Patents by Inventor A. Sinclair

A. Sinclair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3D visualization of multi-layer networks including network topology and encapsulation
    Publication number: 20230224224
    Abstract: Three-dimensional (3D) visualization of multi-layer networks include receiving data associated with a network, wherein the network includes interconnected network elements that operate at a plurality of levels that include any of network layers and encapsulations; displaying a plurality of three-dimensional icons each represent one of a plurality of network elements of the interconnected network elements; and displaying links between the plurality of three-dimensional icons each link representing one of a network layer connection and an encapsulation connection.
    Type: Application
    Filed: January 23, 2023
    Publication date: July 13, 2023
    Inventors: Christopher Stoll, Brett Sinclair, David Fortin, Blair E. P. Moxon, Christiane Louise Campbell, Sophy Pal, Brian Christopher Johnson, Hien Nguyen
  • COMPOSITIONS AND METHODS FOR DNA METHYLATION ANALYSIS
    Publication number: 20230220475
    Abstract: The present invention provides methods, compositions and kits for assembling an enzyme-deoxyribonucleic acid (DNA) complex for use in preparing a double stranded DNA molecule comprising one or more loci of interest for determining the methylation status of the one or more loci of interest therein.
    Type: Application
    Filed: June 11, 2021
    Publication date: July 13, 2023
    Inventors: Patrick Thomas Griffin, David A. Sinclair
  • Multi-channel optical system
    Patent number: 11698526
    Abstract: A multi channel beamsplitter system operating over a wide spectral band has high optical performance despite the fact that the incoming and/or exiting light is not collimated and its material is dispersive. This is achieved using wavefront compensators that are matched to the curvature of the wavefronts of the incoming and/or exiting light.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: July 11, 2023
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Matthew A. Sinclair, Adam F. Kelsey, David A. Landis, Stephanie L. Golmon, Buddy Clemmer, Juha-Pekka Laine
  • PD-1 AGONIST MULTIMERIC BINDING MOLECULES
    Publication number: 20230212293
    Abstract: This disclosure provides multimeric binding molecules that specifically and agonistically bind to programmed cell death protein 1 (PD-1). This disclosure also provides compositions comprising the multimeric binding molecules, polynucleotides that encode the multimeric binding molecules, and host cells that can produce the binding molecules. Further this disclosure provides methods of using the multimeric binding molecules, including methods for treating autoimmune disorders and preventing transplantation rejection.
    Type: Application
    Filed: April 21, 2021
    Publication date: July 6, 2023
    Inventors: Bruce KEYT, Todd METZGER, Angus SINCLAIR
  • DRUG INJECTION DEVICE
    Publication number: 20230201469
    Abstract: A drug injection device includes a last dose setting having a main drive pin, a drive wheel, a driven wheel, an abutment element fixedly coupled to, or integrally formed with, the driven wheel. The drive wheel has a rotation axis parallel to a longitudinal axis and is configured to be driven about the longitudinal axis by a knob and to be periodically driven in rotation about the rotation axis by the main drive pin, during a drug dose setting. The driven wheel has a second rotation axis parallel or coaxial to said longitudinal axis and is configured to be periodically driven about the longitudinal axis by the drive wheel. The abutment element is configured to prevent the rotation of the drive wheel about the longitudinal axis when the knob has made a predetermined number of full and/or partial rotations about the longitudinal axis correlated to the predetermined drug volume.
    Type: Application
    Filed: December 21, 2022
    Publication date: June 29, 2023
    Inventors: Oliver Taylor Harvey, Christopher John Hurlstone, Isobel Rachel Sands, Rhona Ann Sinclair
  • CYCLOTRON HAVING CONTINUOUSLY VARIABLE ENERGY OUTPUT
    Publication number: 20230207247
    Abstract: An apparatus may include a cyclotron to receive an ion beam as an incident ion beam at an initial energy, and output the ion beam as an accelerated ion beam at an accelerated ion energy. The apparatus may further include an RF source to output an RF power signal to the cyclotron chamber, the RF power source comprising a variable power amplifier, and a movable stripper, translatable to intercept the ion beam within the cyclotron at a continuum of different positions.
    Type: Application
    Filed: December 23, 2021
    Publication date: June 29, 2023
    Applicant: Applied Materials, Inc.
    Inventors: Frank Sinclair, Klaus Becker, Joseph C. Olson, Tseh-Jen Hsieh, Morgan Patrick Dehnel, Anand Mathai George
  • Frequency-domain optical coherence tomography with extended field-of-view and reduction of aliasing artifacts
    Patent number: 11686572
    Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: June 27, 2023
    Assignee: Ninepoint Medical, Inc.
