Patents by Inventor C. Bennett

C. Bennett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metal matrix composite structure and method
    Patent number: 7141310
    Abstract: Compound preforms are provided having a first region, including a porous ceramic and a second region including a porous or solid ceramic in which the two regions differ in composition. The compound preform is infiltrated with a liquid metal which is then solidified to form a metal matrix composite.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: November 28, 2006
    Assignee: Ceramics Process Systems Corporation
    Inventors: Richard W. Adams, Grant C. Bennett, Kevin Fennessy, Robert A. Hay, Mark Occhionero
  • Silent operating mode for reducing emissions of a hybrid electric vehicle
    Patent number: 7127337
    Abstract: This novel silent operating mode for a hybrid electric vehicle (HEV) reduces noise and emissions compared to traditional HEV operating modes. It is a complementary series of software control functions that allows the vehicle to operate with reduced noise and emissions where specifically needed, while phasing-in engine power where allowed. The method utilizes an energy storage system budget associated with a modal quantity of energy allocated for the mode, and is adapted to automatically adjust the operation of the vehicle to accommodate deviations from the budgeted energy amount. The mode also adjusts the vehicle operation in conjunction with changes in the parametric conditions of the ESS.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: October 24, 2006
    Assignee: General Motors Corporation
    Inventors: Adam C. Bennett, William R. Cawthorne, Tung-Ming Hsieh, Gregory A. Hubbard
  • Antisense modulation of integrin beta 4 binding protein expression
    Publication number: 20060172957
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Integrin beta 4 binding protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Integrin beta 4 binding protein. Methods of using these compounds for modulation of Integrin beta 4 binding protein expression and for treatment of diseases associated with expression of Integrin beta 4 binding protein are provided.
    Type: Application
    Filed: November 13, 2001
    Publication date: August 3, 2006
    Inventors: C. Bennett, Susan Freler
  • Antisense modulation of CD40 ligand expression
    Publication number: 20060160758
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of CD40 ligand. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD40 ligand. Methods of using these compounds for modulation of CD40 ligand expression and for treatment of diseases associated with expression of CD40 ligand are provided.
    Type: Application
    Filed: January 20, 2005
    Publication date: July 20, 2006
    Inventors: C. Bennett, Susan Freier, Brenda Baker, Brett Monia, Nicholas Dean, Hong Zhang, Susan Murray, Lex Cowsert, Madeline Butler, Robert McKay, Donna Ward, William Gaarde, Ian Popoff, Jacqueline Wyatt, Andrew Watt
  • Stretch removable adhesive articles and methods
    Patent number: 7078582
    Abstract: Pressure sensitive adhesive articles and methods, particularly stretch removable adhesive articles that are preferably for use in adhering to skin or like delicate surfaces. Preferably, stretch removability of the article occurs as a result of the selection of a stretch removable pressure sensitive adhesive. In one embodiment of the articles and methods, the adhesive and backing delaminate upon removal. In another embodiment of the articles and methods, the backing includes a predefined tab located in a central location of the backing.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: July 18, 2006
    Assignee: 3M Innovative Properties Company
    Inventors: William L. Stebbings, Kevin D. Landgrebe, Dave J. Hastings, Wayne K. Dunshee, Albert I. Everaerts, Zhiming Zhou, Robert C. Bennett
  • Modulation of SLC26A2 expression
    Publication number: 20060154885
    Abstract: Compounds, compositions and methods are provided for modulating the expression of SLC26A2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SLC26A2. Methods of using these compounds for modulation of SLC26A2 expression and for diagnosis and treatment of disease associated with expression of SLC26A2 are provided.
