Abstract: The present disclosure provides compounds of Formula (VIIb) and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

Abstract: A system and method for disconnection tolerant network routing, termed Binary State Distance Vector Routing (BSDVR). BSDVR provides for unicast routing on partitioned networks by introducing binary state information for distance vector (DV) entries to compute unicast paths. In the presence of network partitions, BSDVR effectively avoids the count-to-infinity problem and operates with control overhead less than traditional DV routing by an order of magnitude, leading to much better convergence times for failures.

Abstract: Disclosed are therapeutic agent delivery vehicle comprising a modified platelet comprising a therapeutic agent cargo and a targeting moiety and methods for treating cancer comprising administering the same to a subject.

Abstract: Bridge helix-modified variant Cas12a and Cas12b proteins having improved DNA cleavage selectivity in comparison to wild type versions of the Cas12a and Cas12b proteins, nucleic acids encoding the variant proteins, host cells containing the nucleic acids, and methods of their use.

Abstract: The present invention provides compounds useful for treating, ameliorating or preventing a disease or disorder that is caused, induced or characterized by abnormal reduction in glutamate transporter activity or abnormal increase in extracellular CNS glutamate concentration in a subject. In certain embodiments, the compound stimulates a glutamate transporter.

Abstract: DLOS and reflected signal components of an RF carrier signal are received. The reflected component is reflected from a point on the surface of the earth. The DLOS and reflected components are converted to digital DLOS IF and reflected IF signals, respectively. Modeled parameters are generated using the digital DLOS IF signal and locations of one or more antennas, the transmitter, and the point. A reference signal is generated based on the modeled parameters. The reference signal is correlated with the digital reflected IF signal to produce in-phase and quadrature-phase correlation results. A C/N0 and an estimated phase (EP) are calculated for the digital reflected IF signal from the correlation results. A KF is applied to the EP to produce an estimated filter phase (EFP). The KF is adapted to filter the EP using the estimated C/N0 to reduce cycle slips and noise in the EFP.

Abstract: Described herein are immunoresponsive cells which are useful for their preventive and therapeutic potential against autoimmune diseases and rejections of solid organ transplants.

Abstract: Provided herein are long-acting antiparasitic devices comprising parasiticidal isoxazoline active agent for external use on an animal to treat and/or prevent parasitic infestations by ectoparasites, and in some embodiments, also parasitic infections. The disclosure also describes methods and uses of the antiparasitic external devices to treat and/or prevent parasitic infestations and/or infections in an animal.

Abstract: Provided is a functional, low-profile intercranial device (LID). The LID includes a base portion; at least one cavity associated with the base portion and configured to accept at least one functional component; and at least one conduit having a first end in communication with the at least one cavity. The at least one functional component includes a medicinal, electronic, or optic therapeutic. The at least one conduit is configured to accept the medicinal therapeutic and a second end configured to dispense the therapeutic.

Abstract: A thin metal strip continuous casting method using momentum flow distribution, comprising the steps of: adjusting the position of a flow distribution device (2), and starting a double-roller thin strip continuous casting apparatus; molten metal (3) forming a uniform sheet-shaped molten metal flow (4) having an initial momentum after the molten metal (3) passes through the flow distribution device; the sheet-shaped molten metal flow entering a molten pool (5) at a superheat degree of 50-100° C. and an initial velocity of 0.5-2 m/s, wherein the flow distribution device is spaced apart from the molten pool; under the action of the initial velocity of the molten metal and in the molten pool, forming a whirlpool, which is adjacent to surfaces of two cooling rollers and has a momentum stirring action; and completing the solidification of the molten metal under the momentum stirring action of the whirlpool along with the rotation of the two cooling rollers.

Abstract: The present invention relates to compositions and methods for inducing an adaptive immune response against Zika virus (ZIKV) in a subject. In certain embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a ZIKV antigen, adjuvant, or a combination thereof. For example, in certain embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a ZIKV antigen, adjuvant, or a combination thereof.

Abstract: The present invention includes light-controlled and light-independent neurotoxin systems and methods for using such neurotoxin systems for rapidly and locally silencing distinct populations of neurons.

