Patents Examined by Charles F. Warren
  • Novel process to prevent formation of chlorinated by-products in APAP production
    Patent number: 4855499
    Abstract: A novel process for the prevention of the formation of chlorinated by-products during the Beckmann rearrangement of 4-hydroxyacetophenone oxime to APAP by the addition of an inorganic iodide such as potassium iodide to the Beckmann rearrangement reactor is disclosed.
    Type: Grant
    Filed: November 6, 1987
    Date of Patent: August 8, 1989
    Assignee: Hoechst Celanese Corporation
    Inventor: Olan S. Fruchey
  • Novel pesticides, preparation and use
    Patent number: 4855086
    Abstract: The specification describes and claims methods of controlling acarine pests by application of a compound of Formula (I), methods of controlling arthropod pests by application of a compound of Formula (IA), compounds of Formula (IA) per se, pesticidal compositions comprising a compound of Formula (IA), and processes for preparing a compound of Formula (IA).
    Type: Grant
    Filed: October 11, 1983
    Date of Patent: August 8, 1989
    Assignee: Burroughs Wellcome Co.
    Inventors: Malcolm H. Black, Robert J. Blade
  • Double-stranded DNA having sequences complementary to a single-stranded DNA and derived from a bean golden mosaic virus
    Patent number: 4855237
    Abstract: Double-stranded DNA characterized by having sequences complementary to a single-stranded DNA which has a molecular size of about 2.67 Kb and is derived from mungbean yellow mosaic virus, and giving the restriction endonuclease cleavage map shown in FIG. 1 of the accompanying drawings; and double-stranded DNA characterized by having sequences complementary to a single-stranded DNA which has a molecular size of about 2.70 Kb and is derived from mungbean yellow mosaic virus, and giving the restriction endonuclease cleavage map shown in FIG. 2 of the accompanying drawings; and hybrid DNAs having the double-stranded DNAs inserted thereinto.
    Type: Grant
    Filed: August 21, 1984
    Date of Patent: August 8, 1989
    Assignee: Teijin Limited
    Inventors: Tsuto Morinaga, Kin-ichiro Miura, Kunitada Shimotohno, Masato Ikegami, Yataro Ichikawa
  • Molecularly cloned diagnostic product and method of use
    Patent number: 4855224
    Abstract: A molecularly cloned diagnostic product in the form of a polypeptide with antigenic determinants capable of specifically binding complementary antibody, the polypeptide being expressed from a stable continuous cell line. With a glycoprotein D of Herpes Simplex Virus (HSV) as the polypeptide, HSV antibody in a specimen is detected in an immunological procedure. With a glycoprotein C fragment from HSV type 2, HSV type 2 may be distinguished from HSV type 1.
    Type: Grant
    Filed: September 13, 1985
    Date of Patent: August 8, 1989
    Assignee: Genentech, Inc.
    Inventors: Phillip W. Berman, Laurence A. Lasky
  • N-(2-Chloro-4-nitrophenyl)-benezene-sulfonamide derivative and agricultural fungicide containing same
    Patent number: 4851445
    Abstract: Disclosed herein are N-(2-chloro-4-nitrophenyl)benzenesulfonamide derivatives represented by the following general formula (I): ##STR1## wherein X and Y individually mean a hydrogen or chlorine atom and Z denotes a chlorine atom or trifluoromethyl group, and agricultural fungicides containing said derivatives.
    Type: Grant
    Filed: June 28, 1988
    Date of Patent: July 25, 1989
    Assignee: Mitsui Toatsu Chemicals, Incorporated
    Inventors: Takeo Yoshimoto, Mitsumasa Umemoto, Keiichi Igarashi, Yutaka Kubota, Hideo Yamazaki, Yuji Enomoto, Hirohisa Yanagita
  • New substituted derivatives of N-ethyl(meth)acrylamide and a method for the preparation thereof
    Patent number: 4851577
    Abstract: Novel substituted derivatives of N-ethyl(meth)acrylamide complying with the general formula (I): ##STR1## wherein R=H or --CH.sub.3, R.sub.1 =C.sub.1 -C.sub.8 alkyl and R.sub.2 =H or C.sub.1 -C.sub.8 alkyl.They may be obtained by a method in which (meth)acrylamide is reacted with a dialkoxy-2,2 ethanal of the formula (II): ##STR2## wherein R.sub.1 has the meaning indicated above to provide a product of formula (I), in which R.sub.2 =H, and, if desired, by carrying out an etherification with a C.sub.1 -C.sub.8 alkanol.
