Abstract: In one aspect, the disclosure relates to compositions for the extended release of drugs in the retina. In a further aspect, the present disclosure provides methods of preparing extended release compositions comprising a therapeutic agent for use in retinal drug delivery. In various other aspects, the present disclosure provides methods for delivery of the disclosed compositions comprising a therapeutic agent to the retina via intravitreal injection. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.

Abstract: A deep learning fault diagnosis method includes the following steps: a fault diagnosis data set X is processed based on sliding window processing, to obtain a picture-like sample data set {tilde over (X)}, and obtain an attention matrix A of the picture-like sample data set {tilde over (X)}; and a 2D-CNN model is constructed to process the picture-like sample data set {tilde over (X)} to obtain a corresponding feature map F, and in the meantime, the feature map F is processed based on channel-oriented average pooling and channel-oriented maximum pooling to obtain an output P1 of the average pooling and an output P2 of the maximum pooling, and a weight matrix W is obtained based on the attention matrix A, the output P1 of the average pooling, and the output P2 of the maximum pooling, so that an output of the model is a feature map {tilde over (F)} based on an attention mechanism, where {tilde over (F)}=WF.

Abstract: Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for neutralizing a range of HIV strains. Combinations of broadly neutralizing antibodies can also improve potency over a single antibody composition.

Abstract: A cell model for in vitro evaluation of compound-induced skin sensitization and a constructing method therefor. The method for constructing the cell model comprises the steps of: designing and constructing an sgRNA expression vector based on CRISPR/Cas9 vector system; designing and constructing a homologous recombinant vector capable of knocking a reporter gene linked to a self-cleaving peptide sequence into a specific site of the expression frame of the HMOX1 gene; co-transfecting the homologous recombinant vector, an hCas9 plasmid and the sgRNA expression vector into a cell, and carrying out monoclonal expansion to obtain the cell model. The present invention obtains a HaCaT cell model in which a luciferase gene is knocked in before the stop codon of the HMOX1 gene by combination of CRISPR/CAS9 and a monoclonal cell technique. The cell model realizes synchronous expression of the luciferase gene and the HMOX1 gene, thereby effectively distinguishing sensitizing compounds from non-sensitizing compounds.

Abstract: Described herein are methods, compositions, and kits for treating and/or preventing in a subject one or more side effects associated with radiation and/or chemotherapy exposure, including methods, compositions and kits that include an active agent at a low dose. In some embodiments, methods, compositions, and kits for treating and/or preventing tissue damage in a subject are provided, including methods, compositions and kits that include an active agent at a low dose.

Abstract: The disclosure pertains to N-terminal epitopes identified in A-beta, including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.

Abstract: A magnetic material used in the magnetic SF-based composite aerogel is a ferroferric oxide nanocubic particle, which is a magnetic nanomaterial with both excellent magnetocaloric performance and excellent photothermal performance. The magnetic SF-based composite aerogel prepared by the present disclosure exhibits excellent responsiveness to both alternating current (AC) magnetic fields and sunlight. Under an action of an AC magnetic field, the magnetic SF-based composite aerogel exhibits excellent temperature rise performance, which can inhibit the generation of biofouling in pores and channels inside a three-dimensional (3D) porous evaporation material. The magnetic SF-based composite aerogel exhibits excellent water evaporation performance under a sunlight irradiation, with a water evaporation rate of 2.03 kg m?2·h?1.

Abstract: Embodiments of this application disclose an interpolation filter training method and apparatus, a video picture encoding and decoding method, an encoder, and a decoder. According to the training method, a first sub-pixel picture obtained through interpolation by using a conventional interpolation filter is used as label data, to train a second interpolation filter, so that the second interpolation filter obtained through training can be directly used for a pixel value, obtained through interpolation, of a first fractional pixel position. Therefore, the label data is more accurate, and coding performance of a video picture is improved. According to the encoding method, during inter prediction, a target interpolation filter used for a current encoding picture block is determined from a set of candidate interpolation filters, and the encoder selects, according to content of the current encoding picture block, an appropriate interpolation filter to perform an interpolation operation.

