Abstract: Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

Abstract: Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

Abstract: A method, an apparatus, and a software product to process a plurality of input audio signals. The apparatus accepts a plurality of input signals and includes a multi-input, multi-output reverberator arranged to generate a set of output signals including delayed reverberation components simulating the reverberations a listener is likely to hear in a listening environment. The apparatus further includes a multi-input, two-output filter accepting the outputs of the reverberator and the plurality of input terminals, providing outputs for the left and right ears, and configured to implement a set of head related transfer functions corresponding to a listening environment and a set of directions of a listener in the listening environment.

Abstract: A system and method for securing, shipping, storing, loading, unloading, accessing and protecting sensitive heavy electronic assemblies. Integration of container dunnage, recessed hardware and exterior stacking features to protect container and contents during shipping.

Abstract: An apparatus and methods for manipulating and driving casing. The apparatus includes mechanically responsive elements for gripping an interior of a casing joint, and hydraulically responsive elements for gripping an interior of the casing joint responsive to pressure of drilling fluid flowing through the apparatus. One method comprises manipulating a casing joint by mechanically gripping an interior thereof, hydraulically gripping the interior of the casing joint responsive to drilling fluid pressure, and rotating the casing joint. Another method comprises driving casing by applying weight and torque thereto through engagement with an interior thereof.

Abstract: A process for selecting a surrogate part for metallic plating, the metallic plating of the surrogate part predicting results for the metallic plating of a new or predetermined part is disclosed. The process can include providing a reinforcement learning system having a memory circuitry and a processing circuitry. The memory circuitry can have a database with data associated with a plurality of surrogate parts and data associated with the predetermined part can be entered into the data input module. The processing circuitry can compare the data associated with each of the plurality of surrogate parts and the data associated with the predetermined part and select a surrogate part that affords predicting a plating result of the predetermined part.

Abstract: A support stand for supporting a test piece within a corrosion chamber comprises first and second side members interconnected by first and second support rods. The relative position of the support rods is adjustable so as to modify the orientation of the test piece. In some examples, each side member has a base, a first row of spaced-apart holes generally parallel to the base, and a second row of spaced apart holes generally perpendicular to the base. By selecting the holes with which the support rods engage, the orientation of the test piece can be set to a predetermined value.

Abstract: Methods of attaching a crown of a boring shoe to a casing section include attaching an adaptable shank to a crown, and machining the adaptable shank to configure an end thereof for attachment to a casing section after attaching the adaptable shank to the crown. Additional methods include welding an end of an adaptable shank to a crown to form a boring shoe, selecting the adaptable shank to have an average wall thickness greater than about five percent (5%) of a maximum diameter of the crown, and configuring an opposite end of the adaptable shank for attachment to a particular type of casing section after welding the shank to the crown. Boring shoes have an adaptable shank attached to a crown, wherein the shank comprises a generally cylindrical wall having an average wall thickness greater than about five percent (5%) of a maximum diameter of the crown.

Abstract: A wall mounted domestic combined heat and power appliance comprising housing (1) containing a prime mover to generate electrical power and heat output. At least one bracket (2) at each side of the housing mounts the housing to a wall (W). Each bracket comprises a main body which is elongate in a vertical direction and has a L-shape cross section. Each extremity of the L-shape cross section has an enlarged portion (22, 23), a first (23) of which provides a spacer between the main body and the housing, and a second (22) of which provides a spacer between the main body and the wall.

Abstract: An airfoil 11 for attachment to a hub 13 of a windmill 15 or other turbomachine, the airfoil 11 comprises a leading rod 17 and a trailing rod 27, the leading rod 17 and trailing rod 27 preferably are flexible and able to deflect in a direction opposite to that of the direction of rotation, the leading rod 17 having a first end 19 and a second end 21, the first end 19 secured by a leading rod mount 23 of the hub 13 located at a leading mount location 25, the trailing rod 27 has a base end 29 and a tip end 31, the tip end 31 connected with the second end 21 of the leading rod 17, and the base end 29 secured by a trailing rod mount 33 of the hub 13 located at a trailing mount location 35, and fabric sleeve 37 is stretched over the leading rod 17 and the trailing rod 27; the aerodynamic characteristics of each airfoil are configurable by modifying the orientation of the position/alignment of the leading red 17 relative to the trailing rod 27; and the invention including an assembly of airfoils attached to a hub 1

Abstract: An apparatus for creating, utilizing a pair of oppositely opposed headphone speakers, the sensation of a sound source being spatially distant from the area between the pair of headphones, the apparatus comprising: (a) a series of audio inputs representing audio signals being projected from an idealised sound source located at a spatial location relative to the idealised listener; (b) a first mixing matrix means interconnected to the audio inputs and a series of feedback inputs for outputting a predetermined combination of the audio inputs as intermediate output signals; (c) a filter system of filtering the intermediate output signals and outputting filtered intermediate output signals and the series of feedback inputs, the filter system including separate filters for filtering the direct response and short time response and an approximation to the reverberant response, in addition to the feedback response filtering for producing the feedback inputs; and (d) a second matrix mixing means combining the filtered

