Abstract: Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties. In one example, disclosed are high density multiplexed chips with a plurality of groups, each group including a plurality of nanodevices, the chips capable of coupling to one or more multiwell structures for providing samples to each individual group. In this way, the chips can be used for high-throughput analysis of molecules such as DNA.

Abstract: The device of the present disclosure is configured for laparoscopic use, particularly to insert a fastener into a plate at an angle of up to 180° from the plane of insertion. The device is further configured to carry a plurality of fasteners, a tightening tool, a cutting device, and tweezers simultaneously to facilitate a rapid procedure while lessening the chance of infection by limiting the amount of times the device must be removed and re-inserted.

Abstract: Provided is a method for inducing T cells for a cell-based immunotherapy, comprising the steps of: (1) providing Rag 1 and/or Rag 2 gene knockout human pluripotent stem cells bearing genes encoding a T cell receptor specific for a desired antigen, and (2) inducing T cells from the pluripotent stem cells of step (1). Further provided are a cell-based immunotherapy method that uses the T cells for the cell-based immunotherapy and an iPS cell bank for the cell-based immunotherapy.

Abstract: A system for treatment and/or psychology intervention of attention deficit disorders in a user in need thereof. The system uses a head mounted display equipped with an eye tracking device. The system is configured to display a scene that includes a principal object and at least one secondary object, then use the eye tracking device to determine whether the user's gaze is directed to one of the objects. If the user's gaze is directed to one of the secondary objects beyond a threshold criterion, that secondary object is removed from the scene. If the user's gaze is directed to the principal object beyond a threshold criterion, a previously removed secondary object is reintroduced into the scene. The principal object is a desired object of the user's attention, while the secondary object(s) may be potentially or known distracting objects. Corresponding software and methods are also disclosed.

Abstract: An automated inventory monitoring system includes an image capture module able to create an image of an aisle of a retail store. Product images and shelf label and peg label images are identified in the image and products are associated with product labels based on the positioning of the products with respect to the labels. Based on the association between labels and products, out-of-stock products are detected and reported to the retail store.

Abstract: A machine learning-based method for designing a high-strength high-toughness steel, including: (S1) obtaining data and filling in missing parts to form a data set; (S2) selecting feature data in the data set to form a standard data set; (S3) constructing two machine learning models of the high-strength high-toughness steel; (S4) completing training after the two models are evaluated to be qualified; (S5) finding frontier points, drawing a Pareto front, and distinguishing a known region and a feature space; (S6) in the feature space, setting a step for the feature data, drawing a grid space, and performing multiple training predictions on each grid point by using the models, to obtain predicted Gaussian distributions of two objectives; and (S7) searching for an expected improvement point through an efficient global optimization algorithm, and obtaining design parameter values of corresponding features.

Abstract: The invention provides a series of GMPS enzyme inhibitors. The invention includes potent GMPS inhibitors that specifically and covalently bind to GMPS, exhibit broad anti-cancer activity, block the infection efficiency of viruses, and have the potentials to suppress undesired immune responses. These novel inhibitors of GMPS, and their derivatives, have tremendous potentials to be used as therapeutic agents for the treatment of cancers, viral infection and immune disorders.

Abstract: Systems and methods for calibrating a heliostat (104) are disclosed. An imaging device (100) is positioned and oriented so that a calibration target (130) reflected by the heliostat (103) is visible at the imaging device and an image taken. Multiple features of the reflected calibration target in the image are identified and used to determine a centroid of reflection within the image which is then mapped to a corresponding centroid position on the calibration target. A vector t that extends between the centroid position on the calibration target and a known position of the heliostat, as well as a vectors that extends between the known positions of the imaging device and of the heliostat, are determined. A normal vector n of the heliostat is determined as the vector that bisects s and t and is used to calibrate the heliostat by updating parameters of a heliostat tracking model.

Abstract: A method of producing a cathode material for a lithium-ion battery includes combining an electrode precursor material and humic acid in an alkaline slurry, drying the alkaline slurry to produce a powder of humic acid-coated electrode precursor material, and heating the powder to produce the electrode material comprising graphene-coated particles.

Abstract: A system includes a body comprising a conduction path, and first and second modules disposed along, and movable relative to, the body, each of the first and second modules including an energy storage device, a terminal, and a power management unit coupling the energy storage device and the terminal. The terminal of each of the first and second modules is capacitively coupled with the conduction path for bidirectional power transfer between the first and second modules via the conduction path.

