Abstract: The present invention provides compositions and methods for transducing cells (e.g. T cells or immune cells). Also provided herein are methods of treating a disease in a subject in need thereof.

Abstract: A method for determining MTPA, flux-weakening, and MTPV operating points over the full speed range of an IPM motor for the most efficient torque control of the motor using a neural network is provided. The neural network is trained using a cloud-based neural network training algorithm. A special technique is developed to generate neural network training data, that is particularly suitable and favorable, to develop a high-performance neural network-based IPM torque control system, and the impact of variable motor parameters is embedded into the neural network system development and training. The provided method can achieve a fast and accurate current reference generation with a simple neural network structure, for optimal torque control of an IPM motor. The method can handle the MTPA, MTPV, and flux-weakening operation considering physical motor constraints.

Abstract: The invention provides T cells comprising nucleic acid sequence encoding a chimeric antigen receptor and a nucleic acid sequence encoding an enhancer of T cell priming, compositions including the T cells, and methods of using the T cells to treat diseases associated with the expression of disease-associated antigens.

Abstract: The relates, in some aspects, to antisense oligonucleotide compositions and methods for modifying pre-mRNA splicing in a DYSF gene using the same. In some embodiments, the DYSF gene comprises a novel mutation that results in a pseudoexon between exons 50 and 51.

Abstract: A preparation method for a nanocomposite fiber membrane material based on a bio-based liquefied formaldehyde resin is provided. A bio-based raw material is processed through a phenol/polyethylene glycol complex liquefaction process, followed by divalent alkali metal hydroxide high ortho-position induction synthesis resinification and modification with the polymer polyvinyl alcohol to create a spinnable precursor as PVA-BLF. Subsequently, a coaxial electrospinning device is utilized, where PVA-BLF serves as a core layer and a titanium dioxide dispersion is used as a shell layer, to fabricate a PVA-BLF/TiO2 nanocomposite fiber membrane material. The average diameter of the nanocomposite fiber membrane is 150-450 nm, and the specific surface area is 500-700 m2/g. The porosity exceeds 60%, and the fracture elongation ranges from 5.5% to 6.5%, demonstrating excellent filtration performance and excellent regeneration performance, which can be developed as adsorption materials for water and air purification.

Abstract: Disclosed are embodiments of a thin-film photovoltaic technology including a single-junction crystalline silicon solar cell with a photonic-plasmonic back-reflector structure for lightweight, flexible energy conversion applications. The back-reflector enables high absorption for long-wavelength and near-infrared photons via diffraction and light-concentration, implemented by periodic texturing of the bottom-contact layer by nanoimprint lithography. The thin-film crystalline silicon solar cell is implemented in a heterojunction design with amorphous silicon, where plasma enhanced chemical vapor deposition (PECVD) is used for all device layers, including a low-temperature crystalline silicon deposition step. Excimer laser crystallization is used to integrate crystalline and amorphous silicon within a monolithic process, where a thin layer of amorphous silicon is converted to a crystalline silicon seed layer prior to deposition of a crystalline silicon absorber layer via PECVD.

Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

Abstract: A magnetic nanofluid that includes magnetic transition metal ferrite nanoparticles, ferroelectric nanoparticles, and a carrier fluid, and a method of changing the temperature of an object (e.g., heating or cooling) using the magnetic nanofluid. The magnetic transition metal ferrite nanoparticles and ferroelectric nanoparticles can be present as a composite comprising both types of nanoparticles. The use of the magnetic nanofluid is associated with an increase in the Nusselt number in the presence of a magnetic field.

Abstract: Systems, methods, and computer program products are provided for segmenting a brain tumor from various MRI sequencing techniques. A plurality of MRI sequences of a head of a patient are received. Each MRI sequence includes a T1-weighted with contrast image, a Fluid Attenuated Inversion Recovery (FLAIR) image, a T1-weighted image, and a T2-weighted image. Each image of the plurality of MRI sequences is registered to an anatomical atlas. A plurality of modified MRI sequences are generated by removing a skull from each image in the plurality of MRI sequences. A tumor segmentation map is determined by segmenting a tumor within a brain in each image in the plurality of modified MRI sequences. The tumor segmentation map is applied to each of the plurality of MRI sequences to thereby generate a plurality of labelled MRI sequences.

Abstract: A system including a proportional-integral-derivative (PID) controller, a modified relay feedback test (MRFT) block, a memory block, a biasing block, a dq0-to-abc transformation block, a switch configured to selectively couple output signal of the biasing block or the PID controller output signal to the input of the dq0-to-abc transformation block, a three phase digital pulse width modulator, electronic switches, a voltage sensor configured to measure the output of each voltage of the three phases on the load and produce voltage data signals (Voa, Vob, Voc), and an abc-to-dq0 transformation block having an input being a representative of the phase voltages on the load, and producing an output being a representative of these voltages in the dq0 format.

Abstract: The present disclosure refers to a method of electrochemical conversion of organic waste to organic acid and hydrogen, comprising the steps of: (i) subjecting organic waste to ball milling under alkaline or acidic conditions to obtain pre-treated organic waste; (ii) introducing the pre-treated organic waste to a first compartment of an electrochemical cell, wherein the electrochemical cell comprises: the first compartment containing a nickel-based anode, a second compartment containing a cathode, and an electrolyte; and (iii) applying an electrical potential between the anode and the cathode, thereby producing organic acid at the anode, and hydrogen at the cathode. The present disclosure also refers to an organic acid or hydrogen produced from the method disclosed herein.

