Patents Assigned to ZymoGenetics
  • Human thyroid protein ZSIG45
    Patent number: 6500925
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig45, a novel human protein expressed in thyroid. The polypeptides, and polynucleotides encoding them, may be used for detecting human disease states and chromosomal abnormalities, and as a therapeutic. The present invention also includes antibodies to the zsig45 polypeptides.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: December 31, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Theresa A. Deisher, Paul O. Sheppard
  • Testis specific glycoprotein zpep10
    Patent number: 6498235
    Abstract: The present invention relates to zpep10 polypeptides and polynucleotides encoding the same. Zpep10 polypeptide is a testis-specific membrane glycoprotein. Zpep10 polypeptides would be useful for modulating spermatogenesis and egg-sperm interaction and would be useful to study or modulate these functions in in vitro or in vivo systems. The present invention also includes antibodies to the zpep10 polypeptides.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: December 24, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Christopher S. Piddington, Jeff L. Ellsworth
  • Growth factor homolog ZVEGF4
    Patent number: 6495668
    Abstract: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
    Type: Grant
    Filed: May 3, 2000
    Date of Patent: December 17, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Teresa Gilbert, Charles E. Hart, Paul O. Sheppard, Debra G. Gilbertson
  • Pancreatic and ovarian polypeptide, zsig58
    Publication number: 20020182677
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig58, a novel member of the TTGR family of proteins. The polynucleotides encoding zsig58 may, for example, be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: February 26, 2002
    Publication date: December 5, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Yasmin A. Chandrasekher
  • Zace2: a human metalloenzyme
    Publication number: 20020177211
    Abstract: Angiotensin-converting enzyme is a zinc metallopeptidase that plays roles in blood pressure regulation and fertility. The catalytic activities of angiotensin converting enzymes include the production of the potent vasopressor angiotensin II from angiotensin I, and the inactivation of the vasodilatory peptide bradykinin. Zace2 is a new form of human zinc metallopeptidase, characterized as an angiotensin converting enzyme paralog that is expressed primarily in tissues of the digestive system. Two murine orthologs are also described.
    Type: Application
    Filed: October 16, 2001
    Publication date: November 28, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Christopher S. Piddington, Charles Petrie, Kimberly E. Shoemaker, Paul D. Bishop
  • Growth factor homolog zvegf3
    Publication number: 20020177193
    Abstract: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO: 2 or residues 235-345 of SEQ ID NO: 2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
    Type: Application
    Filed: May 2, 2002
    Publication date: November 28, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Zeren Gao, Charles E. Hart, Christopher S. Piddington, Paul O. Sheppard, Kimberly E. Shoemaker, Debra G. Gilbertson, James W. West
  • Antibodies and methods of making antibodies to human thyroid protein zsig45
    Patent number: 6486304
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig45, a novel human protein expressed in thyroid. The polypeptides, and polynucleotides encoding them, may be used for detecting human disease states and chromosomal abnormalities, and as a therapeutic. The present invention also includes antibodies to the zsig45 polypeptides.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: November 26, 2002
    Assignee: Zymogenetics, Inc.
    Inventors: Theresa A. Deisher, Paul O. Sheppard
  • Nucleic acid molecules that encodes human Zven1
    Patent number: 6485938
    Abstract: The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: November 26, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Paul D. Bishop
  • Method for producing dimerized polypeptide fusions
    Publication number: 20020173621
    Abstract: Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof.
    Type: Application
    Filed: September 18, 2001
    Publication date: November 21, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Andrzej Z. Sledziewski, Lillian Anne Bell, Wayne R. Kindsvogel
  • Secreted proteins encoded by human chromosome 13
    Publication number: 20020173624
    Abstract: The present invention relates to polynucleotide and polypeptide molecules a for zsig46 polypeptide, a novel secreted protein located on human chromosome 13. The zsig46 polypeptides, and polynucleotides encoding them, are secreted proteins and may be used in the study of receptors for which a ligand has not yet been identified, of secretory pathways and the like. The present invention also includes antibodies to the zsig46 polypeptides.
