Patents Assigned to University
  • Medical implants containing adenosine receptor agonists and methods for inhibitiing medical implant loosening
    Patent number: 8680070
    Abstract: The invention provides methods and compositions for reducing or inhibiting bone resorption, osteoclast differentiation and stimulation and the loosening of medical prostheses by administering a compound or agent that modulates an adenosine receptor such as the adenosine A2A receptor, in particular, an agonist of an adenosine A2A receptor. The invention also extends to pharmaceutical compositions comprising such an agent that modulates an adenosine receptor such as an adenosine A2A agonist and to prosthetic devices containing such an agent that modulates an adenosine receptor such as an A2A agonist on one or more surfaces or within the prosthetic device such as, for example, suspended in the cement forming the prosthetic device.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: March 25, 2014
    Assignee: New York University
    Inventors: Bruce N. Cronstein, Aranzazu Mediero Munoz
  • Antiviral agent
    Patent number: 8680158
    Abstract: A compound having inhibitory activity on the binding of a substance ? to a PTGS suppressor protein, wherein the substance ? has a property of inducing PTGS and a property of binding to the PTGS suppressor protein and shows a decrease in the property of inducing PTGS upon binding to the PTGS suppressor protein.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: March 25, 2014
    Assignees: Nippon Soda Co., Ltd., Hokkaido University
    Inventors: Shinsuke Sano, Takako Fukagawa, Hirokazu Yamada, Chikara Masuta, Hanako Shimura
  • Curling head for curling broom
    Patent number: 8677548
    Abstract: A curling broom includes an elongate shaft having opposed first and second ends, the first end being graspable by a sweeper and being attached to a broom head attachment plate located at the second end. A curling broom head is attached to the broom head receptacle for sweeping an ice surface. The broom head includes a base section, a reflective constituent selected to reflect infrared radiation which can be a layer secured to a bottom surface of the base section, or the top of the woven fabric or both or a reflective powder incorporated into a foam pad attached to the base section, (or the foam pad being metalized), or an outer surface of an outer fabric layer being metalized and secured to the base section. Infrared radiation generated by sweeping the ice is reflected by the reflective layer back towards the ice surface for further heating the ice surface.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: March 25, 2014
    Assignee: The University of Western Ontario
    Inventors: Thomas Jenkyn, Scott Arnold, Jeffrey Wood
  • Specific N-terminal labeling of peptides and proteins in complex mixtures
    Patent number: 8679771
    Abstract: This invention provides general methods for selective labeling of proteins on their N-termini with synthetic peptides. The methods of this invention can be applied to the global proteomic profiling of complex mixtures of proteins and polypeptides.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: March 25, 2014
    Assignee: The Regents of the University of California
    Inventors: James A. Wells, Sami Mahrus
  • Voltage-gated metal-enhanced fluorescence, chemiluminescence or bioluminescence methods and systems
    Patent number: 8679855
    Abstract: In the present invention, it is demonstrated for the first time, the influence of electrical current on the ability of surface plasmons to amplify fluorescence signatures. An applied direct current across silver island films (SiFs) of low electrical resistance perturbs the fluorescence enhancement of close-proximity fluorophores. For a given applied current, surface plasmons in “just-continuous” low resistance films are sparsely available for fluorophore dipole coupling and hence the enhanced fluorescence is gated as a function of the applied current.
    Type: Grant
    Filed: March 1, 2009
    Date of Patent: March 25, 2014
    Assignee: University of Maryland, Baltimore County
    Inventor: Chris D. Geddes
  • System and method for broadband RF interference cancellation
    Patent number: 8682170
    Abstract: Radio frequency transmission systems often suffer from the problem of co-site interference, where the frequency band of a strong radio transmitter overlaps with the frequency band of a co-located and/or remote radio receiver, such that the transmitter interferes with the ability of the receiver to detect a weak signal of interest. There is a need for a device that can process both the transmitted radio signal and the received radio signal to eliminate such interference. Previous attempts to solve this problem have been unable to cancel in-band interference in excess of 20 to 40 dB stronger than the signal of interest over a broad bandwidth, with large dynamic range, and with a high degree of linearity. Disclosed is a robust system and method for cancelling broadband in-band RF interference that operates in a dynamically changing multipath environment.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: March 25, 2014
    Assignee: The Trustees of Princeton University
    Inventor: Paul Prucnal
  • Methods for applying a powder metal layer to polymer articles as an antifouling coating
    Patent number: 8679583
    Abstract: A method of making an antifouling article includes providing a mold having a mold cavity and a mold surface for defining an article. The method also includes applying a mold release material to the mold surface. The method further includes coating the mold surface with a plurality of metallic powder particles comprising an antifouling agent. Still further, the method includes filling the mold with a curable polymeric material. Yet further, the method includes curing the polymeric material and forming an article having a surface defined by the mold surface, the surface of the article having the plurality of metallic powder particles disposed thereon and comprising an antifouling coating.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: March 25, 2014
    Assignee: The Johns Hopkins University
    Inventors: Charles W. Kerechanin, II, Justin S. Morrison, Craig B. Leese, Paul J. Biermann, Ryan J. Forrest, William R. Setzler
  • Systems, methods, and media for testing software patches
    Patent number: 8683450
    Abstract: Systems, methods, and media for testing software patches are provided (200). The methods include: injecting a software patch into a program (202); running multiple instances of a part of the program containing the software patch (204); obtaining outcomes of the multiple instances (208); and determining, using the outcomes, whether the software patch is executed properly (210).
