Abstract: Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, disclosed are modified cystathionine-?-lyases comprising one or more amino acid substitutions and capable of degrading L-cyst(e)ine. Furthermore, compositions and methods are provided for the treatment of cystinuria using the disclosed modified enzymes or nucleic acids encoding said enzymes.
Type:
Grant
Filed:
October 25, 2019
Date of Patent:
December 10, 2024
Assignee:
Board of Regents, The University of Texas System
Abstract: A fully distributed island micro-grid attack elasticity control system and method are provided. The method includes following specific steps: collecting basic information of a local AC micro-grid bus of a distributed power generation unit and basic information of a neighbor distributed power generation unit connected through a directed communication topology; predicting, based on a dynamic equation of the distributed power generation unit, a sequence of states thereof within a set period of time, namely, the predicted sequence of states; judging whether a system is under attack according to a comparison result of the predicted sequence of states and a real-time state sampling value of a micro-grid, to obtain a sequence of optimal auxiliary control inputs ui*; and calculating an optimal angular frequency reference value ?i* at the next time point according to the sequence of optimal auxiliary control inputs ui*.
Type:
Grant
Filed:
April 30, 2024
Date of Patent:
December 10, 2024
Assignees:
Zhejiang University, Hainan Research Institute of Zhejiang University
Abstract: In a general aspect, an apparatus can include a plate configured for implantation in a body of a patient. The plate can include a plurality of pores and be configured for placement between a cancellous bone of a spinal vertebra and a corresponding cartilaginous endplate as a replacement for a bony endplate of the spinal vertebra.
Type:
Grant
Filed:
December 29, 2021
Date of Patent:
December 10, 2024
Assignee:
Brigham Young University
Inventors:
Danni Joell Porter, Anton Bowden, Brian Jensen
Abstract: The present disclosure provides pharmaceutical compositions for treating fungal and bacterial infections. The pharmaceutical compositions of the disclosure comprise a cationic surfactant, a chelating agent, and at least one solvent. The pharmaceutical compositions of the disclosure can be used to treat drug-sensitive or multi drug-resistant bacterial or fungal infections.
Type:
Grant
Filed:
November 29, 2022
Date of Patent:
December 10, 2024
Assignee:
New Mexico Tech University Research Park Corporation
Abstract: A nanocomposite electrode and a supercapacitor device including said nanocomposite electrode. The nanocomposite electrode includes a mixture of at least one binding compound, at least one conductive additive, and at least one molybdenum doped carbon material coated onto a substrate. The supercapacitor device includes two nanocomposite electrodes disposed facing one another, wherein the substrate of each nanocomposite electrode is coated with the mixture on an inside facing surface and the outer surfaces of the nanocomposite electrodes are not coated with the mixture, and the inside facing surfaces are separated by at least one electrolyte.
Type:
Grant
Filed:
July 29, 2024
Date of Patent:
December 10, 2024
Assignee:
Imam Abdulrahman Bin Faisal University
Inventors:
Sarah Mousa Maadi Asiri, Emre Cevik, Ayhan Bozkurt
Abstract: A kit or composition for in situ simultaneously derivatization of 14 phenol and carboxylic acid metabolites of benzene, toluene, ethyl benzene, and xylene (BTEX) in a urine sample is disclosed. The derivatization imparts a positive charge to phenol and carboxylic acid for subsequent LC-MS analysis. Limit of detection reached part-per-trillion levels for o-Cresol and part-per-billion levels for the remaining BTEX metabolites. BTEX metabolites can be detected in less than 35 mins according to one embodiment of the invention. Methods, kits and compositions disclosed herein can be used for in situ simultaneous derivatization of phenol and carboxylic acid in aqueous solution in general.
Type:
Grant
Filed:
October 24, 2022
Date of Patent:
December 10, 2024
Assignee:
Board of Regents, The University of Texas System
Inventors:
Kevin Albert Schug, Yehia Zakaria Mahmoud Youssef Baghdady
Abstract: The present disclosure provides compounds of Formula (VIIb) and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.