    Type: Application
    Filed: November 9, 2001
    Publication date: November 21, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Debra G. Gilbertson
  • Adipocyte-specific protein homologs
    Patent number: 6482612
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig39, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The polypeptides, and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zsig39 polypeptides.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: November 19, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Jacqueline M. Humes
  • Murine interferon-alpha
    Publication number: 20020168378
    Abstract: Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain autoimmune diseases, the treatment of particular cancers, and the enhancement of the immune response against infectious agents. The present invention provides a new form of murine interferon-&agr;, which has applications in diagnosis and therapy.
    Type: Application
    Filed: September 12, 2001
    Publication date: November 14, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Andrew L. Feldhaus, Zeren Gao
  • Transmembrane polypeptide expressed by lymphocytes
    Publication number: 20020164764
    Abstract: White blood cells protect the body by inactivating and destroying foreign agents, including tumor cells. The specificity of the immune response is mediated by lymphocytes. Lymphocytes express certain transmembrane proteins on their cell surfaces that distinguish between normal lymphocyte cell types, as well as between normal and cancerous cells. These lymphocyte “markers” are used for diagnosis, prognosis, and therapy. Zsig16 is a new transmembrane protein that is expressed by human peripheral blood lymphocytes.
    Type: Application
    Filed: October 18, 2001
    Publication date: November 7, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Betty A. Haldeman, Richard D. Holly
  • Testis specific transcription factor ZGCL-1
    Publication number: 20020160487
    Abstract: Novel ZGCL-1 transcription factor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides, agonists and antagonists may be used within methods for promoting the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.
    Type: Application
    Filed: December 6, 2001
    Publication date: October 31, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: David P. Yee, Theresa A. Deisher
  • Adipocyte-specific protein homologs
    Publication number: 20020156243
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig37, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The polypeptides, and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zsig37 polypeptides.
    Type: Application
    Filed: July 23, 2001
    Publication date: October 24, 2002
    Applicant: ZymoGenetics, Inc.
    Inventor: Paul O. Sheppard
  • Methods for promoting growth of bone using ZVEGF4
    Patent number: 6468543
    Abstract: Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of zvegf4 in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of zvegf4.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: October 22, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Debra G. Gilbertson, Charles E. Hart
  • Human serine protease
    Patent number: 6468776
    Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. These enzymes are also used in a variety of diagnostic, therapeutic, and industrial contexts. Ztryp3 is a new member of the serine protease family.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: October 22, 2002
    Assignee: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Testis specific protein
    Publication number: 20020151492
    Abstract: Tissue-specific markers can be used to enhance diagnosis, staging, and treatment of cancer, as well as to detect metastases of tumors derived from that tissue. The present invention provides a novel human gene, designated as “Zalpha16,” which is preferentially expressed in testicular tissue.
    Type: Application
    Filed: October 25, 2001
    Publication date: October 17, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Andrew L. Feldhaus, Susan D. Holderman
  • Zalpha13: a human secreted protein
    Publication number: 20020151013
    Abstract: Secreted proteins perform many functions that are essential for the metabolism and differentiation of cells. As such, this class of proteins often provides therapeutically useful pharmaceuticals. The present invention provides a new human secreted protein, designated “Zalpha13.
    Type: Application
    Filed: October 31, 2001
    Publication date: October 17, 2002
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Zeren Gao
  • Expression of tissue-type plasminogen activator in bacteria
    Patent number: H2055
    Abstract: A method, and DNA constructs useful therein, is provided for producing plasminogen activator in bacteria. Particular constructs are provided comprising a coding sequence for tissue plasminogen activator and the leader peptide thereof, which is used to transform E. coli to produce protein having activity of tissue plasminogen activator.
    Type: Grant
    Filed: September 20, 1985
    Date of Patent: December 3, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Donald D. Rao, Margaret Y. Insley