Abstract: The present invention provides a temperature sensing circuit, which comprises a switching circuit, a charging circuit, and a judging circuit. The switching circuit receives a supply voltage for generating a switching signal. The charging circuit is coupled to the switching circuit and receives the supply voltage. The switching signal controls the charging circuit for generating a voltage signal according to the supply voltage. The judging circuit is coupled to the charging circuit for generating a judging signal according to the level of the voltage signal. The levels of the switching signal and the voltage signal are related to a temperature state; and the judging signal represents the temperature state. The temperature sensing circuit can be applied to the driving circuit of a display panel for detecting the temperature state. Hence, the level of the driving signal of the driving circuit can be adjusted for improving the image quality.

Abstract: A diffractive multifocal lens is disclosed, comprising an optical element having at least one diffractive surface, the surface profile comprising a plurality of annular concentric zones. The optical thickness of the surface profile changes monotonically with radius within each zone, while a distinct step in optical thickness at the junction between adjacent zones defines a step height. The step heights for respective zones may differ from one zone to another periodically so as to tailor diffraction order efficiencies of the optical element. In one example of a trifocal lens, step heights alternate between two values, the even-numbered step heights being lower than the odd-numbered step heights.

Abstract: The present invention relates to a measuring and compensating method for channel mismatch of an ultra-high speed time-wavelength interleaved optical pulse sequence, by employing a generating module of the to-be tested ultra-high speed time-wavelength interleaved optical pulse sequence, an optical spectrum measuring module, an electrical frequency measuring module, and a data analyzing and processing module. The present invention obtains mismatch information of the pulse sequence for each channel by means of measurement and analysis of the ultra-high speed time-wavelength interleaved optical pulse sequence, thus overcoming the bottleneck of inadequate sampling of time-domain observation via an oscilloscope. The channel mismatch information obtained by the present invention may act as a basis for channel mismatch compensation and correction for the ultra-high speed time-wavelength interleaved optical pulse sequence.

Abstract: This disclosure provides anti-MUC1 binding agents (e.g., antibodies and chimeric antigen receptors) and methods of treatment, prophylaxis, detection, and diagnosis using the same.

Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.

Abstract: A skull-implantable magnet assembly for delivering a static magnetic field to a patient's brain, comprising a rod-shaped magnet housed within a skull screw, removably attached to a casing housing at least one flat magnet, is described. Details of the exterior construction are discussed, as well as magnet arrangements and methods of treating a brain tumor or neurological ailment of a patient.

Abstract: Iron-based crystal structures including FeO4 tetrahedrally coordinated in three dimensions in a framework analogous to a zeolite. The structures having the general formula AyB8Fe12O24(O/OH)6.xH2O in which A is Na, K, Cs, Rb or a combination thereof and B is an alkaline earth element or a combination of alkaline earth elements.

Abstract: A polyphosphonate, a lens including the polyphosphonate, a camera module including the polyphosphonate lens, and a method of producing the lens are provided. The polyphosphonate includes a constitutional repeating unit comprising a phosphate ester group and an aromatic ring, and the phosphate ester group is directly bonded to the aromatic ring in the constitutional repeating unit.

Abstract: Described herein is an enzyme-mediated approach to bioconjugation at nanoparticle (NP) surfaces. This process is enabled by a new synthetic linker compatible with the covalent attachment of alkyne modified substrates, including dyes, peptides and nucleic acids. The methods described herein specifically allow for the linkage of molecules to a DNA-functionalized nanoparticle surface. Enzymatic ligation of molecules to the terminal hydroxyl group of DNA using T4 DNA ligase is achieved through incorporation of a single monophosphate on the approaching substrate. In contrast to previous strategies, the linkers disclosed herein are compatible with alkyne modified molecules of a variety of sizes and charges indicating that the ligase minimally requires the monophosphate and the incoming hydroxyl for conjugation to be successful.

Abstract: The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase inhibitory activity, which are useful as anti-angiogenic and anti-tumor agents. Also provided are methods of utilizing these inhibitors to treat tumor cells and other proliferative diseases and disorders.

Abstract: A composite water purification apparatus and method thereof are provided. The composite water purification apparatus includes a container, a sacrificial anode, a photocatalyst anode and a cathode. The container is employed for receiving liquid including water and gas. The photocatalyst anode includes a photocatalyst for conducting a photocatalytic reaction. The cathode is electrolyzed with the sacrificial anode and the photocatalyst anode. The cathode, the sacrificial anode, and the photocatalyst anode are immersed in the container to contact the liquid. The present invention enhances the purity of the water, while prolonging the service life of the sacrificial anode.