    Inventors: Eman Namati, Muhammad Al-Qaisi, Matthew A. Sinclair, Benedikt Graf, David Vader
  • Autonomous laundry folding devices, systems, and methods of use
    Patent number: 11680365
    Abstract: Devices, systems, and methods for autonomously folding a deformable laundry article are described. A folding device includes a rotatable platform configured to receive the article. A rotatable blade is suspended above the surface and a clamp rod is disposed parallel to a longitudinal axis of the blade. The clamp rod is configured to raise and lower from a surface of the rotatable platform, slidably move parallel to the surface, and clamp the deformable article to the surface in a lowered position. The blade is configured to raise and lower from the surface of the rotatable platform, slidably move parallel to the surface, slide under an unclamped portion of the article, lift the unclamped portion above the clamp rod, pass the unclamped portion over the clamp rod, and lower the free end to a resting position atop another portion of the article to fold the article.
    Type: Grant
    Filed: September 6, 2022
    Date of Patent: June 20, 2023
    Assignee: MONOTONY.AI, INC.
    Inventors: Stuart E. Schechter, Benjamin D. Bixby, Kevin M. LeBlanc, Wilson J. Mefford, Elliot Sinclair Pennington, Laura E. Schwartz, Jesse Sielaff, Madeline R. Hickman, Carter J. Ithier, Samuel Duffley
  • Spinning Disk with Electrostatic Clamped Platens for Ion Implantation
    Publication number: 20230187166
    Abstract: A system comprising a spinning disk is disclosed. The system comprises a semiconductor processing system, such as a high energy implantation system. The semiconductor processing system produces a spot ion beam, which is directed to a plurality of workpieces, which are disposed on the spinning disk. The spinning disk comprises a rotating central hub with a plurality of platens. The plurality of platens may extend outward from the central hub and workpieces are electrostatically clamped to the platens. The plurality of platens may also be capable of rotation. The central hub also controls the rotation of each of the platens about an axis orthogonal to the rotation axis of the central hub. In this way, variable angle implants may be performed. Additionally, this allows the workpieces to be mounted while in a horizontal orientation.
    Type: Application
    Filed: December 10, 2021
    Publication date: June 15, 2023
    Inventors: Robert Mitchell, Frank Sinclair, Joseph C. Olson, William T. Weaver, Nick Parisi
  • Methods and apparatus for profile-guided optimization of integrated circuits
    Patent number: 11675948
    Abstract: Methods and apparatus for performing profile-guided optimization of integrated circuit hardware are provided. Circuit design tools may receive a source code and compile the source code to generate a hardware description. The hardware description may include profiling blocks configured to measure useful information required for optimization. The hardware description may then be simulated to gather profiling data. The circuit design tools may then analyze the gathered profiling data to identify additional opportunities for hardware optimization. The source code may then be modified based on the analysis of the profiling data to produce a smaller and faster hardware that is better suited to the application.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: June 13, 2023
    Assignee: Intel Corporation
    Inventors: Byron Sinclair, John Freeman
  • Sensor device
    Patent number: 11672429
    Abstract: A sensor device is described herein. The sensor device includes a multi-dimensional optical sensor and processing circuitry, wherein the multi-dimensional optical sensor generates images and the processing circuitry is configured to output data that is indicative of hemodynamics of a user based upon the images. The sensor device is non-invasive, and is able to be incorporated into wearable devices, thereby allowing for continuous output of the data that is indicative of the hemodynamics of the user.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: June 13, 2023
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Christian Holz, Eyal Ofek, Michael J. Sinclair
  • USE OF A MULTIMERIC ANTI-DR5 BINDING MOLECULE IN COMBINATION WITH A CANCER THERAPY FOR TREATING CANCER
    Publication number: 20230174660
    Abstract: This disclosure provides therapeutic methods for treating cancer including combination therapy with a multimeric anti-DR5 antibody and a cancer therapy, e.g., radiation, an anthracycline, a folic acid analog, a platinum-based agent, a taxane, a topoisomerase II inhibitor, a SMAC mimetic, a vinca alkaloid, a Brutons tyrosine kinase (BTK) inhibitor, a phosphoinositide 3-kinase delta (PI3K?) inhibitor, a myeloid cell leukemia-1 (Mcl-1) inhibitor, or any combination thereof.
    Type: Application
    Filed: May 12, 2021
    Publication date: June 8, 2023
    Inventors: Beatrice WANG, Thomas J. MATTHEW, Eric William HUMKE, Angus SINCLAIR, Daniel S. CHEN, Bruce Alan KEYT, Ling WANG
  • Systems and methods for installing fiber optic cable onto a powerline conductor
    Patent number: 11668891
    Abstract: The disclosed system may include (1) a drive subsystem that translates along a powerline conductor, (2) a rotation subsystem that rotates a segment of fiber optic cable about the powerline conductor while the drive subsystem translates along the powerline conductor such that the segment of fiber optic cable is wrapped helically about the powerline conductor, and (3) an extension subsystem that (a) mechanically couples the rotation subsystem to the drive subsystem, and (b) selectively extends the rotation subsystem away from the drive subsystem and the powerline conductor to avoid obstacles along the powerline conductor. Various other systems and methods are also disclosed.
