Patents by Inventor C. Bennett

C. Bennett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligomeric compounds and compositions for use in modulation small non-coding RNAs
    Publication number: 20050261218
    Abstract: Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
    Type: Application
    Filed: July 30, 2004
    Publication date: November 24, 2005
    Inventors: Christine Esau, Bridget Lollo, C. Bennett, Susan Freier, Richard Griffey, Brenda Baker, Timothy Vickers, Eric Marcusson, Erich Koller, Eric Swayze, Ravi Jain, Balkrishen Bhat, Eigen Peralta
  • Antisense modulation of TFAP2C expression
    Publication number: 20050227938
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.
    Type: Application
    Filed: December 17, 2004
    Publication date: October 13, 2005
    Inventors: C. Bennett, Brenda Baker, Nicholas Dean, Brett Monia, Susan Freier, James Karras, Hong Zhang, Susan Murray, Madeline Butler, Erich Koller, Thomas Condon, William Gaarde, Andrew Watt, Mark Graham, Jacqueline Wyatt, Lex Cowsert, Kenneth Dobie, Mark Roach
  • Modulation of kallikrein 6 expression
    Publication number: 20050227939
    Abstract: Compounds, compositions and methods are provided for modulating the expression of kallikrein 6. The compositions comprise oligonucleotides, targeted to nucleic acid encoding kallikrein 6. Methods of using these compounds for modulation of kallikrein 6 expression and for diagnosis and treatment of disease associated with expression of kallikrein 6 are provided.
    Type: Application
    Filed: January 14, 2005
    Publication date: October 13, 2005
    Inventors: C. Bennett, Brett Monia, Nicholas Dean, Sanjay Bhanot, Donna Ward, Lex Cowsert, Kenneth Dobie
  • Hepatocyte free uptake assays
    Publication number: 20050221275
    Abstract: The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.
    Type: Application
    Filed: April 14, 2004
    Publication date: October 6, 2005
    Inventors: C. Bennett, Robert McKay, Brett Monia, Brenda Baker, Namir Sioufi
  • Antisense modulation of thyroid hormone receptor interactor 6 expression
    Publication number: 20050222073
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of thyroid hormone receptor interactor 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding thyroid hormone receptor interactor 6. Methods of using these compounds for modulation of thyroid hormone receptor interactor 6 expression and for treatment of diseases associated with expression of thyroid hormone receptor interactor 6 are provided.
    Type: Application
    Filed: March 2, 2005
    Publication date: October 6, 2005
    Inventors: C. Bennett, Brett Monia, Rosanne Crooke, Mark Graham, Susan Freier, Pamela Nero, Edward Wancewicz, Nicholas Dean, Lex Cowsert, Kenneth Dobie
  • Antisense modulation of sterol regulatory element-binding protein-1 expression
    Publication number: 20050215504
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.
    Type: Application
    Filed: December 16, 2004
    Publication date: September 29, 2005
    Inventors: C. Bennett, Susan Freier, Nicholas Dean, Brett Monia, William Gaarde, James Karras, Hong Zhang, Robert McKay, Donna Ward, Lex Cowsert, Erich Koller, Jacqueline Wyatt, Mark Roach, Andrew Watt, Brenda Baker, Kenneth Dobie
  • Modulation of tyrosinase expression
    Publication number: 20050215506
    Abstract: Compounds, compositions and methods are provided for modulating the expression of tyrosinase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding tyrosinase.
    Type: Application
    Filed: March 2, 2005
    Publication date: September 29, 2005
    Inventors: C. Bennett, Thomas Condon, Susan Freier, James Karras, Susan Fitch, Ravi Jain, Kenneth Dobie
  • Antisense modulation of cellular inhibitor of Apoptosis-2 expression
    Publication number: 20050203045
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Cellular Inhibitor of Apoptosis-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Cellular Inhibitor of Apoptosis-2. Methods of using these compounds for modulation of Cellular Inhibitor of Apoptosis-2 expression and for treatment of diseases associated with expression of Cellular Inhibitor of Apoptosis-2 are provided.
    Type: Application
    Filed: February 1, 2005
    Publication date: September 15, 2005
    Inventors: C. Bennett, Elizabeth Ackermann, Lex Cowsert
  • Antisense modulation of dual specific phosphatase 5 expression
    Publication number: 20050197309
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of dual specific phosphatase 5. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding dual specific phosphatase 5. Methods of using these compounds for modulation of dual specific phosphatase 5 expression and for treatment of diseases associated with expression of dual specific phosphatase 5 are provided.
    Type: Application
    Filed: January 14, 2005
    Publication date: September 8, 2005
    Inventors: C. Bennett, Brett Monia, Susan Freier, Christopher Mirabelli, Ian Popoff, Jacqueline Wyatt, Andrew Watt, Kenneth Dobie
  • Compositions and their uses directed to cell growth and maintenance proteins
    Publication number: 20050186594
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of G protein-coupled receptor kinase 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding G protein-coupled receptor kinase 6. Methods of using these compounds for modulation of G protein-coupled receptor kinase 6 expression and for treatment of diseases associated with expression of G protein-coupled receptor kinase 6 are provided.
    Type: Application
    Filed: December 17, 2004
    Publication date: August 25, 2005
    Inventors: C. Bennett, Susan Freier, Nicholas Dean, Ian Popoff, Brett Monia, Donna Ward, Ming-Yi Chiang, Ravi Jain, Kenneth Dobie
  • Modulation of DC-SIGN expression
    Publication number: 20050182004
    Abstract: Compounds, compositions and methods are provided for modulating the expression of DC-SIGN. The compositions comprise oligonucleotides, targeted to nucleic acid encoding DC-SIGN. Methods of using these compounds for modulation of DC-SIGN expression and for diagnosis and treatment of diseases and conditions associated with expression of DC-SIGN are provided.
