Abstract: Protein-polymer composite materials are provided according to embodiments of the present invention that include an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins is mixed with the admixture. The emulsion is mixed with a crosslinker to produce a curable composition. The curable composition is cured, thereby producing the protein-polymer composite material that is useful for facilitating removal of bioorganic stains.
Type:
Grant
Filed:
September 27, 2010
Date of Patent:
March 25, 2014
Assignees:
Toyota Motor Engineering & Manufacturing North America, Inc., Regents of the University of Minnesota, Toyota Motor Corporation
Abstract: This invention provides general methods for selective labeling of proteins on their N-termini with synthetic peptides. The methods of this invention can be applied to the global proteomic profiling of complex mixtures of proteins and polypeptides.
Type:
Grant
Filed:
January 24, 2008
Date of Patent:
March 25, 2014
Assignee:
The Regents of the University of California
Abstract: The invention provides methods permitting the detection of small amounts of different nucleic acids in the presence of an excess amount of wild-type nucleic acids. Also provided herein are method so detecting infectious disease minority variants, methods of forensic identification, methods of diagnosing cancer and monitoring disease progress.
Type:
Grant
Filed:
March 22, 2005
Date of Patent:
March 25, 2014
Assignee:
The Johns Hopkins University
Inventors:
James R. Eshleman, Chanjuan Shi, Susan Henrietta Eshleman
Abstract: Provided is an uplink feedback channel allocation method and apparatus used to feedback data to indicate whether data packets corresponding an enhanced physical downlink control channel (E-PDCCH) were successfully decoded. A terminal may use an additional resource area of an uplink feedback channel or may use an empty resource area of the uplink feedback channel to which feedback information of a data packet corresponding to a physical downlink control channel (PDCCH) is not allocated, to perform feedback.
Type:
Grant
Filed:
August 24, 2011
Date of Patent:
March 25, 2014
Assignees:
Samsung Electronics Co., Ltd., Industry-University Cooperation Foundation Korea Aerospace University
Inventors:
Heun Chul Lee, Bruno Clerckx, Young Ho Jung
Abstract: Stable, bent allenes, organometallic complexes of bent allenes are provided along with methods of conducting chemical processes such as olefin metathesis, comprising contacting an olefin substrate with an organometallic complex as described herein, under suitable conditions.
Type:
Grant
Filed:
January 9, 2009
Date of Patent:
March 25, 2014
Assignee:
The Regents of the University of California
Inventors:
Guy Bertrand, Vincent Lavallo, Adam C. Dyker
Abstract: A silicon nanowire includes metal nanoclusters formed on a surface thereof at a high density. The metal nanoclusters improve electrical and optical characteristics of the silicon nanowire, and thus can be usefully used in various electrical devices such as a lithium battery, a solar cell, a bio sensor, a memory device, or the like.
Type:
Grant
Filed:
March 31, 2011
Date of Patent:
March 25, 2014
Assignees:
Samsung Electronics Co., Ltd., Dongguk University Industry-Academic Cooperation Foundation
Inventors:
Gyeong-su Park, In-yong Song, Sung Heo, Dong-wook Kwak, Hoon Young Cho, Han-su Kim, Jae-man Choi, Moon-seok Kwon
Abstract: Molecules that interact with the NKT cell antigen receptor and its counterpart antigen presenting molecule, but which inhibit the NKT cell immune function, are administered to a patient. Conditions of particular interest include the treatment of systemic lupus erythematosus (SLE), cancer, atherosclerosis, and allergic disease. In some embodiment of the invention, the inhibitory agent is an anergizing glycolipid, for example ?-galactosylceramide. Pharmaceutical formulations of such glycolipids are provided, and find use in the treatment of diseases involving undesirable NKT cell activation.
Type:
Grant
Filed:
February 1, 2010
Date of Patent:
March 25, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Samuel Strober, Everett Hurteau Meyer, Dale T. Umetsu
Abstract: Techniques for determining an equilibrium structure of a protein in a predetermined environment, the protein having Ramachandran angles and a known denatured structure, are disclosed. One example method includes determining a maximum RMS volume of the known denatured structure of the protein and calculating at least one force on the protein in its current structure in the predetermined environment. The net torque resulting from the at least one force for each of the Ramachandran angles of the protein is then determined. Then at least one section of the protein structure on a side of a Ramachandran angle with the greatest torque is rotated to form a new structure. A RMS volume for the new structure is then calculated, and the method is repeated using the new structure until the new RMS volume of the new protein structure is not less than the RMS volume of the starting structure.
Type:
Grant
Filed:
April 27, 2007
Date of Patent:
March 25, 2014
Assignee:
The Research Foundation of State University of New York
Abstract: A nucleic acid cleavage kit is used to cleave a target nucleic acid. The nucleic acid cleavage kit includes a carrier, an oligonucleotide, and a nucleic acid cleavage agent. The oligonucleotide recognizes at least partial sequence of the target nucleic acid. Then, the nucleic acid cleavage agent cleaves the target nucleic acid. A nucleic acid cleavage detection apparatus including the nucleic acid cleaving kit and a gene therapy by administering the nucleic acid cleavage kit are also disclosed.
