Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Phospholipase A2, group IIA (synovial). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Phospholipase A2, group IIA (synovial). Methods of using these compounds for modulation of Phospholipase A2, group IIA (synovial) expression and for treatment of diseases associated with expression of Phospholipase A2, group IIA (synovial) are provided.

Abstract: The present invention provides compositions and methods for reducing levels of a preselected mRNA, using antisense compounds targeted to a splice site or a region up to 50 nucleobases upstream of an exon/intron junction on said mRNA. Preferably, said antisense compounds do not elicit RNAse H cleavage of the mRNA.

Abstract: Compounds, compositions and methods are provided for modulating the expression of CEACAM1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding CEACAM1. Methods of using these compounds for modulation of CEACAM1 expression and for diagnosis and treatment of disease associated with expression of CEACAM1 are provided.

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of calreticulin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding calreticulin. Methods of using these compounds for modulation of calreticulin expression and for treatment of diseases associated with expression of calreticulin are provided.

Abstract: The present invention provides design and synthesis of oligomeric compounds and compositions that can be administered to reduce the activity of SARS virus in vivo or in vitro, to prevent or treat SARS virus-associated disease, to detect AARS virus, and to diagnose SARS virus-associated diseases.

Abstract: Compounds, compositions and methods are provided for modulating the expression of phosphodiesterase 4B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding phosphodiesterase 4B. Methods of using these compounds for modulation of phosphodiesterase 4B expression and for diagnosis and treatment of disease associated with expression of phosphodiesterase 4B are provided.

Abstract: Compounds, compositions and methods are provided for modulating the expression of aminopeptidase N. The compositions comprise oligonucleotides, targeted to nucleic acid encoding aminopeptidase N. Methods of using these compounds for modulation of aminopeptidase N expression and for diagnosis and treatment of disease associated with expression of aminopeptidase N are provided.

Abstract: Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor-? (TNF-?). Antisense oligonucleotides targeted to nucleic acids encoding TNF-? are preferred. Methods of using these oligonucleotides for inhibition of TNF-? expression and for treatment of diseases, particularly inflammatory and autoimmune diseases, associated with overexpression of TNF-? are provided.

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.

Abstract: This novel silent operating mode for a hybrid electric vehicle (HEV) reduces noise and emissions compared to traditional HEV operating modes. It is a complementary series of software control functions that allows the vehicle to operate with reduced noise and emissions where specifically needed, while phasing-in engine power where allowed. The method utilizes an energy storage system budget associated with a modal quantity of energy allocated for the mode, and is adapted to automatically adjust the operation of the vehicle to accommodate deviations from the budgeted energy amount. The mode also adjusts the vehicle operation in conjunction with changes in the parametric conditions of the ESS.

Abstract: An automated voting system comprising single or multiple voting stations for controlling and being a voting station simultaneously. The voting system includes an integrated pointing device with graphical user interface for displaying the ballots. The voting stations may or may not be interconnected and indeed may operate as a single unit as a complete polling station. The voting system will track the number of votes and continuously display the number of votes cast on a counter system as it clearly displays the voter intent. The automated voting system also provides security for the voter and the system both internal and external. The external security system may be controlled by the polling authorities while the internal security system operates independently. The automated voting system is also capable of providing multiple ballot styles in one or more voting units and provides a touch electronic keyboard for write-in candidates.

Abstract: A method is described for use with a server serving requested records among a multiplicity of records, and with a predetermined list of record identifiers, and with a first file containing information about records corresponding to the record identifiers. The method comprises the steps of: selecting at least two of the record identifiers from the list; for each one record identifier of the record identifiers: presenting a request to the server with respect to the record identifier; receiving a record from the server, said record corresponding to the record identifier; parsing the record, thereby deriving received information of interest from the record; comparing the received information of interest with corresponding information in the first file; and annunciating any difference between the received information of interest and the corresponding information in the first file.

Abstract: A method and apparatus reports alarm events detected by an alarm system having a plurality of users, each user having a name and identified by an identifier other than the name. The system detects an event of interest relating to a user, creates a data stream indicative of the event and indicative of the identifier of the user, extracts from the data stream the identifier of the user, determines the name of the user based upon the identifier of the user, selects a message recipient based upon the event of interest, creates a text message addressed to the selected message recipient, the text message communicating the name of the user and communicating information indicative of the event of interest, and transmits the text message via a global communications network.

Abstract: A system and method for reliabe delivery of datagram protocol data unit (PDU) packets generated by a network oriented application at a first computing network element to a second computing network element across a network. The method steps include: at the first computing network element, capturing generated datagram packets destined for the second computing network element; determining a size of a payload associated with the datagram and communicating the size of the payload to the second computing element via a reliable connection-oriented transport service PDU; communicating the actual payload to the second computing element via the reliable connection-oriented transport service PDU; and, at the second computing network element, utilizing payload size and payload to reconstruct a datagram PDU including the payload for a network application at the second computing network element. By this technique, reliable datagram PDU transport over the network is ensured.

Abstract: A system and method for reliably delivery of datagram protocol data unit (PDU) packets generated by a network oriented application at a first computing network element to a second computing network element across a network. The method steps include: at the first computing network element, capturing generated datagram packets destined for the second computing network element; determining a size of a payload associated with the datagram and communicating the size of the payload to the second computing element via a reliable connection-oriented transport service; communicating the actual payload to the second computing element via the reliable connection-oriented transport service; and, at the second computing network element, utilizing payload size and payload to reconstruct a datagram PDU including the payload for a network application at the second computing network element. By this technique, reliable datagram PDU transport over the network is ensured.

Abstract: A framework for service personalization based upon a users personal profile is provided. The framework includes a method of providing service personalization (SP) in which a user agent identifies itself as being service personalization enabled to being a SP session. A SP engine assigns a unique identifier to the user agent for tagging all subsequent traffic from that subscriber. The SP engine establishes direct communications between the user agent and an appropriate entity for obtaining information on the location of the subscriber profile and derives personalization rules to form a personalization rule module that encodes criteria for performing personalization functions on user traffic. When a specific subscriber request for content is received, the SP engine invokes the personalization rules of the personalization rule module for application to content requested. It is important to note that the personalization rules can be invoked in one of four places, in two general categories.

Abstract: A method of redirecting content requests among content distribution network peers. In operation, a client sends a request for content to a content distribution network (CDN). When this CDN does not currently have the capacity to deliver the content, the CDN refers to one or more content distribution tables to see if the neighbour peers are able to provide this content. The content distribution table is populated at the time of distribution of the content. When the neighbour peer has this content, the request is redirected to the neighbour peer. In redirecting request, an address of the neighbour peer is appending to the previous address such that each peer receiving the request knows where the request came from and where it has been previously.

Abstract: Pressure sensitive adhesive articles and methods, particularly stretch removable adhesive articles that are preferably for use in adhering to skin or like delicate surfaces. Preferably, stretch removability of the article occurs as a result of the selection of a stretch removable pressure sensitive adhesive. In one embodiment of the articles and methods, the adhesive and backing delaminate upon removal. In another embodiment of the articles and methods, the backing includes a predefined tab located in a central location of the backing.

Abstract: The present invention is a safety shield assembly having a shield and a collar for connecting the shield to a fluid handling device whereby the shield may be pivoted with respect to the collar. Preferably, the safety shield assembly may be used with a needle assembly, an intravenous infusion set a syringe, a catheter or other fluid handling devices or assemblies that contain piercing elements.