    Type: Application
    Filed: February 11, 2004
    Publication date: August 18, 2005
    Inventors: C. Bennett, Kenneth Dobie, Susan Gregory
  • Modulation of glucocorticoid receptor expression
    Publication number: 20050164271
    Abstract: Compounds, compositions and methods are provided for modulating the expression of glucocorticoid receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucocorticoid receptor. Methods of using these compounds for modulation of glucocorticoid receptor expression and for diagnosis and treatment of diseases and conditions associated with expression of glucocorticoid receptor are provided.
    Type: Application
    Filed: January 20, 2005
    Publication date: July 28, 2005
    Inventors: Sanjay Bhanot, Kenneth Dobie, Susan Freier, Nicholas Dean, C. Bennett
  • Hepatocyte free uptake assays
    Publication number: 20050164209
    Abstract: The present invention provides methods of identifying an oligomeric compound having bioactivity in vivo, methods of identifying a small interfering RNA having bioactivity in vivo, and kits.
    Type: Application
    Filed: January 23, 2004
    Publication date: July 28, 2005
    Inventors: C. Bennett, Robert McKay, Brett Monia, Brenda Baker
  • Compositions and their uses directed to metabolic proteins
    Publication number: 20050164254
    Abstract: Compounds, compositions and methods are provided for modulating the expression of adipophilin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding adipophilin. Methods of using these compounds for modulation of adipophilin expression and for diagnosis and treatment of diseases and conditions associated with expression of adipophilin are provided.
    Type: Application
    Filed: December 9, 2004
    Publication date: July 28, 2005
    Inventors: C. Bennett, Brett Monia, Nicholas Dean, Susan Freier, Sanjay Bhanot, Donna Ward, Alexander Borchers, Tamara Sipes, Kenneth Dobie, Ravi Jain
  • Compositions and their uses directed to transferases
    Publication number: 20050153925
    Abstract: Compounds, compositions and methods are provided for modulating the expression of hepatocyte growth factor receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding hepatocyte growth factor receptor. Methods of using these compounds for modulation of hepatocyte growth factor receptor expression and for diagnosis and treatment of disease associated with expression of hepatocyte growth factor receptor are provided.
    Type: Application
    Filed: December 16, 2004
    Publication date: July 14, 2005
    Inventors: C. Bennett, Brett Monia, Nicholas Dean, Susan Freier, Brenda Baker, Donna Ward, William Gaarde, Lex Cowsert, Andrew Watt, Kenneth Dobie
  • Antisense modulation of interferon gamma receptor 2
    Publication number: 20050153924
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Interferon gamma receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interferon gamma receptor 2. Methods of using these compounds for modulation of Interferon gamma receptor 2 expression and for treatment of diseases associated with expression of Interferon gamma receptor 2 are provided.
    Type: Application
    Filed: December 15, 2004
    Publication date: July 14, 2005
    Inventors: C. Bennett, Brett Monia, Susan Murray, Madeline Butler, Nicholas Dean, Rosanne Crooke, Mark Graham, Hong Zhang, Susan Freier, Brenda Baker, Eric Marcusson, Jacqueline Wyatt, Lex Cowsert, Kenneth Dobie, Andrew Watt
  • Compositions and their uses directed to nucleic acid binding proteins
    Publication number: 20050153336
    Abstract: Compounds, compositions and methods are provided for modulating the expression of STAT2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT2. Methods of using these compounds for modulation of STAT2 expression and for diagnosis and treatment of diseases and conditions associated with expression of STAT2 are provided.
    Type: Application
    Filed: December 3, 2004
    Publication date: July 14, 2005
    Inventors: C. Bennett, Kenneth Dobie
  • Modulation of RANKL expression
    Publication number: 20050148533
    Abstract: Compounds, compositions and methods are provided for modulating the expression of RANKL. The compositions comprise oligonucleotides, targeted to nucleic acid encoding RANKL. Methods of using these compounds for modulation of RANKL expression and for diagnosis and treatment of disease associated with expression of RANKL are provided.
    Type: Application
    Filed: September 17, 2004
    Publication date: July 7, 2005
    Inventors: Brenda Baker, C. Bennett, Kenneth Dobie, Kathleen Myers, Joshua Finger, Lex Cowsert
  • Microrna as ligands and target molecules
    Publication number: 20050142581
    Abstract: The present invention provides methods for the identification of target molecules that bind to ligands, particularly microRNA ligands and mimics thereof and/or microRNA target molecules and mimics thereof, with as little as millimolar (mM) affinity using mass spectrometry. The methods may be used to determine the mode of binding interaction between two or more of these target molecules to the ligand as well as their relative affinities. Also provided are methods for designing compounds having greater affinity to a ligand by identifying two or more target molecules using mass spectrometry methods of the invention and linking the target molecules together to form a novel compound.
    Type: Application
    Filed: September 3, 2004
    Publication date: June 30, 2005
    Inventors: Richard Griffey, C. Bennett, David Ecker, Donna Ward, Susan Freier
  • Antisense modulation of survivin expression
    Publication number: 20050143335
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.
    Type: Application
    Filed: November 8, 2004
    Publication date: June 30, 2005
    Applicant: ISIS PHARMACEUTICALS, INC.
    Inventors: C. Bennett, Eric Swayze, Elizabeth Ackermann, Lex Cowsert