    Type: Grant
    Filed: March 9, 1987
    Date of Patent: July 25, 1989
    Assignee: Societe Francaise Hoechst
    Inventors: Francine J. Chastrette, Abdelhamid Stambouli
  • Microbiological production of essential fatty acids
    Patent number: 4851343
    Abstract: Production of .gamma.-linolenic acid, by growth of a diffused mycelial inoculum of Rhizopus arrhizus in a stirred, aerated nutrient medium containing a carbohydrate energy source and an inorganic nitrogen source at a carbon:nitrogen ratio of 20:1 to 60:1 maintained at a temperature of 25.degree. C..+-.2.degree. C. and a pH of 3.75 to 6.25 in the presence of a foam breaker, until a .gamma.-linolenic concentration of at least 1.0 g/liter of medium is reached, harvesting the organism, and extraction of lipid containing the .gamma.-linolenic acid.
    Type: Grant
    Filed: February 19, 1985
    Date of Patent: July 25, 1989
    Assignee: Efamol Limited
    Inventors: Rodney A. Herbert, Stephen M. Keith
  • Process for producing menaquinone-4
    Patent number: 4849354
    Abstract: Menaquinone-4 is produced by cultivating in culture media a microorganism belonging to the genus Corynebacterium Arthrobactor, Brevibacterium, Microbacterium, Cutobacterium, Auteobacterium or Flavobacterium which produces menaquinone-4 and recovering the same.
    Type: Grant
    Filed: May 14, 1986
    Date of Patent: July 18, 1989
    Assignee: Kyowa Hakko Kogyo Co., Ltd
    Inventors: Kenichiro Takayama, Yukoh Arai, Susumu Tomohiro, Shizuko Shirasuna
  • Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity
    Patent number: 4849563
    Abstract: Compounds of the formula: ##STR1## wherein R.sub.1 s an alkyl of 1-6 carbon atoms, benzyl, phenyl, or phenyl substituted by halogen, alkoxy of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms, amino, or carbonyl substituents, or --RN(R').sub.2 wherein R and R' are each independently an alkyl of 1 to 4 carbon atoms; R.sub.2 is an aromatic substituent selected from the group consisting of phenyl, benzyl, and naphthyl, and A is an aromatic substitution selected from the group consisting of hydrogen, alkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, halogen, --NO.sub.2, --NH.sub.2, --COOH, and --NHCOCH.sub.3. The compounds have been found to be alkylating agents having antineoplastic activity for use in inhibiting the growth of tumors.
    Type: Grant
    Filed: December 28, 1987
    Date of Patent: July 18, 1989
    Assignee: Yale University
    Inventors: Alan C. Sartorelli, Krishnamurthy Shyam, Robert T. Hrubiec
  • Process for resolution of optical isomers
    Patent number: 4849527
    Abstract: A process for resolving a racemic modification of .beta.-adrenergic aryl- or hetaryl-oxypropanolamines such as (.+-.)-2-[2-hydroxy-3-[[2-(1H-indol-3-yl)-)-1,1-dimethylethyl]amino]propox y]benzonitrile into its individual enantiomers is described. The process comprises converting the racemic modification into a pair of diastereomeric urea derivativesby reaction with a chiral aralkylisocyanate; separation into the individual diastereomers; and facile regeneration of the starting amine by cleavage of the intermediate urea compound using hydrazine. This final step is improved by the addition of an .alpha.-keto carboxylic acid, such as pyruvic acid, which functions as a scavenger of nucleophilic by-products.
