Abstract: A downhole releasable tubular connection includes a joint between two tubing strings, wherein one of the two tubing strings is radially expanded and plastically deformed by an expansion device. When the expansion device is moved adjacent to the joint, a threaded connection mechanism in the joint reacts to the radially outward forces of the expansion device and releasably expands, thereby decoupling the tubing strings.

Abstract: A door locking system includes a first door and a second door positioned adjacent to each other and one of which is a sliding door. A mounting plate is mounted on the first door adjacent to the second door. A hinge plate has a hinged edge hingedly coupled to the mounting plate and is selectively positioned in a deployed position extending outwardly from the mounting plate. A stop includes a leg and an arcuate arm attached to the leg. The leg and arm are each hingedly coupled to the mounting plates and traverse the hinge plate. The stop releasably engages the hinge plate when the hinge plate is in the deployed position to retain the hinge plate in the deployed position and prevent the sliding of the first and second doors with respect to each other.

Abstract: A security seal for a latch and hasp closure or a similar closure including a flexible, elongated strap seal having an elongated opening therein for receiving a hasp. The seal further includes a locking post and a corresponding socket provided with one or more locking means for engaging the locking post so that the locking post cannot be removed without damaging the seal. The seal is also provided with an identification flag that is in a fixed positioned relative to the opening of the strap so that information displayed on the flag can be easily read or scanned without having to manipulate the seal.

Abstract: A combination article encircling band and coupon or ticket wherein the band is formed by overlapping and contacting spaced adhesive areas formed on opposite surfaces of a strip of material and the coupon or ticket is severable along a line of weakness in the strip material from the band. The combination may be use for advertising and promoting purposes such that information indicia on the band may be related to information indicia on the coupon or ticket.

Abstract: Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.

Abstract: Provided herein are methods for detection of miRNA in a sample. In certain embodiments, the sample comprises RNA and is derived from a cell or tissue. The methods of detection employ a competitor molecule to allow for detection of an miRNA in the presence of an anti-miRNA oligonucleotide.

Abstract: A method is provided for balancing a disc brake rotor having a first annular friction plate, a second annular friction plate, and a core gap. The first annular friction plate includes a first circumferential surface. The second annular friction plate includes a second circumferential surface. Respective regions are determined for removing material within the first circumferential surface and the second circumferential surface for balancing the disc brake rotor if the disc brake rotor is out of balance. A rotary straddle cutting tool is aligned with respective regions of the first circumferential surface and the second circumferential surface. Material is cut from the respective regions of the first circumferential surface and the second circumferential surface with the rotary straddle cutting tool. Cutting material from the respective regions includes removing material within the width of the first circumferential surface and the second circumferential surface.

Abstract: An orthotic device/system and method including at least one energy storage component and at least one trigger component which prevents release of the stored energy until the desired point in the movement cycle of an extremity. Use of the device/system and method permits, among other things, the orthosis to capture energy from the force present between a patient and a supporting surface and return it at a specified point in the movement cycle of the subject's extremity.

Abstract: Provided herein are methods for detection of miRNA in a sample. In certain embodiments, the sample comprises RNA and is derived from a cell or tissue. The methods of detection employ a competitor molecule to allow for detection of an miRNA in the presence of an anti-miRNA oligonucleotide.

Abstract: A security seal for a latch and hasp closure or a similar closure including a flexible, elongated strap seal having an elongated opening therein for receiving a hasp. The seal further includes a locking post and a corresponding socket provided with one or more locking means for engaging the locking post so that the locking post cannot be removed without damaging the seal. The seal is also provided with an identification flag that is in a fixed positioned relative to the opening of the strap so that information displayed on the flag can be easily read or scanned without having to manipulate the seal.

Abstract: The present invention is a safety shield assembly having a shield and a collar for connecting the shield to a fluid handling device whereby the shield may be pivoted with respect to the collar. Preferably, the safety shield assembly may be used with a needle assembly, an intravenous infusion set a syringe, a catheter or other fluid handling devices or assemblies that contain piercing elements.

Abstract: The present invention is a method for assembling a safety shield assembly and more particularly a method for assembling a safety shield assembly with a fluid handling device. Preferably, the safety shield assembly may be assembled with a needle assembly, an intravenous infusion set a syringe, a catheter or other fluid handling devices or assemblies that contain piercing elements.

Abstract: Compositions and methods for the treatment of asthma with oligonucleotides which specifically hybridize with nucleic acids encoding B7 proteins.

Abstract: A system and method for reliable delivery of datagram protocol data unit (PDU) packets generated by a network oriented application at a first computing network element to a second computing network element across a network. The method steps include: at the first computing network element, capturing generated datagram packets destined for the second computing network element; determining a size of a payload associated with the datagram and communicating the size of the payload to the second computing element via a reliable connection-oriented transport service PDU; communicating the actual payload to the second computing element via the reliable connection-oriented transport service PDU; and, at the second computing network element, utilizing payload size and payload to reconstruct a datagram PDU including the payload for a network application at the second computing network element. By this technique, reliable datagram PDU transport over the network is ensured.

Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of hepcidin in a cell, tissue or animal or preventing, ameliorating or treating anemia. Also provided are methods for prevention, amelioration or treatment of anemia, and for increasing red blood cell count in an animal. Also provided are methods for the prevention, amelioration and/or treatment of low serum iron levels, low red blood cell count and other clinical endpoints of anemia in an animal. These methods may be achieved by administration of compounds or compositions including antisense compounds targeted to a nucleic acid that expresses hepcidin polypeptide combined with an erythropoiesis stimulating agent.

Abstract: Modified oligonucleotides having a GGG motif sequence and a sufficient number of flanking nucleotides to modulate the telomere length of a chromosome are provided. Methods of modulating telomere length of a mammalian chromosome in vitro and in vivo are also provided, as are methods for inhibiting the division of a malignant mammalian cell and for modulating the effects of cellular aging.

Abstract: Compounds, compositions and methods are provided for modulating the expression of thyroid hormone receptor interactor 3. The compositions comprise oligonucleotides, targeted to nucleic acid encoding thyroid hormone receptor interactor 3.

Abstract: Compounds, compositions and methods are provided for modulating the expression of ACE2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding ACE2. Methods of using these compounds for modulation of ACE2 expression and for diagnosis and treatment of diseases and conditions associated with expression of ACE2 are provided.

Abstract: Compounds, compositions and methods are provided for modulating the expression of ACE2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding ACE2. Methods of using these compounds for modulation of ACE2 expression and for diagnosis and treatment of diseases and conditions associated with expression of ACE2 are provided.

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of CD40. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD40. Methods of using these compounds for modulation of CD40 expression and for treatment of diseases associated with CD40 are provided.