Patents Assigned to University
  • Patent number: 12163701
    Abstract: Systems and methods disclosed herein relate to a cryogenic refrigeration system which may use a compression based cryocooler or liquid nitrogen pre-cool to cool a medium to ˜80K, and may in conjunction with a magnetic refrigeration system operating in the sub-80K temperature regime to provide cooling to a medium to temperatures below 80K. In some embodiments, the disclosed system may be useful for cooling on the order of about 3 kg/day to about 300 kg/day of hydrogen gas to liquid form, with higher efficiency than a standard vapor compression based system. This higher efficiency may make the system a more attractive candidate for use in cryogenic cooling applications.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: December 10, 2024
    Assignees: General Engineering & Research LLC, The Regents of the University of California
    Inventors: Robin Ihnfeldt, Renkun Chen, Sungho Jin, Tianshi Feng, Sarath Adapa
  • Patent number: 12161756
    Abstract: A nanocomposite comprising a nanocarrier, a pharmaceutical compound disposed on a surface of the nanocarrier, and a biocompatible coating disposed on the pharmaceutical compound. The nanocarrier comprises nanotubes of a silicate or aluminosilicate material, preferably halloysite, and nanoparticles of a magnetic transition metal ferrite material of formula MFe2O4, where M is selected from the group consisting of zinc, nickel, copper, manganese, and cobalt, the nanoparticles being disposed on an interior and/or an exterior surface of the nanotubes. The pharmaceutical compound is disposed in the pores and/or on the surface of the nanocarrier by a solution phase impregnation process. The nanomedicinal composition is used in a method of treating pulmonary infections. The nanomedicinal composition may be administered by inhalation.
    Type: Grant
    Filed: July 14, 2021
    Date of Patent: December 10, 2024
    Assignee: Imam Abdulrahman Bin Faisal University
    Inventors: B. Rabindran Jermy, Vijaya Ravinayagam, Dana Abdulrahman Almohazey
  • Patent number: 12162911
    Abstract: The treatment of bacterial respiratory infections using bacterially-originating antibiotics known as pyocins are provided. In particular, S-type pyocins are administered by pulmonary administration for the treatment of bacterial infections such as Pseudomonas aeruginosa infections. Methods of using S-type pyocin proteins, particularly those comprising an S2, SD2, S5 or AP41 targeting portion or an S2, SD2, S5 or AP41 effector portion are provided.
    Type: Grant
    Filed: February 23, 2023
    Date of Patent: December 10, 2024
    Assignee: The University Court Of tThe University of Glasgow
    Inventors: Daniel Walker, Laura McCaughey
  • Patent number: 12162935
    Abstract: Compositions and treatment regimen that includes the compositions, suitable for preventing, treating and restoring hearing acuity in a subject are provided. The treatment regimen includes an amount of capsaicin and an amount of a TNF-? inhibitor (such as etanercept) that are delivered relatively simultaneously to a subject. Methods of providing a pretreatment to a subject suitable for preventing hearing loss are also provided. The capsaicin and TNF? inhibitor may be provided in different delivery forms to the subject. Methods of providing a treatment for hearing loss with a TNF? inhibitor alone, such as entanercept, or with capsaicin alone, are also provided.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: December 10, 2024
    Assignee: Board of Trustees of Southern Illinois University
    Inventors: Debashree Mukherjea, Vickram Ramkumar, Leonard Rybak
  • Patent number: 12165673
    Abstract: A radio frequency connection between a far field voice detection device and a further device is used to determine a first angular direction from the far field voice detection device to the further device. The determined first angular direction is then used to emphasize, during a noise processing of a plurality of sounds received via use of a plurality of microphones of the far field voice detection device, a first one of the plurality of sounds relative to a remainder of the plurality of sounds.
    Type: Grant
    Filed: September 13, 2023
    Date of Patent: December 10, 2024
    Assignee: Universal Electronics Inc.
    Inventors: Haiming Huang, Michael Courtney, Jan van Ee, Khanh Nguyen, Jeremy Mickelsen, Arsham Hatambeiki
  • Patent number: 12163148
    Abstract: Disclosed herein is a technology to perform programmable RNA editing at single-nucleotide resolution using RNA-targeting CRISPR/Cas9. This approach, which Applicants have termed “Cas9-directed RNA editing” or “CREDIT,” provides a means to reversibly alter genetic information in a temporal manner, unlike traditional CRISPR/Cas9 driven genomic engineering which relies on permanently altering DNA sequence.
    Type: Grant
    Filed: July 11, 2022
    Date of Patent: December 10, 2024
    Assignee: The Regents of the University of California
    Inventors: Eugene Yeo, Kristopher Brannan, Ryan Marina, David Nelles
  • Patent number: 12161970
    Abstract: A CO2 desorption system suitable for limited space in a complex sailing region comprises an exhaust boiler, a compact CO2 absorber, a compact CO2 lean-rich liquid heat exchanger, a compact CO2 desorber, a compact CO2 rich liquid preheating device, a compact CO2 rich liquid reboiling pre-desorption device and an intelligent control platform. Further, a global optimization control method for the CO2 desorption system suitable for limited space in a complex sailing region is further established based through a knowledge and data-driven exhaust extraction flow accurate-prediction model for a heat source of a CO2 rich liquid preheating device and a steam extraction flow accurate-prediction model for a heat source on an upper section of a CO2 rich liquid reboiling pre-desorption device to realize flexible control of operation parameters of the desorption system under different operating conditions of an engine.