    Type: Grant
    Filed: March 30, 1988
    Date of Patent: July 18, 1989
    Assignee: Bristol-Myers Company
    Inventors: Ronald D. Dennis, Terence M. Dolak, William E. Kreighbaum
  • Biosynthesis of unnatural cephalosporins
    Patent number: 4847200
    Abstract: A process for producing unnatural penicillins and cephalosporin derivatives thereof in which peptide analogs of ACV in which the L-.alpha.-aminodipyl moiety is replaced by L-S-carboxymethyl cysteine or other obvious substituents, are reacted with cyclase, epimerase, ring expansion and hydroxylase enzymes isolated from a cell free extract of a prokaryotic organism such as S. clavuligerus. The product depends upon the presence or absence of co-factors such as ferrous ion, .alpha.-ketoglutarate, and ascorbate. In an alternative embodiment, a penicillin analog having the formula: ##STR1## may be reduced with L-cysteine to produce an analog of isopenicillin N which may be reacted with the enzyme reagent to produce the desired penicillin or cephalosporin.
    Type: Grant
    Filed: September 5, 1986
    Date of Patent: July 11, 1989
    Assignee: Queen's University at Kingston
    Inventors: Saul Wolfe, Donald Westlake, Susan Jensen
  • 1,6-hexanediamides from 3-pentenamides
    Patent number: 4847411
    Abstract: A process for making a diamide of the formula ##STR1## by reacting a monoamide compound of the formula ##STR2## with CO and an amine or ammonia of the formula R.sub.7 R.sub.8 NH in the liquid phase under essentially anhydrous conditions at a temperature in the range from 120.degree. to 210.degree. C., where each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 is selected independently from H and a C.sub.1 to C.sub.12 hydrocarbyl containing no ethylenic or acetylenic unsaturation.
    Type: Grant
    Filed: May 3, 1985
    Date of Patent: July 11, 1989
    Assignee: The Standard Oil Company
    Inventors: Mark C. Cesa, Robert A. Dubbert, James D. Burrington
  • Process for producing antibiotic LL-D42067.alpha.
    Patent number: 4845037
    Abstract: A biologically pure culture of Micromonospora purpureochromogenes ssp. Wuxiensis and its use in an aerobic fermentation process to produce the antibacterial and antiparasitic agent LL-D42067.alpha..
    Type: Grant
    Filed: July 31, 1986
    Date of Patent: July 4, 1989
    Assignee: American Cyanamid Company
    Inventors: Taikwang M. Lee, Joseph J. Goodman, Michael Greenstein, Donald B. Borders
  • Biochemically reacting substrates in subterranean cavities
    Patent number: 4845034
    Abstract: A method for carrying out a biochemical reaction with a culture of microorganisms is performed in a cavity formed in a subterranean formation to produce combustible hydrocarbon gases. The method is especially suitable for the conversion of alkali-oxidized or hydrolyzed coal, such as lignite, to methane. The method may be performed in the cavity as a continuously stirred tank reaction, or plug flow or as a staged reaction. The method may also be done as an anaerobic fixed film process using particles as an anaerobic filter, as a sludge blanket, or as an expanded bed process.
    Type: Grant
    Filed: January 6, 1986
    Date of Patent: July 4, 1989
    Assignee: Houston Industries Incorporated
    Inventors: William M. Menger, Ernest E. Kern, Kermit Allen, O. C. Karkalits, Donald L. Wise, Alfred P. Leuschner
  • Process for regenerating corn
    Patent number: 4843005
    Abstract: The invention is directed to a process for regenerating plants from corn tissue. The process comprises the steps of in vitro conditioning of the corn tissue, culturing the corn tissue on a callus induction medium to induce callus, and regenerating plants from the callus. The callus may optionally be maintained prior to regeneration and the plants may optionally be cultured on an establishment medium prior to transfer to the soil.