Type:
Grant
Filed:
January 13, 2022
Date of Patent:
December 10, 2024
Assignees:
The Regents of the University of California, The United States Government represented by the Department of Veterans Affairs
Inventors:
Matthew Rettig, Michael E. Jung, D. Elshan Nakath G. Ralalage, Jiabin An
Abstract: A document classification method includes: obtaining a document; extracting document keywords and a document abstract from the document; determining, according to the document keywords and the document abstract, a first classification label of the document; receiving a second classification label of the document, the second classification label being determined according to the document keywords, the document abstract, and the first classification label; obtaining a classification efficiency value of the documents, the classification efficiency value indicating a confidence level of the second classification label; and determining the second classification label as a final classification label of the document if the classification efficiency value is greater than or equal to a first threshold. The document classification method described above may improve the speed of document classification by computer, thereby improving the efficiency of document classification.
Type:
Grant
Filed:
February 25, 2022
Date of Patent:
December 10, 2024
Assignees:
State Grid Corporation of China, Jiangxi Normal University
Abstract: The present invention sets forth small novel abscisic acid (ABA) receptor agonist scaffolds and compounds with potent in vivo activity. In some aspects, the present invention provides agricultural formulations and methods comprising the ABA receptor agonists described herein, such as methods of managing crop water use and improving stress tolerance (e.g., drought tolerance). In some preferred embodiments, the inventive compounds have improved properties relative to the current “best in-class” molecules quinabactin and its derivatives.
Type:
Grant
Filed:
December 28, 2020
Date of Patent:
December 10, 2024
Assignee:
The Regents of the University of California
Inventors:
Sean R Cutler, Aditya Vaidya, Jonathan Helander
Abstract: A system and method for disconnection tolerant network routing, termed Binary State Distance Vector Routing (BSDVR). BSDVR provides for unicast routing on partitioned networks by introducing binary state information for distance vector (DV) entries to compute unicast paths. In the presence of network partitions, BSDVR effectively avoids the count-to-infinity problem and operates with control overhead less than traditional DV routing by an order of magnitude, leading to much better convergence times for failures.
Type:
Grant
Filed:
May 5, 2023
Date of Patent:
December 10, 2024
Assignee:
University of Central Florida Research Foundation, Inc.
Abstract: The present invention provides compounds useful for treating, ameliorating or preventing a disease or disorder that is caused, induced or characterized by abnormal reduction in glutamate transporter activity or abnormal increase in extracellular CNS glutamate concentration in a subject. In certain embodiments, the compound stimulates a glutamate transporter.
Type:
Grant
Filed:
June 23, 2022
Date of Patent:
December 10, 2024
Assignee:
Drexel University
Inventors:
Sandhya Kortagere, Andreia C. K. Mortensen, Ole V. Mortensen, Joseph M. Salvino
Abstract: A mannose derivative is an isonitrile-containing mannose derivative of formula (I), including different linking groups X: A radioactive preparation is provided, including a radiolabeled compound formed by radiolabeling the mannose derivative with a radionuclide. An application of the radioactive preparation in the diagnosis and treatment of tumors is also provided.
Type:
Grant
Filed:
November 17, 2023
Date of Patent:
December 10, 2024
Assignee:
Beijing Normal University
Inventors:
Junbo Zhang, Qing Ruan, Guangxing Yin, Xuebin Wang, Zhanbin Zhang, Zhigang Tang, Jie Lu
Abstract: Compositions and methods are disclosed for treating cancer patients and identifying patients with a malignancy that are likely to respond to treatment with anti-PD-1/PD-L1 and other anti-cancer and immune-modulating therapeutics.
Type:
Grant
Filed:
November 9, 2018
Date of Patent:
December 10, 2024
Assignee:
The Trustees of the University of Pennsylvania
Abstract: Ferroelectric materials and more particularly cerium-doped ferroelectric materials and related devices and methods are disclosed. Aspects of the present disclosure relate to ferroelectric layers of hafnium-zirconium-oxide (HZO) doped with cerium that enable reliable ferroelectric fabrication processes and related structures with significantly improved cycling endurance performance. Such doping in ferroelectric layers also provides the capability to modulate polarization to achieve a desired operation voltage range. Doping concentrations of cerium in HZO films are disclosed with ranges that provide a stabilized polar orthorhombic phase in resulting films, thereby promoting ferroelectric capabilities. Exemplary fabrication techniques for doping cerium in HZO films as well as exemplary device structures including metal-ferroelectric-metal (MFM) and metal-ferroelectric-insulator-semiconductor (MFIS) structures are also disclosed.
