Patents Examined by Charles F. Warren
  • Patent number: 4871667
    Abstract: Muconic acid is obtained from the culture of strains of Arthrobacter sp. mutant strains, strains belonging to Corynebacterium acetoacidophilum, Corynebacterium lilium, genus Brevibacterium or genus Microbacterium.
    Type: Grant
    Filed: November 20, 1985
    Date of Patent: October 3, 1989
    Assignees: Agency of Industrial Science & Technology, Ministry of International Trade and Industry of Japan
    Inventors: Yukio Imada, Nobuji Yoshikawa, Sumiko Mizuno, Takashi Mikawa
  • Patent number: 4870107
    Abstract: Disclosed herein are N-(2-chloro-4-nitrophenyl)-benzenesulfonamide derivatives represented by the following general formula (I): ##STR1## wherein X and Y individually mean a hydrogen or chlorine atom and Z denotes a chlorine atom or trifluoromethyl group, and agricultural fungicides containing said derivatives.
    Type: Grant
    Filed: October 7, 1987
    Date of Patent: September 26, 1989
    Assignee: Mitsui Toatsu Chemicals, Incorporated
    Inventors: Takeo Yoshimoto, Mitsumasa Umemoto, Keiichi Igarashi, Yutaka Kubota, Hideo Yamazaki, Yuji Enomoto, Hirohisa Yanagita
  • Patent number: 4869017
    Abstract: Production of macroalgae, e.g., Gracilaria, in a marine culture system is enhanced by improving the manner in which the aqueous culture medium is created, namely, first adjusting the alkalinity of a quantity of freshwater by the addition of an alkaline reagent thereto, diluting seawater with such alkalinity adjusted freshwater to create a saline solution having a salinity of between about 15 to 25 parts per thousand and an alkalinity of between about 3 to 10 meq/l., dissolving carbon dioxide in the resulting solution to bring its pH to between about 7.5 and 8.5, and using such carbon dioxide enriched solution as the culture medium.
    Type: Grant
    Filed: May 29, 1987
    Date of Patent: September 26, 1989
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Kimon T. Bird, Rolland D. Carlson
  • Patent number: 4870012
    Abstract: A method for degrading linalool using Pseudomonas strains is described. Also described are novel Pseudomons putida strains which degrade linalool and in some instances geraniol and citronellol. A method for producing 6-methyl-5-heptene-2-one using certain novel strains is also described.
    Type: Grant
    Filed: July 27, 1988
    Date of Patent: September 26, 1989
    Assignee: Microlife Technics, Inc.
    Inventor: Peter A. Vandenbergh
  • Patent number: 4868117
    Abstract: A novel antibiotic complex designated herein as BBM-1675 complex is produced by fermentation of certain novel strains of Actinomadura verrucosospora. The complex may be separated into two major components, BBM-1675 A.sub.1 and A.sub.2, and four minor components, BBM-1675 A.sub.3, A.sub.4, B.sub.1 and B.sub.2, and such components exhibit both antimicrobial activity and antitumor activity.
    Type: Grant
    Filed: September 25, 1985
    Date of Patent: September 19, 1989
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Kyoichiro Saitoh, Hiroaki Ohkuma, Hiroshi Kawaguchi
  • Patent number: 4866177
    Abstract: A N-alkyl amide derivative is synthesized in one-step by reacting an olefin, nitrogen-containing compound and carbon monoxide with a catalyst comprising a rhodium-containing compound in the presence of water at a pressure of at least 500 psi and a temperature of at least 50.degree. C.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: September 12, 1989
    Assignee: Texaco Inc.
    Inventor: Jiang-Jen Lin
  • Patent number: 4863866
    Abstract: Mutant strains of Bradyrhizobium japonicum having enhanced nodulation properties were created by transposon mutagenesis of known Bradyrhizobium japonicum strain I-110. The mutant strains grow well in a yeast-extract mannitol medium, produce extracellular polysaccharides at a level greater than the parent strain under appropriate conditions, are capable of growth on a nutirent medium containing a normally inhibitory amount of succinic acid, and contain a 21 Kdalton protein absent from the parent strain. Such strains can be used to inoculate soil in which soybean plants are grown, resulting in improved plant yields.
    Type: Grant
    Filed: March 12, 1987
    Date of Patent: September 5, 1989
    Assignee: Lipha Chemicals, Inc.
