Abstract: Devices comprising functionalized materials, and embodiments of a method for making and using such devices, are disclosed. Exemplary devices include ophthalmic devices, nanoparticles, quartz crystal microbalances, microarrays, and nanocomposites. In particular embodiments, device surfaces are modified with monomers and/or polymers, typically carbohydrate monomers and/or polymers. Embodiments of a method for making and using such devices are disclosed. Monomers and/or polymers are covalently bonded to surfaces using functionalized perhalophenylazides. In some embodiments, device surfaces are functionalized with a perhalophenylazide. One or more monomers and/or polymers subsequently are covalently bonded to the device surface using the perhalophenylazide. In other embodiments, monomers and/or polymers are derivatized with a functionalized perhalophenylazide. The derivatized monomers and/or polymers then are covalently bonded to the device surface using the perhalophenylazide.
Type:
Grant
Filed:
May 28, 2009
Date of Patent:
March 25, 2014
Assignees:
State of Oregon by and through the State Board of Higher Education on behalf of Porland State University, State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University
Inventors:
Mingdi Yan, Olof Ramström, Li-Hong Liu, Xin Wang, Michael M. Lerner, Tosapol Maluangnont
Abstract: The present invention provides materials and methods for researching poultry viruses, particularly for researching infectious bronchitis viruses in poultry. Also provided are materials and methods useful for reducing the economic impact that infectious bronchitis disease has on poultry production. In one aspect of the invention, there are provided nucleic acids, amino acids and related materials and compositions useful for combating infectious bronchitis virus in poultry.
Type:
Grant
Filed:
November 22, 2010
Date of Patent:
March 25, 2014
Assignee:
University of Georgia Research Foundation Inc.
Abstract: A Spatial Multiplexing Multiple Input Multiple Output (SM-MIMO) communication system, which generates Q and R matrices through QR decomposing a channel matrix in an array order corresponding to an order of transmission antennas of a signal transmission device, determines a detection order of transmission symbols included in a transmission symbol vector, QR decomposes a reception signal vector and generates the QR decomposed reception signal vector as a transformed reception signal vector, substitutes all of transmittable candidate symbols for a transmission symbol corresponding to a first detection order among the transmission symbols and sequentially removes interference in the transformed reception signal vector, detects candidate symbols of transmission symbols corresponding to a remaining detection order from the interference-removed transformed reception signal vector, combines the detected candidate symbols, detects candidate symbol vectors, and calculates Log-Likelihood Ratio values of bits included in
Type:
Grant
Filed:
January 28, 2011
Date of Patent:
March 25, 2014
Assignees:
Samsung Electronics Co., Ltd., Industry-Academic Cooperation Foundation, Yonsei University
Inventors:
Joo-Yeol Yang, Jae-Seok Kim, In-Hyoung Kim, Yun-Ho Jung, Hae-Dong Yeon, Kil-Hwan Kim, Mi-Suk Cho
Abstract: Disclosed are a method and a system for determining top spreaders in high speed network. The method may comprise: sampling a plurality of packets from the plurality of hosts during an interval of time; determining a difference between a count and a count error for each host based on the sampled packets; ranking the hosts based on the determined difference to identify a first set of hosts that are top in the ranked hosts; and selecting a second set of hosts from the first set of hosts as the top spreaders.
Abstract: An optical sensor, a method of configuring an optical sensor, and a method of using an optical sensor are provided. The optical sensor includes an optical loop having a length and a laser source optically coupled to the loop. The laser source has a coherence length. Light from the source is transmitted to the loop as a first signal and a second signal counterpropagating along the loop. The optical paths of the first signal and the second signal are substantially reciprocal with one another and the first signal and the second signal are combined together after counterpropagating through the loop to generate a third signal. A ratio of the coherence length to the length of the loop is greater than 1.
Type:
Grant
Filed:
March 25, 2013
Date of Patent:
March 25, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Michael J. F. Digonnet, Shanhui Fan, Seth Lloyd
Abstract: This invention provides tandem fluorescent protein construct including a donor fluorescent protein moiety, an acceptor fluorescent protein moiety and a linker moiety that couples the donor and acceptor moieties. The donor and acceptor moieties exhibit fluorescence resonance energy transfer which is eliminated upon cleavage. The constructs are useful in enzymatic assays.