Abstract: Disclosed herein is a highly energy-efficient architecture targeting the ultra-low-power sensor domain. The architecture achieves high energy-efficiency while maintaining programmability and generality. The invention introduces vector-dataflow execution, allowing the exploitation of the dataflows in a sequence of vector instructions and to amortize instruction fetch and decode over a whole vector of operations. The vector-dataflow architecture allows the invention to avoid costly vector register file accesses, thereby saving energy.

Abstract: Provided are antibodies or antigen binding portions thereof that specifically bind Dengue virus, various compositions of such antibodies or antigen binding portions thereof, and methods of their use. Provided are such antibodies, fragments of such antibodies retaining Dengue virus-binding ability, pharmaceutical compositions including such antibodies or antigen binding fragments thereof, and diagnostic compositions including such antibodies or antigen binding fragments thereof. Also provided are isolated nucleic acids encoding such antibodies, amino acid sequences of such antibodies, and host cells transformed therewith. Additionally, provided are prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the disclosure.

Abstract: A single beam plasma or ion source apparatus, including multiple and different power sources, is provided. An aspect of the present apparatus and method employs simultaneous excitation of an ion source by DC and AC, or DC and RF power supplies. Another aspect employs an ion source including multiple magnets and magnetic shunts arranged in a generally E cross-sectional shape.

Abstract: The present invention relates to a nanohelix-substrate complex for controlling adhesion and polarization of macrophages, a manufacturing method thereof, and a method of controlling adhesion and polarization of macrophages by using the nanohelix-substrate complex, and the method of controlling adhesion and polarization of macrophages may temporally and reversibly control adhesion and phenotypic polarization of macrophages in vivo and ex vivo by controlling application/non-application of a magnetic field to the nanohelix-substrate complex.

Abstract: The method for determining the speed of printing of a fiber and the length of a printed fiber comprises: supplying ink to a nozzle; forming an ink drop at the exit of said nozzle; generating an ink jet carrying a net electrostatic charge; deflecting said ink jet periodically by one or a plurality of jet-deflection electrodes; collecting the ink jet on a substrate repetitively forming a printed motif by means of a continuous fiber; determining the width of the printed motif; calculating the speed of printing of fiber from the frequency of the jet-deflection signal and the width of the printed motif; calculating the length of fiber printed in a time interval from the frequency of the jet-deflection signal and from the width of the printed motif.

Abstract: Embodiments of recombinant HIV-1 gp120 proteins that contain a V1 deletion are disclosed. Also provided are gp140, gp145, and gp160 proteins containing the V1 deletion, as well as HIV-1 Env ectodomain trimers containing protomers containing the V1 deletion. Nucleic acid molecules encoding these proteins are also provided. In several embodiments, the disclosed recombinant HIV-1 proteins and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

Abstract: Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method comprising obtaining, by a device, a combined sound signal for signals combined from multiple sound sources in an area in which a person is located, and applying, by the device, speech-separation processing (e.g., deep attractor network (DAN) processing, online DAN processing, LSTM-TasNet processing, Conv-TasNet processing), to the combined sound signal from the multiple sound sources to derive a plurality of separated signals that each contains signals corresponding to different groups of the multiple sound sources. The method further includes obtaining, by the device, neural signals for the person, the neural signals being indicative of one or more of the multiple sound sources the person is attentive to, and selecting one of the plurality of separated signals based on the obtained neural signals. The selected signal may then be processed (amplified, attenuated).

Abstract: An alternative approach to producing iron from iron concentrates produced from low grade iron ore without going through pelletization and induration. Such a method may include providing iron ore concentrate in a small particle form, passing the iron ore concentrate through a moving bed conveyor reduction furnace with at least one of hydrogen or natural gas, wherein the concentrate is present in a layer that is no more than about 5 cm thick, the hydrogen gas or natural gas reducing the concentrate so as to remove oxygen therefrom, converting the iron ore concentrate to iron that has a composition similar to direct reduced iron (DRI) or sponge iron product, having about 90-95% iron, up to about 10% oxygen, with other trace impurities. Energy consumption is reduced by 30-50% and CO2 emissions are reduced by 60-95%, depending on whether natural gas or hydrogen is used.

Abstract: Underwater Deployable Structures (UDSs) capable of achieving inflation via mechanical pumps, moisture-activated expanding foams, water swelling material, or a hybrid of a mechanical pump and water swelling material. Moisture expanding foams begin as polyurethane-based resins of low viscosity, and react in the presence of water to become solid foam. In their final forms, the foams exist as open- or closed-cell, and vary in strength, elasticity, and rigidity. Water swelling material is also disclosed wherein the water swelling material is capable of achieving expansion numerous (e.g., up to about 250) times its initial volume when in contact with water and can shrink back to its initial volume upon dehydration, making the UDSs reusable. A mechanical pump may optionally be used to assist in initial inflation until the water swelling material reaches full expansion.