Abstract: A mechanical adaptation to a vehicle power window controls is provided that require less hand/finger coordination and less force to actuate, therefore becoming useful for persons with limited control of their hands (e.g., arthritis, muscular dystrophy, multiple sclerosis, cerebral palsy, and spinal cord injury, among others). A power window control includes four levers, one on each control switch. Two of the levers are long and the other two are shorter. The long levers are provided on the two switches further away from the user (which control the front and rear left side windows). The short levers are attached to the two switches closer to the user (which control the front and rear right side windows).

Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which are capable of detecting or imaging, more specifically, determining the presence, or measuring the level, of proteases, as well as compositions and uses thereof.

Abstract: A nanotweezer and method of trapping and dynamic manipulation thereby are provided. The nanotweezer comprises a first metastructure including a first substrate, a first electrode, and a plurality of plasmonic nanostructures arranged in an array, and a trapping region laterally displaced from the array; a second metastructure including a second substrate and a second electrode; a microfluidic channel between the first metastructure and the second metastructure; a voltage source configured to selectively apply an electric field between the first electrode and the second electrode; and a light source configured to selectively apply an excitation light to the microfluidic channel at a first location corresponding to the array, thereby to trap a nanoparticle at a second location corresponding to the trapping region.

Abstract: The present disclosure provides a system for functional ultrasound imaging, where the system comprises: a) an apparatus for delivering a nucleic acid encoding a mechanosensitive ion channel to a target neural cell population in a region of a brain; and b) a functional ultrasound imaging device. The present disclosure provides a method for functional ultrasound imaging.

Abstract: Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly.

Abstract: This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics.

Abstract: The present disclosure provides methods for re-programming effector T cells to a central memory phenotype comprising culturing the effector T cells with a histone deacetylase inhibitor (HDACi) and IL-21. Further provided are methods of treating cancer comprising administering the central memory T cells.

Abstract: A holographic imaging system comprises an imaging light source defining an imaging light path, an active light source defining an active light path directed at a target, and a polarizer configured to modify the polarization of the active light path. The system further comprises a polarization beam splitter positioned in the active light path and the imaging light path, configured to separate the active light path and the imaging light path, and a photodetector positioned at a terminus of the active light path. The photodetector is configured to measure a reflection of the active light source. A method of holographic imaging is also described.

Abstract: A spatial Fourier transform spectrometer is disclosed. The Fourier transform spectrometer includes a Fabry-Perot interferometer with first and second optical surfaces. The gap between the first and second optical surfaces spatially varies in a direction that is orthogonal to the optical axis of the Fourier transform spectrometer. The Fabry-Perot interferometer creates an interference pattern from input light. An image of the interference pattern is captured by a detector, which is communicatively coupled to a processor. The processor is configured to process the interference pattern image to determine information about the spectral content of the input light.

Abstract: The disclosure discloses a system for controlling a multi-point synchronous braking of a monorail hoist and a utilization method thereof. The system comprises a contact detection unit, a common end roller unit, a hydraulic unit, a synchronous control unit and connection cables. The contact detection unit is installed on a brake shoe of a monorail hoist. The common end roller unit is installed on a travelling track and connected with a frame of the monorail hoist. The contact detection unit includes a tube in connection with the brake shoe. A metal probe corresponding to the travelling track is arranged inside the tube. A circular boss is formed on the metal probe. A limiting bolt corresponding to the circular boss is formed on an inner side wall of the tube. The metal probe is contactable with the travelling track or the limiting bolt when the brake shoe brakes.

Abstract: Techniques for efficiently capturing targets, such as biological materials, within the air are described. A lightweight, portable device is configured to capture the targets without desiccation by flowing a mixture of air carrying the targets with liquid droplets through a nonlinear path in a partially enclosed interior of the device. For example, a method includes generating an impinging jet comprising a mixture of air, a target, and droplets. A baffle splits the impinging jet into a recirculation zone and coalesces a mixture of the target and the droplets onto an upper surface of the baffle. At least one channel receives the coalesced mixture and transports the coalesced mixture to a collection reservoir.