Type:
Grant
Filed:
November 4, 2009
Date of Patent:
March 25, 2014
Assignees:
The Regents of the University of California, Life Technologies Corporation
Inventors:
Roger Y. Tsien, Roger Heim, Andrew Cubitt
Abstract: In various embodiments, the present disclosure describes fullerene derivatives that are capable of photocatalytically generating reactive oxygen species in the presence of ultraviolet and/or visible light. In some embodiments, the fullerene derivatives are aminofullerenes containing a plurality of amine-terminated moieties covalently bonded to the fullerene cage. The fullerene derivatives may optionally be covalently bonded to a substrate surface for use in photocatalytic disinfection systems for removing various contaminants including, for example, bacteria, viruses, protozoa and chemical pollutants. Methods using the present fullerene and aminofullerene derivatives in various purification processes are also described herein.
Type:
Grant
Filed:
June 24, 2010
Date of Patent:
March 25, 2014
Assignees:
William Marsh Rice University, Georgia Tech Research Corporation
Inventors:
Pedro J. J. Alvarez, Jaesang Lee, Lon J. Wilson, Yuri Mackeyev, Jaehong Kim
Abstract: A magnetoresistive element according to an embodiment includes a first magnetic layer, a second magnetic layer, and a first nonmagnetic layer provided between the first magnetic layer and the second magnetic layer, the first magnetic layer including a magnetic film of MnxGey (77 atm %?x?82 atm %, 18 atm %?y?23 atm %, x+y=100 atm %).
Type:
Grant
Filed:
March 14, 2013
Date of Patent:
March 25, 2014
Assignees:
Kabushiki Kaisha Toshiba, Tohoku University
Abstract: Short hairpin RNA (shRNA) interference therapy targeting hypoxia inducible factor—lot (HIF-1 ?) prolyl-4-hydroxylase protein (HIF-PHD2) is used for treatment of myocardial ischemia. This treatment can be followed noninvasively by molecular imaging. Provided are compositions comprising novel vectors encoding shRNA targeting the HIF-1? and asparaginyl hydroxylase genes. The vectors encoding shRNA are also useful for the treatment of cardiac diseases, peripheral vascular diseases and decubitis ulcers.
Type:
Grant
Filed:
September 15, 2009
Date of Patent:
March 25, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Joseph C. Wu, Mei Huang, Amato J. Giaccia, Denise Chan
Abstract: Device and methods for use of these devices to manipulate substantially non-magnetic particles dispersed inside a magnetic fluid by employing a changeable pattern of local magnetic field maxima and minima are provided.
Abstract: Select phytoestrogen pharmaceutical compositions and methods of use for preventing or reducing one or more symptoms associated with pre menopause, menopause, and/or post menopause are described herein. These select phytoestrogen formulations are composed only of two or more plant-derived estrogenic molecules and/or their structural analogues and exhibit binding preference to ER? over ER? and agonist activity in the brain. These ER?-selective phytoestrogen formulations cross the blood-brain-barrier and promote estrogen-associated neurotrophism and neuroprotection mechanisms in the brain, without activating proliferative mechanisms in the reproductive tissues and are therefore devoid of other estrogen-associated problematic aspects. The formulations can be administered enterally, transdermally, transmucosally, intranasally or parenterally. The formulations preferably contain combinations of compounds, and can be formulated for daily, sustained, delayed or weekly/monthly administration.
Abstract: The invention provides compositions and methods for enhanced gene expression. The invention provides a composition comprising a 28-codon leader sequence operably linked to a desired gene which encodes the desired protein.
Type:
Grant
Filed:
January 4, 2011
Date of Patent:
March 25, 2014
Assignee:
The Trustees of the University of Pennsylvania
Abstract: Devices, methods, and techniques for frequency-dependent optical switching are provided. In one embodiment, a device includes a substrate, a first optical-field confining structure located on the substrate, a second optical-field confining structure located on the substrate, and a composite structure located between the first and second optical-field confining structures. The second optical-field confining structure may be spaced apart from the first optical-field confining structure. The composite structure may include an embedding structure with a surface to receive photons and multiple quantum structures located in the embedding structure.
