Abstract: Systems and methods for wireless simultaneous transmit and receive (STAR) using multi-input multi-output (MIMO) radiofrequency (RF) front-ends are provided. A MIMO front-end can be based on the use of a symmetrical pair of arrays, in which one is used for communication while the other is used inside an RF-shielded chamber to act as a reference for subtracting self-interference between transmitters and receivers. In addition to the two arrays, the system can include two identical passive microwave multi-beam beamforming networks. The beamformer networks can be, for example, Butler Matrix based, true-time delay microwave networks, or Rotman lens based.

Abstract: Compounds and pharmaceutical compositions comprising a derivative of sulfuretin are provided that are inhibitors of the endoplasmic reticulum oxidoreductin-1 alpha. A method of treating a patient having cancer comprising administering to the patient a therapeutically effective amount of a compound that is a derivative of sulfuretin that are inhibitors of the endoplasmic reticulum oxidoreductin-1 alpha to a patient is disclosed.

Abstract: CRISPR RNA-guided nucleases are routinely used for sequence-specific manipulation of DNA. While CRISPR-based DNA editing has become routine, analogous methods for editing RNA have yet to be established. Here we repurpose the type III-A CRISPR RNA-guided nuclease for sequence-specific cleavage of the SARS-COV-2 genome. The type III cleavage reaction is performed in vitro using purified viral RNA, resulting in sequence-specific excision of 6, 12, 18 or 24 nucleotides. Ligation of the cleavage products is facilitated by a DNA splint that bridges the excision and RNA ligase is used to link the RNA products before transfection into mammalian cells. The SARS-COV-2 RNA is infectious and standard plaque assays are used to recover viral clones. Collectively, this work demonstrates how type III CRISPR systems can be repurposed for sequence-specific editing of RNA viruses including SARS-COV-2 and more generally for gene therapy.

Abstract: The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.

Abstract: Provided are compositions and methods of use of a pharmaceutical composition in the manufacture of a medicament for preventing or treating a diabetic kidney disease, the pharmaceutical composition including a chemokine C-C motif ligand 7 (CCL7) antagonist and/or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. The medicament can prevent or treat diabetic kidney disease by protecting tubular epithelial cells, reducing glomerular hypertrophy, glomerulosclerosis, and fibrosis. The present disclosure also provides a method for preventing or treating a diabetic kidney disease in a subject in need thereof, including administering an effective amount of a CCL7 antagonist and/or a pharmaceutically acceptable salt thereof to the subject to inhibit an activity of CCL7.

Abstract: Non-viral delivery platforms are provided for facilitating transport of molecules across cell membranes. In some forms, DNA/RNA nanoshells capable of transporting cargo molecules are formed, and may be formed in order to surround a variety of materials for a variety of purposes.

Abstract: The present invention is a method for quickly determining the position of a signal mouthpiece of spraying equipment. The spraying equipment includes a bolt, a water intake signal mouthpiece, an outlet cover plate, a sprayer body, a water storage vessel, a scale line, a conduit and a water inlet connecting mouthpiece. The water intake signal mouthpiece is adjusted to a critical point, and a reference position of the water intake signal mouthpiece is marked. The water intake signal mouthpiece is adjusted to obtain a water intake area S1. The conduit is disconnected with a water intake port. The time t1 is recorded, and the flow coefficient ? of the signal water of the spraying equipment is calculated. M scale lines are drawn equidistantly on the outlet cover plate, and are marked with scales in turn. The optimization of the position of the signal mouthpiece of the spraying equipment is realized.

Abstract: Systems and methods for a multi-primary color system for display. A multi-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. One embodiment of the multi-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.

Abstract: An improved organic light emitting device is disclosed that includes an emissive layer between an anode and a cathode, where the emissive layer has an aggregate of one or more neutral transition metal complexes having a square planar geometry. At least one of the one or more neutral transition metal complexes has a coordination metal selected from Ni, Pd, and Au. When a voltage is applied across the anode and cathode at room temperature, the emissive layer emits a luminescent radiation that has a first luminescent radiation component produced from exciplex formation by the transition metal complexes present in the emissive layer, and the first luminescent radiation component has a peak maximum wavelength ?max that is ?500 nm at room temperature.

Abstract: A particle discrimination mechanism includes: a channel in which a plurality of first nanoparticles each including an absorber having a predetermined absorption level and a plurality of second nanoparticles each of which does not include the absorber having the predetermined absorption level exist, the channel including a first input section and a second input section; a laser that outputs first light, which is absorbed by the absorber having the predetermined absorption level, in a direction from the first input section toward the second input section; a laser that outputs second light, which is not absorbed by the absorber having the predetermined absorption level but is scattered or absorbed by the second nanoparticles, in a direction from the second input section toward the first input section.

