Abstract: The present invention relates to a recombinant self-assembled protein comprising a target-oriented peptide and a use thereof The recombinant self-assembled protein according to the present invention, comprising a target-oriented peptide, does not require an additional process for providing target-orientedness, and is thus capable of delivering a desired drug to a target tissue or target cell without using additives, such as chemical binders or stabilizers; therefore, the protein can be used for photothermal therapy, drug delivery, imaging, or the like. In particular, according to the present invention, it is possible to prepare gold-protein nanoparticle fusions in which uniform high-density gold nanoparticles having target-orientedness are bound to protein surfaces, without an additional process of surface stabilization or process for providing target-orientedness.

Abstract: The present invention includes siRNAs and antibodies that block the interaction between TEM8 and/or CMG2 cell surface proteins and anthrax toxin and methods of treating anthrax exposure with the same.

Abstract: A molecular structure comprising a targeting moiety, a multi-functional peptide platform and a plurality of controllably released bioactive agents attached thereto is provided herein.

Abstract: A device for manipulating magnetic particles, and the method of fabricating and use thereof. The device includes a substrate; a conductive element formed onto the substrate in a pattern shaped to enhance a magnetic field generated in response to an applied current; an insulating layer to isolate the conductive element from a magnetic element; and a magnetic element formed onto the insulating layer to enhance a magnetic force resulting from the magnetic field generated by the conductive element. The magnetic element can be shaped similarly to the conductive element, and edges of the magnetic element are substantially aligned with edges of the conductive element. During fabrication, the substrate and the conductive element can be heated to cause the substrate to shrink thereby resulting in a wrinkled structure at the conductive element. The device can be used to manipulate the magnetic particles within a biological sample, such as cells and/or biomolecules.

Abstract: Physiologically responsive mechanically adaptive optical fibers that are suitable for optical interfacing with living organisms. The optical fibers are particularly suited for applications in optogenetics. Dry, stiff fibers display a desirable tensile storage modulus and can be readily inserted into biological and in particular cortical tissue. Exposure to conditions encountered in vivo results in reduction, often a drastic reduction in modulus. When coupled with a suitable light source, the construction can be utilized to stimulate neurons in vivo. Methods for producing and utilizing the optical fibers and devices including the optical fibers are disclosed.

Abstract: This invention provides vaccines comprising two or more recombinant Herpes Simplex Virus (HSV) proteins selected from a gD protein, a gC protein and a gE protein; and methods of impeding immune evasion by HSV thereby vaccinating a subject against HSV and treating, suppressing, inhibiting, and/or reducing an incidence of an HSV infection or a symptom or manifestation thereof, comprising administration of a vaccine of the present invention.

Abstract: Methods and compositions to introduce a synthetic pathway based on the 3-hydroxypropionate bicycle into an organism such as the model cyanobacterium, Synechococcus elongatus sp. PCC 7942. The heterologously expressed pathway acts as a photorespiratory bypass as well as an additional carbon fixation cycle orthogonal to the endogenous Calvin-Benson cycle. We demonstrate the function of all six introduced enzymes, which not only has implications on increasing net-photosynthetic productivity, but also key enzymes in the pathway are involved in high-value products that are of biotechnological interest, such as 3-hydroxypropionate.

Abstract: A method for early detection of bone deficiency in a patient, comprising: collecting NMR signals of a bone marrow volume in a bone of the patient having normal bone density levels which are not indicative of bone deficiency as indicated by X-ray; and analyzing said collected NMR signals to detect at least a presence or absence of a preclinical stage of bone deficiency in said bone.

Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.

Abstract: A passive sensing continuous glucose monitoring system and method of use thereof. The system includes a passive antenna formed of biocompatible silicon carbide (SiC), modeled to a desired frequency, which is permanently implanted subcutaneously. The system further includes an external-to-the-body transmitting antenna to detect changes in the blood glucose level by sending a radio signal at the frequency of the implanted passive antenna into the body. This signal is received and reflected by the passive antenna, and the reflected signal is then received at an external-to-the-body receiving antenna. Changes in the glucose level lead to modifications in the signal and can be used to determine the blood glucose level externally.

Abstract: A switched reluctance motor system includes a switched reluctance motor, a rotor including a plurality of salient poles, a stator including a plurality of salient poles, coils of three phases wound around the salient poles of the stator, and an electronic control unit. The electronic control unit is configured to drive the switched reluctance motor in a pole configuration pattern of NSNSNS in which the salient poles of the stator that have different polarities are alternately arranged. The electronic control unit is configured to perform current waveform control when an excitation sound frequency of a given order coincides with a resonance frequency of the switched reluctance motor.