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: March 25, 2014
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Angelos D. Keromytis, Stylianos Sidiroglou
  • Water-soluble AIE luminogen for monitoring and retardation of amyloid fibrillation of insulin
    Patent number: 8679738
    Abstract: The presently described subject matter is directed to a water-soluble conjugated polyene compound and the derivatives thereof that exhibit aggregation induced emission, as well as any water dispersible, fluorescent, polymeric microparticles, nanoparticles, and/or pharmaceutical composition comprising the water-soluble conjugated polyene compound and/or the derivatives thereof. Also provided are methods of making and using the compound, derivatives and particles of the presently described subject matter. The presently described water-soluble conjugated polyene compound are useful as bioprobes for the detection of biomacromolecules, in the manufacture of sensors, in monitoring and retarding formation of amyloid protein fibril in vitro and in vivo, and in developing anti-cancer drugs.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: March 25, 2014
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Benzhong Tang, Yuning Hong, Sijie Chen, Ryan Tsz Kin Kwok
  • Methods, compositions and kits relating to chitnases and chitnase-like molecules and inflammation disease
    Patent number: 8679503
    Abstract: The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic rhinitis, scleroderma, and the like), relating to inhibiting a chitinase-like molecule. The invention further includes methods to identify new compounds for the treatment of inflammatory disease, including, but not limited to, asthma, COPD and the like. This is because the present invention demonstrates, for the first time, that expression of IL-13, and of a chitinase-like molecule, mediates and/or is associated with inflammatory disease and that inhibiting the chitinase-like molecule treats and even prevents, the disease. Thus, the invention relates to the novel discovery that inhibiting a chitinase-like molecule treats and prevents an inflammatory disease.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: March 25, 2014
    Assignee: Yale University
    Inventors: Jack A. Elias, Zhou Zhu
  • Method for producing alumina template of nanorods, alumina template, and nanorods
    Patent number: 8679221
    Abstract: A method for producing an alumina template of nanorods, the alumina template, and the nanorods are provided for overcoming the problems of the conventional alumina template having anodic aluminum oxide that may be peeled off from a substrate or forming a non-conductive oxide easily, and the alumina template includes a conductive substrate composed of an active metal and an inert metal, so that the alumina template can be attached onto the active metal and inert metal at the same time, and the active metal can be used for securing the alumina template and supporting the alumina template on the inert metal, and the anodic aluminum oxide attached onto the inert metal can be used for providing a better conductivity, such that a stable and highly conductive alumina template can be produced.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: March 25, 2014
    Assignee: Southern Taiwan University
    Inventors: Hsyi-en Cheng, Bo-jiun Yeh
  • Esophageal cancer markers
    Patent number: 8679759
    Abstract: The present invention is directed to methods for diagnosing cancer in a subject. Morphologically normal epithelial cells of the esophagus are assayed for marker expression. Characteristic expression of the markers indicates the presence of cancer or the predisposition to cancer. A panel of eleven markers are particularly good at identifying cancer and the predisposition to cancer.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: March 25, 2014
    Assignees: The Johns Hopkins University, University of Maryland, Baltimore
    Inventors: Florin M. Selaru, Stephen J. Meltzer
  • Cell-matrix microspheres, methods for preparation and applications
    Patent number: 8679809
    Abstract: A method has been developed to produce stable cell-matrix microspheres with up to 100% encapsulation efficiency and high cell viability, using matrix or biomaterial systems with poor shape and mechanical stability for applications including cell therapeutics via microinjection or surgical implantation, 3D culture for in vitro expansion without repeated cell splitting using enzymatic digestion or mechanical dissociation and for enhanced production of therapeutic biomolecules, and in vitro modeling for morphogenesis studies. The modified droplet generation method is simple and scalable and enables the production of cell-matrix microspheres when the matrix or biomaterial system used has low concentration, with slow phase transition, with poor shape and mechanical stability.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: March 25, 2014
    Assignee: The University of Hong Kong
    Inventors: Barbara Pui Chan, Godfrey Chi-Fung Chan, Hoi Ling Wong, Pik To Cheung, Song-Eng Kathryn Cheah, Danny Chan
  • Virtual endoscopy with improved image segmentation and lesion detection
    Patent number: 8682045