Abstract: An apparatus for creating, utilizing a pair of oppositely opposed headphone speakers, the sensation of a sound source being spatially distant from the area between the pair of headphones, the apparatus comprising: (a) a series of audio inputs representing audio signals being projected from an idealised sound source located at a spatial location relative to the idealised listener; (b) a first mixing matrix means interconnected to the audio inputs and a series of feedback inputs for outputting a predetermined combination of the audio inputs as intermediate output signals; (c) a filter system of filtering the intermediate output signals and outputting filtered intermediate output signals and the series of feedback inputs, the filter system including separate filters for filtering the direct response and short time response and an approximation to the reverberant response, in addition to the feedback response filtering for producing the feedback inputs; and (d) a second matrix mixing means combining the filtered

Abstract: Methods, storage mediums, and systems for correlating pulses generated from multiple interrogation regions in a flow cytometer to particular particles flowing through the flow cytometer are provided. Embodiments of the methods, storage mediums, and systems include configurations for calibrating a flow cytometer using a calibration particle having a unique signature to determine a time-of-flight for particles flowing through the flow cytometer. Based on the calculated time-of-flight and relative positions of interrogation regions corresponding to collectors of the flow cytometer, the methods, storage mediums, and systems may further include configurations for associating other signal pulses to particles of one or more different particle sets.

Abstract: A flow cytometer is provided which includes an interrogation flow cell and a plurality of assay fluidic lines extending into the interrogation flow cell. A method of operating such a flow cytometer includes priming the interrogation flow cell with a sheath fluid and injecting different assay fluids into a flow of the sheath fluid through the plurality of fluidic lines. A fluidic line assembly is provided which includes a plurality of capillary tubes coupled to a base section configured for coupling to an interrogation flow cell assembly of a flow cytometer. The capillary tubes are dimensionally configured such that when the fluidic line assembly is arranged within the flow cytometer and fluid is dispensed from one or more of the capillary tubes at a given pressure differential with respect to an encompassing sheath fluid within the interrogation flow cell the fluid is substantially centrally aligned within the interrogation flow cell.

Abstract: A method and apparatus generates identifiers of database records apart from the database. One or more application programs may request an identifier of a transaction, and a stored identifier of a prior transaction is incremented or otherwise altered to produce the identifier of the transaction. The identifier is provided to the application program, which uses it as an identifier of a record of a database if such a record is created. If a system failure occurs, the database is scanned to identify the most recently issued identifier stored in the database, for example by requesting from the database the highest transaction number stored, and that number is used to generate the next transaction number.

Abstract: A fluid assay preparation system is provided which includes a reusable reaction apparatus and a plurality of fluidic lines coupled to the reusable reaction apparatus. The reusable reaction apparatus includes a process vessel with a tapered floor and the fluidic lines extend into the process vessel a distance less than approximately 1.0 mm from a bottommost surface of the tapered floor. Inner and outer surfaces of the fluidic lines and an inner surface of the process vessel may include one or more materials having a coefficient of friction less than or equal to approximately 0.1 relative to polished steel. The system further includes an assembly of one or more pumps, one or more valves, and control electronics collectively configured to pass reagents to the process vessel. Methods and storage mediums having program instructions configured to prepare fluid assays using such a system are also provided.

Abstract: Portable systems for processing and analyzing biological or environmental samples as well as different configurations of chip-based flow cytometers are provided. The portable systems include an automated assay preparation module configured to process a sample into a fluid assay with fluorescently tagged particles and a microfluidic analysis module coupled to the fluid assay module, wherein the microfluidic analysis module includes a chip-based flow cytometer.

Abstract: Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula wherein: R1, R2, and R3 independently are hydrogen, halo, hydroxy, C1–C6 alkyl, C1–C6 alkoxy, C2–C6 alkenyl, C2–C6 alkynyl, NO2, NR4R5, CN, or CF3; E is independently O or S; A and B independently are OR4 or NR4R5; each R4 and R5 independently are H, C1–C6 alkyl, C2–C6 alkenyl, C2–C6 alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, (CH2)n heteroaryl, or R4 and R5 when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring, optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted; n is 0 to 6; or a pharmaceutically acceptable salt thereof. The compounds are useful for treating diseases in a mammal that are mediated by MMP enzymes.

Abstract: A computing system architecture is based upon a peer-to-peer, asynchronous model. The architecture specifies a set of infrastructure facilities that comprise an inter-prise operating system. The inter-prise operating system provides all the facilities that make application coding as easy in the peer-to-peer asynchronous model as it is in a hierarchical, synchronous model. Services, which reside in containers, are linked asynchronously by an inter-prise bus and use data from a virtual data store.

Abstract: A method of and system for conducting electronic commerce segments an enterprise is segmented into a single firm side system, and multiple customer facing and street side systems. The firm side system maintains a single system of record for the enterprise. The customer facing systems provide an interface between the enterprise and the customer. The street side systems are in communication with the customer facing systems. The street side systems provide an interface between the enterprise and various markets.