Abstract: Provided are a supported catalyst including: a support body which is formed by a catalyst composition being supported by a carrier, in which the catalyst composition contains an oxide of copper, and the carrier contains ?Al2O3.?B2O3 (? and ? each represent a positive number); and a hydrogen production method for producing hydrogen from ammonia, including: an ammonia combustion step of reacting ammonia with oxygen in the presence of the supported catalyst; and an ammonia decomposition step of decomposing the ammonia into hydrogen and nitrogen by utilizing heat generated by the reaction between the ammonia and the oxygen.

Abstract: An aspect of the invention described herein includes a method for a digestion diagnosis of a subject. The method includes obtaining electrogastrogram (EGG), bowel sound and NIRS signals from one or more sensors positioned about an abdominal region of a subject, removing artifacts from the signals to obtain conditioned signal data, and determining a digestion condition or feeding readiness of the subject based at least in part on the conditioned signal data.

Abstract: A method for computing patient-specific hemodynamics. The method includes receiving three dimensional imaging data of a patent, extracting anatomical data from the three dimensional imaging data, calculating velocity and pressure fields corresponding to the extracted anatomical data, and calculating displacement and velocity of extracted solid particles corresponding to the anatomical data. The anatomical data comprises an anatomical boundary.

Abstract: The thermal sensing layer for a microbolometer includes a Ge1-xSnx film layer, where 0.17?x?0.25. The Ge1-xSnx film layer may be deposited on a substrate layer, such as pure silicon. An additional layer of silicon dioxide may be added, such that the silicon dioxide layer is sandwiched between the silicon substrate and the Ge1-xSnx film, In order to make the Ge1-xSnx thin film layer, germanium (Ge) and tin (Sn) are simultaneously sputter deposited on the substrate, where the atomic ratio of germanium to tin is between 0.83:0.17 and 0.75:0.25 inclusive. The sputter deposition may occur in an argon atmosphere, with the germanium having a deposition rate of 9.776 nm/min, and with the tin having a deposition rate between 2.885 nm/min and 4.579 nm/min.

Abstract: The chemo-thermo-piezoresistive behavior of so-called “smart cement,” or cement modified with conductive fillers, is useful as a bulk sensor for monitoring the changes in the cement due to stresses, cracks, contamination, fluid loss, and temperature change that affect its performance. The smart cement utilizes a special conductive or semi-conductive filler and is useful as a bulk sensor that allows real-time monitoring of its properties.

Abstract: Disclosed are an apparatus and a method for configuring an MMT payload header. The apparatus for configuring an MMT payload header, according to one embodiment, extracts a sequence number of a media processing unit (MPU) comprising one or a plurality of media fragment units, which are to be aggregated into one payload and mapped, and displays the extracted sequence number of the MPU on the MMT payload header. Specifically, the apparatus for configuring an MMT payload header displays the sequence number commonly associated with a plurality of MFUs on the header only once, when the plurality of MFUs in one payload are aggregated in the one payload and mapped.

Abstract: The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor and a use thereof. In particular, the present invention relates to a compound as shown in formula I, a pharmaceutical composition containing the compound as shown in formula I and a use of the compound in the preparation of drugs for treating DPP-4 related diseases or inhibiting DPP-4.

Abstract: A metering delivery apparatus for injecting bone graft cement includes a body portion, a material containment vessel, an actuator, and a control unit. The body portion includes a drive housing that supports an actuator drivetrain and receiver end that supports the material containment vessel. The actuator has a first end connected to the actuator drivetrain and a second end that supports a moveable portion of the vessel to dispense material in the vessel and a retracting movement that relieves pressure applied to the material. The control unit receives actuator parameter inputs and includes a sensor to detect a signal of at least one of a pressure level and a time period. The sensor provides the detected signal to the control unit such that the control unit operates the actuator between the dispensing and retracting movements based on the detected signal and the actuator parameter inputs.

Abstract: A drilling fluid composition comprising an aqueous base fluid, a viscosifier, and a H2S scavenger comprising copper nitrate, wherein the drilling fluid composition has a H2S sorption capacity from about 4.0 to about 6.0 gram per one milliliter of the drilling fluid composition; and a method of drilling a subterranean geological formation using thereof are provided. Various embodiments of the drilling fluid composition and the method are also provided.