Type:
Grant
Filed:
February 4, 2013
Date of Patent:
March 25, 2014
Assignee:
University of Seoul Industry Cooperation Foundation
Abstract: The various embodiments disclosed herein relate to modular medical devices, including various devices with detachable modular components and various devices with pivotally attached modular components. Additional embodiments relate to procedures in which various of the devices are used cooperatively. Certain embodiments of the medical devices are robotic in vivo devices.
Type:
Grant
Filed:
November 26, 2008
Date of Patent:
March 25, 2014
Assignee:
Board of Regents of the University of Nebraska
Inventors:
Shane M. Farritor, Amy Lehman, Mark Rentschler
Abstract: An object of the present invention is to provide a method for controlling microorganisms in food materials, by which bacterial groups that cause deterioration of the quality of food materials such as poultry and pathogenic microorganisms that cause food poisoning can be efficiently controlled. Specifically, the present invention relates to a method for controlling microorganisms in food materials, comprising a step of subjecting a food material immersed in a sterilizing solution to repeated treatment with negative pressure and ordinary pressure and/or a step of subjecting the food material immersed in the sterilizing solution to resonant ultrasonication.
Type:
Grant
Filed:
March 18, 2011
Date of Patent:
March 25, 2014
Assignees:
University of Miyazaki, Kaijo Corporation
Abstract: An in-situ gel ophthalmic drug delivery system for estrogen containing an estrogen, a solubilizing and complexing agent, a humectant, a sorbic acid or sorbic acid based stabilizer, an optional chelating agent and gellan gum in the amount of about 0.1-0.5% w/v, optionally 0.1-0.3% w/v, of the composition.
Type:
Grant
Filed:
September 28, 2010
Date of Patent:
March 25, 2014
Assignee:
Duquesne University of the Holy Spririt
Inventors:
Moji Christianah Adeyeye, Vicki L. Davis, Uday K. Kotreka
Abstract: The present invention discloses a method for fabricating aerogels, a method for fabricating surface-modified aerogels, and a method for fabricating biocomposites. Take the fabricating method of biocomposites for example, first, a precursor solution is provided and the precursor solution comprises a hydrophilic ionic liquid, a catalyzed hydrolysis and/or condensation reagent, at least one biomolecule. Next, a curing process is performed for the precursor solution to hydrolyze and polymerize the at least one alkoxide monomer and/or aryloxide monomer to wrap at least one biomolecule and thus form biocomposite. Afterwards, an extracting process is performed by a solvent for the biocomposite to substitute the ionic liquid in the biocomposite. Finally, a drying process for the biocomposite is carried out after the extracting process so as to remove the solvent in the biocomposite. Therefore, the biocomposite is formed.
Abstract: Provided is an amplifying repeater to intensify and amplify a magnetic field of electromagnetic waves. Also provided is a wireless power conversion charging device using the magnetic field of electromagnetic waves, which is located between an electromagnetic wave generating source transmitter and a receiving coil or attached to a transmitter and a receiving coil. Accordingly, charging power for various electronic devices can be provided and power can be wirelessly supplied to various loads.
Type:
Grant
Filed:
July 26, 2012
Date of Patent:
March 25, 2014
Assignees:
JC Protek Co., Ltd., Andong National University Industry Academic Cooperation Foundation
Abstract: Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
Type:
Grant
Filed:
March 15, 2012
Date of Patent:
March 25, 2014
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Robert Doms, Joseph Rucker, Trevor L Hoffman, Paul Bates, James A Hoxie, Michael J Endres, John Balliet, Dennis L Kolson
Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
Type:
Grant
Filed:
July 25, 2011
Date of Patent:
March 25, 2014
Assignees:
Otonomy, Inc., The Regents of the University of California
Inventors:
Jay Lichter, Benedikt Vollrath, Andrew M. Trammel, Sergio G. Durón, Fabrice Piu, Luis A. Dellamary, Qiang Ye, Carl Lebel, Michael Christopher Scaife, Jeffrey P. Harris