Abstract: Auto-recognizing therapeutic R/DNA chimeric nanoparticles (R/DNA NP) are described that are pairs of DNA/RNA hybrids where the DNA molecules have complementary toehold sequences that promote the re-association of the R/DNA NPs when mixed resulting in the formation of RNA/RNA duplexes that act as siRNAs.

Abstract: The method of making a flexible elastic conductive material for strain sensor and resistance applications using rubbing-in technology is shown. The thin rubber or any conductive material (substrates) is fixed at strained condition on the solid plate, by rubbing-in technology. Nanopowder of nanomaterials (organic semiconductors, carbon nanotubes, copper doped tin oxide, manganese doped tin oxide) at room temperature are embedded into the rubber conductive material to make built-in structure of conductive flexible elastic substrates that can be used for strain sensors, gages and resistance applications. The resultant product showed good sensitivity, stability and reliability during and after the rubbing-in operation.

Abstract: Suppository, hot melt and ophthalmic formulations containing amino esters of the formulae (I), (II) and (III), where R1, R2 and R3 are residues of amino acids such as, but not limited to, valine, sarcosine, leucine, glutamine, tryptophan, tyrosine, alanine and 4(4-aminophenyl)butyric acid or combination thereof, and salts thereof.

Abstract: One or more temporal stimulation parameters of vagus nerve stimulation (VNS) are selected to substantially modulate one or more target physiological functions without substantially modulating one or more non-target physiological functions. In one embodiment, a stimulation duty cycle is selected such that VNS is delivered to the cervical vagus nerve trunk to modulate a cardiovascular function without causing laryngeal muscle contractions.

Abstract: Disclosed are a pre-decoding analysis-based configuration information cache management system, comprising a streaming media processing module, a configuration information prefetch FIFO module, a configuration information storage unit, and a cache controller module. Also disclosed is a management method for the pre-decoding analysis-based configuration information cache management system. The present invention allows for increased dynamic reconfiguration efficiency of a large-scale coarse-grained reconfigurable system.

Abstract: The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.

Abstract: A flexible chemiresistor (CR) sensor for sensing a molecule of interest in a fluid (liquid or gas) is provided. The flexible CR sensor comprises a flexible chemiresistor (CR) module. The flexible CR module comprises a flexible substrate such polyethylene terephthalate (PET), polyethylene naphthalate (PEN) or polyimide (PI), and a thin film nanoparticle assembly assembled on the flexible substrate. The thin film nanoparticle assembly comprises metal or metal alloy core, ligand-capped nanoparticles and molecular linkers connecting the nanoparticles. The flexible CR sensor and an intelligent pattern recognition engine can be incorporated in a handheld device that can detect a molecule of interest in a fluid (e.g., a liquid or gas) accurately, rapidly, and without false positives. Any sensing array nanomaterial, pattern recognition, and compact/or electronic hardware can be integrated to achieve a desired detection limit and response speed.

Abstract: Systems and methods for improving the efficiency of propagating electronic messages are provided. In some embodiments, a feed of activities on a network such as an online social network (OSN) is analyzed to determine influenced activity probabilities and intrinsic activity probabilities for participants in the network. A Helmhotz Green's Function matrix is determined in order to calculate an overall influence weight for each participant in the network. A Woodbury-Sherman-Morrison formula may be used to accelerate computation of the Helmholtz Green's Function matrix, thus allowing efficient updates to the overall influence weights based on newly monitored activities. The participants with the highest overall influence weights may be selected to propagate a new message, thus providing the greatest likely distribution of the message with the fewest originating transmissions.

Abstract: An improved pull-up bolt assembly adapted to be used for supporting a high-weight structure to a hinge component using an opening or recess in the high-weight structure, the bolt assembly having a pull-up bolt member, a nut component, a tapered member, and an expandable friction member, where the improvement includes one or more threads helically disposed about the expandable friction member, the one or more threads each having a height, a width and a helical angle.

Abstract: A reactor and method for production of nanostructures, including metal oxide nanowires or nanoparticles, are provided. The reactor includes a regulated metal powder delivery system in communication with a dielectric tube; a plasma-forming gas inlet, whereby a plasma-forming gas is delivered substantially longitudinally into the dielectric tube; a sheath gas inlet, whereby a sheath gas is delivered into the dielectric tube; and a microwave energy generator coupled to the dielectric tube, whereby microwave energy is delivered into a plasma-forming gas. The method for producing nanostructures includes providing a reactor to form nanostructures and collecting the formed nanostructures, optionally from a filter located downstream of the dielectric tube.