    Type: Grant
    Filed: October 8, 2021
    Date of Patent: June 6, 2023
    Assignee: Meta Platforms, Inc.
    Inventors: Jonathan M. Kuriloff, Benjamin Lagosz-Sinclair, G. Gregory Penza
  • Modular linear accelerator assembly
    Patent number: 11665810
    Abstract: Embodiments herein are directed to a linear accelerator assembly for an ion implanter. In some embodiments, the linear accelerator assembly may include a central support within a chamber, and a plurality of modules coupled to the central support, at least one module of the plurality of modules including an electrode having an aperture for receiving and delivering an ion beam along a beamline axis.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: May 30, 2023
    Assignee: APPLIED Materials, Inc.
    Inventors: Frank Sinclair, Paul J. Murphy, Michael Honan, Charles T. Carlson
  • NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES AND THEIR USES
    Publication number: 20230158053
    Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.
    Type: Application
    Filed: July 26, 2022
    Publication date: May 25, 2023
    Inventors: Karl D. Normington, David A. Sinclair, David J. Livingston, James M. McKearin, Bruce Szczepankiewicz, Jonathan N. Kremsky
  • Network timing trail visualization and method of troubleshooting
    Patent number: 11658888
    Abstract: A network timing view provides enhanced visualization for synch timing in support of mobile (4G/5G deployments) and others requiring sync. It allows network managers to view relevant synch data both textually and graphically displayed on the network map nodes and links in a unified view. The user is able to select the appropriate filter on the network map to show the 1588/SyncE connectivity and relevant nodes that are participating in delivering timing. It allows a user to trace the timing path from any timing device upstream to the clock source. It also allows the user to interactively discover and navigate downstream timing paths from any timing device, similar to exploring a tree hierarchy. The timing topology and path data provided allows a user to investigate the timing network for troubleshooting purposes such as timing alarms and events, sync problems, clock quality levels and clock states.
    Type: Grant
    Filed: February 25, 2022
    Date of Patent: May 23, 2023
    Assignee: Ciena Corporation
    Inventors: Peter Brett Sinclair, David Charles Steele, Blair Edward Paul Moxon
  • Method for treating cancerous and pre-cancerous skin
    Patent number: 11654298
    Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCR) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.
    Type: Grant
    Filed: January 7, 2022
    Date of Patent: May 23, 2023
    Assignee: GenesisCare Ventures Pty Ltd
    Inventors: Christopher Baker, Judith Mary Cole, Robert Sinclair, Warren Weightman, Stephen Shumack, Lynda Spelman, Peter Foley
  • Self-righting trimaran
    Patent number: 11655008
    Abstract: A trimaran which includes a self-righting structure positioned near the stern that substantially raises the center of buoyancy. The trimarans two peripheral hulls are shorter than the main hull and positioned near the one end to create an unstable inverted environment wherein when inverted the vessel rests primarily on the self-righting structure and an end of the main hull, substantially raising the center of gravity and creating an unstable configuration. This causes a pitch or roll about the vessel's longitudinal axis, which continues until the vessel has returned to its more stable upright position resting on three hulls.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: May 23, 2023
    Assignee: Open Ocean Robotics Inc.
    Inventors: Colin Sinclair Angus, Julie Rachel Angus
  • METHODS FOR ENHANCING VASCULAR DENSITY
    Publication number: 20230149437
    Abstract: The present invention relates to methods of increasing vascular density and/or blood flow in tissue of a subject, and to increasing exercise capacity of a subject, the methods include administering to a subject an effective amount of an agent that elevates SIRTI activity in endothelial cells of the subject, the invention further includes administering an NAD+ agonist or NAD+ precursor to a subject to increase vascular density and/or blood flow. The invention includes compositions comprising the said agent.
    Type: Application
    Filed: January 20, 2023
    Publication date: May 18, 2023
    Inventors: Lindsay Edward Wu, David Andrew Sinclair, Abhirup Das
  • Systems and methods for installing fiber optic cable onto a powerline conductor
    Patent number: 11652337
    Abstract: The disclosed robotic system may include (1) a drive subsystem that translates the robotic system along a powerline conductor and (2) a rotation subsystem coupled to the drive subsystem, where (a) the rotation subsystem is coupled to a container that defines an arcuate volume about an axis such that the container partially surrounds the powerline conductor when the axis aligns with the powerline conductor, (b) the container carries a segment of fiber optic cable coupled to the powerline conductor, and (c) the rotation subsystem, while the drive subsystem translates the robotic system along the powerline conductor, rotates the container about the powerline conductor while the axis is aligned with the powerline conductor such that the segment of fiber optic cable is wrapped helically about the powerline conductor. Various other systems and methods are also disclosed.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: May 16, 2023
    Assignee: Meta Platforms, Inc.
    Inventors: Jonathan M. Kuriloff, Benjamin Lagosz-Sinclair, Alex Edwin Symington, John J. Webster, Wayne Michael Kachmar