Abstract: Methods and systems provide a human kidney perfusion model with dual blood supply channels, permitting two kidneys from the same donor to be pumped simultaneously for rigorously controlled therapeutic testing.

Abstract: The present invention relates to an activity recognition apparatus and method in sports videos using CGAM.

Abstract: A method may include delivering stimulation to a nerve of a patient using a first set of stimulation parameters. The method may further include detecting a first heart rate change within a range between a baseline heart rate and a predefined threshold. The method may further include, subsequent to detecting the first heart rate change, detecting a second heart rate change that is outside of the range between the baseline heart rate and the predefined threshold. The method may further include delivering stimulation to the nerve of the patient using a second set of stimulation parameters based on the second heart rate change being outside of the range between the baseline heart rate and the predefined threshold.

Abstract: Provided herein is a tunnel electromagnetic joint scanning detection method and a system thereof. It introduces a new tunnel electromagnetic detection system called TEJS, realizes three-dimensional joint inversion of multi-component, time domain and frequency domain signals, and forms tunnel joint scanning imaging. This method adopts the mode of surface transmission, underground reception, multi-source transmission and multi-component reception. Based on an observation system, a large number of stochastic models are constructed and numerically simulated, and a large number of training data sets are constructed by using the simulated data to complete the training of UNet model. This model can realize real-time and fast imaging of the position of the low-resistance anomalous body in three-dimensional space. An algorithm forms a dual checking mechanism through surface imaging and underground imaging, which constrains the three-dimensional spatial position of anomalous body together to prevent misjudgment.

Abstract: A conjugate cam reducer includes input and output units disposed at two opposite sides of a transmission unit along an output axis. The transmission unit includes input-side and output-side cam discs having first and second grooved surfaces. The input unit includes an input disc having a plurality of first receiving grooves registered with the first grooved surfaces to receive input rollers, and an eccentric shaft rotated to drive rotation of the transmission unit in an eccentric cam motion. The output unit includes an output disc having an inner peripheral wall which engages with the output-side cam disc, and a plurality of second receiving grooves which are registered with the second grooves to receive output rollers. An outer diameter of each first toothed surface and an outer diameter of each second toothed surface is gradually increased along a direction parallel to the output axis.

Abstract: The present invention includes systems and methods for a multi-primary color system for display. A multi-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. One embodiment of the multi-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.

Abstract: Radioisotope-labeled small molecule activity-based probes that target the cancer associated serine hydrolase neutral cholesterol ester hydrolase 1 (NCEH1) are described. The probes can undergo a reaction with the NCEH1, resulting in covalent bonding of a portion of the probe molecule to the NCEH1. Also described are methods of labeling NCEH1 in biological samples, such as cells or tissue, and methods of visualizing tumors using the radioisotope-labeled NCEH1 probes as tracer compounds, either alone or in combination with assessing the efficacy of a cancer treatment or potential cancer treatment.

Abstract: A sense amplifier flip-flop includes a first stage configured to generate, in response to a rising edge of a clock signal, a first latch signal and a second latch signal by pulling down a first pull-down node or a second pull-down node according to a data input and an inverted data input, wherein the first stage includes a bridge circuit configured to electrically connect the first pull-down node and the second pull-down node to each other in response to an activated bridge signal, and a control circuit configured to activate the bridge signal when the data input transitions while the clock signal is logic high.

Abstract: A functional ultrathin battery separator and method for fabricating the same is disclosed. The battery separator includes a polymer substrate that is flexible, and a functional barrier layer deposed on the polymer substrate. The functional barrier layer is polycrystalline and includes a metal-organic framework and a plurality of micropores. The functional barrier layer is able to flex with the polymer substrate. The functional barrier layer is compact, such that diffusion pathways through the functional barrier layer are limited to a cutoff size, and such that the diffusion pathways that are largest are located within grains of the polycrystalline functional barrier layer rather than between grains. The battery separator may be less than 10 ?m thick, and the polymer substrate may be less than 9 ?m thick. The metal-organic framework may be ZIF-8, and the functional barrier layer may be less than 2 ?m thick.

Abstract: Disclosed herein are clay swelling inhibitor compositions and methods for using them to treat oil and gas wells and subterranean formations. In a specific embodiment, the clay swelling inhibitor composition includes: calcium chloride from about 40 wt % to about 60 wt %; potassium bicarbonate from about 15 wt % to about 25 wt %; potassium formate from about 25 wt % to about 35 wt %; and additives. In another specific embodiment, the clay swelling inhibitor composition includes: potassium citrate from about 50 wt % to about 60 wt %; cesium formate from about 20 wt % to about 30 wt %; potassium acetate from about 15 wt % to about 25 wt %; and additives.