    Type: Application
    Filed: March 4, 2005
    Publication date: July 13, 2006
    Inventors: C. Bennett, Brett Monia, Nicholas Dean, Xiaoxing Xu, Sanjay Bhanot, Brenda Baker, Susan Freier, Lex Cowsert, Robert McKay, Muthiah Manoharan, F. Dorr, Jon Holmlund, Alexander Borchers, Vickie Brown-Driver, Jacqueline Wyatt, Shin Flournoy, Elizabeth Ackermann, Hong Zhang, Andrew Watt, Eric Maracusson, Scott Cooper, Erich Koller, Loren Miraglia, William Ricketts, Kenneth Dobie, Tamara Sipes
  • Use of antisense oligonucleotide libraries for identifying gene function
    Publication number: 20060099613
    Abstract: A method for identifying one or more genes involved in a phenotype of cells, tissues or organisms, comprising the steps of contacting cells, tissues or organisms which exhibit the phenotype with a library of antisense oligonucleotides and performing a primary phenotypic assay to determine which antisense oligonucleotides in the library attenuate the phenotype. These antisense oligonucleotides correspond to genes involved in the phenotype. The method may be used to identify genes involved in various disease states.
    Type: Application
    Filed: September 9, 2005
    Publication date: May 11, 2006
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: C. Bennett, Alexander Borchers, James Karras
  • Conjugates for use in hepatocyte free uptake assays
    Publication number: 20060084094
    Abstract: The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.
    Type: Application
    Filed: September 7, 2005
    Publication date: April 20, 2006
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: C. Bennett, Robert McKay, Brett Monia, Brenda Baker, Namir Sioufi, Richard Griffey, Balkrishen Bhat, Eric Swayze
  • Antisense modulation of MEKK4 expression
    Publication number: 20060019920
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.
    Type: Application
    Filed: July 11, 2005
    Publication date: January 26, 2006
    Inventors: C. Bennett, Susan Freier, Brett Monia, Nicholas Dean, Hong Zhang, Robert McKay, Donna Ward, William Gaarde, Jacqueline Wyatt, Andrew Watt, Rosanne Crooke, Mark Graham, Pamela Nero, Kenneth Dobie, Alexander Borchers, Eric Marcusson, Mark Roach
  • Compositions and their uses directed to bone growth modulators
    Publication number: 20060003953
    Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of a bone growth modulator in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
    Type: Application
    Filed: December 3, 2004
    Publication date: January 5, 2006
    Inventors: C. Bennett, Madeline Butler, Nicholas Dean, Kenneth Dobie, Joshua Finger, Ravi Jain, Robert McKay, Brett Monia, Kathleen Myers
  • Antisense modulation of p70 S6 kinase expression
    Publication number: 20050267063
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of p70 S6 kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding p70 S6 kinase. Methods of using these compounds for modulation of p70 S6 kinase expression and for treatment of diseases associated with expression of p70 S6 kinase are provided.
    Type: Application
    Filed: April 27, 2005
    Publication date: December 1, 2005
    Inventors: C. Bennett, Brett Monia, Susan Freier, Brenda Baker, William Gaarde, Erich Koller, Susan Murray, Andrew Watt, Jacqueline Wyatt, Pamela Nero, Mark Roach, Lex Cowsert, Kenneth Dobie
  • Oligomeric compounds and compositions for use in modulation small non-coding RNAs
    Publication number: 20050261218
    Abstract: Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
    Type: Application
    Filed: July 30, 2004
    Publication date: November 24, 2005
    Inventors: Christine Esau, Bridget Lollo, C. Bennett, Susan Freier, Richard Griffey, Brenda Baker, Timothy Vickers, Eric Marcusson, Erich Koller, Eric Swayze, Ravi Jain, Balkrishen Bhat, Eigen Peralta
  • Antisense modulation of interleukin 12 P35 subunit expression
    Publication number: 20050261228
    Abstract: Compounds, compositions and methods are provided for modulating the expression of Interleukin 12 p35 subunit. The compositions comprise chemically modified antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interleukin 12 p35 subunit. Methods of using these compounds for modulation of Interleukin 12 p35 subunit expression and for treatment of diseases associated with expression of Interleukin 12 p35 subunit are provided.