    Type: Grant
    Filed: August 9, 2024
    Date of Patent: December 10, 2024
    Assignees: Jiaxing Research Institute, Zhejiang University, Zhejiang University
    Inventors: Chenghang Zheng, Xiang Gao, Can Zhou, Yongxin Zhang, Qihao Chen, Weihong Wu, Zhiying Zhou, Haitao Shen, Haidong Fan, Qingyi Li, Yifan Wang, Peng Liu, Libin Yu, Tao Wang
  • Patent number: 12162915
    Abstract: The invention provides inhibitors of interferon regulatory factor 5 (IRF5) nuclear localization and methods of using the inhibitors to treat autoimmune diseases such as systemic lupus erythematosus (SLE).
    Type: Grant
    Filed: July 12, 2023
    Date of Patent: December 10, 2024
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Betsy J. Barnes
  • Patent number: 12161874
    Abstract: Disclosed are devices, systems and methods for implantable a biofuel cells. In some aspects, a biofuel cell device for extracting energy from a biological fluid includes a substrate including two compartments each with one or more openings; an anode assembly disposed in the substrate and including an anode electrode and functionalization material to facilitate an oxidative process that releases electrons captured at the anode electrode; and a cathode assembly disposed in the substrate separated from the anode assembly and including a catalytic material facilitate a chemical reduction process such that the biofuel cell device extracts electrical energy from the substance in the biological fluid.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: December 10, 2024
    Assignee: The Regents of the University of California
    Inventors: Joseph Wang, Krishnan Chakravarthy, Itthipon Jeerapan
  • Patent number: 12163189
    Abstract: Methods and kits for uniquely labeling nucleic acid molecules within a plurality of microbial cells are described. In an embodiment, the method comprises fixing and permeabilizing the plurality of microbial cells; dissociating microbial cell aggregates within a suspension comprising the plurality of microbial cells; reverse transcribing mRNA within the plurality of microbial cells to provide cDNA; and combinatorially labelling the cDNA to provide labelled cDNA.
    Type: Grant
    Filed: November 20, 2020
    Date of Patent: December 10, 2024
    Assignee: University of Washington
    Inventors: Georg Seelig, Anna Kuchina, Leandra Brettner, William DePaolo
  • Patent number: 12161766
    Abstract: The presently disclosed subject matter provides methods for continuously generating uniform polyelectrolyte complex (PEC) nanoparticles comprising: flowing a first stream comprising one or more water-soluble polycationic polymers at a first variable flow rate into a confined chamber; flowing a second stream comprising one or more water-soluble polyanionic polymers at a second variable flow rate into the confined chamber; and impinging the first stream and the second stream in the confined chamber until the Reynolds number is from about 1,000 to about 20,000, thereby causing the one or more water-soluble polycationic polymers and the one or more water-soluble polyanionic polymers to undergo a polyelectrolyte complexation process that continuously generates PEC nanoparticles. Compositions produced from the presently disclosed methods and a device for producing the compositions are also disclosed.
    Type: Grant
    Filed: February 7, 2023
    Date of Patent: December 10, 2024
    Assignee: The Johns Hopkins University
    Inventors: Hai-Quan Mao, Jose Luis Santos, Yong Ren, John-Michael Williford
  • Patent number: 12162960
    Abstract: This disclosure relates to selectin inhibitors, compositions, and methods related thereto. In certain embodiments, the disclosure relates to glycopeptides that contain one or more modified amino acids conjugated to a saccharide or polysaccharide. In certain embodiments, the disclosure relates to uses of the glycopeptides as anti-inflammatory, antithrombotic, or anti-metastatic agents.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: December 10, 2024
    Assignees: Beth Israel Deaconess Medical Center, Inc., Emory University
    Inventors: Elliot Chaikof, Richard D. Cummings, Venkata R. Krishnamurthy, Mohammed Sardar
  • Patent number: 12164181
    Abstract: A diffractive multifocal lens is disclosed, comprising an optical element having at least one diffractive surface, the surface profile comprising a plurality of annular concentric zones. The optical thickness of the surface profile changes monotonically with radius within each zone, while a distinct step in optical thickness at the junction between adjacent zones defines a step height. The step heights for respective zones may differ from one zone to another periodically so as to tailor diffraction order efficiencies of the optical element. In one example of a trifocal lens, step heights alternate between two values, the even-numbered step heights being lower than the odd-numbered step heights.