    Inventors: Robert M. Zablotowicz, Robert G. Upchurch, James M. Ligon
  • Patent number: 4863859
    Abstract: A process for preparing optically active glycerol derivatives by a biochemical resolution which comprises (i) subjecting an ester having the general formula [(R,S)-I]: ##STR1## wherein X is a halogen atom, R is an aliphatic hydrocarbon group of C.sub.1 to C.sub.8 and R' is an aromatic hydrocarbon group or an aliphatic hydrocarbon group of C.sub.1 to C.sub.2, to the action of enzymes derived from either microorganisms or animal organs, wherein said enzymes have a stereo selective esterase activity to asymmetrically hydrolyze the ester having the general formula [(R,S)-I] to give a mixture of an optically active alcohol having the general formula (II)*: ##STR2## wherein X and R' are as above and an optically active ester having the general formula (I)*: ##STR3## wherein X, R and R' are as above, and (ii) obtaining the optically active alcohol having the general formula (II)* and the optically active ester having the general formula (I)* by separating operations.
    Type: Grant
    Filed: January 27, 1986
    Date of Patent: September 5, 1989
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Shigeki Hamaguchi, Takehisa Ohashi, Kiyoshi Watanabe
  • Patent number: 4863728
    Abstract: The present invention provides a monoclonal anti-alpha-amylase antibody which non-specifically inhibits the enzyme activity of human alpha-amylase by more than 90%.The present invention also provides a process for obtaining this monoclonal antibody and a medicament containing it.
    Type: Grant
    Filed: February 7, 1986
    Date of Patent: September 5, 1989
    Assignee: Boehringer Mannheim GmbH
    Inventors: Martin Gerber, Kurt W. Naujoks
  • Patent number: 4863863
    Abstract: Somatic hybrid plants of the genus Lycopersicon are produced by fusion of protoplasts of two species, one of which cannot be regenerated from protoplasts. This procedure enables the introduction of certain desirable traits of wild-type members of the genus into cultivated tomato species which do not regenerate from protoplasts.
    Type: Grant
    Filed: February 26, 1986
    Date of Patent: September 5, 1989
    Assignee: DNA Plant Technology Corporation
    Inventors: Edward C. D. Cocking, John B. Power, Ahmed M. Kinsara
  • Patent number: 4863967
    Abstract: A compound having the structural formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are hydrogen, C.sub.1 -C.sub.6 alkyl, halogen or C.sub.1 -C.sub.4 alkoxy is disclosed. These compounds demonstrate utility as hypolipidemic agents.The present invention is also directed to a process for controlling lipidemia in mammals comprising treating mammals with a lipidemia controlling effective amount of the above-defined compound.Yet another aspect of the present invention is embodied in a pharmaceutical composition comprising the above compound and a pharmaceutically acceptable carrier therefor.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: September 5, 1989
    Assignee: Research Corporation
    Inventors: Iris H. Hall, Steven D. Wyrick
  • Patent number: 4864059
    Abstract: Disclosed herein is a method of utilizing inert gases, which are introduced as impurities in the feed raw materials for the synthesis of urea and also as an anti-corrosion agent into a urea process, as a stripping agent of unreacted materials in one or more of the below-mentioned separation steps, in a urea process in which: urea is synthesized from ammonia and carbon dioxide in the presence of an excess ammonia; unreacted materials including the excess ammonia are separated from the resulting urea synthesis solution as gaseous mixtures of ammonia and carbon dioxide successively at a plurality of pressure levels; the gaseous mixtures thus-separated are absorbed in solvents or condensed at the corresponding pressure levels; and the solutions or condensates thus-formed are circulated to the urea synthesis step.
    Type: Grant
    Filed: October 2, 1985
    Date of Patent: September 5, 1989
    Assignee: Toyo Engineering Corporation
    Inventor: Hidetsugu Fujii
  • Patent number: 4861914
    Abstract: Substituted aromatic amines or mixtures thereof containing a discoloration inhibiting amount of a substituted phenol having the structure: ##STR1## or mixtures of such substituted phenols wherein R.sub.1 and R.sub.2 are independently selected alkyl, cycloalkyl, aryl, aralkyl, or alkaryl and p is 0 to 4.A method and composition are provided for inhibiting discoloration of alkylated aromatic amines and diamines. A minor portion of the substituted phenol is combined with a fresh, water white substituted aromatic amine of structure ##STR2## or mixtures thereof wherein m is 1 or 2, n is 1 to 5, m+n is not greater than 6, and the R are independently selected alkyl, cycloalkyl, aryl, aralkyl or alkaryl, said amine being subject to gradual discoloration, and a minor amount by weight of a substituted phenol or mixture of substituted phenols to inhibit color degradation.