    Type: Application
    Filed: March 23, 2005
    Publication date: November 24, 2005
    Inventors: C. Bennett, Brenda Baker, Susan Freier, Susan Gregory, Ronnie Hanecak, Kevin Anderson, Ming-Yi Chiang, Vickie Brown-Driver, David Ecker, Timothy Vickers, Jacqueline Wyatt, Eric Marcusson, Nicholas Dean, Sanjay Bhanot, Elizabeth Ackermann, Lex Cowsert
  • Antisense modulation of TFAP2C expression
    Publication number: 20050227938
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.
    Type: Application
    Filed: December 17, 2004
    Publication date: October 13, 2005
    Inventors: C. Bennett, Brenda Baker, Nicholas Dean, Brett Monia, Susan Freier, James Karras, Hong Zhang, Susan Murray, Madeline Butler, Erich Koller, Thomas Condon, William Gaarde, Andrew Watt, Mark Graham, Jacqueline Wyatt, Lex Cowsert, Kenneth Dobie, Mark Roach
  • Modulation of kallikrein 6 expression
    Publication number: 20050227939
    Abstract: Compounds, compositions and methods are provided for modulating the expression of kallikrein 6. The compositions comprise oligonucleotides, targeted to nucleic acid encoding kallikrein 6. Methods of using these compounds for modulation of kallikrein 6 expression and for diagnosis and treatment of disease associated with expression of kallikrein 6 are provided.
    Type: Application
    Filed: January 14, 2005
    Publication date: October 13, 2005
    Inventors: C. Bennett, Brett Monia, Nicholas Dean, Sanjay Bhanot, Donna Ward, Lex Cowsert, Kenneth Dobie
  • Antisense modulation of thyroid hormone receptor interactor 6 expression
    Publication number: 20050222073
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of thyroid hormone receptor interactor 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding thyroid hormone receptor interactor 6. Methods of using these compounds for modulation of thyroid hormone receptor interactor 6 expression and for treatment of diseases associated with expression of thyroid hormone receptor interactor 6 are provided.
    Type: Application
    Filed: March 2, 2005
    Publication date: October 6, 2005
    Inventors: C. Bennett, Brett Monia, Rosanne Crooke, Mark Graham, Susan Freier, Pamela Nero, Edward Wancewicz, Nicholas Dean, Lex Cowsert, Kenneth Dobie
  • Hepatocyte free uptake assays
    Publication number: 20050221275
    Abstract: The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.
    Type: Application
    Filed: April 14, 2004
    Publication date: October 6, 2005
    Inventors: C. Bennett, Robert McKay, Brett Monia, Brenda Baker, Namir Sioufi
  • Antisense modulation of sterol regulatory element-binding protein-1 expression
    Publication number: 20050215504
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.
    Type: Application
    Filed: December 16, 2004
    Publication date: September 29, 2005
    Inventors: C. Bennett, Susan Freier, Nicholas Dean, Brett Monia, William Gaarde, James Karras, Hong Zhang, Robert McKay, Donna Ward, Lex Cowsert, Erich Koller, Jacqueline Wyatt, Mark Roach, Andrew Watt, Brenda Baker, Kenneth Dobie
  • Modulation of tyrosinase expression
    Publication number: 20050215506
    Abstract: Compounds, compositions and methods are provided for modulating the expression of tyrosinase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding tyrosinase.
    Type: Application
    Filed: March 2, 2005
    Publication date: September 29, 2005
    Inventors: C. Bennett, Thomas Condon, Susan Freier, James Karras, Susan Fitch, Ravi Jain, Kenneth Dobie
  • Antisense modulation of cellular inhibitor of Apoptosis-2 expression
    Publication number: 20050203045
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Cellular Inhibitor of Apoptosis-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Cellular Inhibitor of Apoptosis-2. Methods of using these compounds for modulation of Cellular Inhibitor of Apoptosis-2 expression and for treatment of diseases associated with expression of Cellular Inhibitor of Apoptosis-2 are provided.
    Type: Application
    Filed: February 1, 2005
    Publication date: September 15, 2005
    Inventors: C. Bennett, Elizabeth Ackermann, Lex Cowsert