic sensing elements, a plurality of first electrodes, a plurality of second electrostatic sensing elements, and a plurality of third electrodes located on a substrate. Each first electrostatic sensing element and each second electrostatic sensing element include a single walled carbon nanotube or a few-walled carbon nanotube. The resistances of the plurality of first electrostatic sensing elements and the plurality of second electrostatic sensing elements are changed in process of a sensed object with electrostatic near, but does not touch the plurality of first electrostatic sensing elements and the plurality of second electrostatic sensing elements. The hover control unit is electrically connected to the plurality of first electrostatic sensing elements and the plurality of second electrostatic sensing elements.

Abstract: Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one ESI emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one ESI emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one ESI emitter thereby preferentially directing analyte molecules out of the at least one ESI emitter. The methods, systems and devices are particularly suitable for use with a mass spectrometer.

Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.

Abstract: The invention relates to synthetic liver-specific promoters and expression constructs for producing polypeptides and functional nucleic acids in the liver of a subject. The invention further relates to Factor VIII proteins containing modifications in the amino acid sequence of the Factor VIII protein, as well as nucleic acid constructs encoding the Factor VIII proteins and methods of using these compositions to treat a bleeding disorder.

Abstract: Click reactions may be used to bond polymers to lignin by taking advantage of lignin's terminal hydroxyl and thiol groups via an alkyne-azide click reaction or a thiol-alkene or thiol-alkyne click reaction. By selecting functional polymers, these methods may be used to synthesize lignin-containing polymer materials with an array of different properties, such as self-healing polymers.

Abstract: The present disclosure relates to a pre-5th-Generation (5G) or 5G communication system to be provided for supporting higher data rates Beyond 4th-Generation (4G) communication system such as Long Term Evolution (LTE). The present invention discloses a transmitting and receiving method capable of estimating an accurate time and a frequency synchronization using a sequence in a filter bank multiple transmission system.

Abstract: Secrecy scheme systems and associated methods using list source codes for enabling secure communications in communications networks are provided herein. Additionally, improved information-theoretic metrics for characterizing and optimizing said secrecy scheme systems and associated methods are provided herein. One method of secure communication comprises receiving a data file at a first location, encoding the data file using a list source code to generate an encoded file, encrypting a select portion of the data file using a key to generate an encrypted file, and transmitting the encoded file and the encrypted file to an end user at a destination location, wherein the encoded file cannot be decoded at the destination location until the encrypted file has been received and decrypted by the end user, wherein the end user possesses the key.

Abstract: As described herein, an peptide of SEQ ID NO: 1 is modified at the terminal end. Specifically, the carboxyl-group of the leucine at the terminal end of the amino acid sequence FCIGRL (SEQ ID NO: 1) is modified with a —CONH2. This modified peptide is used as a permeation enhancer to boost the mucous membrane permeation, thereby noticeably increasing the bioavailability of a drug that is administered together with the modified peptide. The drug to be administered with the modified peptide can be cyclosporine A.

Abstract: The present disclosure provides a reconfigurable processor and a timing control method thereof. The reconfigurable processor comprises a reconfigurable cell array (RCA) including a plurality of reconfigurable cells (RCs) and a control unit; the control unit is configured to generate and send a timing control information to the RCA; and the RCA is configured to execute an operation task according to the timing control information, wherein the RC in the RCA starts to execute an operation when receiving the timing control information, and delivers the timing control information to a next level of RC within the RCA according to a preset order after the operation is completed; and when the RCA completes the operation task corresponding to the timing control information, the RCA destroys the timing control information, wherein the operation task includes operations executed by each level of the RCs receiving the timing control information.