Abstract: A method of manufacturing a microfluidic analytical device comprising providing a top lamination layer and a bottom lamination layer, wherein each of the top lamination layer and bottom lamination layer comprises an outer layer and an inner layer, cutting out one or more channel spaces from the at least one of the top lamination layer and the bottom lamination layer, wherein the one or more channel spaces form a microfluidic path, positioning at least one middle layer between the top lamination layer and the bottom lamination layer, such that each of the two inner layers face the at least one middle layer, and subjecting the top lamination layer and the bottom lamination layer to a process, wherein the process allows both the inner layers to permeate substantially through the at least one middle layer.

Abstract: Insulated assemblies, insulation units including an assembly, and methods of forming the assemblies and units are disclosed. Exemplary assemblies include a first pane of material, a second pane of material, and one or more monolithic insulating layers interposed between the first pane of material and the second pane of material. The insulating layer can exhibit a thermal conductivity less than 26 mW/(K.m).

Abstract: Methods and systems for fabricating 3D electronic devices, such as multielectrode arrays, including metalized, 3D printed structures using integrated 3D printing and photolithography techniques are disclosed. As one embodiment, a multielectrode array comprises a flexible substrate, a plurality of photopatterned electrical traces spaced apart and insulated from one another on the substrate, and a plurality of 3D printed electrodes. Each 3D printed electrode comprises a photopolymer coated in metal and has a 3D structure that extends outward from the substrate, and each 3D printed electrode is electrically connected to a corresponding electrical trace of the plurality of photopatterned electrical traces.

Abstract: Systems, methods, network devices, and machine-readable media disclosed herein include executing a secure algorithm for computing on a plurality of machines in a cluster by receiving a large input message and dividing the large input message into a plurality of initial input messages, computing an encryption of initial input messages, and evaluating a cluster computing circuit using a homomorphic encryption scheme.

Abstract: A power generator or sensor apparatus is provided. Another aspect employs a hybrid triboelectric and electromagnetic generator. In still another aspect, a power generator is used for water wave energy harvesting. A further aspect provides a power generator including an outer housing with an electrical conductor on an exterior thereof, radial overlapping electrodes located within the housing with a dielectric layer between the electrodes, a plate linearly moveable within the housing, at least one magnet affixed to the plate, and at least one spring biasing the plate within the housing. Moreover, an aspect of the present power generator includes a modularized connection configuration to linearly secure together multiples of the housing.

Abstract: This invention relates to dermatology and to treatments of infectious skin disease.

Abstract: Examples of a negative pressure wound closure system and methods for using such a system are presented. Certain embodiments facilitate closure of the wound by preferentially contracting to provide for movement of the tissue. Certain embodiments can utilize tissue securing portions that aid in securing the system within a wound.

Abstract: This disclosure provides HIV immunogens and use thereof for generating an immune response in a subject. Also disclosed is a method of isolating anti-HIV antibodies and use thereof. This disclosure further provides a method for treating or preventing a human immunodeficiency type 1 (HIV-1) infection in a subject using the disclosed HIV immunogens and/or antibodies.

Abstract: There is provided a system and method of selectively monitoring ions in a fluid medium using a graphene sensor, the method comprising the step of adjusting an operating frequency of the graphene sensor to a particular resonant frequency for targeting resonance of specific ions in the fluid medium. In the proposed method, dispersive effect of the fluid medium is used to tune the graphene sensor to a desired frequency, thereby obtaining resonance response for specific ions in the fluid medium. Also, the monitoring of a specific ion in the fluid medium is unaffected by presence of a plurality of other ions in the said fluid medium.

Abstract: The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.

Abstract: A self-aware composite mechanical metamaterial, comprising first and second electrically conductive components disposed relative to each other to act as opposite electrodes to induce contact electrification; wherein the first and second electrically conductive components, along with a dielectric component serving as a skeleton of the self-aware composite mechanical metamaterial, form a lattice of snapping curved semicircular-shaped segments, wherein each of the snapping curved semicircular-shaped segments has an elastic snap-through instability mechanism; and wherein the lattice comprises periodic repeatable parallel rows of the snapping curved semicircular-shaped segments.

Abstract: The disclosure relates to Prostnglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, epilepsy, neuroinflammation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof.

Abstract: A mechanical system includes a curved beam and a motor coupled to the curved beam. The curved beam is configured to buckle at two different locations along the positive and negative portions of its load/displacement curve, corresponding to opposite and equal sense bending directions. The motor is configured to impart a flapping motion to the curved beam.

Abstract: An aluminum alloy pre-strengthening and hot forming production line is provided, including a pre-strengthening heat treatment mechanism, a forging mechanism, and a trim press. The pre-strengthening heat treatment mechanism includes a roll forging machine, a solid solution furnace, a quenching water tank, an aging furnace, and a heat preservation furnace. The forging mechanism includes an upsetting press machine, and a forging press machine. The upsetting press machine is configured for blanking an heat preserved aluminum alloy bar-shaped blank, and the forging press machine is configured for forging and forming the blanked aluminum alloy bar-shaped blank. The trim press is configured for trimming the forged and formed aluminum alloy rod-shaped blank, so as to obtain an aluminum alloy member meeting a requirement.

Abstract: The invention develops a novel hole-transporting material (HTM), PTAA-P1 and PTAA-P2 via the backbone engineering strategy to modulate wettability and promote anchoring. The HTM properties can be effectively modified by varying the linkage sites of incorporated pyridine units. The 3,5-linked PTAA-P1 particularly demonstrates a more regulated molecular configuration for interacting with perovskites, forming a highly crystalline perovskite film with uniform back contact and reduced defect density. The invention also develops the perovskite solar cell including the novel HTM with remarkable PCE efficiency and stability for small-area and large-area solar cells. The invention also develops the method for fabricating the perovskite solar cell.

Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.

Abstract: A reconfigurable device-based programmable wiring system includes switches. A total number of switches is based on a total number of peripheral terminals and a total number of microcontroller pins. The total number of switches is based on a product of a total number of peripheral terminals and a total number of microcontroller pins. The reconfigurable device-based programmable wiring system includes multiple microcontroller peripherals.

Abstract: Systems, methods, network devices, and machine-readable media disclosed herein include encoding data for storage or transmission by encoding the data according to a tamper-resistant data encoding scheme that renders the data secure against unbounded polynomial size attacks. The present disclosure further includes subsequently determining whether the data has been tampered with, and notifying a processor when the data has been modified or compromised.

Abstract: The present application relates to a service decision method and a service decision device. The method includes: receiving a task request sent by a terminal, the task request including a terminal identifier, terminal location information and task information of the terminal; determining that the terminal is currently in an overlapping coverage area, generating a decision-making instruction according to the task request and a target decision network, and sending the decision-making instruction to the terminal according to the terminal identifier, the decision-making instruction being used to indicate whether a target unmanned aerial vehicle server provides to the terminal a service corresponding to the task request, and the target decision-making instruction being used by the terminal to select one server from among the target unmanned aerial vehicle server and the other unmanned aerial vehicle servers to provide the service. Using the present method can improve resource utilization.

Abstract: A method of making a polyurethane polymerized high internal phase emulsion (polyHIPE) is disclosed. The method involves preparing a polyurethane prepolymer and crosslinking the polyurethane prepolymer using a thiol-alkene Michael addition, producing a polyurethane polymerized high internal phase emulsion. In one embodiment, the polyurethane prepolymer is prepared by reacting diisocyanate and trimethylolpropaneallylether (TMPAE).