Abstract: A mechanical and magnetic clutch is provided. The clutch includes a clutch device having a first magnet and a movable member having a plurality of magnets. The clutch device has a first position in which the clutch device and the movable member are disengaged and a second position in which the clutch device and the movable member are engaged. One of the plurality of magnets is arranged on the movable member to interact with the first magnet and move the clutch device from the first position to the second position, when the clutch device is moving at a first speed relative to the movable member. The plurality of magnets is arranged on the movable member to interact with the first magnet and keep the clutch device in the first position while the movable member is moving at a second speed relative to the clutch device.

Abstract: Provided are compositions and methods for use in assembling and expressing a plurality of transcription units using, in one aspect, homologous recombination in yeast. Yeast containing the plurality of transcription units, and isolated transcription units, are also provided. Kits for use in making the yeast and the transcript units are further included.

Abstract: Disclosed are compositions and methods for expressing and purifying a peptide of interest using a Flagellar Type III secretion system. Disclosed are nucleic acid sequences that contain a FlgM nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. Also disclosed are polypeptides that contain FlgM, a cleavage site and a peptide of interest. Methods of producing polypeptides that have FlgM, a cleavage site and a peptide of interest are provided.

Abstract: A method and device for the treatment of hypertrophic cardiomyopathy. The device includes a cutting device for resection of a thickened myocardium. The operator positions the cutting device adjacent to the myocardium that is to be resected and then slides a tubular blade within an outer shell of the cutting device to resect the septum.

Abstract: The invention provides x-ray-based breast imaging systems and related methods that are, for example, applicable to contrast enhanced digital mammography and contrast enhanced digital breast tomosynthesis and allow fast, cost-effective and accurate x-ray imaging.

Abstract: A prodrug having antioxidant activity, including a phosphorylated compound having a thiol group. A method of treating oxidative stress by administering a prodrug of a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug, and treating oxidative stress. A method of increasing bioavailability of a thiol compound by creating a prodrug by phosphorylating a thiol compound, administering the prodrug, preventing first pass metabolism of the prodrug, removing a phosphate group from the prodrug, and providing active drug to a site in need of therapy from oxidative stress. A method of preventing radiation damage to healthy tissue by administering a prodrug comprising a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug to provide active drug, and preventing radiation damage to healthy tissue.

Abstract: A non-invasive glucose sensor (10) for detecting an amount of glucose in bodily fluid, comprising: an organic electrochemical transistor (OECT) having a gate electrode (20); wherein a surface of the gate electrode (20) is modified with an enzyme and a nanomaterial to increase sensitivity and selectivity of the gate electrode (20).

Abstract: An impedance matching arrangement for an amplifier includes first and second metallic transmission lines arranged on a ground plane, the first metallic transmission line being connected with a first power amplification stage of the amplifier, the second metallic transmission line being connected with a second power amplification stage of the amplifier; wherein the first and second metallic transmission lines are electrically coupled for transmitting an RF signal amplified by the first power amplification stage to the second power amplification stage.

Abstract: Periodic near field directors (PNFDs) are coupled to a transmitter and a receiver for a short-range millimeter wave wireless (M2W2) interconnect for transmitting and receiving radio frequency (RF) signals at millimeter-wave frequencies for short-range communication with high data rate capability between the transmitter and receiver. Each of the periodic near field directors is comprised of one or more periodic coupling structures (PCSs), wherein the periodic coupling structures are comprised of metallic strips positioned such that their lengthwise dimension is substantially perpendicular to a propagation direction of the radio frequency signals between the transmitter and receiver. Each of the periodic coupling structures is positioned parallel to adjacent periodic coupling structures with a separation distance between each periodic coupling structure being within one wavelength of the radio frequency signal.

Abstract: A thiol-ene polymeric material is disclosed. The material is produced by the photopolymerization of reactants having thiol and olefin moieties. The material can incorporate encapsulated components, including cells. Additionally, the material can be derivatized by reacting the polymeric material with components such as proteins.