Abstract: Disclosed are inhibitors for the ?-catenin/BCL9 interaction. The inhibitors are selective for ?-catenin/BCL9 over ?-catenin/cadhenin interactions. Methods of using the disclosed compounds to treat cancer are also disclosed.
Type:
Grant
Filed:
December 30, 2022
Date of Patent:
February 20, 2024
Assignee:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Abstract: A method for controlling the temperature of a compressor having a motor including a rotor and a stator, and a control assembly operably coupled to the compressor, the method comprising the steps of: applying an initial current to the compressor motor; measuring a voltage across the compressor motor and determining a resistance of the compressor motor based on the initial current and a measured voltage; determining whether the determined resistance is less than or equal to a desired resistance; applying a secondary current to the compressor motor if the determined resistance is less than or equal to the desired resistance.
Abstract: The subject invention pertains to a method of halogenating phenols, yielding a range of halogenated phenols with enantiomeric ratio of up to 99.5:0.5. In certain embodiments, the subject invention pertains to a method of asymmetric halogenation of bisphenol, yielding a range of chiral bisphenol ligands. The novel chiral bisphenols are potent privileged catalyst cores that can be applied to the preparation of ligands for various catalytic asymmetric reactions. The catalyst library can easily be accessed because late-stage modification of the scaffold can readily be executed through cross-coupling of the halogen handles on the bisphenols.
Abstract: The present invention provides a method for preparing 2,2-bis(4-hydroxycyclohexyl)propane, comprising: hydrogenating a reactive solution containing 2,2-bis(4-hydroxyphenyl)propane under a hydrogen atmosphere in a reactor with catalyst within a temperature range of 80-165° C. and a pressure range of 85-110 kg/cm2 to prepare the 2,2-bis(4-hydroxycyclohexyl)propane. The method of present invention has an advantage of high yield properties and achieves mass production easily, thereby enhancing the value of the industrial application.
Type:
Grant
Filed:
June 14, 2022
Date of Patent:
February 20, 2024
Assignee:
CHINA PETROCHEMICAL DEVELOPMENT CORPORATION, TAIPEI (TAIWAN)
Abstract: A semiconductor manufacturing apparatus including a plurality of process modules for performing desired processes on a plurality of substrates and a plurality of transfer modules for serially transferring the plurality of substrates to the plurality of process modules is provided. The semiconductor manufacturing apparatus comprises a scheduler for calculating a cycle time so that a difference in time required for each of the desired processes is within an allowable time range and generating a transfer plan for the plurality of substrates based on the cycle time, and a transfer controller for controlling the plurality of transfer modules so that the plurality of substrates are serially transferred to the process modules according to the generated transfer plan.
Abstract: Embodiments described herein provide a method, comprising reducing pH of a glycol vaporization separator purge stream to form an acid stream; distilling the acid stream to form an overhead stream and a bottoms stream; and recycling the bottoms stream to the vaporization separator.
Abstract: The invention relates to a method and to a delivery apparatus for carrying out the method, wherein the delivery apparatus comprises an eccentric screw pump having a rotor-stator unit with an outlet, a drive unit, a control device and a delivery section, and wherein the delivery apparatus comprises at least one pressure sensor and a characteristic-variable detection device.
Type:
Grant
Filed:
November 6, 2020
Date of Patent:
February 13, 2024
Assignee:
J. Wagner GmbH
Inventors:
Thorsten Schnittger, Lam Huu Nguyen, Florian Spindler, Alfred Göhring
Abstract: System and method for guiding a drill using a subsurface model generated by successive full waveform inversions (FWI) on surface data and seismic-while-drilling (SWD) data. A server receives surface data from at least one surface sensor that records elastic energy radiated from surface seismic source and SWD data from at least one surface or at least one subsurface crosswell sensor (i.e., deployed in a nearby well). The server also receives top-drive measurements. A drillbit source signature estimation is performed, on the SWD data, by the server by blind deconvolution or by using drill string modeling and top-drive measurements. The server then performs FWI on the surface data by using the background subsurface velocity obtained by kinematic analysis of surface seismic data, to obtain an updated approximation of the subsurface velocity. The new approximation along with the drillbit source signature is then used when performing FWI on the SWD data.
Type:
Grant
Filed:
May 31, 2021
Date of Patent:
February 13, 2024
Assignee:
UTI LIMITED PARTNERSHIP
Inventors:
Nasser Kazemi Nojadeh, Roman Jgorevich Shor, Kristopher Albert Holm Innanen
Abstract: In an industrial automation system including a first and a second wireless communication device communicating with each other via a cellular network, the first wireless communication device obtains, while the first wireless communication device is attached to a first base station of the cellular network, knowledge about to which base station the second wireless communication device is attached and if the second wireless communication device is attached to a second allowable base station, the first wireless communication device detaches from the first base station and attaches to the second base station.
Type:
Grant
Filed:
October 13, 2021
Date of Patent:
February 6, 2024
Assignee:
ABB Schweiz AG
Inventors:
Gargi Bag, Krister Landernäs, Petri Hovila