Abstract: A laser accelerator driven electronic brachytherapy system, device, and method for particle based treatment of a tumor or other human diseases and conditions.
Type:
Grant
Filed:
September 30, 2011
Date of Patent:
May 5, 2015
Assignees:
Varian Medical Systems Inc., The Regents of the University of California
Abstract: The present invention relates to compositions and methods of optically imaging tissues or cells using imaging agents have in vivo properties that result in signal-to-background ratios of at least about 1:1. TL is a targeting ligand and n is ?1, 0 or +1.
Type:
Grant
Filed:
February 5, 2010
Date of Patent:
May 5, 2015
Assignees:
Beth Israel Deaconess Medical Center, Georgia State University Research Foundation, Inc.
Abstract: A high-efficacy, long-acting formulation of silibinin, comprising silibinin solid dispersion, silibinin-loaded silica nanoparticles, slow-release matrix material and release enhancer, wherein the mass ratio of these components is silibinin solid dispersion:silibinin-loaded silica nanoparticles:slow-release matrix material:release enhancer=1:0.5˜1.25:0.1˜0.3:0.1˜0.3; the drug loading rate of the said silibinin-loaded silica nanoparticles is 51.29˜51.77%; the said silibinin solid dispersion contains povidone K30, soybean lecithin, acrylic resin IV, wherein the mass ratio between silibinin and other medical accessories is silibinin:povidone K30:soybean lecithin:acrylic resin IV=1:1˜3:0.3˜0.8:0.2˜0.5. Compared with the existing formulations, the half life of the high-efficacy, long-acting formulation of silibinin disclosed in this invention is 14.8 times longer while the mean residence time (MRT) of which is 4.
Abstract: Protein-based photovoltaic cells and the manufacture and use of protein-based photovoltaic cells are described. In one embodiment, bacteriorhodopsin from Halobacterium salinarum, which undergoes structural transitions when irradiated with a given wavelength of light, is used as the protein in the protein-based photovoltaic cells. In another embodiment, mutant bacteriorhodopsin from H. salinarum is used. Exposure of the protein to sunlight causes proton transfer across a membrane resulting in the generation of an electrical charge. The protein can be oriented and/or layered on a substrate and modified by mutation to enhance transmembrane proton transfer, covalent binding to a substrate and layering. The protein-based photovoltaic cells sequentially or simultaneously generate hydrogen gas from water or salt, which also can be harnessed to produce electricity.
Abstract: A 2D or 3D velocity field is reconstructed from a cross-correlation analysis of image pairs of a sample, without first reconstructing images of the sample spatial structure. The method can be implemented via computer tomographic x-ray particle image velocimetry, using multiple projection angles, with phase contrast images forming dynamic speckle patterns. Estimated cross-correlations may be generated via convolution of a measured autocorrelation function with a velocity probability density function, and the velocity coefficients iteratively optimized to minimize the error between the estimated cross-correlations and the measured cross-correlations. The method may be applied to measure blood flow, and the motion of tissue and organs such as heart and lungs.
Abstract: A method of designing arrangement of through silicon vias (TSVs) in a stacked semiconductor device is provided The method includes: determining a plurality of TSV candidate grids representing positions, into which the TSVs are insertable, in each of a plurality of semiconductor dies stacked mutually and included in a stacked semiconductor device; creating a plurality of path graphs representing linkable signal paths for a plurality of signals transmitted through the stacked semiconductor device, respectively, based on the TSV candidate grids; determining initial TSV insertion positions corresponding to shortest signal paths for the signals based on the path graphs; and determining final TSV insertion positions by verifying the initial TSV insertion positions so that a plurality of signal networks corresponding to the shortest signal paths for the signals have routability.
Type:
Grant
Filed:
March 11, 2014
Date of Patent:
May 5, 2015
Assignees:
Samsung Electronics Co., Ltd., Industry-University Cooperation Foundation Hanyang University
Inventors:
Myung-Soo Jang, Jae-Rim Lee, Jong-Wha Chong, Min-Beom Kim, Wen Rui Li, Cheol-Jon Jang
Abstract: A dinuclear zinc complex PPi sensor is provided, that may be represented by the formula where X is hydrogen, —COOEt, —CH?CH2, —OR, or —NR2, wherein X is a monovalent organic group having from 1 to about 20 carbon atoms. A method of preparing the dinuclear zinc complex PPi sensor is also provided. Methods for detecting PPi in an aqueous solution and methods for pyrosequencing by using the dinuclear zinc complex are described.
Abstract: A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components.
Type:
Grant
Filed:
June 24, 2011
Date of Patent:
May 5, 2015
Assignees:
Cireca Theranostics, LLC, Northeastern University
Inventors:
Max Diem, Benjamin Bird, Milos Miljkovic, Stanley H. Remiszewski, Clay M. Thompson
Abstract: Two- and three-terminal molecular electronic devices with ballistic electron transport are described. For example, a two-terminal molecular electronic device includes a conductor 1 layer/molecule 1 layer/conductor2 layer junction, wherein the total thickness of the molecule 1 layer and the conductor2 layer is less than or approximately equal to the mean free path of a charge carrier traveling in the two layers, and wherein ballistic transport can occur for some fraction of a plurality of charge carriers in the two layers.
