Abstract: In some aspects, the present disclosure provides a nanoparticle composition comprising tRNA and an aminolipid delivery compound. The aminolipid delivery compound may be a dendrimer, dendron, or dendritic lipid, a polymer such as a polyamide or polyester, or a lipid with one or more hydrophobic components. In some embodiments, these compositions may be administered to a patient to treat a genetic disease or disorder such as cystic fibrosis, Duchene muscular dystrophy, or cancer.

Abstract: The present invention relates to a polypeptide and application thereof in preparation of an anti-fibrosis drug. The polypeptide of the present invention has an amino acid sequence as shown in SEQ ID NO. 1. The polypeptide of the present invention has good cell penetrability, can efficiently enter target cells, can permanently exist in a target organ after reaching the target organ, and has no obvious toxic or side effect in an effective dose range; can effectively inhibit a classic signaling pathway of fibrosis, thereby inhibiting expression of proteins, such as fibrosis markers and extracellular matrices; and can effectively inhibit fibrosis of a target organ and improve functions of the target organ. A new drug and a solution are provided for clinical treatment of fibrosis diseases, and the polypeptide has important significance for improving a clinical treatment effect of the fibrosis diseases and improving life quality of patients.

Abstract: An aluminum alloy pre-strengthening and hot forming production line is provided, including a pre-strengthening heat treatment mechanism, a forging mechanism, and a trim press. The pre-strengthening heat treatment mechanism includes a roll forging machine, a solid solution furnace, a quenching water tank, an aging furnace, and a heat preservation furnace. The forging mechanism includes an upsetting press machine, and a forging press machine. The upsetting press machine is configured for blanking an heat preserved aluminum alloy bar-shaped blank, and the forging press machine is configured for forging and forming the blanked aluminum alloy bar-shaped blank. The trim press is configured for trimming the forged and formed aluminum alloy rod-shaped blank, so as to obtain an aluminum alloy member meeting a requirement.

Abstract: System and methods for producing synthesis gas are provided. The system includes a reactor and a steam generation system designed to provide precise control of the rate of steam generation to mix steam with fuel gas to produce humidified fuel gas, which is then fed into a combustion chamber of the reactor. The molar ratio of hydrogen to carbon monoxide in the synthesis gas output from the reactor may be accurately controlled by adjusting the humidity of the fuel gas input into the combustion chamber.

Abstract: A single-material-double-process parametric laser-wavelength converter includes a pump-laser source, a nonlinear optical material, a first optical reflective element, and a second optical reflective element. The pump-laser source is configured to emit a pump-laser pulse light. The nonlinear optical material receives the pump-laser pulse and generates a signal-laser pulse and a partially depleted pump-laser pulse through optical parametric amplification. The first optical reflective element is configured to reflect the signal-laser pulse back to the same nonlinear optical material. The second optical reflective element is configured to reflect the partially depleted pump-laser pulse back to the same nonlinear optical material. With an appropriate adjustment on the reflecting path lengths, the nonlinear optical material is configured to receive the temporally synchronized signal-laser pulse and the partially depleted pump-laser pulse to generate an idler output through difference frequency generation.

Abstract: A deep learning based method for integrating demand forecasting and scheduling of online ride-hailing at a hub is provided. The method includes: S1, performing data processing: performing missing value filling, outlier processing and normalization processing on the historical orders of online ride-hailing and relevant feature data of the urban transportation hub; S2, performing feature screening: primarily screening the relevant features by means of a Pearson correlation test and box plot analysis, calculating an influence degree of data of each feature on the orders of online ride-hailing by using an XGBoost algorithm, and secondarily screening the features; S3, performing model construction: constructing an integrated model for demand forecasting and scheduling decision of online ride-hailing at the urban transportation hub; and S4: performing algorithm design: designing a decision tree and deep learning combination algorithm, and calculating the number of online hailed rides to be scheduled.

Abstract: Provided herein are compositions and methods of making high density nucleic acid polymers.

Abstract: Compositions suitable for reversibly storing heat in thermal energy systems (TES) include a salt hydrate represented by the formula: MXq·nH2O. M is a cation selected from Groups 1 to 14 of the IUPAC Periodic Table, X is a halide of Group 17, q ranges from 1 to 4, and n ranges from 1 to 12. The cation (M) may have an electronegativity of ? about 1.8 and a molar mass ? about 28 g/mol. The anion (X) may have an electronegativity of ?about 2.9 to ? about 3.2. A distance between a cation (M) and coordinating water molecules (H2O) is ? about 2.1 ?. Thermal energy systems (TES) incorporating such compositions are also provided that are configured to reversibly store heat in the thermal energy system (TES) via an endothermic dehydration reaction and to release heat in in the thermal energy system (TES) via an exothermic hydration reaction.

Abstract: The present disclosure provides an anti-PD-L1 antibody capable of repeated administration even to animals other than rat. The present disclosure further provides a novel therapeutic strategy using an inhibitor targeting PD-1/PD-L1. A pharmaceutical composition which comprises a COX-2 inhibitor and is administered before, after or simultaneously with the administration of an inhibitor targeting PD-1/PD-L1. A potentiator for the immunostimulatory effect of an inhibitor targeting PD-1/PD-L1, which comprises a COX-2 inhibitor. The present disclosure also provides an anti-PD-1 antibody capable of repeated administration even to animals other than rat.