    Type: Grant
    Filed: June 22, 2023
    Date of Patent: December 10, 2024
    Assignee: Arizona Board of Regents on behalf of the University of Arizona
    Inventor: James T. Schwiegerling
  • Patent number: 12162629
    Abstract: Example coil guns and methods of using coil guns are described herein. An example coil gun includes a first pancake module; a second pancake module, where the first pancake module and the second pancake module are each formed of a winding with an inner superconducting material layer and an outer ordinary conductor layer, where the first pancake module and the second pancake module are physically and/or inductively coupled to propagate a quench of a superconducting state of the first pancake module to the second pancake module.
    Type: Grant
    Filed: November 22, 2022
    Date of Patent: December 10, 2024
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Lance D. Cooley, Christian M. Hubicki
  • Patent number: 12165760
    Abstract: A device may receive, from an imaging device, a two-dimensional image of a patient being operated on by a user, where the two-dimensional image captures a portion of the patient, and where the portion of the patient is provided between a focal point of an imaging source of the imaging device and a detector plane of the imaging device. The device may translate the two-dimensional image along a frustum of the imaging source, and may generate one or more images in a three-dimensional space based on translating the two-dimensional image along the frustum of the imaging source. The device may provide the one or more images in the three-dimensional space to an augmented reality device associated with the user.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: December 10, 2024
    Assignee: The Johns Hopkins University
    Inventors: Javad Fotouhi, Mathias Unberath, Nassir Navab
  • Patent number: 12165068
    Abstract: A method of training a deep neural network, such as would be used in facial recognition, includes training the deep neural network to normalize feature vectors to a learned value representing the radius of a multi-dimensional hypersphere using a convex augmentation of the primary loss function.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: December 10, 2024
    Assignee: Carnegie Mellon University
    Inventors: Marios Savvides, Dipan Kumar Pal, Yutong Zheng
  • Patent number: 12161441
    Abstract: A dental and facial imaging device includes an adjustable arm, an image sensor mounted on a first end of the adjustable arm and an adjustable patient positioning arm mounted on a second end of the adjustable arm. A distance between the adjustable patient positioning arm and the image sensor is adjustable based on an adjustable length of the adjustable arm. A position indicator scale of the adjustable arm includes multiple notches for calibrating the distance between the adjustable patient positioning arm and the image sensor. The adjustable patient positioning arm includes a patient teeth supporting device and a patient chin rest which are positioned at a fixed coordinate reference relative to the image sensor to capture an image of a patient's teeth. The fixed coordinate reference corresponds to co-ordinates of multiple anatomical planes associated with the patient teeth supporting device and a patient chin rest relative to the image sensor.
    Type: Grant
    Filed: July 9, 2024
    Date of Patent: December 10, 2024
    Assignee: Imam Abdulrahman Bin Faisal University
    Inventor: Jamal Al Waked
  • Patent number: 12161700
    Abstract: The present disclosure provides a drug carrier, a brain-targeting nanodrug based on CRISPR gene editing technology and a preparation method and use thereof. The nanodrug contains nanoparticles prepared by coupling Cas9/sgRNA and drug carriers. The drug carrier includes a polymer mPEG-P (GPMA, FPMA) and a polymer Ang-PEG-PGPMA, wherein a structural formula of the mPEG-P (GPMA, FPMA) is: a structural formula of the polymer Ang-PEG-PGPMA is: where n is 35-45, x1 is 15-20, y is 2-4, m is 75-85, and x2=x1. The guanidino group of the drug carrier can be combined with the ribonucleoprotein complex by electrostatic action, salt bridge formation, or hydrogen bonding action. Also provided are methods of suppressing and treating tumors at a gene level using the drug carrier to transport the therapeutic drug to the lesion site.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: December 10, 2024
    Assignee: Henan University
    Inventors: Weimin Ruan, Mingzhu Jiao, Bingyang Shi, Meng Zheng
  • Patent number: 12162216
    Abstract: Self-limiting electrospray compositions including a non-charge-dissipative component and/or a charge-dissipative component. Self-limiting electrospray composition including a plurality of charge-dissipative components and excluding a non-charge-dissipative component. Methods for forming layers of self-limiting thickness. Methods for determining a conductivity of a material. Methods for repairing a flaw in a layer on a surface of an object.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: December 10, 2024
    Assignee: Rutgers, the State University of New Jersey
    Inventors: Jonathan P. Singer, Lin Lei
  • Patent number: 12163090
    Abstract: A magnetic nanofluid that includes magnetic transition metal ferrite nanoparticles, ferroelectric nanoparticles, and a carrier fluid, and a method of changing the temperature of an object (e.g., heating or cooling) using the magnetic nanofluid. The magnetic transition metal ferrite nanoparticles and ferroelectric nanoparticles can be present as a composite comprising both types of nanoparticles. The use of the magnetic nanofluid is associated with an increase in the Nusselt number in the presence of a magnetic field.
    Type: Grant
    Filed: March 23, 2024
    Date of Patent: December 10, 2024
    Assignee: Prince Mohammad Bin Fahd University
    Inventor: Syam Sundar