Abstract: A fixed spool fishing reel having a spool shaft with a coaxial hollow rotor shaft rotatable thereabout. The reel is further provided with a handle shaft which extends transversely of and is offset relative to the spool shaft. First and second mutually orthogonal gears are coupled for rotation with the handle shaft, the first gear having an axis of rotation which is transverse of and offset from the spool shaft. Likewise for third and fourth gears, with the third gear being on the opposite side of the spool shaft relative to the first gear. The axis of the third gear is closer to the spool than that of the first gear. Likewise the fourth is closer than the second. The rotor shaft can be driven by the handle shaft selectively via the first or the third gear to change the gearing ratio.

Abstract: This document describes systems and techniques that may be used to aggregate information about open parking spots from various different parking providers or organizations.

Abstract: Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

Abstract: Methods, systems, and computer readable media for using actuated surface-attached posts for assessing biofluid rheology are disclosed. According to one aspect, a method for testing properties of a biofluid specimen includes placing the specimen onto a micropost array having a plurality of microposts extending outwards from a substrate, wherein each micropost includes a proximal end attached to the substrate and a distal end opposite the proximal end, and generating an actuation force in proximity to the micropost array to actuate the microposts, thereby compelling at least some of the microposts to exhibit motion. The method further includes measuring the motion of at least one of the microposts in response to the actuation force and determining a property of the specimen based on the measured motion of the at least one micropost.

Abstract: Methods, systems, and computer readable media for using actuated surface-attached posts for assessing biofluid rheology are disclosed. According to one aspect, a method for testing properties of a biofluid specimen includes placing the specimen onto a micropost array having a plurality of microposts extending outwards from a substrate, wherein each micropost includes a proximal end attached to the substrate and a distal end opposite the proximal end, and generating an actuation force in proximity to the micropost array to actuate the microposts, thereby compelling at least some of the microposts to exhibit motion. The method further includes measuring the motion of at least one of the microposts in response to the actuation force and determining a property of the specimen based on the measured motion of the at least one micropost.

Abstract: Methods, storage mediums, and systems for correlating pulses generated from multiple interrogation regions in a flow cytometer to particular particles flowing through the flow cytometer are provided. Embodiments of the methods, storage mediums, and systems include configurations for calibrating a flow cytometer using a calibration particle having a unique signature to determine a time-of-flight for particles flowing through the flow cytometer. Based on the calculated time-of-flight and relative positions of interrogation regions corresponding to collectors of the flow cytometer, the methods, storage mediums, and systems may further include configurations for associating other signal pulses to particles of one or more different particle sets.

Abstract: Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

Abstract: A system and method utilizing an online communications network and hardware connecting users in a specific industry with each other for the purposes of facilitating an efficient identification and exchange of relevant goods and services. Industry specific search tools are provided to allow users to quickly delimit an inventory of products and services, thus efficiently locating what they seek. The inventory of products and services is provided by other users who provide the necessary criteria so that search tools can be effective. Additional functionality allows a user to contact another user to request additional information and initiate negotiations wherein a successful transaction may occur either on site or off site.

Abstract: Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

Abstract: A wet/dry auto-mixing injector having a mixing device containing at least one microfluidic channel for mixing or dissolving a dry component with a wet component stored in the injector device.

Abstract: An airfoil 11 for attachment to a hub 13 of a windmill 15 or other turbomachine, the airfoil 11 comprises a leading rod 17 and a trailing rod 27, the leading rod 17 and trailing rod 27 preferably are flexible and able to deflect in a direction opposite to that of the direction of rotation, the leading rod 17 having a first end 19 and a second end 21, the first end 19 secured by a leading rod mount 23 of the hub 13 located at a leading mount location 25, the trailing rod 27 has a base end 29 and a tip end 31, the tip end 31 connected with the second end 21 of the leading rod 17, and the base end 29 secured by a trailing rod mount 33 of the hub 13 located at a trailing mount location 35, and fabric sleeve 37 is stretched over the leading rod 17 and the trailing rod 27; the aerodynamic characteristics of each airfoil are configurable by modifying the orientation of the position/alignment of the leading red 17 relative to the trailing rod 27; and the invention including an assembly of airfoils attached to a hub 1