    Type: Grant
    Filed: May 11, 1987
    Date of Patent: August 29, 1989
    Assignee: Ethyl Corporation
    Inventor: Charles F. Weidig
  • Patent number: 4859593
    Abstract: New physiologically active substances, arphamenine A and arphamenine B which are generically termed arphamenine are produced from a new microorganism, BMG361-CF4 strain identified as FERM P-6521 or FERM BP-286 or ATCC No. 39373. Arphamenine is useful as a host defence stimulator having an activity to enhance cell-mediated immunity, and also as an anti-tumor agent.
    Type: Grant
    Filed: December 16, 1985
    Date of Patent: August 22, 1989
    Assignee: Zaidin Hojin Biseibutsu Kagaku Kenky Kai
    Inventors: Hamao Umezawa, Takaaki Aoyagi, Tomio Takeuchi, Masa Hamada, Masaaki Ishizuka
  • Patent number: 4859598
    Abstract: Antibiotic LL-D42067.beta. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.
    Type: Grant
    Filed: January 21, 1986
    Date of Patent: August 22, 1989
    Assignee: American Cyanamid Company
    Inventors: Guy T. Carter, Donald B. Borders, Joseph J. Goodman, David P. Labeda
  • Patent number: 4859602
    Abstract: The present invention provides a process for the preparation of the stereoisomers of 1-aminoalkylphosphonic acids and of 1-aminoalkylphosphinic acids by enzymatic resolution of their racemic N-acyl derivatives and subsequent deacylation, wherein the enzymatic resolution is carried out with penicillin G amidase.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: August 22, 1989
    Assignee: Boehringer Mannheim GmbH
    Inventors: Gerd Zimmermann, Josef Maier, Manfred Gloger
  • Patent number: 4857662
    Abstract: N-phenylbenzamide derivatives of the general formula I ##STR1## wherein the radicals R.sup.1, R.sup.2, and R.sup.3, which can be the same or different, are a hydrogen atom or a methyl radical, as well as the pharmacologically acceptable salts thereof for controlling malignant, proliferative and auto-immune diseases and for immunosuppressive therapy upon grafting are described.
    Type: Grant
    Filed: February 9, 1984
    Date of Patent: August 15, 1989
    Assignee: Godecke Aktiengesellschaft
    Inventors: Gerhard Satzinger, Manfred Hermann, Edgar Fritschi, Ute Weiershausen
  • Patent number: 4857236
    Abstract: A process for isolating phosphatidylcholine free of lysophospholipid from egg powder wherein the egg powder is treated with a solvent mixture of a low boiling petroleum ether fraction (40.degree. to 80.degree. C.), a lower C.sub.1 -C.sub.4 -alkanol and water, the undissolved material is separated from the solution phase, the solution phase is given onto a column filled with silica gel at a temperature in the range from 20.degree. to 50.degree. C., the elution is carried out at that temperature with the same solvent mixture, the main run is collected and the dissolved phosphatidylcholine is isolated therefrom as usual.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: August 15, 1989
    Assignee: A. Nattermann & Cie GmbH
    Inventor: Bernd-Rainer Gunther
  • Patent number: 4857556
    Abstract: Substituted benzylcycloalkenylurea derivatives of the formula (I) ##STR1## wherein X represents a halogen atom or a lower alkyl group, Y represents an oxygen atom or a sulfur atom,R.sup.1 represents a cycloalkenyl group andR.sup.2 represents a lower alkyl group, a cycloalkyl group, a benzyl group or a phenyl group optionally substituted by 1 to 5 substituents selected from the group consisting of a hydroxyl group or a lower alkoxy groupand their use as fungicides. They can be synthesized, for example, by reacting of a substituted benzyl-cycloalkenylamine with an isocyanate or by reacting of a carbamoyl halide with an amine. The starting material, the substituted benzyl-cycloalkenyl amines, are also new.
    Type: Grant
    Filed: December 8, 1987
    Date of Patent: August 15, 1989
    Assignee: Nihon Tokushu Noyaku Seizo K.K.
    Inventors: Yasuo Yamada, Junichi Saito, Tatsuo Tamura, Shinji Sakawa
  • Patent number: 4857465
    Abstract: A method is provided for the production of organogenic tissue culture and regeneration of whole plants of Glycine species, preferably Glycine max, involving the use of an organogenic culture medium comprising high cytokinin, preferably at least about 10 .mu.M BAP, and also preferably comprising at least about 6 times normal concentration of MS micronutrients. The organogenic culture medium is useful for the production of plants embodying desirable characteristics induced by somaclonal variation.
    Type: Grant
    Filed: December 2, 1986
    Date of Patent: August 15, 1989
    Assignee: Lubrizol Genetics, Inc.
    Inventors: Usha B. Barwale, Jack M. Widholm