Abstract: A method of inspecting a composite structure formed of plies of tows is provided. The method involves receiving an image of an upper ply overlapping lower plies, the upper ply tow ends defining a boundary between plies, and applying extracted sub-images to a trained machine learning model to detect the upper or lower ply. Probability maps are produced in which pixels of the sub-images are associated with probabilities the pixels belong to an object class for the upper or lower ply. The method may also involve transforming the probability maps into reconstructed sub-images, stitching together a composite image, and applying the composite image to a feature detector to detect locations of tow ends of the upper ply. The method may also involve comparing the locations to as-designed locations of the tow ends, inspecting the composite structure, and indicating a result of the comparison.

Abstract: The capillary transfer technology presented here represents a powerful approach to transfer soft films from surface of liquid onto a solid substrate in a fast and defect-free manner. The fundamental theoretical model and transfer criteria validated with comprehensive experiments and finite element analyses, for the first time provides a quantitative guide and optimization for the choice of material systems, operating conditions and environments for scalable on-demand transfers with high yield. The intrinsically moderate capillary transfer force and externally selectable transfer direction offer robust capabilities for achieving deterministic assembly and surface properties of structures with complex layouts and patterns for potentially broad applications in the fabrication of flexible/stretchable electronics, surface wetting structures and optical devices.

Abstract: A nano scale robotic system for single cell DNA sequencing of a strand of DNA positioned on a slide utilizes an atomic force microscope (AFM) having an end effector in the form of a cantilever with a tip. The AFM causes its cantilever tip to scan over the base pairs of the DNA strand. A pair of spaced-apart electrodes at the tip makes contact with opposite sides of the DNA strand and the current between bases of the DNA strand is measured by a current measurement system connected to the electrodes. An artificial intelligence-based data analytic system determines the DNA sequence based on the current from the current measuring system. The AFM tip is guided over the DNA strand by comparing compressed desired intensity local scan images and compressed actual intensity local scan images and using the difference to control the location of the tip.

Abstract: The present invention concerns compositions comprising at least one niclosamide compound, such as niclosamide or a pharmaceutically acceptable salt thereof, and at least one permeability enhancer, such as glycerol or dimethylpalmityl-ammonio propanesulfonate (PPS), and their use of such compositions as niclosamide agents. Advantageously, the niclosamide compound is capable of being transported across a Caco-2 cell membrane by at least 150% relative to the amount capable of being transported across the Caco-2 cell membrane in the absence of the permeability enhancer. Compositions, including oral dosage forms, and methods for delivering niclosamide compounds, such as for treatment or prevention of human coronavirus infections, are also provided.

Abstract: A dynamic vision sensor (DVS) color camera (DVS-CCam) operable to acquire a color image of a scene, the DVS-CCam including a DVS photosensor comprising DVS pixels, an illuminator operable to transmit a light pattern characterized by temporal changes in intensity and color to illuminate a scene, an optical system configured to collect and focus on the pixels of the DVS photosensor light reflected by features in the scene from the light pattern transmitted by the illuminator, and a processor configured to process DVS signals generated by the DVS pixels responsive to temporal changes in the reflected light to provide a color image of the scene.

Abstract: Provided herein are compositions and methods for packaging a recombinant adeno-associated virus (rAAV) particle comprising using inverted terminal repeats (ITRs) and rep genes of different serotypes and/or using chimeric rep genes.

Abstract: An audio analysis platform may receive a portion of an audio input, wherein the audio input corresponds to audio associated with a plurality of speakers. The audio analysis platform may process, using a neural network, the portion of the audio input to determine voice activity of the plurality of speakers during the portion of the audio input, wherein the neural network is trained using reference audio data and reference diarization data corresponding to the reference audio data. The audio analysis platform may determine, based on the neural network being used to process the portion of the audio input, a diarization output associated with the portion of the audio input, wherein the diarization output indicates individual voice activity of the plurality of speakers. The audio analysis platform may provide the diarization output to indicate the individual voice activity of the plurality of speakers during the portion of the audio input.

Abstract: Methods of scintillation, scintillation devices, and metal halide hybrids that may be used as X-ray scintillators. The metal halide hybrids may include organic metal halide hybrids, inorganic metal halide hybrids, or organic-inorganic metal halide hybrids. The metal halide hybrids may have a 0D structure. The metal halide hybrids may be in the form of one or more discrete crystals.