Abstract: A method of identifying an event associated with consumption of a utility comprising the steps of: generating a utility consumption profile from utility consumption data, the utility consumption data comprising a plurality of utility consumption values measured at a corresponding plurality of measurement points; wherein generating the utility consumption profile comprises the step of determining a gradient of rate of change of utility consumption between consecutive measurement points; identifying measurement points at which a change in gradient exceeds a predetermined threshold; and storing in the utility consumption profile the utility consumption value at measurement points where the threshold is exceeded; and identifying an event within the utility consumption profile that matches the profile of an event stored in a database of utility consumption profiles.

Abstract: A data processing method includes storing data as segments. Data requiring processing is identified. Related data segments are identified and copied to storage in an analysis module. The module reviews the data, identifies required analysis tasks and stores the identified tasks in task storage in the module. The module reviews the tasks to identify required data. The module identifies any required data not stored in the module, and required data is copied to the module. The analysis module executes required task. The module removes executed tasks and updates the data in module storage based on the analysis output. The module reviews data in module storage to identify what analysis must be carried out on the identified data. When an analysis tasks stops, the data store is updated based on the updated module data. The data store comprises storage media and the analysis modules are executed in random access memory.

Abstract: A method and apparatus for storing time series data, in which a data structure is defined comprising a plurality of consecutive slices, each slice corresponding to a time period, time series data is stored in the data structure as runs of time series data entries each having a fixed, predetermined size and being associated with a time, each run of time series data entries comprising a number of consecutive time series data values, wherein each run of time series data is stored in a slice corresponding to the time period of the times associated with the time series data entries of the run, and each run of time series data is associated with metadata identifying the duration of the run and an offset of a start time of the run from a start time of the slice in which the run is stored.

Abstract: A flow cytometer is provided which includes an interrogation flow cell and a plurality of assay fluidic lines extending into the interrogation flow cell. A method of operating such a flow cytometer includes priming the interrogation flow cell with a sheath fluid and injecting different assay fluids into a flow of the sheath fluid through the plurality of fluidic lines. A fluidic line assembly is provided which includes a plurality of capillary tubes coupled to a base section configured for coupling to an interrogation flow cell assembly of a flow cytometer. The capillary tubes are dimensionally configured such that when the fluidic line assembly is arranged within the flow cytometer and fluid is dispensed from one or more of the capillary tubes at a given pressure differential with respect to an encompassing sheath fluid within the interrogation flow cell the fluid is substantially centrally aligned within the interrogation flow cell.

Abstract: An apparatus and methods for manipulating and driving casing. The apparatus includes mechanically responsive elements for gripping an interior of a casing joint, and hydraulically responsive elements for gripping an interior of the casing joint responsive to pressure of drilling fluid flowing through the apparatus. One method comprises manipulating a casing joint by mechanically gripping an interior thereof, hydraulically gripping the interior of the casing joint responsive to drilling fluid pressure, and rotating the casing joint. Another method comprises driving casing by applying weight and torque thereto through engagement with an interior thereof.

Abstract: Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

Abstract: Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

Abstract: An apparatus and methods for manipulating and driving casing. The apparatus includes mechanically responsive elements for gripping an interior of a casing joint, and hydraulically responsive elements for gripping an interior of the casing joint responsive to pressure of drilling fluid flowing through the apparatus. One method comprises manipulating a casing joint by mechanically gripping an interior thereof, hydraulically gripping the interior of the casing joint responsive to drilling fluid pressure, and rotating the casing joint. Another method comprises driving casing by applying weight and torque thereto through engagement with an interior thereof.

Abstract: Methods, storage mediums, and systems for correlating pulses generated from multiple interrogation regions in a flow cytometer to particular particles flowing through the flow cytometer are provided. Embodiments of the methods, storage mediums, and systems include configurations for calibrating a flow cytometer using a calibration particle having a unique signature to determine a time-of-flight for particles flowing through the flow cytometer. Based on the calculated time-of-flight and relative positions of interrogation regions corresponding to collectors of the flow cytometer, the methods, storage mediums, and systems may further include configurations for associating other signal pulses to particles of one or more different particle sets.