Type:
Grant
Filed:
November 23, 2021
Date of Patent:
December 10, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Paul C. McIntyre, Wilman Tsai, John D. Baniecki, Zhouchangwan Yu, Balreen Saini
Abstract: A method of removing a metal ion from water is disclosed. The method includes treating the water with a nanocomposite to absorb the metal ion with the nanocomposite, forming a polymer-metal ion composite and removing the polymer-metal ion composite from the water. The nanocomposite includes aluminum oxide dispersed in a matrix of an uncrosslinked graft copolymer that includes a chitosan backbone and side chains of poly (itaconic acid) grafted to the chitosan backbone. The chitosan backbone has a plurality of amino groups that are acetylated by itaconic acid.
Abstract: A cathode is provided for electrolysis of water wherein the cathode material comprises a multi-principal element, transition metal dichalcogenide material that has four or more chemical elements and that is a single phase, solid solution. The pristine cathode material does not contain platinum as a principal (major) component. However, a cathode comprising a transition metal dichalcogenide having platinum (Pt) nanosized islands or precipitates disposed thereon is also provided.
Type:
Grant
Filed:
January 12, 2023
Date of Patent:
December 10, 2024
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Viktor Balema, Sonal Padalkar, Ihor Hlova, Tian Lan, Oleksandr Dolotko, Vitalij K. Pecharsky, Duane D. Johnson, Arjun K. Pathak, Prashant Singh
Abstract: Provided is a functional, low-profile intercranial device (LID). The LID includes a base portion; at least one cavity associated with the base portion and configured to accept at least one functional component; and at least one conduit having a first end in communication with the at least one cavity. The at least one functional component includes a medicinal, electronic, or optic therapeutic. The at least one conduit is configured to accept the medicinal therapeutic and a second end configured to dispense the therapeutic.
Abstract: A thin metal strip continuous casting method using momentum flow distribution, comprising the steps of: adjusting the position of a flow distribution device (2), and starting a double-roller thin strip continuous casting apparatus; molten metal (3) forming a uniform sheet-shaped molten metal flow (4) having an initial momentum after the molten metal (3) passes through the flow distribution device; the sheet-shaped molten metal flow entering a molten pool (5) at a superheat degree of 50-100° C. and an initial velocity of 0.5-2 m/s, wherein the flow distribution device is spaced apart from the molten pool; under the action of the initial velocity of the molten metal and in the molten pool, forming a whirlpool, which is adjacent to surfaces of two cooling rollers and has a momentum stirring action; and completing the solidification of the molten metal under the momentum stirring action of the whirlpool along with the rotation of the two cooling rollers.
Type:
Grant
Filed:
July 21, 2022
Date of Patent:
December 10, 2024
Assignee:
University of Science and Technology Beijing
Abstract: Provided herein are long-acting antiparasitic devices comprising parasiticidal isoxazoline active agent for external use on an animal to treat and/or prevent parasitic infestations by ectoparasites, and in some embodiments, also parasitic infections. The disclosure also describes methods and uses of the antiparasitic external devices to treat and/or prevent parasitic infestations and/or infections in an animal.
Type:
Grant
Filed:
December 6, 2021
Date of Patent:
December 10, 2024
Assignees:
Boehringer Ingelheim Animal Health USA Inc., University of Georgia Research Foundation, Inc.
Inventors:
James Allan, Samuel David Bell, Christian Helmut Epe, Loic Patrick Le Hir De Fallois, Willy W. Lee, Jason J. Locklin
Abstract: The invention relates to a method of treatment of a patient with a ferrochelatase inhibitor, or a pharmaceutically acceptable salt thereof, or a derivative thereof. Also, the invention relates to a method of treatment of a patient with a ferrochelatase inhibitor that is a triazolopyrimidinone, or a derivative thereof, or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
April 30, 2019
Date of Patent:
December 10, 2024
Assignees:
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, Gachon University of Industry—Academic Cooperation
Inventors:
Timothy W. Corson, Kamakshi Sishtla, Seung-Yong Seo, Bit Lee