Abstract: The reconfigurable resonators for chipless RFID applications provide spiral resonators for a multiple resonator passive RFID transponder tag. Each spiral resonator includes a U-shaped frame of conductive material and has a plurality (K?1) of parallel adjusting or shorting elements disposed between the legs of the U-shaped frame. Each resonator has one leg coupled to a transmission line adapted for connection between a receiving antenna and a transmitting antenna (in some embodiments, a single antenna may be used for both receiving and transmitting), and one of the adjusting or shorting elements may be selectively connected to the opposing leg of the frame to configure the resonator to resonate at one of (K?1) different resonant frequencies (K frequencies if none of the elements are connected) by a short metal jumper strip to change the length of the spiral resonator.

Abstract: Provided herein are devices and systems that apply full-field optical coherence tomography (OCT) technology to three-dimensional skin tissue imaging. A special designed Mirau type objective and an optical microscope module allowing both OCT mode and orthogonal polarization spectral imaging (OPSI) mode are disclosed.

Abstract: Methods, systems, and apparatus are provided for determining whether a nucleic acid sequence imbalance exists within a biological sample. One or more cutoff values for determining an imbalance of, for example, the ratio of the two sequences (or sets of sequences) are chosen. The cutoff value may be determined based at least in part on the percentage of fetal DNA in a sample, such as maternal plasma, containing a background of maternal nucleic acid sequences. The percentage of fetal DNA can be calculated from the same or different data used to determine the cutoff value, and can use a locus where the mother is homozygous and the fetus is heterozygous. The cutoff value may be determined using many different types of methods, such as sequential probability ratio testing (SPRT).

Abstract: The present invention relates to an intelligent wind turbine generator, which comprises a first blade module, a second blade module, a power generating module, and a control module. The second blade module is disposed at the first blade module. The power generating module is connected with the first and second blade modules. The control module is connected with the power generating module, the first blade module, and the second blade module. The first and second blade modules rotate, driving the power generating module to generate power. The control module detects a voltage value generated by the power generating module and judges if the voltage value is greater or lower than a predetermined value. The control module controls whether the first and second blade modules overlap or not. The intelligent wind turbine generator is able to switch automatically the blade number of the wind turbine generator.

Abstract: A quadrupole mass filter and method for operating the filter are described. AC voltages are applied to the quadrupole to separate ions based on mass-to-charge ratio. Frequency is scanned with a simultaneous amplitude scan. Ions are measured over a broad m/z range with high resolution. A resolving power of about 1,200 was demonstrated. Ions were observed for m/z values over 150,000 Th.

Abstract: An assist chair includes a base portion, a pair of armrests, a backrest, an uplifting apparatus, a seat cushion and a waist rest cushion, wherein the uplifting apparatus further includes a pair of assist handles. When the uplifting apparatus is activated, the assist handles is capable of being driven out of inner sides of the pair of armrests, leaving the inner sides of the armrests or being retracted back to the inner sides of the pair of armrests after being pushed out of the armrests, such that the configuration can support the elderly when standing up or sitting down.

Abstract: Embodiments concern compositions and methods involving recombinant antibodies to histone post-translational modifications. The invention provides compositions and methods for histone methyltransferase assays. In certain embodiments, the compositions and methods involve a recombinant antibody that binds histone H3 fragment harboring biomarkers such as H3K9me3 mark, H3K4me3 mark, H3K36me3 mark, H3K27me3, H3K9me3 and H3S10phos or a recombinant antibody that binds histone H4 fragment harboring H4K20me3 mark.

Abstract: This disclosure describes devices, system, and a method for the prediction and prevention of acute decompensated heart failure or other patient conditions involving fluid accumulation in legs or hands. In one example, a wearable device contains a drift-free leg-size sensor and a tissue-elasticity sensor. Both sensors may be relatively inexpensive and developed using innovative new sensing ideas. Preliminary tests with the sensor prototypes show promising results: the leg-size sensor is capable of measuring 1 mm changes in leg diameter and the tissue-elasticity sensor can detect 0.15 MPa differences in elasticity. In another example, a wearable system includes sensors for measuring a variety of physiological parameters, a processing module, and a communication module. A low-profile instrumented sock, e.g., a wearable device, with multiple sensors can provide an indication of heart failure status for a patient.

Abstract: A silicon based micro-structured material and methods are shown. In one example, the silicon based micro-structured material is used as an electrode in a battery, such as a lithium ion battery, we have successfully demonstrated the first synthesis of a scalable carbon-coated silicon nanofiber paper for next generation binderless free-standing electrodes for Li-ion batteries that will significantly increase total capacity at the cell level. The excellent electrochemical performance coupled with the high degree of scalability rriake this material an idea candidate for next-generation anodes for electric vehicle applications. C-coated SiNF paper electrodes offer a highly feasible alternative to the traditional slurry-based approach to Li-ion battery electrodes through the elimination of carbon black, polymer binders, and metallic current collectors.