Abstract: A copolymer which includes hydrophilic and hydrophobic blocks, which can form nanoparticles in which a physiologically active substance can be efficiently packaged therein and which are stable under acidic conditions. The hydrophilic segment of the copolymer is composed of polyethylene glycol (PEG) and the hydrophobic segment is composed of polystyrene. The hydrophobic segment has a side chain, and the side chain has ends to which a cyclic nitroxide radical having a radical scavenging function and a trialkoxysilane are covalently bonded.

Abstract: An IL-11 binding receptor capable of binding to IL-11 and inhibiting IL-11 mediated signalling is disclosed. Also disclosed are compositions comprising the IL-11 binding receptor and methods using the IL-11 binding receptor.

Abstract: The present disclosure discloses an electronic device having a hexagonal structure and an addressing method therefor. The electronic device according to one embodiment of the present disclosure includes a first conductor arranged in a first direction, a second conductor disposed on the first conductor and arranged in a second direction, a third conductor disposed on the second conductor and arranged in a third direction, a selection element disposed at a portion between the first and second conductors where the first, second, and third conductors intersect, and a memory element disposed at a portion between the second and third conductors where the first, second, and third conductors intersect.

Abstract: In an embodiment, a duty cycle controller comprises a delay circuit configured to output the feedback clock signal by delaying an output clock signal combined from an input clock signal and a feedback clock signal by a predetermined delay time, wherein the delay circuit comprises a unit delay circuit configured to delay the output clock signal by a time less than the predetermined delay time and configured to delay the feedback clock signal by the predetermined delay time by letting the output clock signal pass the unit delay circuit as many as a predetermined loop count.

Abstract: Provided herein are compositions including a probiotic including at least one strain of live bacteria and a Marek's Disease vaccine. Compositions including a probiotic or a probiotic and a Marek's Disease vaccine may be administered to subjects, including poultry. The compositions may be administered in ovo to increase early lactic acid bacteria in the gastrointestinal tract of the subject, to decrease the gram negative bacteria in the gastrointestinal tract of the subject, to reduce the level of Salmonella in the gastrointestinal tract of the subject and to increase the body weight gain of the subject. Also provided are kits including a probiotic and a Marek's Disease vaccine.

Abstract: Embodiments for systems and methods for third party assessment related to the evaluation of risks associated with third parties in which hacker conversations on websites are filtered and analyzed using keywords as input to uncover relevant forum and marketplace discussions are disclosed herein.

Abstract: A method for extracting thermal energy in an underground high temperature area of a coalfield fire area, including: determining a thermal extraction target area by a natural potential method and a ground detecting borehole; using an injection borehole to send a gaseous thermal medium to an underground high temperature area of the thermal extraction target area; after the thermal exchange between the gaseous thermal medium and a high temperature coal rock mass, the gaseous thermal medium is extracted through an extraction borehole; continuously monitoring a natural potential of the thermal extraction target area; arranging a casing-type borehole thermal exchanger in a potential anomaly region to complete the thermal exchange between the high temperature coal rocks and a liquid thermal medium; stopping the thermal extraction operations when the temperatures of the extracted gaseous thermal medium and the liquid thermal medium reach 70° C. or below.

Abstract: An end effector for a robot comprising: a threaded shaft; a motor coupled to the shaft and configured to rotate the shaft about its axis; a nut threaded onto the shaft; means for preventing the nut from rotating about the axis of the shaft; and an elongate member fixed at one end to the nut and extending from the nut in a direction parallel to the axis of the shaft. The end effector may further comprise a container for containing a fluid comprising: an elongate body portion comprising an opening at one end; and a reciprocable plunger extending into an opposite end of the body portion. A second end of the elongate member may be coupled to the plunger.

Abstract: A so-called molecular-targeted drug acting on a signal transduction pathway in a cell has been developed. However, a side effect of the molecular-targeted drug is not negligible for a patient. Thus, there has been a demand for a substance that exhibits a significant growth inhibitory effect on a cancer cell with fewer side effects as a health food and a pharmaceutical composition. It has been found that a hexane extract fraction of a watermelon sprout has an effect of specifically inhibiting the cell growth of the cancer cell and such an effect is primarily caused by phytol and lutein. A processed food and pharmaceutical composition having these substances as main components can exert an anticancer action without causing side effects.

Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).

Abstract: Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune recruitment, both of which lead to necrosis in the area of the tumor. No adverse effects have been observed.

Abstract: An object of the present invention is to provide a therapeutic strategy in the solid tumor area and a means useful therefor to further advance the clinical application of CAR therapy. There is prepared a gene-modified lymphocyte which expresses a chimeric antigen receptor having an EphrinB2 extracellular domain at the antigen recognition site.

Abstract: The technology of a zero loop-area oblique-incidence Sagnac interferometer and methods of using the Sagnac interferometer to detect magneto-optic Kerr effect is disclosed. An example apparatus includes: a light source configured to generate an optical beam; a beam splitter; a polarizer configured to separate the optical beam into two orthogonal components; a modulator configured to phase-modulating at least one of the two orthogonal components to produce a modulated pair of orthogonal components; a polarization dependent delay optics configured to direct the modulated pair of orthogonal components toward a surface of a sample to cause the modulated pair of orthogonal components to incident on the surface at an oblique angle; a mirror configured to reflecting the modulated pair of orthogonal components back towards the beam splitter; a photo receiver configured to receive a return beam redirected by the beam splitter; and a phase-sensitive detector.

Abstract: A preparation method for a low oxygen content semiconductor core composite material optical fibre preform comprise: (1) in a nitrogen gas atmosphere glovebox, tightly packing semiconductor core raw material powder into a central hole of a cladding glass tube which is sealed at one end; and (2) performing vacuum pumping on the cladding glass tube packed with the semiconductor core raw material powder, and simultaneously sealing another end of the hot-drawn glass tube to vacuum sealing the semiconductor core raw material powder within the cladding glass tube, so as to obtain the low oxygen content semiconductor core composite material optical fibre preform. The method solves problems in the traditional optical fibre preform preparation methods such as poor packing tightness, high oxygen content in drawn fibre cores, and poor transmission performance in prepared optical fibres.

Abstract: The present invention discloses a novel low-temperature fuel reforming unit based on combined external reformer of an engine, comprising an engine cylinder and an external low-temperature fuel reformer; the external low-temperature fuel reformer is winded with a heater strip and is provided with a first temperature controlled meter, the inlet of the external low-temperature fuel reformer is connected with a air inlet pipe and a fuel sample injection pipe, and a flow meter is arranged on the air inlet pipe; the fuel sample injection pipe is connected with a fuel injection pump and a fuel vaporization tank which is provided with a second temperature controlled meter; the outlet of the external low-temperature fuel reformer is connected with the engine inlet pipe via a reforming gas pipe; and the reformed low-temperature products enter into the engine inlet pipe via the reforming gas pipe for combining with the fresh air again to form a uniform hybrid gas, and the hybrid gas is introduced into the engine cylinde

Abstract: Disclosed are systems, components, and methods for sensing a ligand in a cell or a reaction mixture. The disclosed systems, components, and methods may include and/or utilize a fusion protein comprising a ligand-binding protein and a DNA-binding protein. The fusion protein binds the ligand of the ligand-binding protein and modulates expression of a reporter gene operably linked to a promoter that is engineered to include specific binding sites for the DNA-binding protein. The difference in expression of the reporter gene in the presence of the ligand versus expression of the reporter gene in the absence of the ligand can be correlated to the concentration of the ligand in a reaction mixture.

Abstract: The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.

Abstract: The present invention provides for a composition for ionizing a target comprising: a substrate comprising a plurality of nanoparticles bound to a surface of the substrate, which allows one to directly extract undesired contaminants during passive sample drying without require manual interventions, such as washing and vortexing.

Abstract: Disclosed is a DNA methylation signature in Peripheral Blood Mononuclear cells (PBMC) for predicting hepatocellular carcinoma (HCC) stages and chronic hepatitis, which is CG IDs. This invention also disclosed kits and uses for the DNA methylation signature.

Abstract: The present disclosure relates to a humidification-dehumidification desalination system. A humidification subsystem of the humidification-dehumidification desalination system includes a thermal element and a bubble column, in series. The thermal element further comprises a thermal energy storage unit including a phase change material and a thermal conductor. The thermal element can be supplemented by a Fresnel lens canopy. The thermal element and the bubble column of the humidification design are arranged in staircase design such that gravity drives the system.