Abstract: Provided are viral vector and recombinant Simian adenovirus. The viral vector carries at least one recombinant genome preparing from the Simian adenovirus genome by replacing E4orf6 gene, knocking out E3 gene, inserting EGFP gene at the loci of E3, or knocking out E1B55K gene. Recombinant Simian adenovirus could be preparing by transfecting the viral vector into host cells for packaging.

Abstract: The present invention relates to an image encoding and decoding technique, and more particularly, to an image encoder and decoder using unidirectional prediction. The image encoder includes a dividing unit to divide a macro block into a plurality of sub-blocks, a unidirectional application determining unit to determine whether an identical prediction mode is applied to each of the plurality of sub-blocks, and a prediction mode determining unit to determine a prediction mode with respect to each of the plurality of sub-blocks based on a determined result of the unidirectional application determining unit.

Abstract: An epidural needle with a mechanism to receive real-time feedback on the location of the epidural needle during insertion process of the epidural needle. In particular, the epidural needle includes a spring and a pair of needles coupled to a force-measuring sensor for a continuous measurement of the force at a tip of the epidural needle as the epidural needle is inserted. The spring is enclosed in a spring section between a lug section and a needle section. The lug section comprises the force-measuring sensor and the needle section comprises a needle to be inserted. The lug section, the spring section and the needle section are axially aligned along an epidural needle axis. A force is transmitted from the needle section through the spring of the spring section to the force-measuring sensor of the lug section.

Abstract: Embodiments pertain to a computer-implemented method of identifying at least one facial micro-expression pattern of a face of a subject by (1) receiving a plurality of images of the face of the subject, where the plurality of images represent consecutive images of the face of the subject taken sequentially during a period of time; (2) feeding the plurality of images into a machine-learning algorithm, where the machine-learning algorithm includes a diagonal micro attention (DMA) module that identifies at least one facial micro-movement between the plurality of images and correlates the facial micro-movement to at least one facial micro-expression pattern; and (3) outputting the facial micro-expression pattern of the face of the subject. Additional embodiments pertain to computing devices for identifying at least one facial micro-expression pattern of a face of a subject in accordance with the aforementioned processes.

Abstract: A structural control system for civil infrastructures with recovery-based performance under extreme environmental loading is provided. The recovery-based structural control system may be utilized in both newly constructed and existing buildings as a retrofit to reduce the vulnerability to extreme environmental loading. The structural control system combines steel plate shear wall (SPSW) and the shape memory alloy (SMA) to provide extra recovery ability in a building's main element or supplemental structural control systems. The combination of SMA with SPSW, as a lateral resistive force system, develops a self-centering, energy absorber that provides a re-useable and affordable steel plate shear wall, called Smart Self-Centered Shear Wall (SSCSW) system. In the SSCSW system, pre-straining is applied to SMAs to eliminate the residual deformation that is known to appear in long-term use.

Abstract: The presently-disclosed subject matter relates generally to GaAs/GaAsSb core-shell nanowire grown on silicon substrate, methods of growing such nanowire, and the use of said nanowires in various applications, including but not limited to photodetection applications.

Abstract: A field effect transistor including a substrate; a monolayer of a single crystal semiconducting transition metal dichalcogenide (TMD) on the substrate; a source contact and a drain contact to the strained monolayer; and a gate contact on the substrate; wherein the a gate voltage applied to the gate contact with respect to the source contact modulates a ferroelectric response of the monolayer when strained and a current through the monolayer between the source contact and the drain contact; and wherein the substrate is rigid and the monolayer experiences asymmetric lattice expansion when strained against the rigid substrate in response to an external magnetic field or the substrate is a strain engineered substrate inducing asymmetric lattice expansion of the monolayer.

Abstract: An apparatus includes a body and a plurality of members extending from the apparatus configured to form carvings with different geometries along 2D layered semiconductor material. The apparatus includes conductive pins positioned along the plurality of members that accommodate individual sensing of current-voltage characteristics per carving. The carvings can include small stripes and the apparatus can probe the electrical resistance of the small stripes of 2D layered semiconductors where the geometry defines strong current confinement, thus enabling the rapid extraction of sheet resistance for rapid comparison between material quality.

Abstract: The invention relates to methods for simultaneously measuring transcription, chromatin accessibility, surface markers, and immune receptor sequence of a biological sample at the single-cell level, comprising one or more cells.

Abstract: The invention provides anelastase inhibitor for use in the promotion of muscle regeneration in the treatment of a myopa-thy, as well as a method for promoting muscle regeneration in a subject with a myopathy, the method comprising providing the subject with a therapeutically effective amount of an elastase inhibitor. Further provided is a pharmaceutical composition comprising anelastase inhibitor for use in the promotion of muscle regeneration in the treatment of a myopathy. Elastase inhibitors may have a protective effect on muscle progenitor cells and their regenerative potential, which aids muscle cell regeneration. By protecting regenerative potential of muscle progenitor cells, elastase inhibitors enable or enhance the grown of new or existing muscle fibres.

Abstract: Methods and apparatuses for monitoring and regulating physiological states and functions are disclosed. Several embodiments include application of one or more microelectrode arrays to a dorsal root ganglion for measurement of sensory neuron activity, or stimulation of sensory reflex circuits. The methods and apparatuses can be used, for example, for monitoring or controlling bladder function in a patient.