Type:
Grant
Filed:
September 16, 2011
Date of Patent:
May 5, 2015
Assignees:
The Governors of the University of Alberta, National Research Council of Canada
Inventors:
Richard L. McCreery, Adam Johan Bergren
Abstract: A recursive type-IV discrete cosine transform system includes a first permutation device, a recursive type-III discrete cosine/sine transform device, a cosine/sine factor generation device, a recursive type-II discrete cosine/sine transform device, a second permutation device. The first permutation device performs two-dimensional order permutation operation on N digital signals for generating N two-dimensional first temporal signals. The recursive type-III discrete cosine/sine transform device repeats a type-III discrete cosine/sine transform for generating second temporal signals. The cosine/sine factor generation device sequentially performs cosine/sine factor multiplication and corresponding addition operations for generating third temporal signals. The recursive type-II discrete cosine/sine transform device repeats a type-II discrete cosine/sine transform for generating fourth temporal signals.
Abstract: Provided is an electric bus and an electric bus battery exchange system. The electric bus according to the present invention includes: a battery exchange hole disposed on top of the electric bus for exchanging a discharged battery for a charged battery; a front camera unit taking front images in the process of entering the battery exchange station for battery exchange; a communication unit for receiving position information of the battery exchange unit from the battery exchange station; a route output unit outputting a predicted driving route for reaching a swapping point below the battery exchange unit based on the front images taken by the front camera unit and the position information of the battery exchange unit; and a display unit displaying the predicted driving route outputted by the route output unit, superimposed on the front images taken by the front camera unit.
Type:
Grant
Filed:
September 22, 2014
Date of Patent:
May 5, 2015
Assignees:
Kookmin University Industry Academy Cooperation Foundation, Industry-University Cooperation Foundation of Korea Aerospace University
Inventors:
Jun Seok Park, Won-Kyu Kim, Won-Jae Jung
Abstract: Described is the identification of ZnT8 as an autoantigen target in type I autoimmune diabetes (T1D), other autoimmune disease, and other diabetes-linked diseases and conditions. Also described are a variety of therapeutic, diagnostic, and prognostic tools and methods based on this discovery. The identification of genetic variation in ZnT8 as an important player in the initiation of the disease process and the progression of autoimmunity to clinical diabetes is disclosed.
Type:
Grant
Filed:
December 28, 2007
Date of Patent:
May 5, 2015
Assignee:
The Regents of the University of Colorado, a body corporate
Inventors:
John C. Hutton, Janet M. Wenzlau, Jan Jensen, Howard Davidson
Abstract: Provided is an in-pipe inspection robot which moves along a path in a pipe to inspect suspected areas such as cracks in the pipe. An in-pipe inspection robot in accordance with an exemplary embodiment of the present invention has a configuration in which two or more operating units having a plurality of arms, which move forward and backward in a radial direction of a pipe, are connected to each other to move in a straight direction or to be bent relative to each other by means of a flexible link mechanism.
Type:
Grant
Filed:
September 6, 2012
Date of Patent:
May 5, 2015
Assignee:
Industry-Academic Cooperation Foundation Yonsei University
Abstract: This disclosure provides methods for treating asthma or an associated disorder in a patient in need thereof, by administering to the patient an effective amount of an autophagy inducing agent, thereby treating the asthma or the associated disorder. Disorders that can be treated include, allergic asthma, chronic obstructive pulmonary disease, lung inflammation, respiratory tolerance and a lung infection or disorder.
Abstract: The object of the present invention is to provide a method for preparing a nano-sheet array structure of a Group V-VI semiconductor, comprising: (A) providing an electrolyte containing a hydrogen ion and disposing an auxiliary electrode and a working electrode in the electrolyte, wherein the working electrode comprises a Group V-VI semiconductor bulk; and (B) applying a redox reaction bias to the auxiliary electrode and the working electrode to form a nano-sheet array structure on the bulk.
Abstract: A new and distinct cultivar of Lantana plant named ‘PIIL-MHP’, characterized by its mounded to rounded growth habit, papery, scabrous medium green foliage, continuous flowering, and light pink flower buds that open to pale yellow with a bright golden yellow center and age to medium pink with a pale orange center. There are no other cultivars of Lantana with this combination of characteristics known to the inventor.
Type:
Grant
Filed:
January 23, 2013
Date of Patent:
May 5, 2015
Assignees:
Plant Introductions, Inc., University of Georgia Research Foundation, Inc.
Abstract: The new variety Pennisetum ‘Tift 118’ is provided. The new and distinct variety has high ornamental value, cold tolerance for short periods of time, and disease resistance. The asexually reproduced variety is reliably propagated vegetatively.
Type:
Grant
Filed:
June 13, 2013
Date of Patent:
May 5, 2015
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Wayne W. Hanna, S. Kristine Braman, Brian M. Schwartz