Abstract: 2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and N,N-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.

Abstract: The present invention provides materials and methods related to modulation of mismatch repair and genomic stability by miR-155.

Abstract: Apparatus and method for improving the performance of a threshold-based detector or classifier, or a generic detector or classifier and increasing the probability of detecting at least one object in an image using novel algorithms and stochastic resonance noise is provided, where a suitable dose of noise is introduced to the image data such that the performance of the above-referenced detectors or classifiers is improved without altering the detector's or classifier's parameters. Several stochastic resonance (SR) noise-based detection and classification enhancement schemes are presented. The SR noise-enhanced detection and classification schemes can improve any algorithms and systems. To implement these schemes, the only knowledge that is needed is the original input data (no matter 1D, 2D, 3D or others) and the output (detection results) of the existing algorithms and systems.

Abstract: The present invention provides compositions and methods for providing factor replacement therapy. In particular, the present invention provides replacement therapy for subjects suffering from cystinosis.

Abstract: The present invention provides microspheres comprising a plurality of nanocapsules accommodated in a gel forming polymer, the plurality of nanocapsules comprising an oil core carrying a non hydrophilic active agent and a shell of polymeric coating. The invention also provides a method for preparing the microspheres of the invention, pharmaceutical compositions comprising the same as well as methods of use of the microspheres, specifically, in therapeutic, cosmetic and diagnostic applications.

Abstract: The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto. In particular, the antibodies that react immunologically with a particular epitope found in anti-tumor antigen antibodies are not only indicative of favorable therapy using the anti-tumor antigen antibodies, but are therapeutic in and of themselves.

Abstract: Forming a sector for a nacelle lip skin from a sheet metal blank via punch by placing the blank against an outer surface of the punch and clamping a trailing edge of the blank in a clamping member that grips a trailing edge of the blank without slippage; gripping a leading edge of the blank, opposite the trailing edge, in a gripping device at a location axially spaced from the punch with sufficient force to permit the blank to flow therethrough in a controlled manner; displacing the gripping device in a first direction, radially with respect to the punch while drawing the blank through the gripper; displacing the gripping device in a second direction, axially with respect to the punch, to draw the blank over the leading edge of the punch and through the gripping device.

Abstract: Provided is a cell concentration and purification device, having: a function of continuously concentrating cells; a function of then subsequently disposing the cells continuously in a specific region of a channel; a function of simultaneously recognizing, based on an image, the shape and fluorescence emission of each single cell; and a function of recognizing the cells and then separating and purifying the same based on the data relating to the shape and fluorescence emission thereof.

Abstract: An inorganic fiber structure comprising inorganic nanofibers having an average fiber diameter of 3 ?m or less, in which an entirety including the inside thereof is adhered with an inorganic adhesive, and the porosity thereof is 90% or more, is disclosed.

Abstract: A system and method for patient-adaptive hemodynamic management is described. One embodiment includes a system for hemodynamic management including transfusion, volume resuscitation with intravenous fluids, and medications, utilizing monitored hemodynamic parameters including the described dynamic predictors of fluid responsiveness, and including an intelligent algorithm capable of adaptation of the function of the device to specific patients.

Abstract: A chromatic confocal microscope system and signal process method is provided to utilize a first optical fiber module for modulating a light into a detecting light passing through a chromatic dispersion objective and thereby forming a plurality of chromatic dispersion lights to project onto an object. A second optical fiber module conjugated with the first optical fiber module receives a reflected object light for forming a filtered light, which is split into two filtered lights detected by two color sensing units for generating two sets of RGB intensity signals, wherein one set of RGB intensity signals is adjusted relative to the other set of RGB intensity signals. Then two sets of RGB intensity signals are calculated for obtaining a maximum ratio factor. Finally, according to the maximum ratio factor and a depth relation curve, the surface profile of the object can be reconstructed.

Abstract: In one embodiment, there is provided in an ultrasound wave generating apparatus a low output impedance transistor based driver circuit that has the ability to apply a drive signal at a frequency corresponding to an ultrasound transducer's resonant frequency. The low output impedance of the driver circuit allows for a substantial portion of the energy to be delivered to the ultrasound transducer and converted to ultrasound energy. The power transfer efficiency of the presented circuit allows ultrasound drivers to be powered by portable battery packs, while still delivering high ultrasound acoustic power. The ultrasound driver can provide energy in sufficient amounts making it suitable for a range of ultrasound driving application including but not limited to therapeutic low and high power clinical systems, high intensity focused ultrasound HIFU, acoustical welding, industrial inspection, and other various forms of low-to-high power acoustic devices.

Abstract: Methods and Systems for aligning multiple video sequences of a similar scene. It is determined which video sequences should be aligned with each other using linear dynamic system (LDS) modeling. The video sequences are then spatially aligned with each other.

Abstract: In a field emission device, the fundamental cause of spherical aberration in an emitted electron beam trajectory is eliminated or mitigated. An aberration suppressor electrode 31 is provided at a lower vertical position than an extraction gate electrode 13 so its opening inner peripheral edge 31e faces a position near an emitter tip 11tp. The vertical position of the opening inner peripheral edge 31e of the aberration suppressor electrode 31 is made lower than the vertical position of the emitter tip 11tp. An aberration suppressing voltage Vsp is applied to the aberration suppressor electrode 31 that is a lower voltage than the potential of the emitter 11 and controls equipotential lines near the emitter tip 11tp to make them parallel.

Abstract: An absorption cell for microfluidic chemical analysis made from tinted or colored polymers, for example polymethylmethacrylate (PMMA), in which microfluidic channels are cut. Light is coupled into the absorption cell via two windows (typically 200 um thick) that are retained at either end of the channel. Absorption is measured using a light source, such as a light emitting diode (LED) and a photodiode butted against the windows. Spurious scattered and/or reflected light is absorbed by the colored polymer over the length of the measurement cell, while very little light loss occurs at the coupling windows.

Abstract: Isolated DJ-1 related peptides are disclosed and pharmaceutical compositions comprising same for treating oxidative stress-related disorder.

Abstract: A laser accelerator driven electronic brachytherapy system, device, and method for particle based treatment of a tumor or other human diseases and conditions.

Abstract: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.

Abstract: A recursive type-IV discrete cosine transform system includes a first permutation device, a recursive type-III discrete cosine/sine transform device, a cosine/sine factor generation device, a recursive type-II discrete cosine/sine transform device, a second permutation device. The first permutation device performs two-dimensional order permutation operation on N digital signals for generating N two-dimensional first temporal signals. The recursive type-III discrete cosine/sine transform device repeats a type-III discrete cosine/sine transform for generating second temporal signals. The cosine/sine factor generation device sequentially performs cosine/sine factor multiplication and corresponding addition operations for generating third temporal signals. The recursive type-II discrete cosine/sine transform device repeats a type-II discrete cosine/sine transform for generating fourth temporal signals.

Abstract: The new variety Pennisetum ‘Tift 40’ is provided. The new and distinct variety has high ornamental value, cold tolerance for short periods of time, and disease resistance. The asexually reproduced variety is reliably propagated vegetatively.