Abstract: The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of drug discovery, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
Type:
Grant
Filed:
June 26, 2009
Date of Patent:
March 25, 2014
Assignee:
The Regents of the University of California
Inventors:
Felix Olasagasti, Kate Lieberman, Seico Benner, Mark A. Akeson
Abstract: An article of manufacture and a method of defining a photodetector element are provided. The article of manufacture includes a photodector element comprising a junction formed by a first III-V semiconductor layer having a first charge type and a second III-V semiconductor layer comprising a second dopant having a second charge type. The second III-V semiconductor layer is disposed between the first III-V semiconductor layer and a wafer. Patterned dopant regions having a third charge type, the third charge type being the same as the first charge type, are disposed in the first III-V semiconductor layer.
Type:
Grant
Filed:
February 18, 2011
Date of Patent:
March 25, 2014
Assignee:
University of Iowa Research Foundation
Inventors:
John P. Prineas, Jonathan T. Olesberg, Chris Coretsopoulos
Abstract: The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.
Type:
Grant
Filed:
February 13, 2012
Date of Patent:
March 25, 2014
Assignees:
Vermillion, Inc., The Johns Hopkins University
Inventors:
Daniel W. Chan, Zhen Zhang, Eric Fung, Xiao-Ying Meng
Abstract: A hybrid nanostructure array having a substrate and two types of nanostructures, including a set of first nanostructures extending from the substrate and a set of second nanostructures interspersed among the first nanostructures. The first and second nanostructures comprise structures having nanoscale proportions in two dimensions and being elongate in the third dimension. For example, the nanostructures can be nanotubes, nanowires, nanorods, nanocolumns, and/or nanofibers. Also disclosed is a hybrid nanoparticle array using two different types of nanoparticles that have all three dimensions in the nanoscale. The two types of nanostructures or nanoparticles can vary in composition, shape, or size.
Type:
Grant
Filed:
July 22, 2009
Date of Patent:
March 25, 2014
Assignee:
The Regents of The University of Michigan
Abstract: The working support robot system of the present invention includes: a robot arm (11); a measuring unit (12) for measuring the worker's position; a work progress estimation unit (13) for estimating the work progress based on data input from the measuring unit (12) while referring to data on work procedure, and for selecting objects necessary for the next task when the work is found to have advanced to the next procedure; and an arm motion planning unit (14) for planning the trajectory of the robot arm (11) to control the robot arm (11) based on the work progress estimated by the work progress estimation unit (13) and selected objects. The working support robot system can deliver objects such as tools and parts to the worker according to the work to be performed by the worker.
Type:
Grant
Filed:
May 21, 2010
Date of Patent:
March 25, 2014
Assignees:
Toyota Motor East Japan, Inc., Tohoku University
Inventors:
Kazuhiro Kosuge, Yusuke Sugahara, Jun Kinugawa, Yuta Kawaai, Akiyoshi Ito, Yoichi Matsui, Shinji Kawabe
Abstract: A novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed.
Type:
Grant
Filed:
May 3, 2007
Date of Patent:
March 25, 2014
Assignees:
The United States of America, as represented by the Secretary, Department of Health and Human Services, University of Maryland, Baltimore, The United States of America as Represented by the Department of Veterans Affairs
Inventors:
Susan K. Keay, Zoltan Szekely, Thomas Conrads, Timothy Veenstra, Maria Michejda
Abstract: The present invention relates to diarylhydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
Type:
Grant
Filed:
October 24, 2008
Date of Patent:
March 25, 2014
Assignee:
The Regents of the University of California
Abstract: A lighting device such as an electronic ballast or LED driver includes a power factor correction (PFC) controller responsive to input power supply signals to generate control signals, a PFC boost converter responsive to said control signals to generate a boosted output voltage, and a fast start circuit with a power supply source and an energy storage device, a magnitude of the input power supply signal corresponding to energy stored in the energy storage device. During a first mode, the fast start circuit responds to a rectified mains input to enable the power supply source and charge the energy storage device. During a second mode, the fast start circuit responds to a magnitude of the power supply signal to disable the power supply source and discharge the energy storage device. The boost converter during the second operating mode maintains controller operation while the power supply source is disabled.
Abstract: Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.
Type:
Grant
Filed:
November 12, 2008
Date of Patent:
March 25, 2014
Assignees:
The Regents of the University of California, Meritage Pharma, Inc.
Inventors:
Ranjan Dohil, John Bastian, Seema Aceves
Abstract: The present invention discloses a phosphor material for organic optoelectronic devices. The phosphor is a complex comprising a metal (Ir or Pt) and an aryl-modified beta-diketone ligand. The complexes of this invention are useful to function as an emitter in the emissive layer of an organic light emitting diode, even as the complex is the main component of this layer.
Abstract: Compositions and methods are provided for the use of nanoparticles, which may be referred to herein as mass dots, as mass tags for probes such as antibodies, aptamers, nucleic acids, etc. in multiplexed bioassays with ICP-MS detection.
Type:
Grant
Filed:
January 11, 2012
Date of Patent:
March 25, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Garry P. Nolan, Erin F. Simonds, Sean C. Bendall