    Abstract: A system, and computer implemented method are provided for interactively displaying three-dimensional structures. Three-dimensional volume data (34) is formed from a series of two-dimensional images (33) representing at least one physical property associated with the three-dimensional structure, such as a body organ having a lumen. A wire frame model of a selected region of interest is generated (38b). The wireframe model is then deformed or reshaped to more accurately represent the region of interest (40b). Vertices of the wire frame model may be grouped into regions having a characteristic indicating abnormal structure, such as a lesion. Finally, the deformed wire frame model may be rendered in an interactive three-dimensional display.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: March 25, 2014
    Assignee: Wake Forest University Health Sciences
    Inventors: David J. Vining, Gordon W. Hunt, David K. Ahn, David R. Stelts, Yaorong Ge, Paul F. Hemler, Tiffany W. Salido
  • Nanoencapsulation of isocyanates via aqueous media
    Patent number: 8680176
    Abstract: The present invention provides a nanocapsule of a blocked isocyanate encapsulated within a polymeric nanosphere. In one aspect, the polymeric nanosphere is functionalized. Free isocyanate functionality is released upon thermal annealing or UV exposure of the nanospheres containing the blocked isocyanate. This present invention also provides a novel method for encapsulating isocyanates in aqueous media. In one aspect, the method comprises miniemulsion polymerization. The thermally or UV deblocked isocyanate can be used as an active functional group for many potential applications.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: March 25, 2014
    Assignee: The University of Southern Mississippi
    Inventors: James W. Rawlins, Huaxiang Yang, Sharathkumar K. Mendon
  • Controlled release corticosteroid compositions and methods for the treatment of otic disorders
    Patent number: 8680082
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: March 25, 2014
    Assignees: Otonomy, Inc., The Regents of the University of California
    Inventors: Jay Lichter, Benedikt Vollrath, Andrew M. Trammel, Sergio G. Durón, Fabrice Piu, Luis A. Dellamary, Qiang Ye, Carl Lebel, Michael Christopher Scaife, Jeffrey P. Harris
  • Uniform large-grained and gain boundary location manipulated polycrystalline thin film semiconductors formed using sequential lateral solidification and devices formed thereon
    Patent number: 8680427
    Abstract: A device on a supporting substrate is provided including a semiconductor film, having two or more rectangular crystalline regions spaced from each other, wherein each of the two or more rectangular crystalline regions comprises one single crystal region. The device can further include two or more thin-film transistors, wherein each of the two or more thin-film transistors comprises one or more active-channel regions. Each of the one or more active-channel regions can comprise at least one of said two or more rectangular crystalline regions. The device can further include an integrated circuit which comprises of the two or more thin-film transistors.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: March 25, 2014
    Assignee: The Trustees Of Columbia University in The City Of New York
    Inventors: James S. Im, Robert S. Sposili, Mark A. Crowder
  • Film-forming material and method for predicting film-forming material
    Patent number: 8679369
    Abstract: Disclosed is a method for prediction of a film material such as a raw material for organic EL. In the method, a film material having an evaporation rate (V(%)) represented by the formula below can be predicted based on the values of the constant (Ko) and the activation energy (Ea). V=(Ko/P)×e?Ea/kT wherein Ko represents a constant (%·Torr), P represents a pressure (Torr), Ea represents an activation energy (eV), k represents a Boltzmann constant, and T represents an absolute temperature.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: March 25, 2014
    Assignee: Tohoku University
    Inventors: Tadahiro Ohmi, Shozo Nakayama, Hironori Ito
  • Method facilitating removal of bioorganic stains from surfaces
    Patent number: 8679825
    Abstract: Protein-polymer composite materials are provided according to embodiments of the present invention that include an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins is mixed with the admixture. The emulsion is mixed with a crosslinker to produce a curable composition. The curable composition is cured, thereby producing the protein-polymer composite material that is useful for facilitating removal of bioorganic stains.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: March 25, 2014
    Assignees: Toyota Motor Engineering & Manufacturing North America, Inc., Regents of the University of Minnesota, Toyota Motor Corporation
    Inventors: Ping Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Xiaodong Tong, Minjuan Zhang
  • Prochelators useful for inhibiting metal-associated toxicity
    Patent number: 8680077
    Abstract: Prochelator compounds of Formula (I) or Formula (II) are described, along with methods of using the same and pharmaceutical formulations or compositions containing the same.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: March 25, 2014
    Assignee: Duke University
    Inventors: Katherine J. Franz, Marina G. D. Leed