Abstract: A method of electrochemical sensing includes providing an electrochemical sensor comprising a glassy carbon substrate and gold nanoparticles located on a surface of the glassy carbon substrate; and sensing electrochemically a compound selected from the group consisting of polyfluoroalkyl compounds or perfluoroalkyl compounds using the electrochemical sensor. PFOA quantification was performed by Square Wave Adsorptive Cathodic Stripping Voltammetry (SW-AdCSV) in test solutions with a 100-5,000 ppt concentration. The concentration has a linear relationship with the stripping current within this range. Analysis of tap and groundwater samples performed by additions method demonstrated precision and accuracy above 95%. These electrodes show stability throughout 200 cycles, and reproducibility across similarly prepared but different electrodes above 97.5%.

Abstract: An IL-11 binding receptor capable of binding to IL-11 and inhibiting IL-11 mediated signalling is disclosed. Also disclosed are compositions comprising the IL-11 binding receptor and methods using the IL-11 binding receptor.

Abstract: Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure.

Abstract: One object of the present invention is to provide an inhibitor for renal injuries induced by a hemolytic reaction. In this invention, cilastatin or a pharmaceutically acceptable salt thereof is used.

Abstract: Disclosed herein are methods for preparing sporopollenin exine capsules (SECs) and methods for preparing composite materials that comprise SECs that utilize ionic liquid compositions. The composite materials typically include structural polymers and the SECs, and the SECs optionally may encapsulate useful materials, such as flame retardant materials, phase change materials, and therapeutic materials, such as probiotics and prebiotics. The composite materials may be prepared from ionic liquid compositions comprising the structural polymers and the SECs which optionally may encapsulate the useful materials, where the ionic liquid is removed from the ionic liquid compositions to obtain the composite materials comprising the SECs.

Abstract: The present disclosure discloses a method and system for recognizing human action in an apron based on thermal infrared vision, the method comprises: acquiring a plurality of video sequences from an infrared monitoring video; labeling a set target in each image frame in each video sequence with a target box to obtain a target tracking result; intercepting, for each image frame in the video sequence, a target-box enlarged area according to the labeled target box; adding, for each image frame in the video sequence, the position information of the image labeled with target box to the target-box enlarged area to obtain a three-channel sub-image; training an action recognition model by using three-channel sub-image sequences corresponding to a plurality of video sequences as a training set, to obtain a trained action recognition model; obtaining a to-be-recognized video sequence from another infrared monitoring video, and obtaining a three-channel sub-image sequence corresponding to the to-be-recognized video sequ

Abstract: The present disclosure discloses a high-whiteness polyimide microfiber and a preparation method thereof and use. The polyimide fiber includes polyimide obtained from the reaction of wholly alicyclic dianhydride HTDA and an aromatic diamine monomer containing methyl or trifluoromethyl by chemical imidization. In the present disclosure, the polyimide microfiber has both excellent heat-resistant stability and spinning film-forming property, and the fabric has ultra-high whiteness. The microfiber fabric prepared from the polyimide fiber may be used as a component with high-temperature resistant and high-whiteness in personal protective equipment such as mask and protective clothing, and also may be used as an electronic component in the high-tech field such as aerospace, optoelectronic, microelectronic and automobile.

Abstract: A method of managing real-time electrical energy storage management from an electricity storage device to maximise the reduction of the use of a mains electricity grid during peak cost charging periods on the mains electricity grid, including: calculating an ideal offline use of the electricity storage device using ideal predicted parameters; calculate a plurality of electrical storage device storage and electrical discharge models using a plurality of algorithms based on recorded data; calculate the competitive ratio for each of the algorithms and the ideal offline use; and use power from the electricity storage device based on an optimal competitive ratio.

Abstract: The present invention provides a real-time path planning method taking into account dynamic properties of vehicles; the method includes a calculation without connecting to internet of a reachable set and an online path planning; in the calculation without connecting to internet of the reachable set, all vehicle safety states are traversed by means of the vehicle model and the wheel model, thereby predicting the position set capable of being reached by the vehicle at a next moment; in the online path planning, by means of calculating the position set capable of being reached by the vehicle at the next moment with connecting to internet, non-linear dynamic constraints are provided for the exploration of the artificial potential field method, achieving the purpose of real-time planning while taking into account dynamic properties of the vehicles.

Abstract: Provided is a method for driving behavior modeling based on spatio-temporal information fusion, relating to the field of driving behavior simulations. The method includes: constructing a driving behavior model, where the driving behavior model includes a spatial information encoding network, a temporal information encoding network, a feature fusion network, and a feature decoding network, with the feature fusion network being connected to both the spatial information encoding network and the temporal information encoding network, and the feature decoding network being connected to the feature fusion network; determining a future trajectory sequence of a target main vehicle at future time points based on the trained driving behavior model according to spatial information and temporal information of the target main vehicle, where the target main vehicle is controlled to travel according to the future trajectory sequence at the future time points.