    Type: Grant
    Filed: August 18, 1986
    Date of Patent: June 27, 1989
    Assignee: Sungene Technologies Corporation
    Inventors: David S. K. Cheng, Andrew S. Wang
  • Benzoylureas, their production and use
    Patent number: 4843100
    Abstract: This invention relates to a benzoylurea derivative of the formula: ##STR1## wherein X.sup.1 and X.sup.2 are hydrogen, halogen, alkyl or alkoxy; and one of Y.sup.1, Y.sup.2, Y.sup.3, Y.sup.4 and Y.sup.5 is halogenoalkylsulfinyl or halogenoalkylsulfonyl, and the others are hydrogen, halogen or alkyl, exhibiting excellent insecticidal and ovicidal activities (particularly, molt inhibitory activity), their production and use.
    Type: Grant
    Filed: June 19, 1987
    Date of Patent: June 27, 1989
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hiroshi Nagase, Yasuo Sato
  • Novel microorganisms and a novel process for producing antibiotics
    Patent number: 4843008
    Abstract: Novel microorganisms belonging to the genus Micromonospora capable of producing antibiotics YS-02930 K-D, -E or -H represented by formula: ##STR1## wherein R represents a hydrogen atom or a formyl group and a dotted line represents a double bond or a bond shown by: ##STR2## are disclosed. The antibiotics are produced by culturing bacteria belonging to the genus Micromonospora capable of producing at least one antibiotic selected from YS-02930 K-D, -E and -H and, harvesting antibiotic YS-02930 K-D, -E or -H.
    Type: Grant
    Filed: December 18, 1985
    Date of Patent: June 27, 1989
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Harumitsu Imai, Ken-ichi Suzuki, Shigeru Miyazaki, Shigenobu Kadota
  • RecA promoter dependent polypeptide production
    Patent number: 4843006
    Abstract: This invention relates to the expression and accumulation in bacterial cells of heterologous polypeptides under the control of the recA promoter/operator region. One such polypeptide comprises a recA/somatostatin fusion polypeptide. This fusion polypeptide has been expressed and accumulated by E. coli with much greater effectiveness than other somatostatin-containing fusion polypeptides. In addition, use of the recA promoter/opeerator region provides greater induction flexibility than other inducible promoter systems.
    Type: Grant
    Filed: April 21, 1986
    Date of Patent: June 27, 1989
    Assignee: Monsanto Company
    Inventor: Michael L. Bittner
  • Continuous process for ethanol production by bacterial fermentation using pH control
    Patent number: 4840902
    Abstract: A continuous process for the production of ethanol by fermentation of an organism of the genus Zymomonas is provided. The method is carried out by cultivating the organism under substantially steady state, anaerobic conditions and under conditions in which ethanol production is substantially uncoupled from cell growth. By controlling pH in the fermentation medium between a pH of about 3.8 and a pH less than 4.5, it is possible to optimize kinetic parameters, such as q.sub.s (g substrate/g biomass-hr.sup.-1) and q.sub.p (g ethanol/g biomass-hr.sup.-1) without adversely affecting ethanol concentration in the fermentation medium.
    Type: Grant
    Filed: May 4, 1987
    Date of Patent: June 20, 1989
    Assignee: George Weston Limited
    Inventor: Hugh G. Lawford
  • Plant generation method
    Patent number: 4840906
    Abstract: The invention provides a method of generating barley plants comprising culturing barley microspores on a sugar-containing medium and harvesting green plantlets from the medium characterized in that the sugar in the sugar-containing medium is at least one sugar selected from sucrose; glucose; and oligosaccharides and polysaccharides containing at least two glucose residues; wherein the concentration of sucrose and glucose in the medium is not greater than 0.03 mol/l; and a method of generating barley seed which comprises the additional steps of cultivating green plantlets and deriving seed from resulting mature plants.
    Type: Grant
    Filed: May 14, 1987
    Date of Patent: June 20, 1989
    Assignee: Shell Oil Company
    Inventor: Clifford P. Hunter